Assessment the appropriate period to improve nasal breathing disorder using 4D masticatory motion analysis system

• Project/Area Number: 19K19260
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 57070:Developmental dentistry-related
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: Abe Yasunori 東京医科歯科大学, 医歯学総合研究科, 非常勤講師 (20822513)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Project Status: Completed (Fiscal Year 2021)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2021: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 成長期 / 鼻呼吸障害 / 皮質咀嚼野 / 咀嚼運動 / 咀嚼野 / 大脳皮質咀嚼野 / 咀嚼筋活動

Outline of Research at the Start

近年、鼻呼吸障害を有する子どもが増えており、成長期の鼻呼吸障害は顔の形や歯並びに影響を及ぼすとされている。しかし、鼻呼吸障害が見た目だけでなく噛み合わせの機能にどのような変化を引き起こすかは明らかにされていない。本研究では電気生理学的手法に３次元画像解析を統合した４次元解析システムを用いて、「鼻呼吸障害を改善すべき適正時期の解明」を試みる。本研究の成果は、適切な時期に適切な治療を提供する糸口となり、豊かな食生活を提供しQOLの向上に寄与すると考えられる。

Outline of Final Research Achievements

In recent years, the number of children with nasal obstruction during the growth period has been increasing, and it has been reported that nasal obstruction during the growth period impair morphogenesis, motor control function, memory and learning function of maxillofacial region. The purpose of this study was to evaluate the effects of nasal obstruction on the development of cortical masticatory areas and the development of masticatory movements caused by electrical stimulation of cortical masticatory areas at each stage of growth. As a result, it was clarified that the nasal obstruction during the growth period has the physiological effect on both central and peripheral developments of masticatory movement. This study suggests the importance of early diagnosis of deviation from normal development due to nasal obstruction during the growth period and appropriate treatment at the appropriate time.

Academic Significance and Societal Importance of the Research Achievements

本研究では成長期鼻呼吸障害が咀嚼運動の発達に中枢および末梢の両側面に変調を与えることを明らかにし、成長期の鼻呼吸障害は早期に改善すべき重要性を科学的に立証した。本研究から得られる成果は早期矯正歯科治療のガイドラインの一助となりうる。また、従来の生理学的手法に物体の動きをデジタル的に記録する技術であるモーションキャプチャリングを融合した新たな手法を確立したことで、歯学全般、神経生理学、脳神経学、小児歯科学などの多岐にわたる分野への応用や、新しい学問分野の開拓など学術的な波及効果が期待できる。

Research Products

• [Journal Article] Nasal obstruction during the growth period modulates the Wnt/β‐catenin pathway and brain‐derived neurotrophic factor production in association with tyrosine kinase receptor B mRNA reduction in mouse hippocampus (2021)
  • Author(s): Ishidori Hideyuki、Okihara Hidemasa、Ogawa Takuya、Abe Yasunori、Kato Chiho、Aung Phyo Thura、Fujita Akiyo、Kokai Satoshi、Ono Takashi
  • Journal Title: European Journal of Neuroscience Volume: 55 Issue: 1 Pages: 5-17
  • DOI: 10.1111/ejn.15547
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Effects of low occlusal loading on the neuromuscular behavioral development of cortically-elicited jaw movements in growing rats (2021)
  • Author(s): Aung Phyo Thura、Kato Chiho、Fujita Akiyo、Abe Yasunori、Ogawa Takuya、Ishidori Hideyuki、Okihara Hidemasa、Kokai Satoshi、Ono Takashi
  • Journal Title: Scientific Reports Volume: 11.1 Issue: 1 Pages: 1-12
  • DOI: 10.1038/s41598-021-86581-9
  • Peer Reviewed / Open Access
• [Journal Article] Treatment of Class II malocclusion with the improved superelastic nickel-titanium alloy wire and long hooks for mandibular molar protraction (2021)
  • Author(s): Abe Yasunori、Ozaki Shusaku、Matsubara Nozomu、Kirimoto Hiroaki、Ono Takashi
  • Journal Title: AJO-DO Clinical Companion Volume: 1.2 Issue: 2 Pages: 136-153
  • DOI: 10.1016/j.xaor.2021.05.004
  • Peer Reviewed
• [Journal Article] Functional Analysis of Rhythmic Jaw Movements Evoked by Electrical Stimulation of the Cortical Masticatory Area During Low Occlusal Loading in Growing Rats (2020)
  • Author(s): Aung Phyo Thura、Kato Chiho、Abe Yasunori、Ogawa Takuya、Ishidori Hideyuki、Fujita Akiyo、Okihara Hidemasa、Kokai Satoshi、Ono Takashi
  • Journal Title: Frontiers in Physiology Volume: 11 Pages: 1-16
  • DOI: 10.3389/fphys.2020.00034
  • Peer Reviewed / Open Access
• [Presentation] 成長期咀嚼刺激低下はWnt signaling pathwayおよびARHGAP33の分子伝達を変調する (2021)
  • Author(s): 三澤 英里, 沖原 秀政, 小川 卓也, 小海 暁, 阿部 泰典, 加藤 千帆, 石通 秀行, 藤田 秋世, 高野 力磨, 谷川 萌, 孫 文倩, 小野 卓史
  • Organizer: 第80回日本矯正歯科学会
• [Presentation] INVESTIGATION OF THE RELATIONSHIP BETWEEN VERTICAL FACIAL PATTERN, MAXIMUM BITE FORCE, AND CORTICAL BONE THICKNESS OF AN ALVEOLAR PROCESS (2020)
  • Author(s): Yasunori Abe, Yuji Ishida, Shuji Oishi, Makiko Okuzawa-Iwasaki, Aiko Ishizaki, Chiyo Shimizu, Takashi Ono
  • Organizer: The 9th international Orthodontic Congress
  • Int'l Joint Research
• [Presentation] Unilateral nasal obstruction affects development of motor representation in the cortical masticatory area in growing rats (2020)
  • Author(s): Akiyo Fujita, Chiho Kato, Yasunori Abe, Takuya Ogawa, Phyo Thura Aung, Hideyuki Ishidori, Ruixin Li, Hidemasa Okihara, Satoshi Kokai, Takashi Ono
  • Organizer: The 9th international Orthodontic Congress
  • Int'l Joint Research
• [Presentation] Low occlusal loading affects the neuromuscular control of jaw movements induced by anterior part of cortical masticatory area in growing rats (2020)
  • Author(s): Phyo Thura Aung, Chiho Kato, Yasunori Abe, Takuya Ogawa, Hideyuki Ishidori, Akiyo Fujita, Ruixin Li, Hidemasa Okihara, Satoshi Kokai, Takashi Ono
  • Organizer: The 9th international Orthodontic Congress
  • Int'l Joint Research
• [Presentation] Nasal obstruction during growth period modulates the Wnt signaling pathway of mouse (2019)
  • Author(s): 石通秀行、沖原秀政、小川卓也、小海暁、阿部泰典、加藤千帆、ピョースラアン、藤田秋世、小野卓史
  • Organizer: The 78th Annual Meeting of the Japanese Orthodontic Society.