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The relationship between primary cilia and environmental factors during tooth development

Research Project

Project/Area Number 19K19305
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 57070:Developmental dentistry-related
Research InstitutionKanazawa University (2022)
Fukuoka Dental College (2019-2021)

Principal Investigator

OGATA Kayoko  金沢大学, 医学系, 助教 (70830123)

Project Period (FY) 2019-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2021: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2019: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
KeywordsMIM / 形成異常 / 歯 / 歯の発生 / 石灰化 / 歯根形成 / MIH / 発生 / 石灰化機構
Outline of Research at the Start

本研究では、特定の歯種に限局して形成異常を生じる、Molar Incisor Hypomineralization(MIH)やMolar Incisor Malformation(MIM)の原因解明を行うことを目的としている。これらの形成異常を呈する歯は、成長発達期である小児においては健全な口腔機能の獲得に不利となる。そこで、培養細胞と実験動物を用いて、MIHとMIM発症原因を遺伝的因子と環境因子の両方向から探索し、歯の形成への個々の影響とその相乗効果を検証する。

Outline of Final Research Achievements

In recent years, it was reported that a new type of localized abnormal tooth root morphology, Molar-root incisor malformation (MIM). MIM showed root abnormality of regional teeth such as permanent first molars (PFM) and incisors. However, the mechanism of MIM symptoms remains unclear.
We confirmed ectopic mineralization of pulp cavity in and clarified characteristics of it by histological analyses using human teeth diagnosed with MIM. We finally conclude that based on considering the result of in vitro, environmental factors during the period of developing the PFM and incisor possible cause involved in the ectopic calcification of MIM.

Academic Significance and Societal Importance of the Research Achievements

Molar-incisor malformation(MIM)のような形成異常を呈する歯は、保存が困難となり早期に抜歯が必要となる場合があり、成長発達期である小児においては健全な口腔機能の獲得に不利となる。本研究により、MIMの歯に現れる異所性石灰化の原因として、第一大臼歯や切歯の形成時期である出生時や出生後早期の環境因子が関与している可能性が示唆された。この成果は、MIMの原因解明へ向けた端緒となると考えられる。

Report

(5 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (5 results)

All 2020 2019

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Open Access: 3 results) Presentation (1 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Transforming Growth Factor-Beta and Sonic Hedgehog Signaling in Palatal Epithelium Regulate Tenascin-C Expression in Palatal Mesenchyme During Soft Palate Development2020

    • Author(s)
      Shirabe Ohki, Kyoko Oka, Kayoko Ogata, Shigeru Okuhara, Mihoko Rikitake, Masako Toda-Nakamura, Shougo Tamura, Masao Ozaki, Sachiko Iseki, Takayoshi Sakai
    • Journal Title

      Frontiers in physiology

      Volume: 11 Pages: 532-532

    • DOI

      10.3389/fphys.2020.00532

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Ectopic junctional epithelium adhered to the buccal crown surface of an upper central incisor2020

    • Author(s)
      Nakamura Masako Toda、Oka Kyoko、Harada Hana、Ogata Kayoko、Matsuo Satoru、Rikitake Mihoko、Ohki Shirabe、Kumagai Tetsuya、Kato Yoko、Baba Atsuko、Ozaki Masao
    • Journal Title

      Pediatric Dental Journal

      Volume: 30 Issue: 1 Pages: 51-55

    • DOI

      10.1016/j.pdj.2019.11.002

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cyclophosphamide Promotes Arrested Development of the Dental Root in Mice2020

    • Author(s)
      Matsuo S, Toda-Nakamura M, Oka K, Kajiya H, Ogata K, Ishii H, Ozaki M, Ohno J
    • Journal Title

      Journal of Hard Tissue Biology

      Volume: 29 Issue: 2 Pages: 63-70

    • DOI

      10.2485/jhtb.29.63

    • NAID

      130007833321

    • ISSN
      1341-7649, 1880-828X
    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The reduced susceptibility of mouse keratinocytes to retinoic acid may be involved in the keratinization of oral and esophageal mucosal epithelium.2019

    • Author(s)
      Miyazono S, Otani T, Ogata K, Kitagawa N, Iida H, Inai Y, Matsuura T, Inai T
    • Journal Title

      Histochemistry and Cell Biology

      Volume: 153 Issue: 4 Pages: 225-237

    • DOI

      10.1007/s00418-020-01845-1

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Presentation] Role of TRPM7 in cranial neural crest cell during craniofacial development2019

    • Author(s)
      Ogata Kayoko, Oka Kyoko, Shin Masashi, Inai Tetsuichiro, Okabe Koji
    • Organizer
      The 7th Tripartite Conference on Tooth and Bone in Development & Regeneration
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research

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Published: 2019-04-18   Modified: 2024-01-30  

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