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Determinating oral health factors for preventing cognitive impairment

Research Project

Project/Area Number 19K19325
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 57080:Social dentistry-related
Research InstitutionTohoku University

Principal Investigator

Komiyama Takamasa  東北大学, 歯学研究科, 助教 (70803550)

Project Period (FY) 2019-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2021: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords口腔保健 / 高齢者 / 認知症 / 認知機能 / コホート研究 / 咀嚼能力 / 舌圧 / 口腔状態
Outline of Research at the Start

本研究は岩手県花巻市大迫地区に居住する55歳以上住民を対象としたオープンコホートを用いて検討する.検診参加者に対して,口腔内診査および質問紙調査,咬合力や咀嚼能率等の口腔機能検査も実施する予定である.採取した口腔保健指標が認知機能低下と関連するかを横断的,縦断的に検討する.口腔に関する病識の欠如が認知機能低下の予測因子となるかについても検討する.

Outline of Final Research Achievements

We conducted a cross-sectional study of the association between oral health and cognitive function in a community-dwelling population aged 50 years or older living in the district of Ohasama. It has shown that the absence of regular dental visits (odds ratio: 3.5) and decreased tongue pressure (odds ratio: 2.5) were significantly associated with cognitive dysfunction. In analyses stratified by age, due to insufficient statistical power, it hasn't been shown that oral health indicators were significantly associated with cognitive impairment in those with <65, 65-74, and >=75 age groups.
The results of the present study suggest that maintaining adequate oral health contributes to maintaining cognitive function.

Academic Significance and Societal Importance of the Research Achievements

今後も増加すると予測される認知症を予防し、認知機能低下を遅らせることは本邦のみならず、世界的な課題である。不良な口腔状態および機能が認知症および認知機能低下のリスクであることはこれまでの研究からも示唆されているが、様々な角度からの議論がある。
本研究では、横断的な検討ではあるが、口腔の状態および機能が認知機能低下と関連することを明らかにしており、認知症対策の一環として歯科保健を推進することを支持するものである。

Report

(5 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (28 results)

All 2022 2021 2020 2019

All Journal Article (9 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 9 results,  Open Access: 3 results) Presentation (19 results) (of which Int'l Joint Research: 3 results,  Invited: 4 results)

  • [Journal Article] Regular dental visits, periodontitis, tooth loss, and atherosclerosis: The Ohasama study2022

    • Author(s)
      Sho Yamada,Takamasa Komiyama,Takashi Ohi,Takahisa Murakami,Yoshitada Miyoshi,Kosei Endo,Takako Hiratsuka,Azusa Hara,Michihiro Satoh,Yukako Tatsumi,Ryusuke Inoue,Kei Asayama,Masahiro Kikuya,Atsushi Hozawa,Hirohito Metoki,Yutaka Imai,Takayoshi Ohkubo,Yoshinori Hattori
    • Journal Title

      J Periodontal Res.

      Volume: 57 Issue: 3 Pages: 615

    • DOI

      10.1111/jre.12990

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Oral health-related quality of life is associated with the prevalence and development of depressive symptoms in older Japanese individuals: The Ohasama Study2022

    • Author(s)
      Ohi Takashi、Murakami Takahisa、Komiyama Takamasa、Miyoshi Yoshitada、Endo Kosei、Hiratsuka Takako、Satoh Michihiro、Asayama Kei、Inoue Ryusuke、Kikuya Masahiro、Metoki Hirohito、Hozawa Atsushi、Imai Yutaka、Watanabe Makoto、Ohkubo Takayoshi、Hattori Yoshinori
    • Journal Title

      Gerodontology

      Volume: 39 Issue: 2 Pages: 204

    • DOI

      10.1111/ger.12557

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Relationship between maximum occlusal force and gastrointestinal cancer in community-dwelling older Japanese adults2022

    • Author(s)
      Komiyama Takamasa、Ohi Takashi、Ito Wakana、Miyoshi Yoshitada、Hiratsuka Takako、Matsuyama Sanae、Tsuji Ichiro、Watanabe Makoto、Hattori Yoshinori
    • Journal Title

      Scientific Reports

      Volume: 12 Issue: 1 Pages: 440-440

    • DOI

      10.1038/s41598-021-04158-y

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Relationship Between Oral Health and Fractures in Community-Dwelling Older Japanese Adults2021

    • Author(s)
      Ito Wakana、Komiyama Takamasa、Ohi Takashi、Hiratsuka Takako、Matsuyama Sanae、Sone Toshimasa、Tsuji Ichiro、Watanabe Makoto、Hattori Yoshinori
    • Journal Title

      Journal of the American Medical Directors Association

      Volume: in press Issue: 6 Pages: 1184-1189.e1

    • DOI

      10.1016/j.jamda.2021.01.058

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] 26.Verification of the criteria for reduced occlusal force to diagnose oral hypofunction in older Japanese people: A prospective cohort study on incident functional disability2020

    • Author(s)
      Takamasa Komiyama, Takashi Ohi, Yoshitada Miyoshi, Yasutake Tomata, Shu Zhang, Ichiro Tsuji, Makoto Watanabe, Yoshinori Hattori.
    • Journal Title

      Journal of Oral Rehabilitation

      Volume: 47 Issue: 8 Pages: 989-997

    • DOI

      10.1111/joor.13021

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] 25.Cognitive impairment and depressive symptoms lead to biases in self-evaluated masticatory performance among community-dwelling older Japanese adults: the Tsurugaya Project2020

    • Author(s)
      Takamasa Komiyama, Takashi Ohi, Takako Hiratsuka, Yoshitada Miyoshi, Yasutake Tomata, Shu Zhang, Ichiro Tsuji, Makoto Watanabe, Yoshinori Hattori.
    • Journal Title

      Journal of Dentistry

      Volume: 99 Pages: 103403-103403

    • DOI

      10.1016/j.jdent.2020.103403

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] The Association between Number of Remaining Teeth and Maintenance of Successful Aging in Japanese Older People: A 9-Year Longitudinal Study2020

    • Author(s)
      Fumiya Tanji, Takamasa Komiyama, Takashi Ohi, Yoshinori Hattori, Makoto Watanabe, Yukai Lu, Ichiro Tsuji.
    • Journal Title

      The Tohoku Journal of Experimental Medicine

      Volume: 252 Issue: 3 Pages: 245-252

    • DOI

      10.1620/tjem.252.245

    • NAID

      130007937235

    • ISSN
      0040-8727, 1349-3329
    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The association between bilateral maximum occlusal force and all-cause mortality among community-dwelling older adults: The Tsurugaya project2020

    • Author(s)
      Ohi Takashi、Komiyama Takamasa、Miyoshi Yoshitada、Murakami Takahisa、Tsuboi Akito、Tomata Yasutake、Tsuji Ichiro、Watanabe Makoto、Hattori Yoshinori
    • Journal Title

      Journal of Prosthodontic Research

      Volume: 64 Issue: 3 Pages: 289-295

    • DOI

      10.1016/j.jpor.2019.08.005

    • NAID

      130007885755

    • ISSN
      1883-1958, 1883-9207
    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Contribution of systemic inflammation and nutritional status to the relationship between tooth loss and mortality in a community-dwelling older Japanese population: a mediation analysis of data from the Tsurugaya project.2019

    • Author(s)
      Takako Hiratsuka, Takamasa Komiyama, Takashi Ohi, Fumiya Tanji, Yasutake Tomata, Ichiro Tsuji, Makoto Watanabe, Yoshinori Hattori.
    • Journal Title

      Clinical Oral Investigations

      Volume: in press

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Presentation] Supporting General Health of Older People Through Oral Health Management: From an Aspect of Inclusion2022

    • Author(s)
      Takamasa Komiyama
    • Organizer
      21st Yonsei Dental International Symposium
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 要介護高齢者における口腔と栄養との関連 を歯科訪問診療の現場より探る2022

    • Author(s)
      福山 完, 小宮山貴将, 服部佳功
    • Organizer
      第75回東北地区歯科医学会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 舌がん患者の外科的治療術前・後における舌圧と口腔機能との関連2022

    • Author(s)
      互野 亮, 小山重人, 白石 成, 泉田一賢, 小宮山貴将, 佐藤奈央子, 小川 徹, 佐々木啓一
    • Organizer
      日本補綴歯科学会 第131回学術大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 現在歯数と歯周炎の交互作用が脳形態変化に与える影響 大迫研究における縦断 MRI 解析2022

    • Author(s)
      山口哲史, 小宮山貴将, 大井 孝, 村上任尚, 佐藤倫広, 沼崎貴子, 三好慶忠, 遠藤耕生, 山田 唱, 目時弘仁, 大久保孝義, 服部佳功
    • Organizer
      日本補綴歯科学会 第131回学術大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 在宅療養者の口腔状態はキーパーソンの介護負担感に関連するのか: 混合研究法を用いた検討2022

    • Author(s)
      岸 さやか, 小宮山 貴将, 岡橋 美奈子, 阿部 吏芳, 板橋 志保, 遠藤 千恵, 成田 憲司, 小菅 玲, 服部 佳功
    • Organizer
      日本老年歯科学会第33回学術大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 歯科訪問診療患者における低栄養と関連する口腔保健指標の検討2022

    • Author(s)
      福山 完, 小宮山 貴将, 服部 佳功
    • Organizer
      日本老年歯科学会第33回学術大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Achieving healthy aging through oral health management: an epidemiological study2022

    • Author(s)
      Takamasa Komiyama
    • Organizer
      International Oral Health Symposium 2022
    • Related Report
      2022 Annual Research Report
  • [Presentation] 地域高齢者における最大咬合力と消化器がんとの関連:鶴ケ谷プロジェクト2022

    • Author(s)
      小宮山貴将,大井 孝,伊藤和花菜,三好慶忠,平塚貴子,松山紗奈江,辻 一郎,渡邉 誠,服部佳功.
    • Organizer
      第32回日本疫学会学術総会
    • Related Report
      2021 Research-status Report
  • [Presentation] 地域高齢者における口腔保健指標と転倒による骨折発生との関連2021

    • Author(s)
      伊藤和花菜, 小宮山貴将, 大井孝, 平塚貴子, 渡邉誠, 服部佳功
    • Organizer
      日本補綴歯科学会第130回学術大会
    • Related Report
      2021 Research-status Report
  • [Presentation] 地域一般住民における歯科定期受診とアテローム性動脈硬化との関連 - 大迫研究 -2021

    • Author(s)
      山田 唱, 小宮山貴将, 大井 孝, 村上任尚, 平塚貴子, 三好慶忠, 遠藤耕生, 大久保孝義, 服部佳功
    • Organizer
      日本老年歯科学会第32回学術大会
    • Related Report
      2021 Research-status Report
  • [Presentation] 地域高齢者における現在歯数および最大咬合力と要介護認定との関連2020

    • Author(s)
      伊藤 和花菜, 小宮山 貴将, 大井 孝, 平塚 貴子, 山田 唱, 服部 佳功.
    • Organizer
      日本老年歯科医学会第31回学術大会
    • Related Report
      2020 Research-status Report
  • [Presentation] 口腔機能検査の基準値を考える2019

    • Author(s)
      小宮山貴将
    • Organizer
      日本補綴歯科学会第128回学術大会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 超高齢社会における高齢者歯科の在り方を考える2019

    • Author(s)
      小宮山貴将
    • Organizer
      第75回東北大学歯学会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] Geriatric dentistry contributes not only oral health but systemic health: From the results of our prospective cohort study in Japan2019

    • Author(s)
      Takamasa Komiyama
    • Organizer
      Tohoku-Taiwan- YangMing Dental Symposium
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Deviation of Subjective and Objective Masticatory Ability in Older Adults.2019

    • Author(s)
      Takamasa Komiyama, Takashi Ohi, Yoshitada Miyoshi, Takako Hiratsuka, Yasutake Tomata, Shu Zhang, Ichiro Tsuji, Makoto Watanabe, Yoshinori Hattori.
    • Organizer
      97th General Session & Exhibition of the IADR
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] 20歯未満の地域高齢者における介護予防と関連する口腔保健指標の検討.2019

    • Author(s)
      小宮山貴将, 大井孝, 三好慶忠, 平塚貴子, 渡邉誠, 服部佳功.
    • Organizer
      第31回日本老年学会総会
    • Related Report
      2019 Research-status Report
  • [Presentation] 地域高齢者の低栄養が咬合力低下と死亡発生との関連を媒介する効果: 鶴ケ谷プロジェクト.2019

    • Author(s)
      平塚貴子, 小宮山貴将, 大井孝, 渡邉誠, 服部佳功
    • Organizer
      日本補綴歯科学会第128回学術大会
    • Related Report
      2019 Research-status Report
  • [Presentation] 地域在住有歯顎高齢者の低咬合力と要介護発生リスク-残存歯数の層別化に基づく検討-2019

    • Author(s)
      山田唱, 小宮山貴将, 大井孝, 平塚貴子, 服部佳功
    • Organizer
      第63回日本顎口腔機能学会
    • Related Report
      2019 Research-status Report
  • [Presentation] 重度歯周病罹患歯の保有数と血圧との関連-大迫研究-2019

    • Author(s)
      村上任尚, 佐藤倫広, 小宮山貴将, 大井孝, 遠藤耕生, 平塚貴子, 浅山敬, 菊谷昌浩, 井上隆輔, 坪田恵, 目時弘仁, 寳澤篤, 今井潤, 服部佳功, 大久保孝義
    • Organizer
      第31回血圧管理研究会
    • Related Report
      2019 Research-status Report

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Published: 2019-04-18   Modified: 2024-01-30  

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