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Modeling the potential impact of vaccination on Ebola virus disease epidemic

Research Project

Project/Area Number 19K19343
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 58010:Medical management and medical sociology-related
Research InstitutionHokkaido University

Principal Investigator

Lee Hyojung  北海道大学, 医学研究院, 助教 (40823365)

Project Period (FY) 2019-04-01 – 2020-03-31
Project Status Discontinued (Fiscal Year 2019)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2021: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
KeywordsEbola virus disease / Forecasting / Reporting delay / Reproduction number / Ebola Virus Disease / Vaccination coverage / Mathematical model
Outline of Research at the Start

The goal is to estimate the vaccine coverage by age and provinces, accounting for the sexual transmission. A province-specific model is formulated to estimate reporting delay. Sensitivity analysis and cost-effectiveness analysis are conducted to assess the economic burden until the end of epidemic.

Outline of Annual Research Achievements

Ebola virus disease (EVD) epidemic occurred in Democratic Republic of the Congo (DRC) from 2018-19 was analyzed.
The EVD epidemic including spatial heterogeneities and vaccination was forecasted in real time. We estimated the future reproduction numbers accounting for the reporting delay. This work was published as follows:
A.R. Akhmetzhanov*, H Lee*, S.M. Jung, et. al, Analyzing and forecasting the Ebola incidence in North Kivu, the Democratic Republic of the Congo from 2018-19 in real time, Epidemics, 27, 123-131, 2019 (* represents the co-first author)

Report

(1 results)
  • 2019 Annual Research Report
  • Research Products

    (1 results)

All 2019

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results)

  • [Journal Article] Analyzing and forecasting the Ebola incidence in North Kivu, the Democratic Republic of the Congo from 2018-19 in real time2019

    • Author(s)
      Akhmetzhanov AR*, Lee H*, Jung SM, Kayano T, Yuan B, Nishiura H (* represents co-first author)
    • Journal Title

      Epidemics

      Volume: 27 Pages: 123-131

    • DOI

      10.1016/j.epidem.2019.05.002

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access

URL: 

Published: 2019-04-18   Modified: 2021-01-27  

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