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Development of a novel risk assessment method to detect 'disturbance of stress response systems' by environmental chemicals

Research Project

Project/Area Number 19K19406
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 58020:Hygiene and public health-related: including laboratory approach
Research InstitutionUniversity of Toyama

Principal Investigator

Tetsushi Hirano  富山大学, 学術研究部薬学・和漢系, 助教 (70804590)

Project Period (FY) 2019-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2021: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2020: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywordsストレス応答系 / 化学物質 / AOP / リスク評価 / ストレス応答 / 農薬 / 雌雄差 / バイオマーカー / ネオニコチノイド / 神経毒性 / 環境化学物質 / リスク評価法
Outline of Research at the Start

近年急増しているうつ病や不安障害等のストレス関連精神疾患の原因として,遺伝要因のみならず化学物質等の環境要因が指摘され,発症に関わるメカニズムとして「ストレス応答系のかく乱」が注目されている.しかし,げっ歯類の脳組織変性や肉眼観察を主とする現行の神経毒性試験では,環境化学物質が「ストレス応答系」に及ぼす影響を検出することは不可能である.
本研究では,近代特有の環境要因である環境化学物質が引き起こす「ストレス応答系のかく乱」に関するメカニズムを解明し、新規バイオマーカーおよびリスク評価法を開発することを目的とする.

Outline of Final Research Achievements

In this study, we focused on chemical-induced “disturbance of the stress response system”, and through mechanistic analysis using animal models, we were able to elucidate some aspects of a new adverse effect pathway (AOP), with behavioural abnormalities and changes in neural activity as key events during exposure to neonicotinoid pesticides. . Furthermore, omics analysis revealed a set of genes related to neurotransmitter signalling and calcium signalling as candidate biomarkers. In addition, a novel risk assessment system that can efficiently detect synergistic effects of chemicals on neurotoxicity was established using a cellular model, using changes in the activity of proteolytic systems as an indicator.

Academic Significance and Societal Importance of the Research Achievements

従来の中枢神経系における化学物質の毒性評価はげっ歯類の脳組織変性や運動失調等を指標としているため、高次脳機能に及ぼす影響に対する検出感度、スループット、再現性の低さが問題点として指摘されている。そのため、「化学物質の曝露が高次脳機能に対して影響を及ぼすのか否か」を検出可能な新規リスク評価法の開発が切望されている。本研究により明らかになったAOPやリスク評価系は、今後、中枢神経系に対する化学物質のリスク評価の高度化を通じて、動物実験の削減や環境負荷の低減に貢献することで持続可能な開発目標(SDGs2, 12, 15等)の達成に寄与することが期待できる。

Report

(5 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (57 results)

All 2023 2022 2021 2020 2019 Other

All Journal Article (17 results) (of which Int'l Joint Research: 6 results,  Peer Reviewed: 17 results,  Open Access: 15 results) Presentation (37 results) (of which Int'l Joint Research: 6 results,  Invited: 2 results) Remarks (3 results)

  • [Journal Article] Quantitative elucidation of the transfer of the neonicotinoid pesticide clothianidin to the breast milk in mice2023

    • Author(s)
      Shoda Asuka、Nishi Misaki、Murata Midori、Mantani Youhei、Yokoyama Toshifumi、Hirano Tetsushi、Ikenaka Yoshinori、Hoshi Nobuhiko
    • Journal Title

      Toxicology Letters

      Volume: 373 Pages: 33-40

    • DOI

      10.1016/j.toxlet.2022.10.006

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Next-generation effects of fetal and lactational exposure to the neonicotinoid pesticide clothianidin on the immune system and gut microbiota2023

    • Author(s)
      MURATA Midori、SHODA Asuka、KIMURA Mako、HARA Yukako、YONOICHI Sakura、ISHIDA Yuya、MANTANI Youhei、YOKOYAMA Toshifumi、MATSUO Eiko、HIRANO Tetsushi、HOSHI Nobuhiko
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 85 Issue: 4 Pages: 434-442

    • DOI

      10.1292/jvms.23-0038

    • ISSN
      0916-7250, 1347-7439
    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sex-specific behavioral effects of acute exposure to the neonicotinoid clothianidin in mice2022

    • Author(s)
      Kubo Shizuka、Hirano Tetsushi、Miyata Yuka、Ohno Shuji、Onaru Kanoko、Ikenaka Yoshinori、Nakayama Shouta M.M.、Ishizuka Mayumi、Mantani Youhei、Yokoyama Toshifumi、Hoshi Nobuhiko
    • Journal Title

      Toxicology and Applied Pharmacology

      Volume: 456 Pages: 116283-116283

    • DOI

      10.1016/j.taap.2022.116283

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Elucidation of the neurological effects of clothianidin exposure at the no-observed-adverse-effect level (NOAEL) using two-photon microscopy <i>in vivo</i> imaging2022

    • Author(s)
      NISHI Misaki、SUGIO Shouta、HIRANO Tetsushi、KATO Daisuke、WAKE Hiroaki、SHODA Asuka、MURATA Midori、IKENAKA Yoshinori、TABUCHI Yoshiaki、MANTANI Youhei、YOKOYAMA Toshifumi、HOSHI Nobuhiko
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 84 Issue: 4 Pages: 585-592

    • DOI

      10.1292/jvms.22-0013

    • ISSN
      0916-7250, 1347-7439
    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Ca2+ imaging with two-photon microscopy to detect the disruption of brain function in mice administered neonicotinoid insecticides2022

    • Author(s)
      Hirai Anri、Sugio Shouta、Nimako Collins、Nakayama Shouta M. M.、Kato Keisuke、Takahashi Keisuke、Arizono Koji、Hirano Tetsushi、Hoshi Nobuhiko、Fujioka Kazutoshi、Taira Kumiko、Ishizuka Mayumi、Wake Hiroaki、Ikenaka Yoshinori
    • Journal Title

      Scientific Reports

      Volume: 12 Issue: 1 Pages: 5114-5114

    • DOI

      10.1038/s41598-022-09038-7

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The effects of fipronil on emotional and cognitive behaviors in mammals2021

    • Author(s)
      Suzuki Tomohiro、Hirai Anri、Khidkhan Kraisiri、Nimako Collins、Ichise Takahiro、Takeda Kazuki、Mizukawa Hazuki、Nakayama Shouta M.M.、Nomiyama Kei、Hoshi Nobuhiko、Maeda Mizuki、Hirano Tetsushi、Sasaoka Kazuyoshi、Sasaki Noboru、Takiguchi Mitsuyoshi、Ishizuka Mayumi、Ikenaka Yoshinori
    • Journal Title

      Pesticide Biochemistry and Physiology

      Volume: 3 Pages: 104847-104847

    • DOI

      10.1016/j.pestbp.2021.104847

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Neurotoxicity of a pyrethroid pesticide deltamethrin is associated with the imbalance in proteolytic systems caused by mitophagy activation and proteasome inhibition2021

    • Author(s)
      Hirano Tetsushi、Suzuki Nihei、Ikenaka Yoshinori、Hoshi Nobuhiko、Tabuchi Yoshiaki
    • Journal Title

      Toxicology and Applied Pharmacology

      Volume: 430 Pages: 115723-115723

    • DOI

      10.1016/j.taap.2021.115723

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Influence of acute exposure to a low dose of systemic insecticide fipronil on locomotor activity and emotional behavior in adult male mice2021

    • Author(s)
      MAEDA Mizuki、YOKOYAMA Toshifumi、KITAUCHI Sayaka、HIRANO Tetsushi、MANTANI Youhei、TABUCHI Yoshiaki、HOSHI Nobuhiko
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 83 Issue: 2 Pages: 344-348

    • DOI

      10.1292/jvms.20-0551

    • NAID

      130007995004

    • ISSN
      0916-7250, 1347-7439
    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Chronic low-dose exposure to imidacloprid potentiates high fat diet-mediated liver steatosis in C57BL/6J male mice2021

    • Author(s)
      NIMAKO Collins、IKENAKA Yoshinori、OKAMATSU-OGURA Yuko、BARIUAN Jussiaea V.、KOBAYASHI Atsushi、YAMAZAKI Ryo、TAIRA Kumiko、HOSHI Nobuhiko、HIRANO Tetsushi、NAKAYAMA Shouta M. M.、ISHIZUKA Mayumi
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 83 Issue: 3 Pages: 487-500

    • DOI

      10.1292/jvms.20-0479

    • NAID

      130008021217

    • ISSN
      0916-7250, 1347-7439
    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Fetal and lactational exposure to the no-observed-adverse-effect level (NOAEL) dose of the neonicotinoid pesticide clothianidin inhibits neurogenesis and induces different behavioral abnormalities at the developmental stages in male mice2021

    • Author(s)
      MAEDA Mizuki、KITAUCHI Sayaka、HIRANO Tetsushi、IKENAKA Yoshinori、NISHI Misaki、SHODA Asuka、MURATA Midori、MANTANI Youhei、TABUCHI Yoshiaki、YOKOYAMA Toshifumi、HOSHI Nobuhiko
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 83 Issue: 3 Pages: 542-548

    • DOI

      10.1292/jvms.20-0721

    • NAID

      130008021184

    • ISSN
      0916-7250, 1347-7439
    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effects of <i>in utero</i> and lactational exposure to the no-observed-adverse-effect level (NOAEL) dose of the neonicotinoid clothianidin on the reproductive organs of female mice2021

    • Author(s)
      KITAUCHI Sayaka、MAEDA Mizuki、HIRANO Tetsushi、IKENAKA Yoshinori、NISHI Misaki、SHODA Asuka、MURATA Midori、MANTANI Youhei、YOKOYAMA Toshifumi、TABUCHI Yoshiaki、HOSHI Nobuhiko
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 83 Issue: 4 Pages: 746-753

    • DOI

      10.1292/jvms.21-0014

    • NAID

      130008029536

    • ISSN
      0916-7250, 1347-7439
    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Aging-related changes in the sensitivity of behavioral effects of the neonicotinoid pesticide clothianidin in male mice2021

    • Author(s)
      Hirano Tetsushi、Miyata Yuka、Kubo Shizuka、Ohno Shuji、Onaru Kanoko、Maeda Mizuki、Kitauchi Sayaka、Nishi Misaki、Tabuchi Yoshiaki、Ikenaka Yoshinori、Ichise Takahiro、Nakayama Shouta M.M.、Ishizuka Mayumi、Arizono Koji、Takahashi Keisuke、Kato Keisuke、Mantani Youhei、Yokoyama Toshifumi、Hoshi Nobuhiko
    • Journal Title

      Toxicology Letters

      Volume: 342 Pages: 95-103

    • DOI

      10.1016/j.toxlet.2021.02.010

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Bioinformatics analysis of the microRNA-mRNA network in sebaceous gland carcinoma of the eyelid2020

    • Author(s)
      Hirano Tetsushi、Yunoki Tatsuya、Furusawa Yukihiro、Tabuchi Yoshiaki、Hayashi Atsushi
    • Journal Title

      Molecular Medicine Reports

      Volume: 23 Issue: 1 Pages: 1-1

    • DOI

      10.3892/mmr.2020.11682

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Immunotoxicity evaluation by subchronic oral administration of clothianidin in Sprague-Dawley rats2020

    • Author(s)
      ONARU Kanoko、OHNO Shuji、KUBO Shizuka、NAKANISHI Satoki、HIRANO Tetsushi、MANTANI Youhei、YOKOYAMA Toshifumi、HOSHI Nobuhiko
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 82 Issue: 3 Pages: 360-372

    • DOI

      10.1292/jvms.19-0689

    • NAID

      130007814905

    • ISSN
      0916-7250, 1347-7439
    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Combined exposure to dinotefuran and chronic mild stress counteracts the change of the emotional and monoaminergic neuronal activity induced by either exposure singly despite corticosterone elevation in mice2020

    • Author(s)
      TAKADA Tadashi、YONEDA Naoki、HIRANO Tetsushi、ONARU Kanoko、MANTANI Youhei、YOKOYAMA Toshifumi、KITAGAWA Hiroshi、TABUCHI Yoshiaki、NIMAKO Collins、ISHIZUKA Mayumi、IKENAKA Yoshinori、HOSHI Nobuhiko
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 82 Issue: 3 Pages: 350-359

    • DOI

      10.1292/jvms.19-0635

    • NAID

      130007814907

    • ISSN
      0916-7250, 1347-7439
    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Quantitative elucidation of maternal-to-fetal transfer of neonicotinoid pesticide clothianidin and its metabolites in mice2020

    • Author(s)
      Ohno Shuji、Ikenaka Yoshinori、Onaru Kanoko、Kubo Shizuka、Sakata Nanami、Hirano Tetsushi、Mantani Youhei、Yokoyama Toshifumi、Takahashi Keisuke、Kato Keisuke、Arizono Koji、Ichise Takahiro、Nakayama Shouta M.M.、Ishizuka Mayumi、Hoshi Nobuhiko
    • Journal Title

      Toxicology Letters

      Volume: 322 Pages: 32-38

    • DOI

      10.1016/j.toxlet.2020.01.003

    • NAID

      120006811093

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Growth and neurite stimulating effects of the neonicotinoid pesticide clothianidin on human neuroblastoma SH-SY5Y cells2019

    • Author(s)
      Hirano Tetsushi、Minagawa Satsuki、Furusawa Yukihiro、Yunoki Tatsuya、Ikenaka Yoshinori、Yokoyama Toshifumi、Hoshi Nobuhiko、Tabuchi Yoshiaki
    • Journal Title

      Toxicology and Applied Pharmacology

      Volume: 383 Pages: 114777-114777

    • DOI

      10.1016/j.taap.2019.114777

    • NAID

      120006941664

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Molecular mechanism of neurotoxicity of a pyrethroid pesticide deltamethrin via dysfunction in proteolytic systems.2022

    • Author(s)
      Hirano T, Ikenaka Y, Hoshi N, Tabuchi Y.
    • Organizer
      61th SOT annual meeting
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 神経毒性のAOPにおける共通Key Eventを指標とした農薬類の複合影響評価.2022

    • Author(s)
      平野哲史,池中良徳,星 信彦,田渕圭章.
    • Organizer
      環境化学物質 3 学会合同大会(第 30 回環境化学討論会,第 26 回日本環境毒性学会研究発表会,第 24 回環境ホルモン学会研究発表会)
    • Related Report
      2022 Annual Research Report
  • [Presentation] 神経毒性に関するAdverse Outcome Pathway (AOP) に基づいた農薬類の複合影響評価.2022

    • Author(s)
      平野哲史,池中良徳,星 信彦,田渕 圭章.
    • Organizer
      第49回日本毒性学会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 環境ストレス負荷下におけるネオニコチノイド系農薬曝露が腸内細菌叢に及ぼす影響.2022

    • Author(s)
      世ノ一さくら,石田祐也,原 悠佳子,木村真子,正田明日香,村田 碧,万谷洋平,横山俊史,平野哲史,池中良徳,星 信彦.
    • Organizer
      第165回日本獣医学会学術集会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 胎子授乳期ネオニコチノイド系農薬曝露が海馬記憶と運動学習に及ぼす次世代影響.2022

    • Author(s)
      原 悠佳子,世ノ一さくら,石田祐也,正田明日香,村田 碧,木村真子,万谷洋平,横山俊史,平野哲史,池中良徳,星 信彦.
    • Organizer
      第165回日本獣医学会学術集会
    • Related Report
      2022 Annual Research Report
  • [Presentation] ジアミド系農薬がマウスの行動および神経活動に及ぼす影響について.2022

    • Author(s)
      木村真子,正田明日香,村田 碧,原 悠佳子,世ノ一さくら,石田祐也,平野哲史,万谷洋平,横山俊史,池中良徳,星 信彦.
    • Organizer
      第98 回日本解剖学会近畿支部学術集会.
    • Related Report
      2022 Annual Research Report
  • [Presentation] ジアミド系農薬がマウスの行動および神経活動に及ぼす影響評価.2022

    • Author(s)
      木村真子,正田明日香,村田 碧,原 悠佳子,世ノ一さくら,石田祐也,平野哲史,万谷洋平,横山俊史,池中良徳,星 信彦.
    • Organizer
      第150回関西実験動物研究会研究発表会.
    • Related Report
      2022 Annual Research Report
  • [Presentation] ネオニコチノイド系農薬が哺乳類に及ぼす神経行動学的影響評価とメカニズム解析.2022

    • Author(s)
      平野哲史.
    • Organizer
      金沢大学 環日本海域環境研究センター主催講演会「環境汚染物質に関する近年の課題と研究」
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] Neurotoxic mechanisms of a pyrethroid pesticide deltamethrin induced by imbalance of proteolytic system2022

    • Author(s)
      Hirano T, Hoshi N, Ikenaka Y, Tabuchi Y
    • Organizer
      5th International Chemical Hazard Symposium
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] ニコチン性アセチルコリン受容体アゴニストによるマウスの脳機能攪乱~二光子顕微鏡を用いた検出法の開発~2021

    • Author(s)
      平井杏梨,杉尾翔太,Collins Nimako,中山翔太,加藤恵介,高橋圭介,有薗幸司,平野哲史,星 信彦,石塚真由美,和氣弘明,池中良徳
    • Organizer
      第29回環境化学討論会
    • Related Report
      2021 Research-status Report
  • [Presentation] タンパク質分解系を指標としたピレスロイド系農薬デルタメトリンによる神経毒性メカニズムの解析2021

    • Author(s)
      平野哲史,鈴木二平,池中良徳,星 信彦,田渕圭章
    • Organizer
      第48回日本毒性学会学術年会
    • Related Report
      2021 Research-status Report
  • [Presentation] 二光子顕微鏡を用いたニコチン性アセチルコリン受容体アゴニストによる脳機能障害の検出2021

    • Author(s)
      平井杏梨,杉尾翔太,Collins Nimako,中山翔太,加藤恵介,高橋圭介,有薗幸司,平野哲史,星 信彦,藤岡一俊,平久美子,石塚真由美,和氣弘明,池中良徳
    • Organizer
      第48回日本毒性学会学術年会
    • Related Report
      2021 Research-status Report
  • [Presentation] ネオニコチノイド系農薬クロチアニジンのマウス母乳中移行量に関する定量的評価2021

    • Author(s)
      正田明日香,村田 碧,西 美咲,平野哲史,万谷洋平,横山俊史,池中良徳,星 信彦
    • Organizer
      第61回日本先天異常学会学術集会
    • Related Report
      2021 Research-status Report
  • [Presentation] ネオニコチノイド系農薬クロチアニジンが次世代マウスの免疫系および腸内細菌叢に及ぼす影響2021

    • Author(s)
      村田 碧,西 美咲,正田明日香,池中良徳,佐伯圭一,松尾栄子,平野哲史,万谷洋平,横山俊史,星 信彦
    • Organizer
      第61回日本先天異常学会学術集会
    • Related Report
      2021 Research-status Report
  • [Presentation] 神経回路形成期におけるステージ別ネオニコチノイド系農薬曝露と発達神経毒性評価2021

    • Author(s)
      正田明日香,村田 碧,西 美咲,万谷洋平,横山俊史,池中良徳,平野哲史,星 信彦
    • Organizer
      第164回日本獣医学会学術集会
    • Related Report
      2021 Research-status Report
  • [Presentation] ネオニコチノイド系農薬クロチアニジンの胎子・授乳期曝露が次世代マウスの免疫系および腸内細菌叢に及ぼす影響2021

    • Author(s)
      村田 碧,西 美咲,正田明日香,佐伯圭一,松尾栄子,万谷洋平,横山俊史,平野哲史,池中良徳,星 信彦
    • Organizer
      第164回日本獣医学会学術集会
    • Related Report
      2021 Research-status Report
  • [Presentation] Imbalance in proteolytic systems caused by mitophagy activation and proteasome inhibition underlies neurotoxicity of pyrethroid pesticide deltamethrin2021

    • Author(s)
      Hirano T, Ikenaka Y, Hoshi N, Tabuchi Y
    • Organizer
      フォーラム2021:衛生薬学・環境トキシコロジー
    • Related Report
      2021 Research-status Report
  • [Presentation] ンパク質分解系の不均衡状態を介したピレスロイド系農薬による神経毒性の発現機序2021

    • Author(s)
      平野哲史,池中良徳,星 信彦,田渕圭章
    • Organizer
      環境ホルモン学会第23回研究発表会
    • Related Report
      2021 Research-status Report
  • [Presentation] 低用量クロチアニジンの神経回路形成期におけるステージ別曝露と発達神経毒性評価2021

    • Author(s)
      正田明日香,村田 碧,西 美咲,平野哲史,万谷洋平,横山俊史,池中良徳,星 信彦
    • Organizer
      環境ホルモン学会第23回研究発表会
    • Related Report
      2021 Research-status Report
  • [Presentation] ネオニコチノイド系農薬クロチアニジンの胎子・授乳期曝露による次世代マウスの免疫系および腸内細菌叢の変化2021

    • Author(s)
      村田 碧,西 美咲,正田明日香,池中良徳,佐伯圭一,松尾栄子,平野哲史,万谷洋平,横山俊史,星 信彦
    • Organizer
      環境ホルモン学会第23回研究発表会
    • Related Report
      2021 Research-status Report
  • [Presentation] Neurobehavioral and neurofunctional effects of a neonicotinoid pesticide clothianidin on mammalian nervous system2021

    • Author(s)
      Tetsushi Hirano, Nobuhiko Hoshi, Yoshinori Ikenaka, Yoshiaki Tabuchi
    • Organizer
      4th International Chemical Hazard Symposium
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] Fetal and lactational exposure to the no observed adverse effect level (NOAEL) dose of the neonicotinoid pesticide clothianidin inhibits neurogenesis and induces different behavioral abnormalities at the developmental stages in the next generation of male mice2021

    • Author(s)
      Mizuki MAEDA , Sayaka KITA UCHI , Tetsushi HIRANO , Yoshinori IKENAKA, Misaki NISHI , Asuka SHODA , Midori MURATA , Youhei MANTANI , Yoshiaki TABUCHI , Toshifumi YOKOYAMA, Nobuhiko HOSHI
    • Organizer
      4th International Chemical Hazard Symposium
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] Transgenerational inheritance effects and the adverse outcome pathway (AOP) of the exposure to the no observed adverse effect level (NOAEL) dose of the neonicotinoid clothianidin in the reproductive organs of female mice2021

    • Author(s)
      Sayak a KITAUCHI , Mizuki MAEDA , Tetsushi HIRANO , Yoshinori IKENAKA , Misaki NISHI , Asuka SHODA , Midori MURATA , Youhei MANTANI , Toshifumi YOKOYAMA, Yoshiaki TABUCHI, Nobuhiko HOSHI
    • Organizer
      4th International Chemical Hazard Symposium
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] 無毒性量ネオニコチノイド系農薬が次世代のマウス雌性生殖機能に及ぼす影響.2020

    • Author(s)
      北内佐也可,前田瑞稀,平野哲史,万谷洋平,横山俊史,星 信彦.
    • Organizer
      第60回日本先天異常学会学術集会
    • Related Report
      2020 Research-status Report
  • [Presentation] 無毒性量の浸透性農薬のマウス胎子・授乳期曝露による神経行動学的影響.2020

    • Author(s)
      前田瑞稀,北内佐也加,平野哲史,万谷洋平,横山俊史,星 信彦.
    • Organizer
      第60回日本先天異常学会学術集会
    • Related Report
      2020 Research-status Report
  • [Presentation] 極微量ネオニコチノイド系農薬がマウスの継世代雌性生殖器に及ぼす影響.2020

    • Author(s)
      北内佐也可,前田瑞稀,西美咲,正田明日香,村田碧,平野哲史,万谷洋平,横山俊史,星 信彦.
    • Organizer
      第163回日本獣医学会学術集会
    • Related Report
      2020 Research-status Report
  • [Presentation] In vivo and in vitro effects of neonicotinoid pesticide, clothianidin on mammal nervous function2019

    • Author(s)
      Hirano T, Minagawa S, Furusawa Y, Yunoki T, Yokoyama T, Hoshi N, Tabuchi Y.
    • Organizer
      IUTOX 15th International Congress of Toxicology
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] ネオニコチノイド系農薬がヒト神経芽細胞腫に及ぼすシグナル毒性的影響に関するメカニズム解析2019

    • Author(s)
      平野哲史,皆川沙月,古澤之裕,柚木達也,池中良徳,横山俊史,星 信彦,田渕圭章.
    • Organizer
      第46回日本毒性学会学術年会
    • Related Report
      2019 Research-status Report
  • [Presentation] ネオニコチノイド系殺虫剤の曝露実態の解明と毒性評価2019

    • Author(s)
      池中良徳,一瀬貴大,Collins NIMAKO,中山翔太,平野哲史,市川 剛,加藤惠介,高橋圭介,長谷川 浩,平 久美子,有薗幸司,星 信彦,藤岡一俊,石塚真由美.
    • Organizer
      第46回日本毒性学会学術年会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] ネオニコチノイド系農薬クロチアニジンが哺乳類に及ぼす神経行動学的影響とそのメカニズム2019

    • Author(s)
      平野哲史,大成果乃子,大野周嗣,久保静花,杉田晄佑,宮田結佳,前田瑞稀,北内佐也可,西 美咲,横山俊史,田渕 圭章,星 信彦.
    • Organizer
      第2回極みプロジェクトシンポジウム・第6回イメージング数理研究会
    • Related Report
      2019 Research-status Report
  • [Presentation] GABA攪乱物質フィプロニルがマウスの情動行動に及ぼす影響2019

    • Author(s)
      前田瑞稀,大成果乃子,大野周嗣,久保静花,杉田晄佑,宮田結佳,北内佐也加,西 美咲,高田 匡,平野哲史,万谷洋平,横山俊史,池中良徳,星 信彦.
    • Organizer
      第162回日本獣医学会
    • Related Report
      2019 Research-status Report
  • [Presentation] クロチアニジンの亜急性摂取はラット腸内細菌叢を変化させる2019

    • Author(s)
      大成果乃子,大野周嗣,久保静花,中西怜稀,平野哲史,万谷洋平,横山俊史,星 信彦.
    • Organizer
      第22回環境ホルモン学会研究発表会
    • Related Report
      2019 Research-status Report
  • [Presentation] 低用量クロチアニジンによるマウスの物体認識・空間学習記憶障害とその性差2019

    • Author(s)
      久保静花,宮田結佳,大成果乃子,大野周嗣,平野哲史,万谷洋平,横山俊史,星 信彦.
    • Organizer
      第22回環境ホルモン学会研究発表会
    • Related Report
      2019 Research-status Report
  • [Presentation] クロチアニジンおよびその代謝産物の母子間移行における組織分布・蓄積性の定量的解明2019

    • Author(s)
      大野周嗣,大成果乃子,久保静花,平野哲史,万谷洋平,横山俊史,石塚真由美,池中良徳,星 信彦
    • Organizer
      第22回環境ホルモン学会研究発表会
    • Related Report
      2019 Research-status Report
  • [Presentation] 低用量クロチアニジンによる情動変容への加齢の影響評価2019

    • Author(s)
      宮田結佳,久保静花,大野周嗣,大成果乃子,前田瑞稀,中西怜稀,平野哲史,万谷洋平,横山俊史,石塚真由美,池中良徳,星 信彦.
    • Organizer
      第22回環境ホルモン学会研究発表会
    • Related Report
      2019 Research-status Report
  • [Presentation] 低用量クロチアニジンの胎子・授乳期曝露による神経行動学的影響2019

    • Author(s)
      前田瑞稀,北内佐也可,宮田結佳,久保静花,平野哲史,万谷洋平,横山俊史,星 信彦.
    • Organizer
      第22回環境ホルモン学会研究発表会
    • Related Report
      2019 Research-status Report
  • [Presentation] ネオニコチノイド系農薬クロチアニジンが次世代雌性生殖器に及ぼす影響2019

    • Author(s)
      北内佐也可,前田瑞稀,久保静花,大成果乃子,宮田結佳,平野哲史,万谷洋平,横山俊史,星 信彦.
    • Organizer
      第22回環境ホルモン学会研究発表会
    • Related Report
      2019 Research-status Report
  • [Remarks] researchmap-平野哲史

    • URL

      https://researchmap.jp/thirano0128/published_papers/36763931

    • Related Report
      2022 Annual Research Report 2021 Research-status Report
  • [Remarks] 富山大学 生命科学先端研究支援ユニット ゲノム機能解析研究室

    • URL

      http://www.lsrc.u-toyama.ac.jp/mgrc/html/laboratory.html

    • Related Report
      2022 Annual Research Report 2021 Research-status Report 2020 Research-status Report 2019 Research-status Report
  • [Remarks] researchmap-平野哲史

    • URL

      https://researchmap.jp/thirano0128/

    • Related Report
      2020 Research-status Report 2019 Research-status Report

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Published: 2019-04-18   Modified: 2024-01-30  

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