セレノプロテインＰが糖代謝異常に寄与するメカニズムの縦断的な解明

• Project/Area Number: 19K19419
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 58020:Hygiene and public health-related: including laboratory approach
• Research Institution: Fujita Health University
• Principal Investigator: 李 媛英 藤田医科大学, 医学部, 助教 (20701288)
• Project Period (FY): 2019-04-01 – 2024-03-31
• Project Status: Granted (Fiscal Year 2022)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2021: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000); Fiscal Year 2020: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2019: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: コロナ禍 / 生活習慣変化 / 退職者 / 質問紙 / 検体測定 / コロナ / 生活習慣 / セレノプロテインP / アディポサイトカイン / 糖代謝 / 脂質代謝 / 運動 / セレノプロテイン / 脂肪肝 / 身体組成 / セレノプロテインＰ / 糖尿病 / サルコペニア

Outline of Research at the Start

セレノプロテインＰは肝から分泌され、抗酸化作用、すなわち組織保護的作用を有するホルモン様物質であるが、筋肉に作用し、運動の効果や運動耐容能を減弱させる働き、すなわち「運動抵抗性」を誘発するものとして最近注目が集まっている。本研究は、中年期の血清セレノプロテインＰと糖・脂質代謝マーカーとの横断的な関連、追跡期間中の運動習慣の変化、糖尿病発症との関連をコホート的に解析し、また、高齢期におけるセレノプロテインＰと肝臓の脂肪量、サルコペニアとの関連を調べることによって、運動の効果や運動耐容能の個人差の起こるメカニズム、糖・脂質代謝異常の病態形成の機序を明らかにすることを目指している。

Outline of Annual Research Achievements

コロナ禍の影響により計画していたバイオマーカーの測定が難しくなった。同時に、コロナ禍の影響を対象集団において調査する必要性が認識され、質問紙調査及び保存検体の測定の実施へと変更した。
そして、2021年度に、対象集団である愛知職域コホートの退職者約3,400名に生活習慣、身体・心理状況に関する質問紙調査を実施した。2022年度には、回収された質問紙の回答の入力作業を終え、データクリーニングを順次に進めている。また、保存検体の測定も測定対象検体の選定と抽出作業は終えた。

Current Status of Research Progress

4: Progress in research has been delayed.

Reason

質問紙調査の配布と回収は概ね予定した通りであるが、データベース化がやや遅れている。
また、保存検体の測定も測定対象検体の選定と抽出作業は終えたが、実際の測定まで実施できなかった。

Strategy for Future Research Activity

質問紙回答のデータクリーニング作業が終わり次第、コロナ禍前の生活習慣等のデータと突合し、集計と統計解析を実施する予定である。同時に、コロナ禍前の血液保存検体も測定し、データベース化する予定である。

Research Products

• [Journal Article] Impact of Body Mass Index on Obesity-Related Cancer and Cardiovascular Disease Mortality; The Japan Collaborative Cohort Study (2022)
  • Author(s): Matsunaga M, Yatsuya H, Iso H, Li Y, Yamagishi K, Tanabe N, Wada Y, Ota A, Tamakoshi K, Tamakoshi A ; The JACC Study Group.
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 29 Issue: 10 Pages: 1547-1562
  • DOI: 10.5551/jat.63143
  • NAID: 130008126173
  • ISSN: 1340-3478, 1880-3873
  • Year and Date: 2022-10-01
  • Description: in press
  • Peer Reviewed / Open Access
• [Journal Article] Stoma creation is associated with a low incidence of midline incisional hernia after colorectal surgery: the "fighting over the fascia" theory concerning the incision and stoma hole (2022)
  • Author(s): Noriaki Ohara, Kay Uehara, Atsushi Ogura, Masanori Sando, Toshisada Aiba, Yuki Murata, Takashi Mizuno, Kokuryo Toshio, Yukihiro Yokoyama, Satoko Ishigaki, Yuanying Li, Hiroshi Yatsuya, Tomoki Ebata
  • Journal Title: Surg Today. Volume: 52 Issue: 6 Pages: 953-963
  • DOI: 10.1007/s00595-021-02434-y
  • Peer Reviewed
• [Journal Article] Dietary Patterns Derived from Reduced Rank Regression Are Associated with the 5-Year Occurrence of Metabolic Syndrome: Aichi Workers' Cohort Study (2022)
  • Author(s): Yuanying Li, Hiroshi Yatsuya, Chaochen Wang, Mayu Uemura, Masaaki Matsunaga, Yupeng He, Maythet Khine, Atsuhiko Ota
  • Journal Title: Nutrients. Volume: 14 Issue: 15 Pages: 3019-3019
  • DOI: 10.3390/nu14153019
  • Peer Reviewed / Open Access
• [Journal Article] Recent findings on subjective well-being and physical, psychiatric, and social comorbidities in individuals with schizophrenia: A literature review (2022)
  • Author(s): Yupeng He, Ayako Tanaka, Taro Kishi, Yuanying Li, Masaaki Matsunaga, Shinichi Tanihara, Nakao Iwata, Atsuhiko Ota
  • Journal Title: Neuropsychopharmacol Rep. Volume: 42 Issue: 4 Pages: 430-436
  • DOI: 10.1002/npr2.12286
  • Peer Reviewed
• [Journal Article] Long-term variability and change trend of systolic blood pressure and risk of type 2 diabetes mellitus in middle-aged Japanese individuals: findings of the Aichi Workers' Cohort Study (2022)
  • Author(s): Zean Song, Yupeng He, Chifa Chiang, Abubakr A A Al-Shoaibi, K M Saif-Ur-Rahman, Md Razib Mamun, Atsuko Aoyama, Yoshihisa Hirakawa, Masaaki Matsunaga, Atsuhiko Ota, Koji Tamakoshi, Yuanying Li, Hiroshi Yatsuya
  • Journal Title: Hypertens Res. Volume: 45 Issue: 11 Pages: 1772-1780
  • DOI: 10.1038/s41440-022-00993-2
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Comparison of laminoplasty and posterior fusion surgery for cervical ossification of posterior longitudinal ligament (2022)
  • Author(s): Hiroaki Nakashima, Shiro Imagama, Toshitaka Yoshii, Satoru Egawa, Kenichiro Sakai, et al., Yuanying Li, Hiroshi Yatsuya, et al.
  • Journal Title: Sci Rep. Volume: 12 Issue: 1 Pages: 748-748
  • DOI: 10.1038/s41598-021-04727-1
  • Peer Reviewed / Open Access
• [Journal Article] Estimation of 10-Year Risk of Death from Coronary Heart Disease, Stroke, and Cardiovascular Disease in a Pooled Analysis of Japanese Cohorts: EPOCH-JAPAN (2021)
  • Author(s): Li Yuanying、Yatsuya Hiroshi、Tanaka Sachiko、Iso Hiroyasu、Okayama Akira、Tsuji Ichiro、Sakata Kiyomi、Miyamoto Yoshihiro、Ueshima Hirotsugu、Miura Katsuyuki、Murakami Yoshitaka、Okamura Tomonori、EPOCH-JAPAN Research Group
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 28 Issue: 8 Pages: 816-825
  • DOI: 10.5551/jat.58958
  • NAID: 130008070351
  • ISSN: 1340-3478, 1880-3873
  • Year and Date: 2021-08-01
  • Peer Reviewed / Open Access
• [Journal Article] Work-related factors among people with diabetes and the risk of cardiovascular diseases: A systematic review (2021)
  • Author(s): K M Saif-Ur-Rahman, Razib Mamun, Yuanying Li , Masaaki Matsunaga, Atsuhiko Ota, Hiroshi Yatsuya
  • Journal Title: Journal of Occupational Health Volume: 63 Issue: 1 Pages: n/a
  • DOI: 10.1002/1348-9585.12278
  • NAID: 130008120353
  • ISSN: 1341-9145, 1348-9585
  • Peer Reviewed
• [Journal Article] Working cancer survivors' physical and mental characteristics compared to cancer-free workers in Japan: a nationwide general population-based study (2020)
  • Author(s): Atsuhiko Ota Yuanying Li, Hiroshi Yatsuya, Kozo Tanno, Kiyomi Sakata, Kazumasa Yamagishi, Hiroyasu Iso, Nobufumi Yasuda, Isao Saito, Tadahiro Kato, Kazuhiko Arima, Yoko Sou, Taichi Shimazu, Taiki Yamaji, Atsushi Goto, Manami Inoue, Motoki Iwasaki, Norie Sawada, Shoichiro Tsugane
  • Journal Title: J Cancer Surviv. Volume: 12 Issue: 6 Pages: 0-0
  • DOI: 10.1007/s11764-020-00984-7
  • Peer Reviewed
• [Journal Article] Positive Association of Physical Activity with Both Objective and Perceived Measures of the Neighborhood Environment among Older Adults: The Aichi Workers' Cohort Study (2020)
  • Author(s): Li Y, Yatsuya H, Hanibuchi T, Ota A, Naito H, Otsuka R, Murata C, Hirakawa Y, Chiang C, Uemura M, Tamakoshi K, Aoyama A
  • Journal Title: Int J Environ Res Public Health Volume: 17 Issue: 21 Pages: 7971-7971
  • DOI: 10.3390/ijerph17217971
  • Peer Reviewed / Open Access
• [Journal Article] Pelvic exenteration associated with future renal dysfunction (2020)
  • Author(s): Masanori Sando, Kay Uehara, Yuanying Li, Toshisada Aiba, Atsushi Ogura, Tomoki Ebata, Yasuhiro Kodera, Hiroshi Yatsuya, Masato Nagino
  • Journal Title: Surg Today. Volume: 50 Issue: 12 Pages: 1601-1609
  • DOI: 10.1007/s00595-020-02036-0
  • Peer Reviewed
• [Journal Article] Body Mass Index and Risks of Incident Ischemic Stroke Subtypes: The Japan Public Health Center-Based Prospective (JPHC) Study (2019)
  • Author(s): Yatsuya H, Li Y, Hirakawa Y, Ota A, Matsunaga M, Haregot HE, Chiang C, Zhang Y, Tamakoshi K, Toyoshima H, Aoyama A.
  • Journal Title: Journal of Epidemiology Volume: 29 Issue: 9 Pages: 325-333
  • DOI: 10.2188/jea.JE20170298
  • NAID: 130007703036
  • ISSN: 0917-5040, 1349-9092
  • Year and Date: 2019-09-05
  • Peer Reviewed / Open Access
• [Journal Article] Risk and Population Attributable Fraction of Metabolic Syndrome and Impaired Fasting Glucose for the Incidence of Type 2 Diabetes Mellitus Among Middle-Aged Japanese Individuals: Aichi Worker's Cohort Study (2019)
  • Author(s): Kayo Kaneko, Hiroshi Yatsuya, Yuanying Li, Mayu Uemura, Chifa Chiang, Yoshihisa Hirakawa, Atsuhiko Ota, Koji Tamakoshi, Atsuko Aoyama
  • Journal Title: J Diabetes Investig Volume: Online ahead of print. Issue: 5 Pages: 1-7
  • DOI: 10.1111/jdi.13230
  • Peer Reviewed / Open Access
• [Journal Article] Smoking Results in Accumulation of Ectopic Fat in the Liver (2019)
  • Author(s): Ayako Kato, Yuanying Li, Atsuhiko Ota, Hisao Naito, Hiroya Yamada, Takashi Nihashi, Yo Hotta, Chifa Chiang, Yoshihisa Hirakawa, Atsuko Aoyama, Koji Tamakoshi, Hiroshi Yatsuya
  • Journal Title: Diabetes Metab Syndr Obes Volume: 12 Pages: 1075-1080
  • DOI: 10.2147/dmso.s212495
  • Peer Reviewed / Open Access
• [Journal Article] Association of gamma-glutamyl transferase and alanine aminotransferase with type 2 diabetes mellitus incidence in middle-aged Japanese men: 12-year follow up. (2018)
  • Author(s): Kaneko K, Yatsuya H, Li Y, Uemura M, Chiang C, Hirakawa Y, Ota A, Tamakoshi K, Aoyama A.
  • Journal Title: J Diabetes Investig Volume: - Issue: 3 Pages: 837-845
  • DOI: 10.1111/jdi.12930
  • Peer Reviewed / Open Access
• [Presentation] 中年期の空腹時血糖と高齢期の認知機能との関連：愛知職域コホート研究 (2020)
  • Author(s): 霜田真子, 八谷寛, 加藤綾子, 金子佳世, 中川威, 河野直子, 大塚礼, 太田充彦, 内藤久雄, 李媛英, 市野直浩, 山田宏哉, 江啓発, 平川仁尚, 玉腰浩司, 青山温子
  • Organizer: 第30回日本疫学会学術総会
• [Presentation] 特定保健指導レベルと空腹時血糖異常有無による2型糖尿病発症リスク：愛知職域コホート研究 (2020)
  • Author(s): 金子佳世, 八谷寛, 太田充彦, 李媛英, 上村真由, 江啓発, 平川仁尚, 玉腰浩司, 青山温子
  • Organizer: 第30回日本疫学会学術総会
• [Presentation] 特定保健指導レベルと2型糖尿病発症の関連およびその臨床疫学的指標：愛知職域コホート研究 (2019)
  • Author(s): 金子佳世, 八谷寛, 李媛英, 上村真由, 江啓発, 平川仁尚, 内藤久雄, 太田充彦, 玉腰浩司, 青山温子
  • Organizer: 第92回日本産業衛生学会