| Budget Amount *help |
¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Outline of Final Research Achievements |
We set up a short-time sleep model in which sleep can be taken during the same time period, and a combined sleep disorder model in which the sleep quality was reduced by randomly setting the sleep securing time zone every day. Focusing on the amount of food intake, the arcuate nucleus of the hypothalamus of the feeding center, and the hippocampal dentate gyrus of the cognitive memory center, microglia, inflammatory cytokines (TNFα, IL6), and neurogenesis were also evaluated. For cognitive function, the Y maze test and the Burns maze test were used.
As a result, cognitive behavior showed a significant decrease in the combined sleep disorder model, and the amount of food intake also decreased. However, no difference was observed by Iba1 staining, and no difference was observed in TNFα and IL6 in the hippocampus and cerebrum. In addition, there was no difference in Double cortin, which is an index of neurogenesis.
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