• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Large-scale epigenome-wide meta-analysis of resistin to elucidate the pathogenesis of lifestyle-related diseases.

Research Project

Project/Area Number 19K19434
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 58030:Hygiene and public health-related: excluding laboratory approach
Research InstitutionNagoya University

Principal Investigator

Nakatochi Masahiro  名古屋大学, 医学系研究科(保健), 准教授 (10559983)

Project Period (FY) 2019-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2021: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2020: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2019: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Keywordsエピゲノム / レジスチン / バイオインフォマティクス / DNAメチル化 / 生活習慣病
Outline of Research at the Start

レジスチンの分泌異常は、肥満、2型糖尿病、冠動脈疾患等の生活習慣病の発症に深く関与することが知られているが、レジスチンの発現調節機構の全貌は未だ解明されていない。
本研究ではDNAメチル化に注目し、①国内外のコホートを基にゲノムワイドDNAメチル化情報を基に大規模エピゲノムワイドメタ解析を実施し、血中レジスチン濃度に寄与するDNAメチル化サイトを網羅的に同定する。更に②国内のコホートを対象に、同定したDNAメチル化情報とSNP・生活習慣・疾患情報との統合解析を行い、DNAメチル化が血中レジスチン濃度を介して生活習慣病の発症に如何なる影響を与えるのか調査・解明を行う。

Outline of Final Research Achievements

To investigate how DNA methylation affects the development of lifestyle-related diseases via blood resistin levels, we conducted a meta-analysis of epigenome-wide association studies (EWASs) for resistin level in our own cohort study and in public available data. As a result, we identified two new DNA methylation sites associated with resistin. None of these DNA methylation sites were located near the RETN gene encoding resistin. This indicates that resistin levels may be epigenetically regulated by genes other than the RETN gene.

Academic Significance and Societal Importance of the Research Achievements

レジスチンの分泌異常である高レジスチン血症は、肥満、メタボリックシンドローム、冠動脈疾患など様々な病態において認められ、これらの生活習慣病の発症および進展に深く関与する。高レジスチン血症の改善による疾患発症リスク低減の方策を考えるためには、レジスチンが増加する分子メカニズムの解明と、そのメカニズムに沿った介入戦略・治療戦略の開発が必要である。本研究で得られた成果は、これまでに分かっていたRETN遺伝子以外によるレジスチン濃度増減メカニズムの可能性を提示しており、レジスチ濃度調節機構の全貌解明の手掛かりとなる。

Report

(5 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (9 results)

All 2023 2022 2021

All Journal Article (7 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 7 results,  Open Access: 5 results) Presentation (2 results)

  • [Journal Article] A saturated map of common genetic variants associated with human height2022

    • Author(s)
      Yengo L, Nakatochi M, Yamamoto K, Ichihara S, Yokota M, et al
    • Journal Title

      Nature

      Volume: 610 Issue: 7933 Pages: 704-712

    • DOI

      10.1038/s41586-022-05275-y

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids2022

    • Author(s)
      Ramdas Shweta、Judd Jonathan、Graham Sarah E.、Kanoni Stavroula、Wang Yuxuan、...、Narita Akira、...、Tamiya Gen、...、Brown Christopher D.
    • Journal Title

      The American Journal of Human Genetics

      Volume: 109 Issue: 8 Pages: 1366

    • DOI

      10.1016/j.ajhg.2022.06.012

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis2022

    • Author(s)
      Kanoni Stavroula、Graham Sarah E.、Wang Yuxuan、Surakka Ida、Ramdas Shweta、...、Narita Akira、...、Tamiya Gen、...、Peloso Gina M.
    • Journal Title

      Genome Biology

      Volume: 23 Issue: 1 Pages: 268-268

    • DOI

      10.1186/s13059-022-02837-1

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Genome-wide meta-analysis between renal overload type and renal underexcretion type of clinically defined gout in Japanese populations2022

    • Author(s)
      Toyoda Yu、Nakayama Akiyoshi、Nakatochi Masahiro、Kawamura Yusuke、Nakaoka Hirofumi、Yamamoto Ken、Shimizu Seiko、Ooyama Hiroshi、Ooyama Keiko、Shimizu Toru、Nagase Mitsuo、Hidaka Yuji、Ichida Kimiyoshi、Inoue Ituro、Shinomiya Nariyoshi、Matsuo Hirotaka
    • Journal Title

      Molecular Genetics and Metabolism

      Volume: - Issue: 3 Pages: 00126-3

    • DOI

      10.1016/j.ymgme.2022.01.100

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] An X chromosome-wide meta-analysis based on Japanese cohorts revealed that non-autosomal variations are associated with serum urate2021

    • Author(s)
      Nakatochi Masahiro、Toyoda Yu、Kanai Masahiro et al. 13th out of 17
    • Journal Title

      Rheumatology

      Volume: - Issue: 9 Pages: 4430-4432

    • DOI

      10.1093/rheumatology/keab404

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The power of genetic diversity in genome-wide association studies of lipids2021

    • Author(s)
      Graham SE, et al. (Tamiya G; 513th in 530 authors)
    • Journal Title

      Nature

      Volume: 600 Issue: 7890 Pages: 675-679

    • DOI

      10.1038/s41586-021-04064-3

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] The Trans-Ancestral Genomic Architecture of Glycemic Traits2021

    • Author(s)
      Chen J, Spracklen CN, Marenne G, Varshney A, Corbin L, ..., Nakatochi M et al.
    • Journal Title

      Nature Genetics

      Volume: -

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] 血中レジスチン濃度の人種横断型エピゲノムワイドメタ解析による新規DNAメチル化サイトの同定2023

    • Author(s)
      中杤昌弘, 市原佐保子, 山本 健, 大中佳三, 松原達昭, 横田充弘
    • Organizer
      第22回分子予防環境医学研究会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Identification of DNA methylation sites by a trans-ethnic epigenome-wide meta-analysis for circulating resistin levels2022

    • Author(s)
      Masahiro Nakatochi, Sahoko Ichihara, Ken Yamamoto, Keizo Ohnaka, Tatsuaki Matsubara, Mitsuhiro Yokoya
    • Organizer
      日本人類遺伝学会第67回大会
    • Related Report
      2022 Annual Research Report

URL: 

Published: 2019-04-18   Modified: 2024-01-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi