| Project/Area Number |
19K19449
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 58030:Hygiene and public health-related: excluding laboratory approach
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| Research Institution | National Cancer Center Japan |
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Principal Investigator |
Abe Sarah 国立研究開発法人国立がん研究センター, がん対策研究所, 研究員 (60739530)
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| Project Period (FY) |
2019-04-01 – 2022-03-31
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| Project Status |
Completed (Fiscal Year 2021)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2021: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2019: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | Dementia / Ageing / Epidemiology / Nutrition / Japan / dementia / nutrition / stress / epidemiology |
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| Outline of Research at the Start |
-Study design: Nested Case Control. This study will include participants with dementia matched with controls in areas of the JPHC Study with available insurance care records.
-Exposures: We will analyze risk factors related to dementia: particularly fish and omega-3-fatty acid intake and stress (measured by cortisol biomarker).
-Outcome: Dementia cases were identified by "kaigo" insurance care records. The primary outcome of our study will be all subjects with dementia Grade IIa+ and higher. Possible secondary outcomes will include sensitivity
analyses by dementia level (activity grade).
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| Outline of Final Research Achievements |
The underlying purpose of the study remained to explore risk factors of dementia with a slight shift in the focus due to feasibility. The main risk factors analysed in the study were polyunsaturated fatty acids (PUFA) and fish intake and risk of disabling dementia. Total n-3 and n-6 PUFA and as well as n-3 PUFA eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), docosapentaenoic acid (DPA) and alpha-linolenic acid (ALA) and the risk of disabling dementia were analysed in multivariable Cox proportional hazard models to obtain hazard ratios (HR) and 95% confidence intervals (CI) . The manuscript is currently being submitted to a journal for peer review and concrete results of the study will therefore not be released in this report.
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| Academic Significance and Societal Importance of the Research Achievements |
Prioritizing dementia research, diagnosis and control is a public health priority. We expect that using reliable data from a large-scale Japanese cohort will contribute to Japan’s dementia-related goals established by the Ministry of Health Labor and the WHO’s global dementia goals.
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