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Dementia prevention within the ageing Japanese society

Research Project

Project/Area Number 19K19449
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 58030:Hygiene and public health-related: excluding laboratory approach
Research InstitutionNational Cancer Center Japan

Principal Investigator

Abe Sarah  国立研究開発法人国立がん研究センター, がん対策研究所, 研究員 (60739530)

Project Period (FY) 2019-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2021: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2019: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
KeywordsDementia / Ageing / Epidemiology / Nutrition / Japan / dementia / nutrition / stress / epidemiology
Outline of Research at the Start

-Study design: Nested Case Control. This study will include participants with dementia matched with controls in areas of the JPHC Study with available insurance care records.
-Exposures: We will analyze risk factors related to dementia: particularly fish and omega-3-fatty acid intake and stress (measured by cortisol biomarker).
-Outcome: Dementia cases were identified by "kaigo" insurance care records. The primary outcome of our study will be all subjects with dementia Grade IIa+ and higher. Possible secondary outcomes will include sensitivity
analyses by dementia level (activity grade).

Outline of Final Research Achievements

The underlying purpose of the study remained to explore risk factors of dementia with a slight shift in the focus due to feasibility. The main risk factors analysed in the study were polyunsaturated fatty acids (PUFA) and fish intake and risk of disabling dementia. Total n-3 and n-6 PUFA and as well as n-3 PUFA eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), docosapentaenoic acid (DPA) and alpha-linolenic acid (ALA) and the risk of disabling dementia were analysed in multivariable Cox proportional hazard models to obtain hazard ratios (HR) and 95% confidence intervals (CI) . The manuscript is currently being submitted to a journal for peer review and concrete results of the study will therefore not be released in this report.

Academic Significance and Societal Importance of the Research Achievements

Prioritizing dementia research, diagnosis and control is a public health priority. We expect that using reliable data from a large-scale Japanese cohort will contribute to Japan’s dementia-related goals established by the Ministry of Health Labor and the WHO’s global dementia goals.

Report

(4 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report

URL: 

Published: 2019-04-18   Modified: 2023-01-30  

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