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Association between the environment and the development of acute aortic dissection: A nationwid study

Research Project

Project/Area Number 19K19470
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 58030:Hygiene and public health-related: excluding laboratory approach
Research InstitutionNippon Medical School

Principal Investigator

Kato Katsuhito  日本医科大学, 医学部, 講師 (40409157)

Project Period (FY) 2019-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords週末入院 / 急性大動脈解離 / スタンフォード分類 / 自然環境 / 院内死亡 / 気温 / 循環器疾患診療実態調査 / 疫学研究 / 時間生物学的研究 / 発症日 / 大気汚染
Outline of Research at the Start

循環器救急疾患のひとつである急性大動脈解離の入院に気温・大気汚染物質等の自然環境が与える影響について、日本循環器学会の循環器疾患診療実態調査データベース(日本全国の循環器専門施設の入院データ)と気象庁の気象データ、国立環境研究所の環境数値データベースを用い検討する。

Outline of Final Research Achievements

Using the JROAD-DPC database, we presented a conference and wrote a paper on the impact of weekend hospitalization on in-hospital mortality in acute aortic dissection (AAD).The total 33,706 patients for AAD hospitalized higher on weekdays compared to weekends, with an in-hospital mortality rate of 21.9%. Patients admitted on Sundays and holidays showed a significant increase in in-hospital mortality compared to weekdays. In particular, stratified analysis of the Stanford classification by site of dissection showed that only type A patients admitted on Sundays and holidays had a significant increase in in-hospital mortality.
In conclusion, our results suggest that the risk of in-hospital mortality may be higher for AAD Stanford type A patients admitted on Sundays and holidays.

Academic Significance and Societal Importance of the Research Achievements

急性大動脈解離の疫学研究が限られている中、全国の循環器専門施設データであるJROAD-DPCデータベースを用いて国内の急性大動脈解離の入院について網羅的に検討を行うことが可能となった。週末に入院をする急性大動脈解離、特に緊急手術など医療資源がより必要となるスタンフォードA型の急性大動脈解離では院内死亡リスクが高いことが示唆され、今後は長期予後を含めた検討や、死亡リスクが高い理由の詳細な検討が必要である。

Report

(4 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (2 results)

All 2021

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (1 results)

  • [Journal Article] Effect of holiday admission for acute aortic dissection on in-hospital mortality in Japan: A nationwide study2021

    • Author(s)
      Kato Katsuhito、Otsuka Toshiaki、Nakai Michikazu、Sumita Yoko、Seino Yoshihiko、Kawada Tomoyuki
    • Journal Title

      PLOS ONE

      Volume: 16 Issue: 11 Pages: e0260152-e0260152

    • DOI

      10.1371/journal.pone.0260152

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 急性大動脈解離の院内死亡における週末入院の影響について:日本循環器学会 循環器疾患 診療実態調査による検討2021

    • Author(s)
      加藤活人、大塚俊昭、清野精彦、川田智之
    • Organizer
      日本医科大学医学会総会
    • Related Report
      2021 Annual Research Report

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Published: 2019-04-18   Modified: 2023-01-30  

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