The associations of serum amino acid profile and dietary amino acid intake with impaired glucose metabolism: a prospective cohort study

• Project/Area Number: 19K19474
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 58030:Hygiene and public health-related: excluding laboratory approach
• Research Institution: Hiroshima University (2021); Kyushu University (2019-2020)
• Principal Investigator: Chen Sanmei 広島大学, 医系科学研究科(保), 助教 (70808659)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Project Status: Completed (Fiscal Year 2021)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2021: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2020: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000); Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
• Keywords: アミノ酸 / 糖代謝障害 / 前向きコホート研究 / 糖尿病 / 疫学

Outline of Research at the Start

近年、糖尿病の予防におけるアミノ酸の効果に関心が高まっているものの、アミノ酸の組成が早期の糖代謝障害の進展にどのような影響を与えるかは明らかでない。そこで本研究では、職域前向きコホート研究の成績を用いて糖代謝障害の進展に関連するアミノ酸（血中アミノ酸および食事アミノ酸摂取量）を特定することを目的とする。本研究の成果は、糖代謝障害の形成におけるアミノ酸の寄与について病態生理学的機序の理解につながるほか、栄養改善を通じた糖尿病予防のための公衆衛生指針の基礎的な知見となり得る。

Outline of Final Research Achievements

This study aimed to examine the prospective association of amino acid composition at baseline with the development of impaired glucose metabolism among a cohort of Japanese workers. A total of 1,131 non-diabetic participants who underwent the health examinations in the Furukawa Nutrition and Health Study 2015-2016 were prospectively followed-up for 3 years. Our data showed that blood concentrations of branched-chain amino acids, aromatic amino acids, and methionine at baseline were statistically significantly associated with insulin resistance at the 3-year follow-up. The associations for those amino acids showed a significant interaction with obesity status, with more pronounced associations observed in the overweight/obese group than in the underweight/normal weight group. These findings suggest that blood amino acid composition is associated with the subsequent progression of insulin resistance in Japanese workers.

Academic Significance and Societal Importance of the Research Achievements

糖尿病の発症には、インスリン抵抗性といった早期の糖代謝障害が重要な役割を果たすことから、糖代謝障害の進展に関わる因子の同定が求められている。近年、糖尿病の予防におけるアミノ酸の効果に関心が高まっているものの、アミノ酸の組成がインスリン抵抗性などの早期の糖代謝障害の進展にどのような影響を与えるかは十分に明らかでない。本研究の知見は、インスリン抵抗性などの糖代謝障害の形成におけるアミノ酸の寄与について病態生理学的機序の理解につながるほか、日本人のみならず、日本人と体質を含め背景要因が似ている他のアジア諸国における糖尿病予防に資する疫学的知見である。

Research Products

• [Journal Article] Development and Validation of a Risk Prediction Model for Atherosclerotic Cardiovascular Disease in Japanese Adults: The Hisayama Study (2022)
  • Author(s): Honda, Takanori; Chen, Sanmei; Hata, Jun; Yoshida, Daigo; Hirakawa, Yoichiro; Furuta, Yoshihiko; Shibata, Mao; Sakata, Satoko; Kitazono, Takanari; Ninomiya, Toshiharu;
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 29 Issue: 3 Pages: 345-361
  • DOI: 10.5551/jat.61960
  • NAID: 130008165681
  • ISSN: 1340-3478, 1880-3873
  • Year and Date: 2022-03-01
  • Peer Reviewed / Open Access
• [Journal Article] Changes in Body Weight and Concurrent Changes in Cardiovascular Risk Profiles in Community Residents in Japan: the Hisayama Study (2022)
  • Author(s): Honda, Takanori; Ishida, Yuki; Oda, Masaaki; Noguchi, Kenichi; Chen, Sanmei; Sakata, Satoko; Oishi, Emi; Furuta, Yoshihiko; Yoshida, Daigo; Hirakawa, Yoichiro;
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 29 Issue: 2 Pages: 252-267
  • DOI: 10.5551/jat.59394
  • NAID: 130008149940
  • ISSN: 1340-3478, 1880-3873
  • Year and Date: 2022-02-01
  • Peer Reviewed / Open Access
• [Journal Article] Associations of Objectively-Measured Sedentary Time and Patterns with Cognitive Function in Non-Demented Japanese Older Adults: A Cross-Sectional Study (2022)
  • Author(s): Chen, Sanmei; Chen, Tao; Honda, Takanori; Nofuji, Yu; Kishimoto, Hiro; Narazaki, Kenji;
  • Journal Title: International journal of environmental research and public health Volume: 19 Issue: 4 Pages: 1999-1999
  • DOI: 10.3390/ijerph19041999
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Long-term association of vegetable and fruit intake with risk of dementia in Japanese older adults: the Hisayama study (2022)
  • Author(s): Kimura, Yasumi; Yoshida, Daigo; Ohara, Tomoyuki; Hata, Jun; Honda, Takanori; Hirakawa, Yoichiro; Shibata, Mao; Oishi, Emi; Sakata, Satoko; Furuta, Yoshihiko;
  • Journal Title: BMC geriatrics Volume: 22 Issue: 1 Pages: 44574-44574
  • DOI: 10.1186/s12877-022-02939-2
  • Peer Reviewed / Open Access
• [Journal Article] Validation of the Chinese version of the Family Crisis Oriented Personal Evaluation Scales in families of patients with dementia (2022)
  • Author(s): Wang, Qingyan; Chen, Sanmei; Liu, Weiwei; Zan, Chang; Sheng,Yu;
  • Journal Title: Geriatric Nursing Volume: 45 Pages: 131-139
  • DOI: 10.1016/j.gerinurse.2022.03.008
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Development of a risk prediction model for incident hypertension in Japanese individuals: the Hisayama Study (2021)
  • Author(s): Oishi, Emi; Hata, Jun; Honda, Takanori; Sakata, Satoko; Chen, Sanmei; Hirakawa, Yoichiro; Yoshida, Daigo; Shibata, Mao; Ohara, Tomoyuki; Furuta, Yoshihiko;
  • Journal Title: Hypertension Research Volume: 44 Issue: 9 Pages: 1221-1229
  • DOI: 10.1038/s41440-021-00673-7
  • Peer Reviewed
• [Journal Article] Potential utility of physical function measures to improve the risk prediction of functional disability in community-dwelling older Japanese adults: a prospective study (2021)
  • Author(s): Chen, Tao; Honda, Takanori; Chen, Sanmei; Kishimoto, Hiro; Kumagai, Shuzo; Narazaki, Kenji;
  • Journal Title: BMC geriatrics Volume: 21 Issue: 1 Pages: 44569-44569
  • DOI: 10.1186/s12877-021-02415-3
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Prospective study on the association between serum amino acid profiles and depressive symptoms among the Japanese working population (2021)
  • Author(s): Miki, Takako; Eguchi, Masafumi; Kochi, Takeshi; Fukunaga, Ami; Chen, Sanmei; Nanri, Akiko; Kabe, Isamu; Mizoue, Tetsuya;
  • Journal Title: Plos One Volume: 16 Issue: 8 Pages: e0256337-e0256337
  • DOI: 10.1371/journal.pone.0256337
  • Peer Reviewed / Open Access
• [Journal Article] High serum folate concentrations are associated with decreased risk of mortality among Japanese adults (2021)
  • Author(s): Sanmei Chen, Takanori Honda, Jun Hata, Satoko Sakata, Yoshihiko Furuta, Daigo Yoshida, Mao Shibata, Tomoyuki Ohara, Yoichiro Hirakawa, Emi Oishi, Takanari Kitazono, Toshiharu Ninomiya
  • Journal Title: The Journal of Nutrition Volume: 151 Issue: 3 Pages: 657-665
  • DOI: 10.1093/jn/nxaa382
  • Peer Reviewed / Open Access
• [Journal Article] Validity of the prognostication tool PREDICT version 2.2 in Japanese breast cancer patients (2021)
  • Author(s): Karen Zaguirre, Masaya Kai, Makoto Kubo, Mai Yamada, Kanako Kurata, Hitomi Kawaji, Kazuhisa Kaneshiro, Yurina Harada, Saori Hayashi, Akiko Shimazaki, Takafumi Morisaki, Hitomi Mori, Yoshinao Oda, Sanmei Chen, Taiki Moriyama, Shuji Shimizu, Masafumi Nakamura
  • Journal Title: Cancer Medicine Volume: 10 Issue: 5 Pages: 1605-1613
  • DOI: 10.1002/cam4.3713
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Midlife and late-life diabetes and sarcopenia in a general older Japanese population: the Hisayama Study (2021)
  • Author(s): Kimitaka Nakamura, Daigo Yoshida, Takanori Honda, Jun Hata, Mao Shibata, Yoichiro Hirakawa, Yoshihiko Furuta, Hiro Kishimoto, Tomoyuki Ohara, Sanmei Chen, Takanari Kitazono, Yasuharu Nakashima, Toshiharu Ninomiya
  • Journal Title: J Diabetes Investig Volume: in press Issue: 10 Pages: 1-26
  • DOI: 10.1111/jdi.13550
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] N-Terminal Pro B-Type Natriuretic Peptide and Incident CKD (2021)
  • Author(s): Sasaki, Takaya; Oishi, Emi; Nagata, Takuya; Sakata, Satoko; Chen, Sanmei; Furuta, Yoshihiko; Honda, Takanori; Yoshida, Daigo; Hata, Jun; Tsuboi, Nobuo;
  • Journal Title: Kidney International Reports Volume: 6 Issue: 4 Pages: 976-985
  • DOI: 10.1016/j.ekir.2021.01.006
  • Peer Reviewed / Open Access
• [Journal Article] Physical frailty and its associated factors among elderly nursing home residents in China. (2020)
  • Author(s): Weiwei Liu, Martine Puts, Fen Jiang, Chuyi Zhou, Siyuan Tang, Sanmei Chen
  • Journal Title: BMC Geriatrics Volume: 20 Issue: 1 Pages: 294-294
  • DOI: 10.1186/s12877-020-01695-5
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Education and the moderating roles of age, sex, ethnicity and apolipoprotein epsilon 4 on the risk of cognitive impairment (2020)
  • Author(s): Makkar S, Lipnicki D, Crawford J, ..., Lam L, Fung A, Chan W, Guaita A, Vaccaro R, Davin A, Kim K, Han J, Suh S, Riedel-Heller S, Roehr S, Pabst A, Ganguli M, Hughes T, Jacobsen E, Anstey K, Cherbuin N, Haan M, Aiello A, Dang K, Kumagai S, Narazaki K, Chen S, ..., Sachdev P
  • Journal Title: Archives of Gerontology and Geriatrics Volume: 91 Pages: 104112-104112
  • DOI: 10.1016/j.archger.2020.104112
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The association of leisure-time physical activity and walking during commuting to work with depressive symptoms among Japanese workers: A cross-sectional study (2020)
  • Author(s): Kota Fukai, Keisuke Kuwahara, Sanmei Chen, Masafumi Eguchi, Takeshi Kochi, Isamu Kabe, Tetsuya Mizoue
  • Journal Title: Journal of Occupational Health Volume: 62 Issue: 1 Pages: n/a
  • DOI: 10.1002/1348-9585.12120
  • NAID: 130007879807
  • ISSN: 1341-9145, 1348-9585
  • Peer Reviewed
• [Journal Article] Association between serum glycated albumin and risk of cardiovascular disease in a Japanese community: The Hisayama Study (2020)
  • Author(s): Mihara, Akane; Ohara, Tomoyuki; Hata, Jun; Honda, Takanori; Chen, Sanmei; Sakata, Satoko; Oishi, Emi; Hirakawa, Yoichiro; Nakao, Tomohiro; Kitazono, Takanari;
  • Journal Title: Atherosclerosis Volume: 311 Pages: 52-59
  • DOI: 10.1016/j.atherosclerosis.2020.08.016
  • Peer Reviewed
• [Journal Article] Estimating prevalence of subjective cognitive decline in and across international cohort studies of aging: a COSMIC study (2020)
  • Author(s): Rohr S, Pabst A, Riedel-Heller SG, …, Jacobsen EP, Snitz BE, Anstey KJ, Cherbuin N, Kumagai S, Chen S, Narazaki K, Ng TP, Gao Q, Gwee X, Brodaty H, Kochan NA, Trollor J, Lobo A, ..., Crawford JD, Lipnicki DM, Perminder S
  • Journal Title: Alzheimer's Research & Therapy Volume: 12 Issue: 1 Pages: 167-167
  • DOI: 10.1186/s13195-020-00734-y
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Serum homocysteine and risk of dementia in Japan (2020)
  • Author(s): Chen Sanmei、Honda Takanori、Ohara Tomoyuki、Hata Jun、Hirakawa Yoichiro、Yoshida Daigo、Shibata Mao、Sakata Satoko、Oishi Emi、Furuta Yoshihiko、Kitazono Takanari、Ninomiya Toshiharu
  • Journal Title: Journal of Neurology, Neurosurgery & Psychiatry Volume: 91 Issue: 5 Pages: 540-546
  • DOI: 10.1136/jnnp-2019-322366
  • Peer Reviewed / Open Access
• [Journal Article] Dose-Response Association Between Accelerometer-Assessed Physical Activity and Incidence of Functional Disability in Older Japanese Adults: A 6-Year Prospective Study (2020)
  • Author(s): Chen Tao、Honda Takanori、Chen Sanmei、Narazaki Kenji、Kumagai Shuzo
  • Journal Title: The Journals of Gerontology: Series A Volume: - Issue: 9 Pages: 129-136
  • DOI: 10.1093/gerona/glaa046
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Malnutrition and physical frailty among nursing home residents: A cross-sectional study in China (2020)
  • Author(s): Liu Weiwei, Chen Sanmei, Jiang Fen, Zhou Chuyi, Tang Siyuan
  • Journal Title: The Journal of Nutrition, Health & Aging Volume: － Issue: 5 Pages: 500-506
  • DOI: 10.1007/s12603-020-1348-x
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Serum amino acid profiles and risk of type 2 diabetes among Japanese adults in the Hitachi Health Study (2019)
  • Author(s): Chen Sanmei、Akter Shamima、Kuwahara Keisuke、Matsushita Yumi、Nakagawa Tohru、Konishi Maki、Honda Toru、Yamamoto Shuichiro、Hayashi Takeshi、Noda Mitsuhiko、Mizoue Tetsuya
  • Journal Title: Scientific Reports Volume: 9 Issue: 1 Pages: 7010-7010
  • DOI: 10.1038/s41598-019-43431-z
  • Peer Reviewed / Open Access
• [Journal Article] Smoking cessation, weight Gain, and the trajectory of estimated risk of coronary heart disease: 8-Year Follow-up From a Prospective Cohort Study (2019)
  • Author(s): Chen Sanmei、Kawasaki Y、Hu H、Kuwahara K、Yamamoto M、Uehara A、Honda T、Yamamoto S、Nakagawa T、Miyamoto T、Okazaki H、Hori A、Shimizu M、Murakami T、Kochi T、Eguchi M、Imai T、Nishihara A、Tomita K、Akter S、Kabe I、Mizoue T、Dohi S
  • Journal Title: Nicotine & Tobacco Research Volume: － Issue: 1 Pages: 85-91
  • DOI: 10.1093/ntr/ntz165
  • Peer Reviewed / Open Access
• [Journal Article] Serum cholesterol levels preceding to suicide death in Japanese workers: a nested case-control study (2019)
  • Author(s): Chen Sanmei、Mizoue T、Hu H、Kuwahara K、Honda T、Yamamoto S、Nakagawa T、Miyamoto T、Okazaki、Shimizu M、Murakami T、Eguchi M、Kochi T、Yamamoto M、Ogasawara T、Sasaki N、Uehara A、Imai T、Nishihara A、Hori Ai、Nagahama S、Tomita K、Konishi M、Kabe I、Dohi S
  • Journal Title: Acta Neuropsychiatrica Volume: 31 Issue: 05 Pages: 266-269
  • DOI: 10.1017/neu.2019.26
  • Peer Reviewed / Open Access
• [Journal Article] Physical frailty and risk of needing long-term care in community-dwelling older adults: a 6-year prospective study in Japan (2019)
  • Author(s): Chen Sanmei, Honda Takanori, Narazaki Kenji, Chen Tao, Kishimoto Hiro, Kumaga Shuzo
  • Journal Title: The Journal of Nutrition, Health & Aging Volume: 23 Issue: 9 Pages: 856-861
  • DOI: 10.1007/s12603-019-1242-6
  • Peer Reviewed
• [Journal Article] Trajectories of body mass index and waist circumference before the onset of diabetes among people with prediabetes (2019)
  • Author(s): Hu H、Kawasaki Y、Kuwahara K、Nakagawa To、Honda T、Yamamoto S、Eguchi M、Kochi T、Nishihara A、Imai T、Yamamoto M、Okazaki H、Miyamoto T、Tomita K、Uehara A、Ogasawara T、Sasaki N、Hori A、Nagahama S、Shimizu M、Murakami T、Chen Sanmei、Kabe I、Mizoue T、Sone T、Dohi S
  • Journal Title: Clinical Nutrition Volume: － Issue: 9 Pages: 2881-2888
  • DOI: 10.1016/j.clnu.2019.12.023
  • Peer Reviewed / Open Access
• [Presentation] Prospective associations of serum amino acids with insulin resistance among Japanese adults (2022)
  • Author(s): 陳三妹、三木貴子、福永亜美、江口将史、幸地 勇、南里 明子、加部 勇、溝上 哲也
  • Organizer: 第32回日本疫学会学術総会
• [Presentation] 活動的な通勤および通勤形態と糖尿病発症リスクの関連：久山町研究 (2022)
  • Author(s): 本田貴紀、平川洋一郎、秦 淳、陳三妹、柴田舞欧、坂田智子、古田芳彦、東岡真由、大石絵美、北園孝成、二宮利治
  • Organizer: 第32回日本疫学会学術総会
• [Presentation] Cognitive Frailty And Risk Of Functional Disability In Older Japanese Adults: A 4-Year Prospective Study. (2021)
  • Author(s): Chen S, Honda T, Chen T, Matsuzaki H, Kishimoto H, Kumagai S, Narazaki K.
  • Organizer: Geriatrics Society of America Annual Scientific Meeting
  • Int'l Joint Research
• [Presentation] Dose-response associations between accelerometer measured physical activity and sedentary time and all-cause mortality in community-dwelling older Japanese adults: A 9-year prospective study. (2021)
  • Author(s): Chen T, Chen S, Honda T, Kishimoto H, Nofuji Y, Kumagai S, Narazaki K
  • Organizer: 3rd international Academic Forum on Sports Medicine and Health
  • Int'l Joint Research
• [Presentation] 地域高齢住民における魚介類摂取量と認知症発症の関連：久山町研究 (2021)
  • Author(s): 陳三妹、本田貴紀、小原知之、秦 淳、吉田大悟、平川洋一郎、柴田舞欧、坂田智子、中尾智博、二宮利治
  • Organizer: 第57回日本循環器病予防学会
• [Presentation] 地域一般住民において家族機能低下は抑うつ症状に関連する：久山町研究 (2021)
  • Author(s): 長澤史、柴田舞欧、平林直樹、陳三妹、吉田大悟、秦 淳、須藤 信行、二宮利治
  • Organizer: 第28回日本未病学会学術総会
• [Presentation] Association of serum folate and vitamin B-12 concentrations with all-cause mortality: the Hisayama Study (2021)
  • Author(s): Sanmei Chen, Takanori Honda, Jun Hata, Satoko Sakata, Yoshihiko Furuta, Daigo Yoshida, Mao Shibata, Tomoyuki Ohara, Yoichiro Hirakawa, Emi Oishi, Takanari Kitazono, Toshiharu Ninomiya
  • Organizer: 第31回日本疫学会学術総会
• [Presentation] 動脈硬化性心血管疾患発症リスク予測モデルの開発：久山町研究 (2021)
  • Author(s): 本田貴紀, 陳三妹, 秦 淳, 吉田大悟, 平川洋一郎, 古田芳彦, 柴田舞欧, 坂田智子, 北園孝成, 二宮利治
  • Organizer: 第31回日本疫学会学術総会
• [Presentation] Association between serum homocysteine and risk of dementia in Japanese elderly: the Hisayama Study (2020)
  • Author(s): Chen Sanmei, Honda Takanori, Ohara Tomoyuki , Hata Jun, Hirakawa Yoichiro, Yoshida Daigo, Shibata Mao, Kitazono Takanari, Ninomiya Toshiharu
  • Organizer: 第30回日本疫学会学術総会
• [Presentation] Physical frailty and risk of needing long-term care in community-dwelling Japanese elderly (2020)
  • Author(s): Chen Sanmei
  • Organizer: 第1回身体活動・運動科学に関する日中韓学術研究集会教育講演
  • Invited
• [Remarks] 国立国際医療研究センター 疫学予防研究部のホームページ
  • URL: http://www.schoolhealth.jp/deih/index.html