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Establishment of an objective evaluation method for equilibrium disorder and its application to the development of effective vestibular rehabilitation programs.

Research Project

Project/Area Number 19K19800
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 59010:Rehabilitation science-related
Research InstitutionNara Medical University

Principal Investigator

Shiozaki Tomoyuki  奈良県立医科大学, 医学部, 助教 (70812668)

Project Period (FY) 2019-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2021: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2020: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2019: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Keywords前庭リハビリテーション / 前庭脊髄路興奮性 / めまい / 身体活動量 / 直流前庭電気刺激 / H反射 / 前庭脊髄反射 / 前庭動眼反射 / めまい平衡リハビリテーション
Outline of Research at the Start

めまい平衡障害に対する治療法の一つとしてめまい平衡リハビリテーションが注目されつつある。しかし本邦において、質の高いエビデンスに基づいためまい平衡リハビリテーションの確立とその実践には未だ至っていない。その原因の一つとしてめまい平衡リハビリテーションの評価が客観的かつ定量的に行われていないことがあげられる。本研究の目的は,1)客観的で定量的なめまい平衡リハビリテーションの評価方法の確立,2)現在本邦で施行されているめまい平衡リハビリテーションのエビデンスの構築,3)疾患、病態別めまい平衡リハビリテーションの効果の検討である。

Outline of Final Research Achievements

We conducted the first-ever randomized controlled trial in Japan to investigate the effects of vestibular rehabilitation. Our study revealed that vestibular rehabilitation performed by physical therapists led to an increased subjective sense of vertigo and improved daily activity compared to the lifestyle and exercise guidance provided solely by physicians. Additionally, we established a reliable method for assessing vestibulospinal tract excitability and demonstrated its appropriateness. Utilizing this method, we examined whether a dynamic balance task could induce changes in the excitability of the vestibulospinal tract in healthy individuals. While not all participants showed an increase in vestibulospinal tract excitability, we observed an immediate improvement in postural control ability as the excitability of the vestibulospinal tract increased. Moving forward, we aim to apply these findings to patients suffering from vertigo.

Academic Significance and Societal Importance of the Research Achievements

日本でのエビデンスが少ない前庭リハビリテーションの効果を示し、今後国内における治療の一般化に重要な知見を示した。また、主観的な評価が中心である前庭リハビリテーションの効果判定に身体活動量や前庭脊髄路興奮性の評価を実施したことは学術的な意義が高いと考える。

Report

(5 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (19 results)

All 2023 2022 2021 2020 2019

All Journal Article (9 results) (of which Int'l Joint Research: 6 results,  Peer Reviewed: 9 results,  Open Access: 6 results) Presentation (10 results) (of which Invited: 1 results)

  • [Journal Article] Relationships between changes in lateral vestibulospinal tract excitability and postural control by dynamic balance intervention in healthy individuals: A preliminary study2023

    • Author(s)
      Shiozaki Tomoyuki、Okada Yohei、Nakamura Junji、Ueta Kozo、Tanaka Hiroaki、Moritani Mako、Kitahara Tadashi
    • Journal Title

      Frontiers in Human Neuroscience

      Volume: 17 Pages: 1-10

    • DOI

      10.3389/fnhum.2023.1109690

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Superficial Siderosis with Bilateral Vestibulopathy2022

    • Author(s)
      Tanaka Akihisa、Shiozaki Tomoyuki、Kitahara Tadashi
    • Journal Title

      Nippon Jibiinkoka Tokeibugeka Gakkai Kaiho(Tokyo)

      Volume: 125 Issue: 2 Pages: 173-178

    • DOI

      10.3950/jibiinkotokeibu.125.2_173

    • ISSN
      2436-5793, 2436-5866
    • Year and Date
      2022-02-20
    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Vestibulo-Ocular Reflex Is Modulated by Noisy Galvanic Vestibular Stimulation2022

    • Author(s)
      Matsugi Akiyoshi、Shiozaki Tomoyuki、Tanaka Hiroaki
    • Journal Title

      Frontiers in Neurology

      Volume: 13

    • DOI

      10.3389/fneur.2022.826739

    • Related Report
      2022 Annual Research Report 2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of Vestibular Rehabilitation on Physical Activity and Subjective Dizziness in Patients With Chronic Peripheral Vestibular Disorders: A Six-Month Randomized Trial2021

    • Author(s)
      Shiozaki Tomoyuki、Ito Taeko、Wada Yoshiro、Yamanaka Toshiaki、Kitahara Tadashi
    • Journal Title

      Frontiers in Neurology

      Volume: 12 Pages: 1-10

    • DOI

      10.3389/fneur.2021.656157

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Changes in the Results of the Subjective Visual Vertical Test After Endolymphatic Sac Drainage for Intractable Meniere’s Disease2021

    • Author(s)
      Shiozaki Tomoyuki、Wada Yoshiro、Ito Taeko、Yamanaka Toshiaki、Kitahara Tadashi
    • Journal Title

      The Journal of International Advanced Otology

      Volume: 17 Issue: 2 Pages: 121-126

    • DOI

      10.5152/jiao.2021.9056

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Posture influences on vestibulospinal tract excitability2021

    • Author(s)
      Tanaka Hiroaki、Nakamura Junji、Siozaki Tomoyuki、Ueta Kozo、Morioka Shu、Shomoto Koji、Okada Yohei
    • Journal Title

      Experimental Brain Research

      Volume: 239 Issue: 3 Pages: 997-1007

    • DOI

      10.1007/s00221-021-06033-8

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Reliability and laterality of the soleus H-reflex following galvanic vestibular stimulation in healthy individuals2021

    • Author(s)
      Nakamura Junji、Okada Yohei、Shiozaki Tomoyuki、Tanaka Hiroaki、Ueta Kozo、Ikuno Koki、Morioka Shu、Shomoto Koji
    • Journal Title

      Neuroscience Letters

      Volume: 755 Pages: 135910-135910

    • DOI

      10.1016/j.neulet.2021.135910

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] No Impact of Stochastic Galvanic Vestibular Stimulation on Arterial Pressure and Heart Rate Variability in the Elderly Population2021

    • Author(s)
      Matsugi Akiyoshi、Nagino Koji、Shiozaki Tomoyuki、Okada Yohei、Mori Nobuhiko、Nakamura Junji、Douchi Shinya、Oku Kosuke、Nagano Kiyoshi、Tamaru Yoshiki
    • Journal Title

      Frontiers in Human Neuroscience

      Volume: 15 Pages: 646127-646127

    • DOI

      10.3389/fnhum.2021.646127

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] What diagnosis should we make for long-lasting vertiginous sensation after acute peripheral vertigo?2020

    • Author(s)
      Shiozaki Tomoyuki、Sakagami Masaharu、Ito Taeko、Ota Ichiro、Wada Yoshiro、Kitahara Tadashi
    • Journal Title

      Acta Oto-Laryngologica

      Volume: 140 Issue: 12 Pages: 1001-1006

    • DOI

      10.1080/00016489.2020.1813327

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] めまい患者に対する前庭リハビリテーションの年齢による効果の違い2023

    • Author(s)
      塩崎 智之,北原 糺
    • Organizer
      第12回保健医療学学会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 理学療法士によるまほろば式前庭リハビリテーション2022

    • Author(s)
      塩崎 智之
    • Organizer
      第81回日本めまい平衡医学会総会・学術講演会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 片側末梢前庭障害症例の前庭脊髄路興奮性と平衡障害の関係性についての予備的検討2022

    • Author(s)
      塩崎 智之,北原 糺
    • Organizer
      第20回日本神経理学療法学会学術大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 一側末梢前庭障害症例に対する前庭リハビリテーションの障害部位による効果の違い~第2報~2021

    • Author(s)
      塩崎智之
    • Organizer
      第80回日本めまい平衡医学会学術集会
    • Related Report
      2021 Research-status Report
  • [Presentation] 前庭リハビリテーションによる前庭動眼反射の改善効果について2021

    • Author(s)
      塩崎智之
    • Organizer
      第19回日本神経理学療法学会学術大会
    • Related Report
      2021 Research-status Report
  • [Presentation] 動的バランス課題が姿勢制御と直流前庭電気刺激を用いた前庭脊髄路機能評価に及ぼす影響2021

    • Author(s)
      塩崎智之
    • Organizer
      第1回物理療法部門研究会
    • Related Report
      2020 Research-status Report
  • [Presentation] 一側末梢前庭障害症例に対する前庭リハビリテーションの障害部位による効果の違い2020

    • Author(s)
      塩崎智之
    • Organizer
      第79回日本めまい平衡医学会総会・学術講演会
    • Related Report
      2020 Research-status Report
  • [Presentation] 前庭リハビリテーションにおける客観的指標と主観的指標の改善の関係性について2020

    • Author(s)
      塩崎智之
    • Organizer
      第18回日本神経理学療法学会学術大会
    • Related Report
      2020 Research-status Report
  • [Presentation] 慢性期めまい平衡障害症例に対するMAHOROBA式前庭リハビリテーションの効果2019

    • Author(s)
      塩崎智之
    • Organizer
      第17回日本神経理学療法学会学術大会
    • Related Report
      2019 Research-status Report
  • [Presentation] 前庭リハビリテーション開始初期の活動性の変化がリハビリテーションの効果に及ぼす影響2019

    • Author(s)
      塩崎智之
    • Organizer
      第78回日本めまい平衡医学会総会学術講演会
    • Related Report
      2019 Research-status Report

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Published: 2019-04-18   Modified: 2024-01-30  

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