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Human spinal circuits related to finger movements

Research Project

Project/Area Number 19K19827
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 59010:Rehabilitation science-related
Research InstitutionYamagata University

Principal Investigator

Nito Mitsuhiro  山形大学, 医学部, 助教 (70732692)

Project Period (FY) 2019-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2021: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Keywords運動制御 / 脊髄反射 / 筋電図 / 電気刺激 / 上肢 / 手根 / 手指機能 / 脳血管障害 / 上肢運動機能 / 粗大把握 / 巧緻運動 / 運動麻痺 / 巧緻動作 / 脊髄神経 / リハビリテーション
Outline of Research at the Start

脳血管障害などによる運動麻痺では、手指の把持力や巧緻性が低下し、日常生活に様々な支障がもたらされる。このような患者の手根の力を徒手筋力検査法により調べると、伸展力が減弱していることが多く認められる。本研究では、運動麻痺患者を対象に、申請者らが作製した力計測装置を用いて45°毎8方向の手根の力を計測して定量化し、減弱していると予測される手根の力と手指機能検査との関連を調べる。また、健常者を対象にこれらの運動時に働くと考えられる神経機構について調べる。以上から、手指機能と手根運動の関連について多角的に調べる。

Outline of Final Research Achievements

To elucidate the relationship between wrist and hand movements, we measured the wrist-bending force, maximal grip/pinch force, and finger function tests in subacute stroke patients. The wrist-bending force produced by maximal isometric force was decreased in all directions in individuals with motor paralysis. In addition, delayed finger movements and reduction of maximal force were observed in these subjects. We also investigated the effects of electrical stimulation to the radial nerve innervating extensor carpi radialis (ECR) on motoneurons supplying intrinsic and extrinsic hand muscles in healthy volunteers. We found that monosynaptic facilitation mediated by group Ia afferents originated from muscle spindles of ECR to these motoneruons exists in human spinal cord. Enhancing these spinal circuits may contribute to the recovery of finger motor function after stoke.

Academic Significance and Societal Importance of the Research Achievements

本研究は、急性期脳卒中患者の手根と手指機能の関連を調べ、リハビリテーションへの応用の可能性を探る基礎的な研究である。手根の力は麻痺側において、どの方向でも減弱しており、手指運動の遅延・機能低下を認めた。健常者でヒトの脊髄神経機構について調べたところ、橈側手根伸筋から手指筋の運動細胞に対して単シナプス性促通を持つことが明らかとなった。以上から、手根伸筋群への介入により手指運動機能を改善させる可能性があることが示唆された。

Report

(5 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (32 results)

All 2023 2022 2021 2020 2019

All Journal Article (9 results) (of which Peer Reviewed: 9 results,  Open Access: 6 results) Presentation (23 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] Combined neuromuscular electrical stimulation and transcutaneous spinal direct current stimulation increases motor cortical plasticity in healthy humans2023

    • Author(s)
      Koseki Tadaki,Kudo Daisuke,Yoshida Kaito,Nito Mitsuhiro,Takano Keita,Jin Masafumi,Tanabe Shigeo,Sato Toshiaki,Katoh Hiroshi,Yamaguchi Tomofumi
    • Journal Title

      Frontiers in Neuroscience

      Volume: 16 Pages: 1034451-1034451

    • DOI

      10.3389/fnins.2022.1034451

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Monosynaptic facilitation of motoneurons innervating intrinsic hand muscles mediated by group Ia afferents from the extensor carpi radialis in humans2022

    • Author(s)
      Nito Mitsuhiro、Yoshimoto Takuya、Hashizume Wataru、Shindo Masaomi、Naito Akira
    • Journal Title

      Physiological Reports

      Volume: 10 Issue: 16

    • DOI

      10.14814/phy2.15431

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Monosynaptic facilitation of flexor digitorum superficialis motoneurons mediated by Group Ia afferents from the extensor carpi radialis in humans2022

    • Author(s)
      Nito Mitsuhiro、Yoshimoto Takuya、Hashizume Wataru、Sato Tomomi、Shimada Kazuto、Shindo Masaomi、Naito Akira
    • Journal Title

      European Journal of Neuroscience

      Volume: 56 Issue: 6 Pages: 4901-4913

    • DOI

      10.1111/ejn.15784

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The combined effects of transcutaneous spinal direct current stimulation and neuromuscular electrical stimulation on corticospinal excitability and gait performance in humans.2022

    • Author(s)
      小関 忠樹、仁藤 充洋、田辺 茂雄、山口 智史、関口 航、押野 真央、竹村 直、齋藤 佑規、吉田 海斗、工藤 大輔、髙野 圭太、神 将文
    • Journal Title

      Japanese Journal of Electrophysical Agents

      Volume: 29 Issue: 1 Pages: 55-64

    • DOI

      10.57337/jjeapt.21-2

    • ISSN
      2188-9805, 2758-1063
    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Monosynaptic facilitation mediated by group Ia afferents from deltoid to biceps brachii motoneurons in humans2022

    • Author(s)
      Yoshimoto Takuya、Nito Mitsuhiro、Hashizume Wataru、Miyasaka Takuji、Shindo Masaomi、Naito Akira
    • Journal Title

      Experimental Brain Research

      Volume: 240 Issue: 4 Pages: 1057-1067

    • DOI

      10.1007/s00221-022-06332-8

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Individualized beta-band oscillatory transcranial direct current stimulation over the primary motor cortex enhances corticomuscular coherence and corticospinal excitability in healthy individuals2022

    • Author(s)
      Kudo Daisuke、Koseki Tadaki、Katagiri Natsuki、Yoshida Kaito、Takano Keita、Jin Masafumi、Nito Mitsuhiro、Tanabe Shigeo、Yamaguchi Tomofumi
    • Journal Title

      Brain Stimulation

      Volume: 15 Issue: 1 Pages: 46-52

    • DOI

      10.1016/j.brs.2021.11.004

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Vibration decreases the responsiveness of Ia afferents and spinal motoneurons in humans2021

    • Author(s)
      Nito Mitsuhiro、Yoshimoto Takuya、Hashizume Wataru、Shindo Masaomi、Naito Akira
    • Journal Title

      Journal of Neurophysiology

      Volume: 126 Issue: 4 Pages: 1137-1147

    • DOI

      10.1152/jn.00168.2021

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Electrical stimulation of the common peroneal nerve and its effects on the relationship between corticomuscular coherence and motor control in healthy adults2021

    • Author(s)
      Koseki Tadaki、Kudo Daisuke、Katagiri Natsuki、Nanba Shigehiro、Nito Mitsuhiro、Tanabe Shigeo、Yamaguchi Tomofumi
    • Journal Title

      BMC Neuroscience

      Volume: 22 Issue: 1 Pages: 61-61

    • DOI

      10.1186/s12868-021-00665-w

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Repetitive Peripheral Magnetic Stimulation of Wrist Extensors Enhances Cortical Excitability and Motor Performance in Healthy Individuals2021

    • Author(s)
      Mitsuhiro Nito, Natsuki Katagiri, Kaito Yoshida, Tadaki Koseki, Daisuke Kudo, Shigehiro Nanba, Shigeo Tanabe, Tomofumi Yamaguchi
    • Journal Title

      Frontiers in Neuroscience

      Volume: 15 Pages: 632716-632716

    • DOI

      10.3389/fnins.2021.632716

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Oligosynaptic inhibition of group Ia afferents between the anterior and posterior parts of the deltoid in humans.2022

    • Author(s)
      Yoshimoto Takuya, Nito Mitsuhiro, Shimada Kazuto, Sato Tomomi, Hashizume Wataru, Naito Akira.
    • Organizer
      第128回日本解剖学会総会・全国学術集会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Facilitation from the biceps brachii to the middle part of the deltoid in humans: an electromyogram-averaging study.2022

    • Author(s)
      Shimada Kazuto, Nito Mitsuhiro, Sato Tomomi, Yoshimoto Takuya, Hashizume Wataru, Naito Akira.
    • Organizer
      第128回日本解剖学会総会・全国学術集会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Spinal reflex arc from biceps brachii to the middle and posterior parts of deltoid in humans;a post-stimulus time-histogram study.2022

    • Author(s)
      Sato Tomomi, Nito Mitsuhiro, Yoshimoto Takuya, Shimada Kazuto, Hashizume Wataru, Naito Akira.
    • Organizer
      第128回日本解剖学会総会・全国学術集会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Inhibitory spinal reflex arc from the anterior to the posterior part of the deltoid in humans.2022

    • Author(s)
      Yoshimoto Takuya, Nito Mitsuhiro, Hashizume Wataru, Shimada Kazuto, Sato Tomomi, Naito Akira.
    • Organizer
      第68回東北・北海道連合支部学術集会
    • Related Report
      2022 Annual Research Report
  • [Presentation] ヒト上腕二頭筋から三角筋中部・後部への脊髄反射の解析.2022

    • Author(s)
      島田 和人, 佐藤 友美, 仁藤 充洋, 吉元 拓也, 橋爪 和足, 内藤 輝
    • Organizer
      第39回山形形態機能研究会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Monosynaptic facilitation mediated by group Ia afferents from the extensor carpi radialis to the abductor digiti minimi motoneurons in humans2021

    • Author(s)
      Mitsuhiro Nito, Takuya Yoshimoto, Wataru Hashizume, Akira Naito
    • Organizer
      第127回日本解剖学会総会・全国学術集会
    • Related Report
      2021 Research-status Report
  • [Presentation] Inhibition of group Ia afferents from the anterior part to the posterior part of the deltoid in humans2021

    • Author(s)
      Takuya Yoshimoto, Mitsuhiro Nito, Wataru Hashizume, Akira Naito
    • Organizer
      第127回日本解剖学会総会・全国学術集会
    • Related Report
      2021 Research-status Report
  • [Presentation] 最大手背屈強度の末梢神経反復磁気刺激が皮質興奮性と疲労に与える影響2021

    • Author(s)
      吉田 海斗, 仁藤 充洋, 田辺 茂雄, 藤井 浩美, 山口 智史
    • Organizer
      第28回山形県作業療法学会
    • Related Report
      2021 Research-status Report
  • [Presentation] 個別の生体信号を刺激周波数に使用した律動的経頭蓋直流電気刺激(otDCS)が皮質脊髄路興奮性に与える影響2021

    • Author(s)
      工藤大輔, 小関忠樹, 吉田海斗, 髙野圭太,神将史, 仁藤充洋, 田辺茂雄, 山口智史
    • Organizer
      第2回物理療法研究会学術大会
    • Related Report
      2021 Research-status Report
  • [Presentation] 異なる刺激強度の末梢神経反復磁気刺激が皮質脊髄路興奮性に及ぼす効果2021

    • Author(s)
      吉田海斗, 仁藤充洋, 小関忠樹, 工藤大輔, 神将文, 髙野圭太, 片桐夏樹, 田辺茂雄, 山口智史
    • Organizer
      第2回物理療法研究会学術大会
    • Related Report
      2021 Research-status Report
  • [Presentation] Monosynaptic facilitation mediated by group Ia afferents from the extensor carpi radialis to the first dorsal interosseous motoneurons in humans2021

    • Author(s)
      Mitsuhiro Nito, Takuya Yoshimoto, Wataru Hashizume, Akira Naito
    • Organizer
      第126回日本解剖学会総会・全国学術集会
    • Related Report
      2020 Research-status Report
  • [Presentation] 末梢神経反復磁気刺激が大脳皮質興奮性および運動パフォーマンスに及ぼす影響2021

    • Author(s)
      仁藤 充洋, 片桐 夏樹, 吉田 海斗, 小関 忠樹, 工藤 大輔, 難波 樹央, 田辺 茂雄, 山口 智史
    • Organizer
      第1回物理療法部門研究会
    • Related Report
      2020 Research-status Report
  • [Presentation] Monosynaptic facilitation of group Ia afferents from the extensor carp radialis to the flexor digitorum superficialis motoneurons in humans2020

    • Author(s)
      Mitsuhiro Nito, Takuya Yoshimoto, Wataru Hashizume, Akira Naito
    • Organizer
      第43回日本神経科学大会
    • Related Report
      2020 Research-status Report
  • [Presentation] ヒト三角筋前部から後部への脊髄反射回路の解析2020

    • Author(s)
      吉元 拓也, 仁藤 充洋, 橋爪 和足, 内藤 輝
    • Organizer
      第37回山形形態機能研究会
    • Related Report
      2020 Research-status Report
  • [Presentation] The duration and frequency of vibration modulate the recovery time of the post-vibration depression of monosynaptic Ia facilitation in humans2019

    • Author(s)
      Nito M, Yoshimoto T, Hashizume W, Jimenji M, Naito A
    • Organizer
      The 49th Annual Meeting of the Society for Neuroscience
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Facilitation from the anterior and middle parts of the deltoid to biceps brachii motoneurons in humans2019

    • Author(s)
      Yoshimoto T, Nito M, Jimenji M, Hashizume W, Naito A
    • Organizer
      The 49th Annual Meeting of the Society for Neuroscience
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] 末梢神経反復磁気刺激による皮質脊髄路興奮性の経時的変化2019

    • Author(s)
      仁藤充洋,片桐夏樹,吉田海斗,田辺茂雄,山口智史
    • Organizer
      第3回日本リハビリテーション医学会秋季学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] Effects of tonic vibration stimulation on monosynaptic Ia facilitation of homonymous and heteronymous motoneurons in humans2019

    • Author(s)
      Nito M, Yoshimoto T, Hashizume W, Shindo M, Naito A
    • Organizer
      第42回日本神経科学大会
    • Related Report
      2019 Research-status Report
  • [Presentation] Patterns of neural projections from deltoid to biceps brachii motoneurons in humans: a post-stimulus time-histogram study2019

    • Author(s)
      Yoshimoto T, Nito M, Hashizume W, Jimenji M, Miyasaka T, Shindo M, Naito A
    • Organizer
      第42回日本神経科学大会
    • Related Report
      2019 Research-status Report
  • [Presentation] The frequency of vibration affects the recovery of the post-vibration depression of monosynaptic Ia facilitation in the human upper limb2019

    • Author(s)
      Nito M, Yoshimoto T, Hashizume W, Jimenji M, Shindo M, Naito A
    • Organizer
      第124回日本解剖学会総会・全国学術大会
    • Related Report
      2019 Research-status Report
  • [Presentation] Modulation of biceps brachii motoneuron excitabilities by electrical stimulation to group I afferents of the middle and posterior parts of the deltoid in humans.2019

    • Author(s)
      Yoshimoto T, Nito M, Hashizume W, Jimenji M, Miyasaka T, Shindo M, Naito A
    • Organizer
      第124回日本解剖学会総会・全国学術大会
    • Related Report
      2019 Research-status Report
  • [Presentation] Spinal reflex arcs of group I afferents from the middle and posterior parts of the deltoid to the biceps brachii motoneuron pool in humans: A study using an electromyogram-averaging method.2019

    • Author(s)
      Yoshimoto T, Nito M, Hashizume W, Jimenji M, Naito A
    • Organizer
      第65回東北・北海道連合支部学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] ヒト三角筋から上腕二頭筋への脊髄反射回路の解析2019

    • Author(s)
      吉元 拓也, 仁藤 充洋, 橋爪 和足, 内藤 輝
    • Organizer
      第36回山形形態機能研究会
    • Related Report
      2019 Research-status Report

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Published: 2019-04-18   Modified: 2024-01-30  

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