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Novel Noninvasive Brain Stimulation Strategies to Promote Motor Learning

Research Project

Project/Area Number 19K19835
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 59010:Rehabilitation science-related
Research InstitutionIbaraki Prefectural University of Health Science

Principal Investigator

Satoshi Yamamoto  茨城県立医療大学, 保健医療学部, 助教 (00735334)

Project Period (FY) 2019-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2021: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2020: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2019: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Keywords機能的核磁気共鳴 / 運動関連領野 / 経頭蓋直流電気刺激 / 上肢到達運動 / 非侵襲的脳刺激 / 経頭蓋直流電気刺激法 / 学習 / 機能的核磁気共鳴画像法 / 運動学習 / 反復経頭蓋磁気刺激 / 機能的MRI / 半球間抑制 / 再学習
Outline of Research at the Start

脳卒中片麻痺の回復を促進する方法として、反復経頭蓋磁気刺激(rTMS)によって左右の大脳半球の活動バランスを変化させる方法の有効性が多数報告されている。しかし脳卒中片麻痺者の運動の再学習を促進する領域は十分には同定されていない。運動学習を促進する刺激部位を同定することで、より有効な機能回復促進法を開発できる可能性がある。
そこで本研究は健常成人を対象に運動学習機能低下モデルを開発し、このモデルを用いて運動再学習を促進するrTMS刺激領域の同定を行う。これによりrTMSを用いて、脳卒中片麻痺をより短期間かつより大きく回復させる刺激方法に関して、理論と実験の両面から体系化する研究開発基盤を構築する。

Outline of Final Research Achievements

Focusing on the important role of motor relearning in the recovery of motor function from brain injury, we will construct a new noninvasive brain stimulation method to promote recovery in stroke hemiplegia. Currently, the regions that promote motor relearning in stroke hemiplegics have not been fully identified. Identification of the stimulation areas that promote motor learning may lead to the development of more effective methods to promote functional recovery. Therefore, this study will develop a model of impaired motor learning function in healthy adults and use this model to identify the stimulus areas that promote motor relearning. This research will establish a foundation for systematizing both theoretical and experimental methods of stimulating hemiplegic symptoms in stroke patients to recover more rapidly and to a greater extent.

Translated with www.DeepL.com/Translator (free version)

Academic Significance and Societal Importance of the Research Achievements

脳血管疾患はその療養が長期に及ぶことが多く、介護費用は2兆円を超え、総介護費用の29%もの割合を占めるため、脳血管疾患を持つ多くの患者の機能回復を促進し、自立して日常生活を送るための新たな治療法の構築が必要である。そこで本研究は、運動機能回復には運動の再学習が重要な役割を担っている点に着目し、脳卒中片麻痺の回復を促進する新たな刺激法の開発へと展開するための基盤研究を行う。運動の再学習を促進する刺激法を確立することは、効果的な治療法の開発に貢献できると考えている。

Report

(5 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (33 results)

All 2023 2022 2021 2020 2019 2018

All Journal Article (22 results) (of which Int'l Joint Research: 9 results,  Peer Reviewed: 22 results,  Open Access: 13 results) Presentation (11 results) (of which Int'l Joint Research: 4 results)

  • [Journal Article] Use of Robot-Assisted Ankle Training in a Patient with an Incomplete Spinal Cord Injury: A Case Report2023

    • Author(s)
      Koseki Kazunori、Takahashi Kazushi、Yamamoto Satoshi、Yoshikawa Kenichi、Abe Atsushi、Mutsuzaki Hirotaka
    • Journal Title

      Journal of Functional Morphology and Kinesiology

      Volume: 8 Issue: 1 Pages: 31-31

    • DOI

      10.3390/jfmk8010031

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Short knee–ankle–foot orthosis use led to independence in locomotion and toileting in a chronic stroke patient: A case report2022

    • Author(s)
      安部 厚志、若旅 正弘、石橋 清成、岡本 善敬、内田 武正、山本 哲
    • Journal Title

      Journal of Rehabilitation Neurosciences

      Volume: 22 Issue: JPN Pages: n/a

    • DOI

      10.24799/jrehabilneurosci.222402

    • ISSN
      2434-2629, 2434-2637
    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Post Stroke Mirror Movements Preventing Performance of Bilateral Movements and Activities of Daily Living2022

    • Author(s)
      Suzuki Hokuto、Yamamoto Satoshi、Wakatabi Masahiro、Ohtsuka Hiroyuki
    • Journal Title

      Case Reports in Neurology

      Volume: 14 Issue: 3 Pages: 456-463

    • DOI

      10.1159/000525907

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Robot-Assisted Ankle Rehabilitation Using the Hybrid Assistive Limb for Children after Equinus Surgery: A Report of Two Cases2022

    • Author(s)
      Takahashi Kazushi、Mutsuzaki Hirotaka、Yoshikawa Kenichi、Yamamoto Satoshi、Koseki Kazunori、Takeuchi Ryoko、Mataki Yuki、Iwasaki Nobuaki
    • Journal Title

      Pediatric Reports

      Volume: 14 Issue: 3 Pages: 338-351

    • DOI

      10.3390/pediatric14030041

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Transcranial Direct Current Stimulation of the Dorsolateral Prefrontal Cortex Modulates Cognitive Function Related to Motor Execution During Sequential Task: A Randomized Control Study2022

    • Author(s)
      Yamamoto Satoshi、Ishii Daisuke、Ishibashi Kiyoshige、Kohno Yutaka
    • Journal Title

      Frontiers in Human Neuroscience

      Volume: 16 Pages: 1-9

    • DOI

      10.3389/fnhum.2022.890963

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of short-term upper limb immobilization on sensory information processing and corticospinal excitability2022

    • Author(s)
      Okamoto Yoshitaka、Ishii Daisuke、Yamamoto Satoshi、Ishibashi Kiyoshige、Kohno Yutaka、Numata Kenji
    • Journal Title

      Experimental Brain Research

      Volume: 240 Issue: 7-8 Pages: 1979-1989

    • DOI

      10.1007/s00221-022-06371-1

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Progress of the Gait Impairment and Brain Activation in a Patient with Post-stroke Hemidystonia2021

    • Author(s)
      YAMAMOTO Satoshi、ISHII Daisuke、KANAE Kyoko、ENDO Yusuke、YOSHIKAWA Kenichi、KOSEKI Kazunori、NAKAZAWA Ryo、TAKANO Hanako、MONMA Masahiko、YOZU Arito、MATSUSHITA Akira、KOHNO Yutaka
    • Journal Title

      Physical Therapy Research

      Volume: 24 Issue: 2 Pages: 176-186

    • DOI

      10.1298/ptr.E10032

    • NAID

      130008076825

    • ISSN
      2189-8448
    • Year and Date
      2021-08-20
    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Interaction of the Left?Right Somatosensory Pathways in Patients With Thalamic Hemorrhage: A Case Report2021

    • Author(s)
      Ishii Daisuke、Ishibashi Kiyoshige、Takeda Kotaro、Yuine Hiroshi、Yamamoto Satoshi、Kaku Yuki、Yozu Arito、Kohno Yutaka
    • Journal Title

      Frontiers in Human Neuroscience

      Volume: 15 Pages: 1-8

    • DOI

      10.3389/fnhum.2021.761186

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effectiveness of Long-Term Physiotherapy in Parkinson’s Disease: A Systematic Review and Meta-Analysis2021

    • Author(s)
      Okada Yohei、Ohtsuka Hiroyuki、Kamata Noriyuki、Yamamoto Satoshi、Sawada Makoto、Nakamura Junji、Okamoto Masayuki、Narita Masaru、Nikaido Yasutaka、Urakami Hideyuki、Kawasaki Tsubasa、Morioka Shu、Shomoto Koji、Hattori Nobutaka
    • Journal Title

      Journal of Parkinson's Disease

      Volume: 11 Issue: 4 Pages: 1619-1630

    • DOI

      10.3233/jpd-212782

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A patient with bilateral medial medullary infarction: Clinical and magnetic resonance imaging findings2021

    • Author(s)
      Sako Rikitaro、Yamamoto Satoshi、Takeda Kotaro、Wakatabi Masahiro、Daira Minoru、Hondera Tetsuichi、Oota Takayuki、Fujii Ami、Okamoto Yoshitaka、Sugiyama Satoshi、Ozasa Yoshifumi
    • Journal Title

      Interdisciplinary Neurosurgery

      Volume: 25 Pages: 101126-101126

    • DOI

      10.1016/j.inat.2021.101126

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Contralateral and Ipsilateral Interactions in the Somatosensory Pathway in Healthy Humans2021

    • Author(s)
      Ishii Daisuke、Ishibashi Kiyoshige、Yuine Hiroshi、Takeda Kotaro、Yamamoto Satoshi、Kaku Yuki、Yozu Arito、Kohno Yutaka
    • Journal Title

      Frontiers in Systems Neuroscience

      Volume: 15 Pages: 1-6

    • DOI

      10.3389/fnsys.2021.698758

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Relationship Between Motor Function, DTI, and Neurophysiological Parameters in Patients with Stroke in the Recovery Rehabilitation unit2021

    • Author(s)
      Okamoto Yoshitaka、Ishii Daisuke、Yamamoto Satoshi、Ishibashi Kiyoshige、Wakatabi Masahiro、Kohno Yutaka、Numata Kenji
    • Journal Title

      Journal of Stroke and Cerebrovascular Diseases

      Volume: 30 Issue: 8 Pages: 105889-105889

    • DOI

      10.1016/j.jstrokecerebrovasdis.2021.105889

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Asymmetry of Interhemispheric Connectivity during Rapid Movements of Right and Left Hands: A TMS-EEG Study2021

    • Author(s)
      Ishibashi Kiyoshige、Ishii Daisuke、Yamamoto Satoshi、Okamoto Yoshitaka、Wakatabi Masahiro、Kohno Yutaka
    • Journal Title

      Journal of Motor Behavior

      Volume: 54 Issue: 2 Pages: 135-145

    • DOI

      10.1080/00222895.2021.1930993

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Opposite modulations of corticospinal excitability by intermittent and continuous peripheral electrical stimulation in healthy subjects2021

    • Author(s)
      Ishibashi Kiyoshige、Ishii Daisuke、Yamamoto Satoshi、Noguchi Akira、Tanamachi Kenya、Kohno Yutaka
    • Journal Title

      Neuroscience Letters

      Volume: 740 Pages: 135467-135467

    • DOI

      10.1016/j.neulet.2020.135467

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Ipsilesional spatial bias after a focal cerebral infarction in the medial agranular cortex: A mouse model of unilateral spatial neglect2021

    • Author(s)
      Daisuke Ishii, Hironobu Osaki, Arito Yozu, Kiyoshige Ishibashi, Kenta Kawamura, Satoshi Yamamoto, Mariko Miyata, Yutaka Kohno
    • Journal Title

      Behavioural Brain Research

      Volume: 401 Pages: 113097-113097

    • DOI

      10.1016/j.bbr.2020.113097

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A study on the immediate effects of neuromuscular electrical stimulation on the corticospinal tract excitability of the infraspinatus muscle2021

    • Author(s)
      Endo Naoto、Ishii Daisuke、Ishibashi Kiyoshige、Yamamoto Satoshi、Takeda Kotaro、Kohno Yutaka
    • Journal Title

      Journal of Back and Musculoskeletal Rehabilitation

      Volume: - Issue: 4 Pages: 1-7

    • DOI

      10.3233/bmr-200298

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Experience of After-Effect of Memory Update Reduces Sensitivity to Errors During Sensory-Motor Adaptation Task2021

    • Author(s)
      Tanamachi Kenya、Izawa Jun、Yamamoto Satoshi、Ishii Daisuke、Yozu Arito、Kohno Yutaka
    • Journal Title

      Frontiers in Human Neuroscience

      Volume: 15 Pages: 1-8

    • DOI

      10.3389/fnhum.2021.602405

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] パーキンソン病患者におけるHonda歩行アシストを用いた歩行訓練の即時的な効果2020

    • Author(s)
      山本 哲, 吉川 憲一, 古関 一則, 石井 大典, 仲澤 諒, 高野 華子, 遠藤 悠介, 四津 有人, 松下 明, 河野 豊
    • Journal Title

      運動障害

      Volume: 30 Pages: 23-30

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] A Short-Duration Combined Exercise and Education Program to Improve Physical Function and Social Engagement in Community-Dwelling Elderly Adults2019

    • Author(s)
      Yamamoto Satoshi、Ishii Daisuke、Noguchi Akira、Tanamachi Kenya、Okamoto Yoshitaka、Takasaki Yuka、Miyata Kazuhiro、Fujita Yoshihiko、Kishimoto Hiroshi、Hotta Kazushi、Iwai Koichi、Kohno Yutaka
    • Journal Title

      International Quarterly of Community Health Education

      Volume: 40 Issue: 4 Pages: 281-287

    • DOI

      10.1177/0272684x19896732

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Adjusting Assistance Commensurates with Patient Effort During Robot-Assisted Upper Limb Training for a Patient with Spasticity After Cervical Spinal Cord Injury: A Case Report2019

    • Author(s)
      Yoshikawa、Koseki、Endo、Yamamoto、Kanae、Takeuchi、Yozu、Mutsuzaki
    • Journal Title

      Medicina

      Volume: 55 Issue: 8 Pages: 404-404

    • DOI

      10.3390/medicina55080404

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 非対称的な症状を呈したパーキンソン病患者に対するHonda歩行アシストを用いた歩行訓練の効果について2019

    • Author(s)
      高野華子, 吉川憲一, 古関一則, 前沢孝之, 仲澤諒, 山本哲, 四津有人, 松下明, 河野豊
    • Journal Title

      ひろき: 茨城県立医療大学付属病院研究誌

      Volume: 22 Pages: 9-14

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Cathodal tDCS on the motor area decreases the tactile threshold of the distal pulp of the hallux2018

    • Author(s)
      Yamamoto Satoshi、Ishii Daisuke、Ichiba Nao、Yozu Arito、Kohno Yutaka
    • Journal Title

      Neuroscience Letters

      Volume: 印刷中 Pages: 133887-133887

    • DOI

      10.1016/j.neulet.2018.10.032

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] 脳血管障害患者における新たな上肢到達動作の評価方法の構築及び聴覚フィードバックを用いた介入方法の検討2022

    • Author(s)
      山本哲, 石井大典, 石橋清成, 河野豊
    • Organizer
      第20回日本神経理学療法学会学術集会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 機能的磁気共鳴画像を用いた到達動作の計測環境の構築 ー脳血管障害患者における検討ー2022

    • Author(s)
      山本哲, 石井大典, 石橋清成, 河野豊
    • Organizer
      第27回日本基礎理学療法学会学術大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 経頭蓋直流電気刺激による系列動作課題の学習促進効果の検証-健常者に対する二重盲検ランダム化比較試験による検討-2021

    • Author(s)
      山本哲,石井大典,石橋清成,河野豊
    • Organizer
      26回日本基礎理学療法学会学術大会
    • Related Report
      2021 Research-status Report
  • [Presentation] 磁気共鳴血管撮影(MRA)と椎骨・脳底動脈の外観表示画像(BPAS-MRI)を用いた両側延髄内側梗塞症例の発症メカニズムの検討2021

    • Author(s)
      山本哲,迫力太郎,武田湖太郎,若旅正弘,大良実,太田隆之,岡本善敬,杉山聡,小笹佳史
    • Organizer
      第27回脳機能とリハビリテーション研究会学術集会
    • Related Report
      2021 Research-status Report
  • [Presentation] Appropriate MRI acquisition parameters to analyze functional connectivity in resting state motor networks with a 1.5 T scanner2020

    • Author(s)
      S YAMAMOTO, D ISHII, H KAWAGUCHI, T YAMADA, K MATSUDA, T IWANO, Y FUJII, M MONMA, Y KOHNO
    • Organizer
      12th FENS Forum of Neuroscience
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] Appropriate MRI acquisition parameters to analyze functional connectivity in resting state motor networks with a 1.5 T scanner2020

    • Author(s)
      Satoshi Yamamoto, Daisuke Ishii, Hiroshi Kawaguchi, Toru Yamada, Keiji Matsuda, Takayuki Iwano, Yoshihiro Fujii, Masahiko Monma, Yutaka Kohno
    • Organizer
      FENS 2020 Virtual Forum
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] 脳卒中後慢性期に発症した症候性ジストニーによる歩行障害に対する免荷トレッドミル歩行介入の効果2019

    • Author(s)
      山本 哲, 金榮香子, 遠藤悠介, 吉川憲一, 古関一則, 仲澤諒, 高野華子, 四津有人, 松下明, 河野豊
    • Organizer
      第24回日本基礎理学療法学会学術大会
    • Related Report
      2019 Research-status Report
  • [Presentation] Afferent pathway to the ipsilateral somatosensory cortex in human2019

    • Author(s)
      D. ISHII, K. ISHIBASHI, Y. KAKU, H. YUINE, S. YAMAMOTO, A. YOZU, Y. KOHNO
    • Organizer
      Society for Neuroscience 2019
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] パーキンソン病患者の歩行障害に対する 「Honda歩行アシスト」の単回介入による効果2019

    • Author(s)
      山本 哲, 吉川 憲一, 古関 一則, 石井 大典, 仲澤 諒, 高野 華子, 遠藤 悠介, 四津 有人, 松下 明, 河野 豊
    • Organizer
      第17回日本神経理学療法学会学術大会
    • Related Report
      2019 Research-status Report
  • [Presentation] 安静時機能的 MRI の撮影条件の検討 ―3T-MRI 装置と 1.5T-MRI 装置の比較―2019

    • Author(s)
      山本 哲, 石井 大典, 川口 拓之, 山田 亨, 松田 圭司, 岩野 孝之, 藤井 義大, 門間 正彦, 河野 豊
    • Organizer
      第26回脳機能とリハビリテーション研究会学術集会(Brain and Rehabilitation 2019)
    • Related Report
      2019 Research-status Report
  • [Presentation] Electromyographic Effect of Single-Joint Hybrid Assistive Limb on Upper Limb Rehabilitation for a Patient with Hemiplegia after Botulinum Toxin Injection Therapy: A Case Study2019

    • Author(s)
      Yusuke Endo, Akira Matsushita, Arito Yozu, Kenichi Yoshikawa, Kazunori Koseki, Satoshi Yamamoto, Hirotaka Mutsuzaki, Masafumi Mizukami, Yutaka Kohno
    • Organizer
      13th International Society of Physical and Rehabilitation Medicine World Congress
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research

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Published: 2019-04-18   Modified: 2024-01-30  

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