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The effect of Enrich Environment intervention cause to improvement of the behavior and cerebral function of the ASD model mice

Research Project

Project/Area Number 19K19863
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 59010:Rehabilitation science-related
Research InstitutionHirosaki University

Principal Investigator

Koeda Shuhei  弘前大学, 保健学研究科, 講師 (00455734)

Project Period (FY) 2019-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2021: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords自閉症 / リハビリテーション / 動物実験 / 行動 / 運動 / 疾患モデル / 脳機能 / 母子分離 / 行動実験 / 環境エンリッチメント / 機能
Outline of Research at the Start

自閉症児のリハビリテーション現場では、他者との関わりや遊具を用いた感覚・運動遊びを提供する。これらは脳の発達に良い影響を与えるといわれているが、その影響は十分に解明されていない。本研究ではリハビリテーションで実施されているような豊かな生育環境の提供が自閉症モデルマウスの行動や脳機能に与える影響を調査することにより、自閉症児に対する療育のエビデンス向上につなげることを目的にする。

Outline of Final Research Achievements

In this study, we performed forced running exercise and breeding in the Enrich Environment (EE) as treatments for the autism spectrum disorder (ASD) model mice and examined effect on emotion and behavior. As a result of forced running exercise intervention, they had the increase of the anxiety and inhibition of the improvement of the sociability. Whereas, as a result of EE intervention, they had the decrease of the anxiety and the improvement of the sociability. It is thought that voluntary exercise and security by the EE intervention was associated with the improvement of the behavior test. In the case of rehabilitation treatment of the ASD children, offering the voluntary exercise under free environment were led to improvement of the behavior of the ASD children was suggested.

Academic Significance and Societal Importance of the Research Achievements

本研究は、リハビリテーション治療で用いられる運動や遊具の設置が自閉症モデルマウスの行動の改善につながるかを検証した。強制的な運動は不安を増大させ、社会性の改善が妨げたが、遊具のある環境で自由に運動をした場合は、不安や社会性改善の効果があった。自由な環境で自発的な運動を行うことの効果を示した研究は少なく、本研究成果は、現在行われている自閉症のリハビリテーション治療の根拠となる研究である。

Report

(4 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (15 results)

All 2022 2021 2020 2019

All Journal Article (2 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 2 results,  Open Access: 2 results) Presentation (13 results) (of which Int'l Joint Research: 5 results)

  • [Journal Article] Atypical Sensory Processing Profiles and Their Associations With Motor Problems In Preschoolers With Developmental Coordination Disorder2020

    • Author(s)
      Mikami Misaki、Hirota Tomoya、Takahashi Michio、Adachi Masaki、Saito Manabu、Koeda Shuhei、Yoshida Kazutaka、Sakamoto Yui、Kato Sumi、Nakamura Kazuhiko、Yamada Junko
    • Journal Title

      Child Psychiatry & Human Development

      Volume: 52 Issue: 2 Pages: 311-320

    • DOI

      10.1007/s10578-020-01013-5

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effects of voluntary and forced exercises on motor function recovery in intracerebral hemorrhage rats2020

    • Author(s)
      Chihiro Sato, Kunikazu Tanji, Shuji Shimoyama, Mitsuru Chiba, Misaki Mikami, Shuhei Koeda, Koshi Sumigawa,Kazuki Akahira, Junko Yamada
    • Journal Title

      Neuroreport

      Volume: 31 Issue: 2 Pages: 189-195

    • DOI

      10.1097/wnr.0000000000001396

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Enrich environment causes the emotional and behavioral changes to the mouse model of autism spectrum disorder.2022

    • Author(s)
      Shuhei Koeda, Honami Yanagimachi, Misaki Mikami, Chihiro Sato, Junko Yamada
    • Organizer
      第99回日本生理学会大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 自閉症モデルマウスに対する強制運動の悪影響2021

    • Author(s)
      小枝周平 , 三上美咲 , 佐藤ちひろ , 山田順子
    • Organizer
      第55回日本作業療法学会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Forced exercise causes the negative emotional and behavioral changes to the mouse model of autism spectrum disorder.2021

    • Author(s)
      Shuhei Koeda, Ayaka Monden, Misaki Mikami, Chihiro Sato, Junko Yamada
    • Organizer
      The 44th Annual Meeting of the Japan Neuroscience Society
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The motor recovery synaptic plasticity after stroke were affected by the types of exercise2020

    • Author(s)
      Chihiro Sato, Kunikazu Tanji, Mitsuru Chiba, Shuhei Koeda, Misaki Mikami, Junko Yamada
    • Organizer
      The 43th Annual Meeting of the Japan Neuroscience Society
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] The motor recovery and synaptic plasticity was affected by the types of exercise in the hemorrhage model rat2020

    • Author(s)
      Chihiro Sato, Kunikazu Tanji, Shuhei Koeda, Mana Kishimoto, Shun Mori, Misaki Mikami, Junko Yamada
    • Organizer
      the 98th Annual Meeting of The Physiological Society of Japan, the 126th Annual Meeting of The Japanese Association of Anatomists
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] Sensory processing abnormalities and their associations with behavioral and emotional difficulties in preschoolers with Developmental Coordination Disorder2020

    • Author(s)
      Misaki Mikami, Masaki Adachi, Michio Takahashi, Tomoya Hirota, Manabu Saito, Shuhei Koeda, Kazutaka Yoshida, Kazuhiko Nakamura, Junko Yamada
    • Organizer
      The International Association for Child and Adolescent Psychiatry and Allied Professions
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] 日本人の自閉症児における栄養と食物摂取2020

    • Author(s)
      小枝周平, 三上美咲, 斉藤まなぶ, 中村和彦, 山田順子
    • Organizer
      第54回日本作業療法学会
    • Related Report
      2020 Research-status Report
  • [Presentation] 幼児期における発達障害児の筆記具操作と描線運動2020

    • Author(s)
      三上美咲, 小枝周平 , 斉藤まなぶ, 中村和彦, 山田順子
    • Organizer
      第54回日本作業療法学会
    • Related Report
      2020 Research-status Report
  • [Presentation] 脳出血モデルラットにおける運動種類の違いが運動麻痺回復および脳可塑性関連因子に及ぼす影響2020

    • Author(s)
      佐藤ちひろ, 小枝周平, 三上美咲, 山田順子
    • Organizer
      第54回日本作業療法学会
    • Related Report
      2020 Research-status Report
  • [Presentation] The motor recovery and synaptic plasticity was affected by the exercise in the hemorrhage model rat.2020

    • Author(s)
      Chihiro Sato, Kunikazu Tanji, Koeda Suhei, Mana Kishimoto, Shun Mori, Misaki Mikami, Junko Yamada
    • Organizer
      第97回日本生理学会大会
    • Related Report
      2019 Research-status Report
  • [Presentation] 脳出血モデルラットにおける異なる種類の運動が機能回復に与える影響2020

    • Author(s)
      佐藤ちひろ、小枝周平、三上美咲、赤平一樹、山田順子
    • Organizer
      第157回弘前医学例会
    • Related Report
      2019 Research-status Report
  • [Presentation] The comparison of the synaptic changes with voluntary and forced rehabilitation in intracerebral hemorrhage model rats2019

    • Author(s)
      Chihiro Sato, Kunikazu Tanji, Kazuki Akahira, Koshi Sumigawa, Shuhei Koeda, Misaki Mikami, JunkoYamada
    • Organizer
      The 1st Japan-Korea-Taiwan Neurorehabilitation Conference
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] 脳出血モデルラットにおける運動に伴うモチベーションが麻痺回復および脳機能に及ぼす効果2019

    • Author(s)
      佐藤ちひろ, 澄川幸志, 小枝周平 , 赤平一樹 , 山田順子
    • Organizer
      第53回日本作業療法学会
    • Related Report
      2019 Research-status Report

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Published: 2019-04-18   Modified: 2023-01-30  

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