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The role of spinal interneurons receiving sensory input in motor control

Research Project

Project/Area Number 19K19907
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 59010:Rehabilitation science-related
Research InstitutionOsaka University

Principal Investigator

Nakagawa Hiroshi  大阪大学, 免疫学フロンティア研究センター, 特任助教(常勤) (10732901)

Project Period (FY) 2019-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2021: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords脊髄介在ニューロン / 神経可塑性
Outline of Research at the Start

本研究では、ウイルスベクターを利用した神経ネットワーク解析や解剖学・行動学的解析を駆使して、脊髄介在ニューロン(INs)を介した末梢からの感覚入力が運動機能に及ぼす影響を明らかにする。具体的には、一側四肢から生じる固有感覚を同側もしくは対側小脳に伝達するそれぞれの脊髄INsの機能を神経回路特異的に阻害することにより、運動機能がどのように変化するのかを明らかにする。そして新規運動学習および中枢神経損傷後の運動機能回復の神経基盤の確立につなげることを目的とする。

Outline of Final Research Achievements

Spinal interneurons which were located in thoracic cord projected axons into ipsi- and contralateral lumbar cord. Only the spinal interneurons which were located in ipsilateral thoracic cord contributed to motor behavior and recovery of the ipsilateral hindlimb function in the intact condition and after spinal cord injury, respectively. We confirmed the projection pattern in each type of spinal interneurons. Some type of spinal interneurons projected axons into the both sides of lumbar cord. We investigated their function in the intact condition by using genetic tool. As a result, it depended on the difference of the subtype of spinal interneurons.

Academic Significance and Societal Importance of the Research Achievements

正確な動作の遂行には、運動コマンドの適切な出力と感覚情報の入力制御が重要である。脊髄INsは、この両者を担っている部分のひとつでありその神経基盤を明らかにすることは、運動の学習メカニズムのみならず中枢神経損傷後の機能回復メカニズムの解明にもつながる。これまで正常な状態では、胸髄に位置する脊髄INsは後肢の運動機能には関わっていないと考えられていた。しかし、本成果よりある種の脊髄INsは同側の後肢機能の一部を制御しており、それらは中枢神経損傷後に失われた機能の一部を代償することが明らかとなった。これらの成果は、中枢神経損傷後の機能回復を促す治療法の開発にもつながるものであると考える。

Report

(4 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (7 results)

All 2022 2021 2020 Other

All Journal Article (5 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 5 results,  Open Access: 5 results) Remarks (2 results)

  • [Journal Article] A multisynaptic pathway from the ventral midbrain toward spinal motoneurons in monkeys2022

    • Author(s)
      Suzuki Michiaki、Inoue Ken‐ichi、Nakagawa Hiroshi、Ishida Hiroaki、Kobayashi Kenta、Isa Tadashi、Takada Masahiko、Nishimura Yukio
    • Journal Title

      The Journal of Physiology

      Volume: 600 Issue: 7 Pages: 1731-1752

    • DOI

      10.1113/jp282429

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Origin of Multisynaptic Corticospinal Pathway to Forelimb Segments in Macaques and Its Reorganization After Spinal Cord Injury2022

    • Author(s)
      Ninomiya Taihei、Nakagawa Hiroshi、Inoue Ken-ichi、Nishimura Yukio、Oishi Takao、Yamashita Toshihide、Takada Masahiko
    • Journal Title

      Frontiers in Neural Circuits

      Volume: 16 Pages: 847100-847100

    • DOI

      10.3389/fncir.2022.847100

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Morphological features of large layer V pyramidal neurons in cortical motor-related areas of macaque monkeys: analysis of basal dendrites.2021

    • Author(s)
      Takata Y, Nakagawa H, Ninomiya T, Yamanaka H, Takada M
    • Journal Title

      Sci Rep

      Volume: 11 Issue: 1 Pages: 4171-4171

    • DOI

      10.1038/s41598-021-83680-5

    • Related Report
      2021 Annual Research Report 2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] An enhanced therapeutic effect of repetitive transcranial magnetic stimulation combined with antibody treatment in a primate model of spinal cord injury2021

    • Author(s)
      Yamanaka Hajime、Takata Yu、Nakagawa Hiroshi、Isosaka-Yamanaka Tomoko、Yamashita Toshihide、Takada Masahiko
    • Journal Title

      PLOS ONE

      Volume: 16 Issue: 6 Pages: e0252023-e0252023

    • DOI

      10.1371/journal.pone.0252023

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Olig2-Induced Semaphorin Expression Drives Corticospinal Axon Retraction After Spinal Cord Injury2020

    • Author(s)
      Ueno Masaki、Nakamura Yuka、Nakagawa Hiroshi、Niehaus Jesse K、Maezawa Mari、Gu Zirong、Kumanogoh Atsushi、Takebayashi Hirohide、Lu Qing Richard、Takada Masahiko、Yoshida Yutaka
    • Journal Title

      Cerebral Cortex

      Volume: 30 Issue: 11 Pages: 5702-5716

    • DOI

      10.1093/cercor/bhaa142

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Remarks] 大阪大学大学院医学系研究科 分子神経科学講座

    • URL

      https://www.med.osaka-u.ac.jp/pub/molneu/

    • Related Report
      2021 Annual Research Report
  • [Remarks] 大阪大学大学院医学系研究科 分子神経科学

    • URL

      http://www.med.osaka-u.ac.jp/pub/molneu/

    • Related Report
      2020 Research-status Report

URL: 

Published: 2019-04-18   Modified: 2023-01-30  

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