• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Elucidation of the pathophysiology of defecation dysfunction in diabetes from a novel perspective of central nervous system disorders

Research Project

Project/Area Number 19K19923
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 59010:Rehabilitation science-related
Research InstitutionKyorin University

Principal Investigator

Oshiro Naomi  杏林大学, 保健学部, 助教 (20646939)

Project Period (FY) 2019-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords外肛門括約筋 / 排便機能 / 糖尿病 / 腹壁筋 / 排便機能障害
Outline of Research at the Start

排泄は生きていく上で欠かせない行為であり、特に排便機能の障害は年々増加している糖尿病でも起こるため、この障害に対するリハビリテーションの需要は高い。これまで排便動作に重要な腹壁筋において、糖尿病によって中枢神経と筋の形態変化が起こることを私たちは明らかにし、排便動作の主要な筋である外肛門括約筋についても調べた。これら形態変化の要因を明らかにするためにはさらに免疫組織学的手法や電気生理学的手法による実験が必須である。
よって本研究では、排便機能に重要な腹壁筋と外肛門括約筋を新たな視点から解析することによって病態変化の機序を明らかにし、排便機能障害のリハビリテーションの発展を目指す。

Outline of Final Research Achievements

This study examined the motoneurons of the external anal sphincter in diabetic rats and control rats and found no significant difference in the number and size of neurons. This suggests that the central nervous system of the external anal sphincter, which is a voluntary muscle directly involved in bowel function, is not significantly affected by hyperglycemia caused by diabetes.
Previous studies on motoneurons in the lower limbs have reported a reduction in motoneuron size and mentioned the impact on the lower limbs under prolonged hyperglycemic conditions. However, this study yielded different results from previous studies on the lower limbs, suggesting that the motoneurons of the external anal sphincter were less susceptible to the effects of high blood sugar.

Academic Significance and Societal Importance of the Research Achievements

糖尿病はもはや国民病といっても過言でなく、糖尿病患者は様々な合併症がある。その中で本研究では、特に羞恥心を伴う便失禁に着目し、排便機能について調べることとした。便失禁の原因については未だ不明な点が多く、排便機能に重要である随意筋の外肛門括約筋を調べることは学術的意義となる。また、便失禁に対するリハビリテーションは確立されていないため、本研究による成果が新たなリハビリテーションの開発に一助となることで、社会的意義に繋がると考えた。

Report

(5 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (3 results)

All 2023 2021 2019

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (2 results)

  • [Journal Article] External anal sphincter motoneurons and their muscle in streptozotocin-induced diabetic rats are resistant to diabetic neuropathy2023

    • Author(s)
      Naomi Oshiro, Ken Muramatsu, Yaoko Iwasaki, Masatoshi Niwa
    • Journal Title

      Japanese Journal of physical Therapy for Diabetes Mellitus

      Volume: 2 Pages: 35-45

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Comparison of contractile characteristics of the abdominal and external anal sphincter muscle involved in defecation function in rats2021

    • Author(s)
      Naomi Oshiro, Ken Muramatsu, Yaoko Iwasaki, Masatoshi Niwa
    • Organizer
      第44回 日本神経科学大会
    • Related Report
      2021 Research-status Report
  • [Presentation] Effects of hyperglycemia on motoneurons and muscles of the external anal sphincter in STZ rats2019

    • Author(s)
      Naomi Oshiro
    • Organizer
      神経科学学会
    • Related Report
      2019 Research-status Report

URL: 

Published: 2019-04-18   Modified: 2024-01-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi