| Project/Area Number |
19K19932
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 59010:Rehabilitation science-related
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| Research Institution | Kurume University |
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Principal Investigator |
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| Project Period (FY) |
2019-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2019: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 閉塞性睡眠時無呼吸 / 機能的MRI / 疑似的いびき音 / リハビリテーション |
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| Outline of Research at the Start |
久留米大学病院睡眠外来を受診し、かつ顔面骨格に異常なく、OSAに影響を及ぼす他疾患・薬物等投与が無く、PSG検査を施行した方あるいは受ける方を被験者として登録し、咽頭部dynamicMRI撮影を用いて“咽頭壁の緩み“の定量化と無呼吸・低呼吸指数（AHI）との相関およびAHIに対する舌骨筋群への周期的電気刺激療法によるリハビリテーションの効果を検証する。
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| Outline of Final Research Achievements |
A dynamic MRI of the pharynx during awake "pseudo-snoring" vocalizations was performed to prove "collapse of the pharyngeal wall". Among 8 subjects with OSA who were non-obese and had no other risk factors, 6 were obtained written informed consents. Number of subjects with left-right, antero-posterior, and all-around types based on the classifications during awake "pseudo-snoring" vocalization by a laryngeal endoscopy were 0, 2 and 4, respectively. In dynamic MRI, OSA subjects had a higher rate of collapse of the pharyngeal cavity than healthy subjects, and the rate in subjects with the all-around type was higher than that in the anterior-posterior type. However, there was no correlation between the collapse rate and Apnea Hypopnea Index among those subjects (correlation coefficient = 0.38, P value = 0.13).
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| Academic Significance and Societal Importance of the Research Achievements |
本研究課題を通じて、後ろ向きおよび前向き試験において、睡眠障害の約10%に睡眠時無呼吸の危険因子が不明なOSA患者が存在することがわかった。またダイナミックMRIを用いた検討で、その原因として、咽頭腔の虚脱、いわゆる“咽頭壁の緩み”が原因であろうと推察された。おそらく女性は閉経との関係が予想される。本研究結果はOSAの新たな治療開発に貢献すると考えられる。
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