Intracranial Fluid Dynamics and Cerebral Small Vessel Disease: Association with Age and Physical Activity
| Project/Area Number |
19K19970
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 59020:Sports sciences-related
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| Research Institution | National Institute of Advanced Industrial Science and Technology |
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Principal Investigator |
Tarumi Takashi 国立研究開発法人産業技術総合研究所, 情報・人間工学領域, 主任研究員 (40825858)
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| Project Period (FY) |
2019-04-01 – 2022-03-31
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| Project Status |
Completed (Fiscal Year 2021)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2021: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2020: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2019: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 脳機能 / 循環機能 / 運動生理学 / 認知症 / 予防医学 / 加齢 / 脳循環 / 運動 / 脳 / 予防 / 循環 / 大動脈 / MRI / 脳血管障害 / 神経機能 / 身体活動 / 動脈硬化 |
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| Outline of Research at the Start |
現在、国内外において認知症予防対策の構築が火急的課題となっている。一方、加齢に伴う循環器機能の低下や疾患は、認知症発症リスクを上昇することで知られる。本研究では、認知症の強力なリスク因子である脳微小血管障害（CSVD）の「発症メカニズム解明」と、「習慣的持久性運動による予防対策の構築」を目的とした基礎研究の一環として、最先端MRI測定手法を用い生理学的エビデンスを集積する。
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| Outline of Final Research Achievements |
The establishment of dementia prevention program is an important challenge in Japan, which currently confronts the super aging society. In this project, we investigated the efficacy of physical exercise on brain function in middle-aged and older adults, and further examined the role of cerebral circulation as a potential physiological mechanism. Our findings showed that regular aerobic exercise improves brain function in patients with mild cognitive impairment and healthy middle-aged adults, particularly the white matter fiber integrity. Furthermore, we found that resistance exercise can acutely alter intracranial fluid dynamics including the cerebral blood and cerebrospinal fluid flows. High-intensity endurance training was associated with increased compliance of the ascending aorta. All in all, we published 28 peer-reviewed international research articles from this project.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究成果の意義は主に3つある。第一に、中年期における有酸素運動が脳機能を改善する知見は、より早期から認知症予防に運動が有効であることが示せたので意義が大きい。第二に、運動が白質神経線維統合性を改善する知見は、運動の効果は灰白質だけでなく、白質にも及ぶことを示せた点で学術的意義が大きい。第三に、運動が脳脊髄液の循環動態に影響を与える知見は、新規性が高く学術的意義が大きい。近年の動物研究によると、脳脊髄液は神経細胞から排出された老廃物除去に寄与することが示されている。したがって、我々の研究成果は、運動が脳内の微小環境をきれいに保ち、神経細胞の恒常性維持に貢献する可能性を示唆した。
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Report
(4 results)
Research Products
(47 results)
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[Journal Article] Assessment of dynamic cerebral autoregulation in humans: Is reproducibility dependent on blood pressure variability?2020
Author(s)
Elting JW, Sanders ML, Panerai RB, Aries M, Bor-Seng-Shu E, Caicedo A, Chacon M, Gommer ED, Van Huffel S, Jara JL, Kostoglou K, Mahdi A, Marmarelis VZ, Mitsis GD, Muller M, Nikolic D, Nogueira RC, Payne SJ, Puppo C, Shin DC, Simpson DM, Tarumi T, Yelicich B, Zhang R, Claassen JAHR
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Journal Title
PLOS ONE
Volume: 15
Issue: 1
Pages: 1-17
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Dynamic Cerebral Autoregulation Reproducibility Is Affected by Physiological Variability2019
Author(s)
Sanders ML, Elting JWJ, Panerai RB, Aries M, Bor-Seng-Shu E, Caicedo A, Chacon M, Gommer ED, Van Huffel S, Jara JL, Kostoglou K, Mahdi A, Marmarelis VZ, Mitsis GD, Muller M, Nikolic D, Nogueira RC, Payne SJ, Puppo C, Shin DC, Simpson DM, Tarumi T, Yelicich B, Zhang R, Claassen JAHR
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Journal Title
Frontiers in Physiology
Volume: 10
Pages: 1-11
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] Hippocampal and Anterior Cingulate Perfusion is Associated with Affective Symptoms in Chronic Traumatic Brain Injury2021
Author(s)
Binu P Thomas, Takashi Tarumi, Ciwen Wang, David C. Zhu, Tsubasa Tomoto, C. Munro Cullum, Marisara Dieppa, Ramon Diaz-Arrastia, Kathleen Bell, Christopher Madden, Rong Zhang, Kan Ding
Organizer
ISMRM 29th Annual Meeting & Exhibition
Related Report
Int'l Joint Research
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[Presentation] Effect Of Exercise Training On The Cerebral White Matter Integrity In Chronic Traumatic Brain Injury2021
Author(s)
Takashi Tarumi, Binu P Thomas, Ciwen Wang, David C. Zhu, Tsubasa Tomoto, C. Munro Cullum, Marisara Dieppa, Ramon Diaz-Arrastia, Kathleen Bell, Christopher Madden, Rong Zhang, Kan Ding
Organizer
2021 Annual Meeting of the American College of Sports Medicine
Related Report
Int'l Joint Research
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