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Intracranial Fluid Dynamics and Cerebral Small Vessel Disease: Association with Age and Physical Activity

Research Project

Project/Area Number 19K19970
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 59020:Sports sciences-related
Research InstitutionNational Institute of Advanced Industrial Science and Technology

Principal Investigator

Tarumi Takashi  国立研究開発法人産業技術総合研究所, 情報・人間工学領域, 主任研究員 (40825858)

Project Period (FY) 2019-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2021: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2020: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2019: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords脳機能 / 循環機能 / 運動生理学 / 認知症 / 予防医学 / 加齢 / 脳循環 / 運動 / 脳 / 予防 / 循環 / 大動脈 / MRI / 脳血管障害 / 神経機能 / 身体活動 / 動脈硬化
Outline of Research at the Start

現在、国内外において認知症予防対策の構築が火急的課題となっている。一方、加齢に伴う循環器機能の低下や疾患は、認知症発症リスクを上昇することで知られる。本研究では、認知症の強力なリスク因子である脳微小血管障害(CSVD)の「発症メカニズム解明」と、「習慣的持久性運動による予防対策の構築」を目的とした基礎研究の一環として、最先端MRI測定手法を用い生理学的エビデンスを集積する。

Outline of Final Research Achievements

The establishment of dementia prevention program is an important challenge in Japan, which currently confronts the super aging society. In this project, we investigated the efficacy of physical exercise on brain function in middle-aged and older adults, and further examined the role of cerebral circulation as a potential physiological mechanism. Our findings showed that regular aerobic exercise improves brain function in patients with mild cognitive impairment and healthy middle-aged adults, particularly the white matter fiber integrity. Furthermore, we found that resistance exercise can acutely alter intracranial fluid dynamics including the cerebral blood and cerebrospinal fluid flows. High-intensity endurance training was associated with increased compliance of the ascending aorta. All in all, we published 28 peer-reviewed international research articles from this project.

Academic Significance and Societal Importance of the Research Achievements

本研究成果の意義は主に3つある。第一に、中年期における有酸素運動が脳機能を改善する知見は、より早期から認知症予防に運動が有効であることが示せたので意義が大きい。第二に、運動が白質神経線維統合性を改善する知見は、運動の効果は灰白質だけでなく、白質にも及ぶことを示せた点で学術的意義が大きい。第三に、運動が脳脊髄液の循環動態に影響を与える知見は、新規性が高く学術的意義が大きい。近年の動物研究によると、脳脊髄液は神経細胞から排出された老廃物除去に寄与することが示されている。したがって、我々の研究成果は、運動が脳内の微小環境をきれいに保ち、神経細胞の恒常性維持に貢献する可能性を示唆した。

Report

(4 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (47 results)

All 2022 2021 2020 2019 Other

All Int'l Joint Research (3 results) Journal Article (27 results) (of which Int'l Joint Research: 27 results,  Peer Reviewed: 27 results,  Open Access: 6 results) Presentation (16 results) (of which Int'l Joint Research: 15 results,  Invited: 1 results) Remarks (1 results)

  • [Int'l Joint Research] IEEM(米国)

    • Related Report
      2021 Annual Research Report
  • [Int'l Joint Research] UT Southwestern Medical Center(米国)

    • Related Report
      2021 Annual Research Report
  • [Int'l Joint Research] Michigan State University(米国)

    • Related Report
      2021 Annual Research Report
  • [Journal Article] Influence of water immersion on the airway impedance measured by forced oscillation technique2022

    • Author(s)
      Hoshi Daisuke、Fukuie Marina、Tamai Shinsuke、Momma Reiko、Tarumi Takashi、Sugawara Jun、Watanabe Koichi
    • Journal Title

      Respiratory Physiology & Neurobiology

      Volume: 295 Pages: 103779-103779

    • DOI

      10.1016/j.resp.2021.103779

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] One-year aerobic exercise altered cerebral vasomotor reactivity in mild cognitive impairment2021

    • Author(s)
      Tomoto Tsubasa、Tarumi Takashi、Chen Jason N.、Hynan Linda S.、Cullum C. Munro、Zhang Rong
    • Journal Title

      Journal of Applied Physiology

      Volume: 131 Issue: 1 Pages: 119-130

    • DOI

      10.1152/japplphysiol.00158.2021

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Renal hemodynamics across the adult lifespan: Relevance of flow pulsatility to chronic kidney disease2021

    • Author(s)
      Kosaki Keisei、Tarumi Takashi、Sugawara Jun、Tanahashi Koichiro、Kumagai Hiroshi、Matsui Masahiro、Sugaya Takeshi、Osuka Yosuke、Tanaka Kiyoji、Kuro-o Makoto、Saito Chie、Yamagata Kunihiro、Maeda Seiji
    • Journal Title

      Experimental Gerontology

      Volume: 152 Pages: 111459-111459

    • DOI

      10.1016/j.exger.2021.111459

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Hippocampal and rostral anterior cingulate blood flow is associated with affective symptoms in chronic traumatic brain injury2021

    • Author(s)
      Thomas Binu P.、Tarumi Takashi、Wang Ciwen、Zhu David C.、Tomoto Tsubasa、Munro Cullum C.、Dieppa Marisara、Diaz-Arrastia Ramon、Bell Kathleen、Madden Christopher、Zhang Rong、Ding Kan
    • Journal Title

      Brain Research

      Volume: 1771 Pages: 147631-147631

    • DOI

      10.1016/j.brainres.2021.147631

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Carotid Arterial Compliance and Aerobic Exercise Training in Chronic Traumatic Brain Injury2021

    • Author(s)
      Tomoto Tsubasa、Le Tran、Tarumi Takashi、Dieppa Marisara、Bell Kathleen、Madden Christopher、Zhang Rong、Ding Kan
    • Journal Title

      Journal of Head Trauma Rehabilitation

      Volume: Online ahead of print Issue: 5 Pages: 1-9

    • DOI

      10.1097/htr.0000000000000722

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Midlife aerobic exercise and dynamic cerebral autoregulation: associations with baroreflex sensitivity and central arterial stiffness2021

    • Author(s)
      Tomoto Tsubasa、Repshas Justin、Zhang Rong、Tarumi Takashi
    • Journal Title

      Journal of Applied Physiology

      Volume: 131 Issue: 5 Pages: 1599-1612

    • DOI

      10.1152/japplphysiol.00243.2021

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Resting-state functional MRI signal fluctuation amplitudes are correlated with brain amyloid-<b>β</b> deposition in patients with mild cognitive impairment2021

    • Author(s)
      Scheel Norman、Tarumi Takashi、Tomoto Tsubasa、Cullum C Munro、Zhang Rong、Zhu David C
    • Journal Title

      Journal of Cerebral Blood Flow &amp; Metabolism

      Volume: 42 Issue: 5 Pages: 876-890

    • DOI

      10.1177/0271678x211064846

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Exercise in Water Provides Better Cardiac Energy Efficiency Than on Land2021

    • Author(s)
      Fukuie Marina、Hoshi Daisuke、Hashitomi Tatsuya、Watanabe Koichi、Tarumi Takashi、Sugawara Jun
    • Journal Title

      Frontiers in Cardiovascular Medicine

      Volume: 8 Pages: 1-10

    • DOI

      10.3389/fcvm.2021.747841

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Older age and male sex are associated with higher cerebrovascular impedance2021

    • Author(s)
      Sugawara Jun、Tarumi Takashi、Xing Changyang、Liu Jie、Tomoto Tsubasa、Pasha Evan P.、Zhang Rong
    • Journal Title

      Journal of Applied Physiology

      Volume: 130 Issue: 1 Pages: 172-181

    • DOI

      10.1152/japplphysiol.00396.2020

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Midlife aerobic exercise and brain structural integrity: Associations with age and cardiorespiratory fitness2021

    • Author(s)
      Tarumi Takashi、Tomoto Tsubasa、Repshas Justin、Wang Ciwen、Hynan Linda S.、Cullum C. Munro、Zhu David C.、Zhang Rong
    • Journal Title

      NeuroImage

      Volume: 225 Pages: 117512-117512

    • DOI

      10.1016/j.neuroimage.2020.117512

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Brain blood and cerebrospinal fluid flow dynamics during rhythmic handgrip exercise in young healthy men and women2021

    • Author(s)
      Tarumi Takashi、Yamabe Takayuki、Fukuie Marina、Zhu David C.、Zhang Rong、Ogoh Shigehiko、Sugawara Jun
    • Journal Title

      The Journal of Physiology

      Volume: 599 Issue: 6 Pages: 1799-1813

    • DOI

      10.1113/jp281063

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] One-Year Aerobic Exercise Reduced Carotid Arterial Stiffness and Increased Cerebral Blood Flow in Amnestic Mild Cognitive Impairment2021

    • Author(s)
      Tomoto Tsubasa、Liu Jie、Tseng Benjamin Y.、Pasha Evan P.、Cardim Danilo、Tarumi Takashi、Hynan Linda S.、Munro Cullum C.、Zhang Rong
    • Journal Title

      Journal of Alzheimer's Disease

      Volume: 80 Issue: 2 Pages: 841-853

    • DOI

      10.3233/jad-201456

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Proximal Aortic Compliance in Young Male Endurance Athletes: An MRI Study2020

    • Author(s)
      TARUMI TAKASHI、YAMABE TAKAYUKI、FUKUIE MARINA、Kimura RYOTA、ZHU DAVID C.、OHYAMA-BYUN KEIGO、MAEDA SEIJI、SUGAWARA JUN
    • Journal Title

      Medicine & Science in Sports & Exercise

      Volume: 53 Issue: 3 Pages: 543-550

    • DOI

      10.1249/mss.0000000000002508

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Cerebral Vasomotor Reactivity in Amnestic Mild Cognitive Impairment2020

    • Author(s)
      Tomoto Tsubasa、Tarumi Takashi、Chen Jason、Pasha Evan P.、Cullum C. Munro、Zhang Rong
    • Journal Title

      Journal of Alzheimer's Disease

      Volume: 77 Issue: 1 Pages: 191-202

    • DOI

      10.3233/jad-200194

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Middle-aged endurance athletes exhibit lower cerebrovascular impedance than sedentary peers2020

    • Author(s)
      Sugawara Jun、Tomoto Tsubasa、Repshas Justin、Zhang Rong、Tarumi Takashi
    • Journal Title

      Journal of Applied Physiology

      Volume: 129 Issue: 2 Pages: 335-342

    • DOI

      10.1152/japplphysiol.00239.2020

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Impaired cerebral blood flow regulation in chronic traumatic brain injury2020

    • Author(s)
      Ding Kan、Tarumi Takashi、Tomoto Tsubasa、Mccolloster Max、Le Tran、Dieppa Marisara、Diaz-Arrastia Ramon、Bell Kathleen、Madden Christopher、Cullum C. Munro、Zhang Rong
    • Journal Title

      Brain Research

      Volume: 1743 Pages: 146924-146924

    • DOI

      10.1016/j.brainres.2020.146924

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Central autonomic network functional connectivity: correlation with baroreflex function and cardiovascular variability in older adults2020

    • Author(s)
      Ding Kan、Tarumi Takashi、Wang Ciwen、Vernino Steven、Zhang Rong、Zhu David C.
    • Journal Title

      Brain Structure and Function

      Volume: 225 Issue: 5 Pages: 1575-1585

    • DOI

      10.1007/s00429-020-02075-w

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Steady-state cerebral autoregulation in older adults with amnestic mild cognitive impairment: linear mixed model analysis2020

    • Author(s)
      Zhang Li、Pasha Evan P.、Liu Jie、Xing Chang-Yang、Cardim Danilo、Tarumi Takashi、Womack Kyle、Hynan Linda S.、Cullum C. Munro、Zhang Rong
    • Journal Title

      Journal of Applied Physiology

      Volume: 129 Issue: 2 Pages: 377-385

    • DOI

      10.1152/japplphysiol.00193.2020

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Brain Perfusion Change in Patients with Mild Cognitive Impairment After 12 Months of Aerobic Exercise Training2020

    • Author(s)
      Thomas Binu P.、Tarumi Takashi、Sheng Min、Tseng Benjamin、Womack Kyle B.、Cullum C. Munro、Rypma Bart、Zhang Rong、Lu Hanzhang
    • Journal Title

      Journal of Alzheimer's Disease

      Volume: 75 Issue: 2 Pages: 617-631

    • DOI

      10.3233/jad-190977

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Dynamic Cerebral Autoregulation in Preclinical Atherosclerotic Cardiovascular Disease2020

    • Author(s)
      Liu Yumei、Tarumi Takashi、Liu Beibei、Li Jingzhi、Wu Xiaoguang、Zhang Nan、Hua Yang
    • Journal Title

      Journal of Stroke and Cerebrovascular Diseases

      Volume: 29 Issue: 6 Pages: 104810-104810

    • DOI

      10.1016/j.jstrokecerebrovasdis.2020.104810

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Carotid Stiffness is Associated with Brain Amyloid-β Burden in Amnestic Mild Cognitive Impairment2020

    • Author(s)
      Pasha Evan P.、Rutjes Elmer、Tomoto Tsubasa、Tarumi Takashi、Stowe Ann、Claassen Jurgen A.H.R.、Munro Cullum C.、Zhu David C.、Zhang Rong
    • Journal Title

      Journal of Alzheimer's Disease

      Volume: 74 Issue: 3 Pages: 925-935

    • DOI

      10.3233/jad-191073

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Assessment of dynamic cerebral autoregulation in humans: Is reproducibility dependent on blood pressure variability?2020

    • Author(s)
      Elting JW, Sanders ML, Panerai RB, Aries M, Bor-Seng-Shu E, Caicedo A, Chacon M, Gommer ED, Van Huffel S, Jara JL, Kostoglou K, Mahdi A, Marmarelis VZ, Mitsis GD, Muller M, Nikolic D, Nogueira RC, Payne SJ, Puppo C, Shin DC, Simpson DM, Tarumi T, Yelicich B, Zhang R, Claassen JAHR
    • Journal Title

      PLOS ONE

      Volume: 15 Issue: 1 Pages: 1-17

    • DOI

      10.1371/journal.pone.0227651

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Cerebral White Matter Integrity in Amnestic Mild Cognitive Impairment: A 1-Year Randomized Controlled Trial of Aerobic Exercise Training2020

    • Author(s)
      Tarumi Takashi、Thomas Binu P.、Tseng Benjamin Y.、Wang Ciwen、Womack Kyle B.、Hynan Linda、Lu Hanzhang、Cullum C. Munro、Zhang Rong
    • Journal Title

      Journal of Alzheimer's Disease

      Volume: 73 Issue: 2 Pages: 489-501

    • DOI

      10.3233/jad-190875

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Aging and Physiological Lessons from Master Athletes2019

    • Author(s)
      Tanaka Hirofumi、Tarumi Takashi、Rittweger Jorn
    • Journal Title

      Comprehensive Physiology

      Volume: 10 Pages: 261-296

    • DOI

      10.1002/cphy.c180041

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Cerebral blood flow regulation and cognitive function: a role of arterial baroreflex function2019

    • Author(s)
      Ogoh S, Tarumi T
    • Journal Title

      The Journal of Physiological Sciences

      Volume: 69 Issue: 6 Pages: 813-823

    • DOI

      10.1007/s12576-019-00704-6

    • NAID

      40022093888

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Dynamic Cerebral Autoregulation Reproducibility Is Affected by Physiological Variability2019

    • Author(s)
      Sanders ML, Elting JWJ, Panerai RB, Aries M, Bor-Seng-Shu E, Caicedo A, Chacon M, Gommer ED, Van Huffel S, Jara JL, Kostoglou K, Mahdi A, Marmarelis VZ, Mitsis GD, Muller M, Nikolic D, Nogueira RC, Payne SJ, Puppo C, Shin DC, Simpson DM, Tarumi T, Yelicich B, Zhang R, Claassen JAHR
    • Journal Title

      Frontiers in Physiology

      Volume: 10 Pages: 1-11

    • DOI

      10.3389/fphys.2019.00865

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Comparing model‐based cerebrovascular physiomarkers with DTI biomarkers in MCI patients2019

    • Author(s)
      Marmarelis Vasilis Z.、Shin Dae C.、Tarumi Takashi、Zhang Rong
    • Journal Title

      Brain and Behavior

      Volume: 9 Issue: 8 Pages: 1-10

    • DOI

      10.1002/brb3.1356

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] 高齢者の脳と運動:認知症予防のための生理学研究2021

    • Author(s)
      樽味孝
    • Organizer
      第29回日本運動生理学会大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Proximal Aorta and Intracranial Fluid Dynamics in Endurance Athletes: The Findings from MRI Studies2021

    • Author(s)
      Takashi Tarumi
    • Organizer
      26th Annual Congress of the European College of Sports Science
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Hippocampal and Anterior Cingulate Perfusion is Associated with Affective Symptoms in Chronic Traumatic Brain Injury2021

    • Author(s)
      Binu P Thomas, Takashi Tarumi, Ciwen Wang, David C. Zhu, Tsubasa Tomoto, C. Munro Cullum, Marisara Dieppa, Ramon Diaz-Arrastia, Kathleen Bell, Christopher Madden, Rong Zhang, Kan Ding
    • Organizer
      ISMRM 29th Annual Meeting & Exhibition
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Resting-state functional MRI signal fluctuations are correlated with brain amyloid-β deposition2021

    • Author(s)
      Norman Scheel, Takashi Tarumi, Tsubasa Tomoto, C. Munro Cullum, Rong Zhang, David C. Zhu
    • Organizer
      Organization for Human Brain Mapping 2021 Annual Meeting
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effect Of Exercise Training On The Cerebral White Matter Integrity In Chronic Traumatic Brain Injury2021

    • Author(s)
      Takashi Tarumi, Binu P Thomas, Ciwen Wang, David C. Zhu, Tsubasa Tomoto, C. Munro Cullum, Marisara Dieppa, Ramon Diaz-Arrastia, Kathleen Bell, Christopher Madden, Rong Zhang, Kan Ding
    • Organizer
      2021 Annual Meeting of the American College of Sports Medicine
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Differences in Cardiovascular Response to Water- and Land-Based Cycling at the Matched Exercise Intensity2021

    • Author(s)
      Marina Fukuie, Daisuke Hoshi, Tatsuya Hashitomi, Koichi Watanabe, Takashi Tarumi, Jun Sugawara
    • Organizer
      2021 Annual Meeting of the American College of Sports Medicine
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effect Of A Low-To-Moderate Intensity Water Exercise On The Prefrontal Cortical Activity2021

    • Author(s)
      Tatsuya Hashitomi, Daisuke Hoshi, Marina Fukuie, Takashi Tarumi, Jun Sugawara, Koichi Watanabe
    • Organizer
      2021 Annual Meeting of the American College of Sports Medicine
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Influence of Different Exercise Intensities on the Respiratory Function and Breathing Pattern during Underwater Cycling2021

    • Author(s)
      Daisuke Hoshi, Marina Fukuie, Tatsuya Hashitomi, Takashi Tarumi, Jun Sugawara, Koichi Watanabe
    • Organizer
      2021 Annual Meeting of the American College of Sports Medicine
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Cerebrospinal Fluid Flow Dynamics during Handgrip Exercise in Young Healthy Adults: An MRI study2021

    • Author(s)
      Takashi Tarumi, Takayuki Yamabe, Marina Fukuie, David C. Zhu, Rong Zhang, Shigehiko Ogoh, Jun Sugawara
    • Organizer
      Experimental Biology
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] Marina Fukuie, Daisuke Hoshi, Tatsuya Hashitomi, Koichi Watanabe, Takashi Tarumi, Jun Sugawara2021

    • Author(s)
      Impact of Pedaling Cadence and Resistance on Cardiovascular Response during Underwater Cycling
    • Organizer
      Experimental Biology
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] Daisuke Hoshi, Marina Fukuie, Tatsuya Hashitomi, Takashi Tarumi, Jun Sugawara, Koichi Watanabe2021

    • Author(s)
      Respiratory Response To Underwater And Land-based Cycling At The Matched Oxygen Uptake
    • Organizer
      Experimental Biology
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] Vascular Aging Index of the Finger Photoplethysmogram: A validation study with vascular stiffness, mental stress, and day-to-day variability2019

    • Author(s)
      Tarumi T, Yamabe T, Sugawara J
    • Organizer
      Artery
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Dynamic Carotid Pressure-Area Relation across the Adult Lifespan2019

    • Author(s)
      Tarumi T, Tomoto T, Sugawara J
    • Organizer
      Experimental Biology
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Cerebrovascular Impedance across the Adult Life Span2019

    • Author(s)
      Sugawara J, Tarumi T, Xing C, Liu J, Tomoto T, Pasha E, Zhang R
    • Organizer
      Experimental Biology
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] CEREBRAL PERFUSION IN MIDDLE-AGED MASTERS ATHLETES: ASSOCIATIONS WITH AGE AND CARDIORESPIRATORY FITNESS2019

    • Author(s)
      Tarumi T, Tomoto T, Pasha E, Wang C, Zhang R
    • Organizer
      International Society of Cerebral Blood Flow and Metabolism
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Does regular physical exercise slow brain aging and prevent dementia? Current evidence on cognition, brain structure, and cerebrovascular function2019

    • Author(s)
      Tarumi T
    • Organizer
      2019 International Conference on Exercise Physiology and Fitness
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research / Invited
  • [Remarks] APS Select Awardプレスリリース

    • URL

      https://www.newswise.com/articles/exercise-during-middle-age-may-prevent-age-related-chronic-diseases?ta=home

    • Related Report
      2021 Annual Research Report

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Published: 2019-04-18   Modified: 2023-01-30  

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