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A new approach of exercise intervention for pediatric metabolic syndrome

Research Project

Project/Area Number 19K20002
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 59020:Sports sciences-related
Research InstitutionIbaraki Children's Hospital

Principal Investigator

Lin Lisheng  茨城県立こども病院(小児医療・がん研究センター), 小児医療研究部門, 研究員 (00752510)

Project Period (FY) 2019-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2020: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Keywords小児肥満 / メタボリックシンドローム / 運動療法 / アディポカイン / 慢性炎症 / 小児メタボリックシンドローム / 炎症マーカー / 凝固線溶
Outline of Research at the Start

本研究は肥満学童に対して低密度の集団運動療法を組み込んだ介入プログラム(週1回、3か月間)を行い、メタボリックシンドローム関連の血液指標、動脈硬化度、酸化ストレス値、心肺機能などの変化を包括的に解析し、その結果に基づき効果的かつ日常診療で実行可能な予防方法を確立することを目的とする。

Outline of Final Research Achievements

We conducted an intervention program for obese children that included short-term, low-density group exercise therapy, which is feasible in daily practice. Anthropometric data and metabolic syndrome-related hematological parameters of the subjects, before and after the intervention were analyzed. Comparison between intervention group and control group was also done.
Even a low-density, short-term exercise intervention promoted improvement in the exercise habits of obese children, and significant improvements in obesity and other metabolic syndrome-related factors were observed, compared to the control group.

Academic Significance and Societal Importance of the Research Achievements

本研究は肥満小児に対して短期間で低密度、日常診療ベースで実施可能な介入プログラムを構築した。短期間であっても肥満児童の運動習慣(運動時間)の改善が促され、肥満をはじめとするメタボリックシンドローム関連因子を改善させる効果があった。小児~成人期の健康向上に役立つと考えられる。

Report

(3 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • Research Products

    (20 results)

All 2021 2020 2019

All Journal Article (7 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 7 results,  Open Access: 4 results) Presentation (12 results) Book (1 results)

  • [Journal Article] Soluble thrombomodulin and cardiovascular disease risk factors in Japanese children2021

    • Author(s)
      Kikuchi T, Lin L, Horigome H
    • Journal Title

      Blood Coagulation and Fibrinolysis

      Volume: ― Issue: 4 Pages: 273-277

    • DOI

      10.1097/mbc.0000000000001035

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Congenital right ventricular diverticulum formed by pulmonary regurgitative jet flow in a fetus with Tetralogy of Fallot and absent pulmonary valve2021

    • Author(s)
      Lin L, Murakami T, Shiono J, Kodama O, Yamada N, Ohtani H, Horigome H
    • Journal Title

      Cardiovascular Pathology

      Volume: 50 Pages: 107295-107295

    • DOI

      10.1016/j.carpath.2020.107295

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical Course and Prognosis of Acute Rheumatic Fever with Carditis in Six Patients2020

    • Author(s)
      Ishiodori Takumi、Horigome Hitoshi、Yano Yusuke、Shima Yuriko、Nozaki Yoshihiro、Ishikawa Nobuyuki、Lin Lisheng、Takahashi Miho、Murakami Takashi、Shiono Junko、Takada Hidetoshi
    • Journal Title

      Pediatric Cardiology and Cardiac Surgery

      Volume: 36 Issue: 4 Pages: 277-284

    • DOI

      10.9794/jspccs.36.277

    • NAID

      130007966365

    • ISSN
      0911-1794, 2187-2988
    • Year and Date
      2020-12-01
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Successful trans-maternal nadolol pharmacotherapy in a fetus presenting with long QT syndrome type 2 complicated by torsade de pointes.2020

    • Author(s)
      Shima Y, Horigome H, Nozaki Y, Lin L, Ishiodori T, Yano Y, Takahashi M, Murakami T, Yamasaki H, Taskada H.
    • Journal Title

      J Cardiol Cases

      Volume: 22 Issue: 6 Pages: 265-268

    • DOI

      10.1016/j.jccase.2020.07.006

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] An autopsy case of acute myocarditis with unique lymph node findings characterized by the proliferation of reactive plasmablasts2020

    • Author(s)
      Ohtani Haruo、Nozaki Yoshihiro、Murakami Takashi、Lin Lisheng、Shiono Junko、Miyazawa Masaaki
    • Journal Title

      Journal of Clinical and Experimental Hematopathology

      Volume: 60 Issue: 3 Pages: 108-112

    • DOI

      10.3960/jslrt.20023

    • NAID

      130007907559

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Promoting physical activity through walking to treat childhood obesity, mainly for mild to moderate obesity.2020

    • Author(s)
      Masao Yoshinaga , Ayumi Miyazaki , Machiko Aoki , Hiromitsu Ogata , Yoshiya Ito , Takashi Hamajima , Masakuni Tokuda , Lisheng Lin , Hitoshi Horigome , Hideto Takahashi , Masami Nagashima
    • Journal Title

      Pediatrics international

      Volume: 0 Issue: 8 Pages: 0-0

    • DOI

      10.1111/ped.14253

    • Related Report
      2020 Annual Research Report 2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Multivariate analysis of TU wave complex on electrocardiogram in Andersen-Tawil syndrome with KCNJ2 mutations2019

    • Author(s)
      Horigome H, Ishikawa Y, Kokubun N, Yoshinaga M, Sumitomo N, Lin L, Kato Y, Tanabe‐Kameda Y, Ohno S, Nagashima M, Horie M
    • Journal Title

      Annals of Noninvasive Electrocardiology

      Volume: Epub Issue: 3

    • DOI

      10.1111/anec.12721

    • NAID

      120007127652

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 複雑先天性心疾患児の早期発達とそのリスク因子2021

    • Author(s)
      林 立申, 黒澤奈々子, 矢野悠介, 塩野淳子, 堀米仁志
    • Organizer
      第124回日本小児科学会学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 母体塩酸リトドリン投与中止後に停止した胎児上室性頻拍の1例2021

    • Author(s)
      村上 卓, 堀米仁志, 高橋実穂, 野崎良寛, 石踊 巧, 嶋 由里子, 林 立申, 児玉 理, 小畠真奈, 濱田洋実
    • Organizer
      第27回日本胎児心臓病学会学術総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] リウマチ性弁膜症6例の臨床経過と予後2020

    • Author(s)
      石踊 巧, 村上 卓, 矢野悠介, 嶋 侑里子, 野崎良寛, 林 立申, 高橋実穂, 塩野淳子, 堀米仁志
    • Organizer
      第56回日本小児循環器学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 小児の心室期外収縮の管理の現状2020

    • Author(s)
      塩野淳子, 矢野悠介, 林 立申, 村上 卓, 堀米仁志
    • Organizer
      第56回日本小児循環器学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 多くの患者集積が認められた大動脈弁上狭窄症の1家系 ~胎児心エコー診断を含めて~2020

    • Author(s)
      林 立申, 矢野悠介, 塩野淳子, 杉山香緒里, 柳沢裕美, 堀米仁志
    • Organizer
      第56回日本小児循環器学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 先天性心疾患に壊死性腸炎を合併した9症例の検討2020

    • Author(s)
      矢野悠介, 林 立申, 塩野淳子, 堀米仁志
    • Organizer
      第56回日本小児循環器学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 未診断で失神をきたした先天性QT延長症候群の2小児例2020

    • Author(s)
      飯島将由, 矢野悠介, 林 立申, 佐藤良滉, 砂押瑞史, 鬼澤裕太郎, 塩野淳子, 堀米仁志
    • Organizer
      第124回茨城小児科学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] β遮断薬使用例の食物アレルギーの合併2020

    • Author(s)
      塩野淳子, 林立申, 村上卓, 堀米仁志, 黒田わか
    • Organizer
      第123回日本小児科学会学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 先天性心疾患術後患者に対する呼吸介助は横隔膜運動を改善させる2020

    • Author(s)
      伍藤新平, 林立申, 塩田逸人, 勝田絵梨, 稲川恵, 野崎良寛, 小池和俊, 阿部正一, 坂有希子
    • Organizer
      第123回日本小児科学会学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 胸痛を主訴に受診された基礎疾患のない小児患者の臨床像2020

    • Author(s)
      林立申, 矢野悠介, 塩野淳子, 堀米仁志
    • Organizer
      第123回日本小児科学会学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 10歳以降に診断された川崎病の2例2020

    • Author(s)
      神徳穂乃香, 矢野悠介, 林 立申, 塩野淳子, 堀米仁志
    • Organizer
      第123回茨城小児科学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 肥満小児に対する短期間の運動療法がメタボリックシンドローム関連指標に与える影響2019

    • Author(s)
      菊池 敏弘, 林 立申, 中村 昭宏, 亀田 有里, 山脇 英範, 堀米 仁志
    • Organizer
      第122回日本小児科学会学術集会
    • Related Report
      2019 Research-status Report
  • [Book] QT延長症候群,Brugada症候群 (特集 研修医必携!心電図判読のコツ) 小児科診療2020

    • Author(s)
      林 立申 , 堀米 仁志
    • Total Pages
      7
    • Publisher
      (株)診断と治療社
    • Related Report
      2020 Annual Research Report

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Published: 2019-04-18   Modified: 2022-01-27  

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