Improving effects of Haskap fruit extracts on primary biliary cholangitis and primary sclerosing cholangitis
| Project/Area Number |
19K20122
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 59040:Nutrition science and health science-related
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| Research Institution | International University of Health and Welfare |
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Principal Investigator |
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| Project Period (FY) |
2019-04-01 – 2023-03-31
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| Project Status |
Completed (Fiscal Year 2022)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2021: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2020: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2019: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | PSC / PBC / Haskap / Fruit extract / animal model / Low dose / Medium dose / High dose / 原発性胆汁性胆管炎 / 原発性硬化性胆管炎 / ハスカップ |
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| Outline of Research at the Start |
本研究では、ハスカップ果実抽出物の原発性胆汁性胆管炎（PBC）および原発性硬化性胆管炎（PSC）モデルマウスに対する効果を明らかにし、その分子的機序を解明する。
PBCおよびPSCは、成人における最も一般的な慢性胆汁うっ滞性疾患である。現在のところPBCの薬物治療には限界があり、またPSCの薬物治療は確立されていない。ハスカップの果実は抗炎症や抗酸化物質を含み、いくつかの肝疾患に対する有効性が示されているが、PBCやPSCに対する効果は分かっていない。
本研究によりハスカップ果実抽出物のPBCやPSC動物モデルに対する有効性が明らかになれば、新しい治療薬の開発に結びつきうると考えられる。
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| Outline of Final Research Achievements |
In the first study, investigating the effects of haskap fruit extract on a mouse model of primary biliary cholangitis, showed improved serological markers of hepatocellular injury, cholestasis, cholangitis. and histopathological findings of fibrosis in the medium- and high-dose haskap fruit extracts administrating groups. Total T-lymphocyte infiltration in liver tissue was significantly suppressed in the medium-dose haskap administration group.
In the second study, investigating the effects of haskap fruit extract on primary sclerosing cholangitis model mice, the serum levels of ALT were significantly improved by administration of low-dose haskap fruit extract, and ALP levels were significantly improved by administration of high-dose haskap fruit extract. Total bilirubin levels were significantly lower in the high-dose group than in the low-dose haskap group.
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| Academic Significance and Societal Importance of the Research Achievements |
The Haskap fruit extract improves PBC and PSC in model mice through reducing inflammation, bile duct damage, or fibrosis. Thus, Based on above findings we believe that this our preliminary achievement will lead to the development of new therapeutic agents for PBC and PSC.
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Report
(5 results)
Research Products
(21 results)
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[Journal Article] Effects of caffeine and chlorogenic acid on nonalcoholic steatohepatitis in mice induced by choline-deficient, L-amino acid-defined, high-fat diet2020
Author(s)
Dungubat E, Watabe S, Togashi-Kumagai A, Watanabe M, Kobayashi Y, Harada N, Yamaji R, Fukusato T, Lodon G, Sevjid B, Takahashi Y
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Journal Title
Nutrients
Volume: 12
Issue: 12
Pages: 3886-3886
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Effects of low ethanol consumption on nonalcoholic steatohepatitis in mice2020
Author(s)
Takahashi Y, Watabe S, Togashi-Kumagai A, Watanabe M, Dungubat E, Kusano H, Kobayashi Y, Harada N, Yamaji R, Sugimoto K, Fukusato T
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Journal Title
Alcohol
Volume: 87
Pages: 51-61
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Presentation] Age-dependent sex difference of non-alcoholic fatty liver disease in TSOD and db/db model mice2022
Author(s)
Dungubat E, Kusano H, Mori I, Tawara H, Sutoh M, Ohkura N, Takanashi M, Kuroda M, Udo E, Souda M, Furusato B, Fukusato T, Takahashi Y
Organizer
APASL Oncology 2022 (APASL Single Topic Conference “Liver Cancer: Clinical and Basic Research”)
Related Report
Int'l Joint Research
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[Presentation] Age-dependent sex difference of nonalcoholic fatty liver disease in TSOD and db/db mice2021
Author(s)
Dungubat E, Kusano H, Maenishi S, Utsugi R, Tawara H, Ohkura N, Takanashi M, Kuroda M, Udo E, Hayata M, Furusato B, Fukusato T, Takahashi Y
Organizer
第11回国際医療福祉大学学会学術大会
Related Report
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[Book] Advances in Medicine2023
Author(s)
Dungubat E, Kusano H, Mori I, Tawara H, Sutoh M, Ohkura N, Takanashi M, Kuroda M, Harada N, Udo E, Souda M, Furusato B, Fukusato T, Takahashi Y
Total Pages
30
Publisher
Academic Reads
Related Report
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[Book] Prime Archives in Nutrition2021
Author(s)
Dungubat E, Watabe S, Togashi-Kumagai A, Watanabe M, Kobayashi Y, Harada N, Yamaji R, Fukusato T, Lodon G, Sevjid B, Takahashi Y
Publisher
Vide Leaf
Related Report
