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Elucidation of exercise conditions and underlying brain mechanisms for enhancing working memory in the older adults

Research Project

Project/Area Number 19K20138
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 59040:Nutrition science and health science-related
Research InstitutionPhysical Fitness Research Institute, Meiji Yasuda Life Foundation of Health and Welfare

Principal Investigator

Hyodo Kazuki  公益財団法人明治安田厚生事業団体力医学研究所, その他部局等, 研究員(移行) (60782563)

Project Period (FY) 2019-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2020: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2019: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords高齢者 / 低強度運動 / 実行機能 / ワーキングメモリ / 作業記憶 / 前頭前野 / 近赤外線分光法 / fNIRS / n-back課題 / 有酸素運動 / 運動 / 認知機能 / 一過性
Outline of Research at the Start

ワーキングメモリ (WM) は、高齢者の自立した生活に必須の認知機能である。一過性および習慣的な運動は長期記憶や抑制機能など様々な認知機能を高めることが報告されているが、WMに関する研究は不十分であり、どのような運動条件がWMを高めるのかや、その脳内機構は不明な点が多い。そこで本研究は、近赤外光脳機能イメージング装置(fNIRS)を用いて、強度の異なる有酸素運動の一過性効果および3ヶ月の運動実践効果を検討し、高齢期のWMを高める運動条件とその脳内機構を明らかにする。

Outline of Final Research Achievements

In this study, we examined the effects of acute and chronic exercise on working memory (WM) performance and its brain mechanisms using functional near-infrared spectroscopy (fNIRS) in the older adults.
Although preliminary study (n = 6), we found that an acute bout of moderate intensity cycling exercise enhanced the task-related prefrontal activation and WM performance in the older adults. In addition, three months of aerobic dance exercise did not affect WM performance in the older adults, but task-related prefrontal activation became more efficient. Further examination of the effects of different exercise periods, exercise modes, etc. is required to search for exercise conditions that are more effective for WM in the older adults.

Academic Significance and Societal Importance of the Research Achievements

多くの研究が運動による高齢者の認知機能の維持増進効果を報告しているが、ワーキングメモリ (WM) への効果に関しての報告数が少なく、どのような運動条件が効果的か、またそのメカニズムは明らかではなかった。本研究課題において、3ヶ月間の短時間低強度運動(軽体操)の実践ではWMの課題成績は高まらないが、効率的に前頭前野を動員して課題を遂行できるようになる可能性が示された。本成果から、WMを高める運動条件の確立には至らなかったが、運動が高齢者のWMに与える影響に関する一つの知見となると考えられる。今回の結果を基に、さらなる研究が求められる。

Report

(5 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (11 results)

All 2023 2022 2021 2020

All Journal Article (4 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 4 results,  Open Access: 4 results) Presentation (7 results) (of which Invited: 2 results)

  • [Journal Article] Feasibility, Safety, Enjoyment, and System Usability of Web-Based Aerobic Dance Exercise Program in Older Adults: Single-Arm Pilot Study2023

    • Author(s)
      Hyodo Kazuki、Kidokoro Tetsuhiro、Yamaguchi Daisuke、Iida Michitaka、Watanabe Yuya、Ueno Aiko、Noda Takayuki、Kawahara Kenji、Nishida Sumiyo、Kai Yuko、Arao Takashi
    • Journal Title

      JMIR Aging

      Volume: 6 Pages: e39898-e39898

    • DOI

      10.2196/39898

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association between intensity or accumulating pattern of physical activity and executive function in community-dwelling older adults: A cross-sectional study with compositional data analysis2023

    • Author(s)
      Hyodo Kazuki、Kitano Naruki、Ueno Aiko、Yamaguchi Daisuke、Watanabe Yuya、Noda Takayuki、Nishida Sumiyo、Kai Yuko、Arao Takashi
    • Journal Title

      Frontiers in Human Neuroscience

      Volume: 16 Pages: 1018087-1018087

    • DOI

      10.3389/fnhum.2022.1018087

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mild exercise improves executive function with increasing neural efficiency in the prefrontal cortex of older adults2023

    • Author(s)
      Kyeongho Byun, Kazuki Hyodo, Kazuya Suwabe, Takemune Fukuie, Min-seong Ha, Chorphaka Damronthai, Ryuta Kuwamizu, Hikaru Koi-zumi, Michael A. Yassa, Hideaki Soya
    • Journal Title

      GeroScience

      Volume: - Issue: 1 Pages: 309-325

    • DOI

      10.1007/s11357-023-00816-3

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Comparison Between the Effects of Continuous and Intermittent Light-Intensity Aerobic Dance Exercise on Mood and Executive Functions in Older Adults2021

    • Author(s)
      Hyodo Kazuki、Suwabe Kazuya、Yamaguchi Daisuke、Soya Hideaki、Arao Takashi
    • Journal Title

      Frontiers in Aging Neuroscience

      Volume: 13

    • DOI

      10.3389/fnagi.2021.723243

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Effect of web-based light-intensity aerobic dance exercise on mental health and cognitive function in older adults: the second report2023

    • Author(s)
      Kazuki Hyodo, Yuya Watanabe, Daisuke Yamaguchi, Aiko Ueno, Takayuki Noda, Sumiyo Nishida, Yuko Kai, Hideaki Soya, and Takashi Arao
    • Organizer
      ARIHHP Human High Performance Forum 2023
    • Related Report
      2022 Annual Research Report
  • [Presentation] 一過性の運動が高齢者の認知機能・気分に与える効果-軽体操に着目して2022

    • Author(s)
      兵頭和樹
    • Organizer
      第77回日本体力医学会大会(招待講演)
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 自宅型の高齢者向けオンライン運動教室プログラムの実行可能性とメンタルヘルスへの影響―予備的検討2021

    • Author(s)
      兵頭和樹, 城所哲宏, 野田隆行, 山口大輔, 西田純世, 河原賢二, 甲斐裕子,荒尾孝
    • Organizer
      第76回日本体力医学会大会
    • Related Report
      2021 Research-status Report
  • [Presentation] 高齢者の認知機能維持・向上に資する 運動の役割2021

    • Author(s)
      兵頭和樹
    • Organizer
      日本体育・スポーツ・健康学会 第71回大会
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] Acceptability of a home-based online exercise program in older adults – a pilot study2021

    • Author(s)
      K. Hyodo, T. Kidokoro, Y. Kai, T. Noda, D. Yamaguchi, K. Kawahara, S. Nishida, H.Soya , and T. Arao
    • Organizer
      ARIHHP science week2021
    • Related Report
      2020 Research-status Report
  • [Presentation] 音楽に合わせた軽体操の間欠的な実施は高齢者の気分・実行機能をより高めるか。2020

    • Author(s)
      兵頭和樹, 諏訪部和也, 山口大輔, 荒尾孝
    • Organizer
      第75回日本体力医学会大会
    • Related Report
      2020 Research-status Report
  • [Presentation] The effects of acute exercise on working memory in older adults: a preliminary study2020

    • Author(s)
      Kazuki Hyodo, Daisuke Yamaguchi, Kazuya Suwabe, Hideaki Soya
    • Organizer
      ARIHHP science week 2020
    • Related Report
      2019 Research-status Report

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Published: 2019-04-18   Modified: 2024-01-30  

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