Perilla Oil and Bifidobacterium for Alleviating Fear of Cancer Recurrence (POB study)

• Project/Area Number: 19K20171
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 59040:Nutrition science and health science-related
• Research Institution: National Center of Neurology and Psychiatry
• Principal Investigator: Okubo Ryo 国立研究開発法人国立精神・神経医療研究センター, 病院 臨床研究・教育研修部門, 室長 (00803470)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Project Status: Completed (Fiscal Year 2021)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2020: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000); Fiscal Year 2019: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: プロバイオティクス / オメガ3系脂肪酸 / がん再発不安 / 臨床試験 / 乳がん / 腸内細菌 / 不安 / 抑うつ / メンタルヘルス / がんサバイバー / がん / 栄養療法

Outline of Research at the Start

がん再発不安は、がん罹患後の生活の中で最大のアンメットニーズであるが、安全かつ普及可能な対策が確立されていない。先行研究からオメガ3系脂肪酸欠乏による恐怖記憶制御不全と、化学療法による腸内環境の増悪が、がん再発不安の病態に関与している可能性が示唆されている。
本研究では、栄養学的介入が、がん患者のがん再発不安に対して有効かどうかを、プラセボを比較対照としたランダム化二重盲検比較試験で明らかにする。また、摂取開始時の栄養状態を測定することで、個々のがん患者の栄養状態に応じた、がん再発不安の克服を目的とした個別的な栄養学的介入法の開発に繋げる。

Outline of Final Research Achievements

Fear of cancer recurrence is the greatest unmet need in life after having cancer, but no safe and widely available treatment options have been established. In this study, we investigated the effects of consumption of perilla oil and Bifidobacterium-containing foods on psychological distress, including fear of cancer recurrence, among female breast cancer survivors after completion of chemotherapy in a randomized controlled trial. 48 participants were randomized into 3 groups (Perilla oil + Bifidobacterium group, Bifidobacterium group, and treatment as usual group). The baseline profile of gut microbiota and the changes in the gut microbiota after treatment were also examined, leading to the development of individualized nutritional interventions to overcome the fear of cancer recurrence according to the condition of each cancer patient.

Academic Significance and Societal Importance of the Research Achievements

がん再発不安については、薬物療法や精神療法が研究されているが、副作用と治療者の確保が社会実装の際に大きな課題となる。一方、オメガ3系脂肪酸、プロバイオティクスともに誰もが豊富な食経験を有する安全な栄養成分であり、サプリメントによる社会実装が容易であり、本研究の成果は社会に広く影響を与える可能性が高い。

Research Products

• [Journal Article] Temporary employment and suicidal ideation in COVID-19 pandemic in Japan: A cross-sectional nationwide survey (2022)
  • Author(s): Sasaki Natsu、Tabuchi Takahiro、Okubo Ryo、Ishimaru Tomohiro、Kataoka Mayumi、Nishi Daisuke
  • Journal Title: Journal of Occupational Health Volume: 64 Issue: 1 Pages: n/a
  • DOI: 10.1002/1348-9585.12319
  • ISSN: 1341-9145, 1348-9585
  • Peer Reviewed / Open Access
• [Journal Article] Emotional Exhaustion of Burnout Among Medical Staff and Its Association With Mindfulness and Social Support: A Single Center Study During the COVID-19 Pandemic in Japan (2022)
  • Author(s): Sampei Makiko、Okubo Ryo、Sado Mitsuhiro、Piedvache Aurelie、Mizoue Tetsuya、Yamaguchi Koushi、Morisaki Naho
  • Journal Title: Frontiers in Psychiatry Volume: 13 Pages: 774919-774919
  • DOI: 10.3389/fpsyt.2022.774919
• [Journal Article] Sex Differences in Social Cognition and Association of Social Cognition and Neurocognition in Early Course Schizophrenia (2022)
  • Author(s): Kubota Ryotaro、Okubo Ryo、Ikezawa Satoru、Matsui Makoto、Adachi Leona、Wada Ayumu、Fujimaki Chinatsu、Yamada Yuji、Saeki Koji、Sumiyoshi Chika、Kikuchi Akiko、Omachi Yoshie、Takeda Kazuyoshi、Hashimoto Ryota、Sumiyoshi Tomiki、Yoshimura Naoki
  • Journal Title: Frontiers in Psychology Volume: 13 Pages: 867468-867468
  • DOI: 10.3389/fpsyg.2022.867468
  • Peer Reviewed / Open Access
• [Journal Article] Impact of state of emergency for coronavirus disease 2019 on hospital visits and disease exacerbation: the Japan COVID-19 and Society Internet Survey (2022)
  • Author(s): Yoshida Satomi、Okubo Ryo、Katanoda Kota、Tabuchi Takahiro
  • Journal Title: Family Practice Volume: xx Issue: 5 Pages: 1-8
  • DOI: 10.1093/fampra/cmac016
  • Peer Reviewed
• [Journal Article] Subthreshold Change in Glycated Hemoglobin and Body Mass Index After the Initiation of Second-Generation Antipsychotics Among Patients With Schizophrenia or Bipolar Disorder (2022)
  • Author(s): Sawagashira Ryo、Yamamura Ryodai、Okubo Ryo、Hashimoto Naoki、Ishikawa Shuhei、Ito Yoichi M.、Sato Norihiro、Kusumi Ichiro
  • Journal Title: The Journal of Clinical Psychiatry Volume: 83 Issue: 3
  • DOI: 10.4088/jcp.21m14099
• [Journal Article] Perilla Oil and Bifidobacterium for Alleviating Fear of Cancer Recurrence in Breast Cancer Survivors: Study Protocol for a Three-Arm Phase II Randomized Controlled Study (POB Study) (2021)
  • Author(s): Sasaki Y, Honyashiki M, Kinoshita T, Matsui A, Nakashoji A, Inagawa T, Ikezawa S, Yoshimura N, Yamamura R, Amano M, Tomo Y, Tachimori H, Matsuoka YJ, Okubo R.
  • Journal Title: Methods Protoc . Volume: 4 Issue: 3 Pages: 46-46
  • DOI: 10.3390/mps4030046
  • Peer Reviewed / Open Access
• [Journal Article] Lipid and Energy Metabolism of the Gut Microbiota Is Associated with the Response to Probiotic Bifidobacterium breve Strain for Anxiety and Depressive Symptoms in Schizophrenia (2021)
  • Author(s): Yamamura Ryodai、Okubo Ryo、Katsumata Noriko、Odamaki Toshitaka、Hashimoto Naoki、Kusumi Ichiro、Xiao Jinzhong、Matsuoka Yutaka J.
  • Journal Title: Journal of Personalized Medicine Volume: 11 Issue: 10 Pages: 987-987
  • DOI: 10.3390/jpm11100987
  • Peer Reviewed / Open Access
• [Journal Article] Oncology care providers’ awareness and practice related to physical activity promotion for breast cancer survivors and barriers and facilitators to such promotion: a nationwide cross-sectional web-based survey (2021)
  • Author(s): Shimizu Yoichi、Tsuji Katsunori、Ochi Eisuke、Okubo Ryo、Kuchiba Aya、Shimazu Taichi、Tatematsu Noriatsu、Sakurai Naomi、Iwata Hiroji、Matsuoka Yutaka J.
  • Journal Title: Supportive Care in Cancer Volume: 30 Issue: 4 Pages: 3105
  • DOI: 10.1007/s00520-021-06706-8
  • Peer Reviewed / Open Access
• [Journal Article] 精神疾患患者への健康行動支援 (2021)
  • Author(s): 大久保亮
  • Journal Title: 認知療法研究 Volume: 14 Pages: 33-35
  • Peer Reviewed
• [Journal Article] がんサバイバーのメンタルヘルスと食・栄養 (2021)
  • Author(s): 大久保亮、佐々木洋平
  • Journal Title: 行動医学研究 Volume: 25 Pages: 127-134
  • NAID: 130008036459
  • Peer Reviewed
• [Journal Article] Smoking and drinking among patients with mental disorders: Evidence from a nationally representative Japanese survey (2021)
  • Author(s): Okubo Ryo、Tabuchi Takahiro
  • Journal Title: Journal of Affective Disorders Volume: 279 Pages: 443-450
  • DOI: 10.1016/j.jad.2020.10.037
  • Peer Reviewed
• [Journal Article] Impact of peritraumatic distress on posttraumatic stress disorder symptoms at 6 months after acute coronary syndrome: a prospective cohort study (2021)
  • Author(s): Narisawa Tomomi、Nishi Daisuke、Okubo Ryo、Noguchi Hiroko、Hamazaki Kei、Yamashita Akihiro、Matsuoka Yutaka J.
  • Journal Title: European Journal of Psychotraumatology Volume: 12 Issue: 1 Pages: 1854511-1854511
  • DOI: 10.1080/20008198.2020.1854511
  • Peer Reviewed / Open Access
• [Journal Article] Urbanization level and neighborhood deprivation, not COVID-19 case numbers by residence area, are associated with severe psychological distress and new-onset suicidal ideation during the COVID-19 pandemic (2021)
  • Author(s): Okubo Ryo、Yoshioka Takashi、Nakaya Tomoki、Hanibuchi Tomoya、Okano Hiroki、Ikezawa Satoru、Tsuno Kanami、Murayama Hiroshi、Tabuchi Takahiro
  • Journal Title: Journal of Affective Disorders Volume: 287 Pages: 89-95
  • DOI: 10.1016/j.jad.2021.03.028
  • Peer Reviewed / Open Access
• [Journal Article] Impact of chemotherapy on the association between fear of cancer recurrence and the gut microbiota in breast cancer survivors (2020)
  • Author(s): Okubo Ryo、Kinoshita Takayuki、Katsumata Noriko、Uezono Yasuhito、Xiao Jinzhong、Matsuoka Yutaka J.
  • Journal Title: Brain, Behavior, and Immunity Volume: 85 Pages: 186-191
  • DOI: 10.1016/j.bbi.2019.02.025
  • Peer Reviewed
• [Journal Article] Study protocol for a nationwide questionnaire survey of physical activity among breast cancer survivors in Japan (2020)
  • Author(s): Shimizu Yoichi、Tsuji Katsunori、Ochi Eisuke、Arai Hirokazu、Okubo Ryo、Kuchiba Aya、Shimazu Taichi、Sakurai Naomi、Narisawa Tomomi、Ueno Taro、Iwata Hiroji、Matsuoka Yutaka
  • Journal Title: BMJ Open Volume: 10 Issue: 1 Pages: e032871-e032871
  • DOI: 10.1136/bmjopen-2019-032871
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Association between blood omega-3 polyunsaturated fatty acids and the gut microbiota among breast cancer survivors (2019)
  • Author(s): Horigome A.、Okubo R.、Hamazaki K.、Kinoshita T.、Katsumata N.、Uezono Y.、Xiao J.Z.、Matsuoka Y.J.
  • Journal Title: Beneficial Microbes Volume: 10 Issue: 7 Pages: 751-758
  • DOI: 10.3920/bm2019.0034
  • Peer Reviewed / Open Access
• [Journal Article] Expectations of and recommendations for a cancer survivorship guideline in Japan: a literature review of guidelines for cancer survivorship. (2019)
  • Author(s): Okubo R, Wada S, Shimizu Y, Tsuji K, Hanai A, Imai K, Uchitomi Y, Fujiwara Y, Tsugane S, Matsuoka YJ.
  • Journal Title: Jpn J Clin Oncol Volume: 49 Issue: 9 Pages: 812-822
  • DOI: 10.1093/jjco/hyz070
  • Peer Reviewed / Open Access
• [Journal Article] Effect of home-based high-intensity interval training and behavioural modification using information and communication technology on cardiorespiratory fitness and exercise habits among sedentary breast cancer survivors: Habit-B study protocol for a randomised controlled trial (2019)
  • Author(s): Tsuji Katsunori、Ochi Eisuke、Okubo Ryo、Shimizu Yoichi、Kuchiba Aya、Ueno Taro、Shimazu Taichi、Kinoshita Takayuki、Sakurai Naomi、Matsuoka Yutaka
  • Journal Title: BMJ Open Volume: 9 Issue: 8 Pages: e030911-e030911
  • DOI: 10.1136/bmjopen-2019-030911
  • Peer Reviewed / Open Access
• [Journal Article] Developing the structure of Japan’s cancer survivorship guidelines using an expert panel and modified Delphi method. (2019)
  • Author(s): Matsuoka YJ, Okubo R, Shimizu Y, Tsuji K, Narisawa T, Sasaki J, Sasai H, Akashi-Tanaka S, Hamaguchi T, Iwasa T, Iwata S, Kato T, Kurotani K, Maruyama D, Mori A, Ogawa A, Sakurai N, Shimazu T, Shimizu C, Tabuchi T, Takahashi M, Takano T, Tatematsu N, Uchitomi Y, Watanabe C, Fukui T.
  • Journal Title: J Cancer Surviv Volume: - Issue: 3 Pages: 273-283
  • DOI: 10.1007/s11764-019-00840-3
  • Peer Reviewed
• [Presentation] がんサバイバーのメンタルヘルスと食・栄養 (2019)
  • Author(s): 大久保亮
  • Organizer: 第26回 日本行動医学会学術総会
  • Invited
• [Presentation] Clinical research of gut-microbiota-brain axis (2019)
  • Author(s): Ryo Okubo
  • Organizer: 6th Congress of Asian College of Neuropsychopharmacology
  • Int'l Joint Research / Invited
• [Presentation] 健康行動に資する認知行動療法 (2019)
  • Author(s): 大久保亮
  • Organizer: 第19回 日本認知療法・認知行動療法学会
  • Invited
• [Book] Potential beneficial effects of Bifidobacterium breve A1 on cognitive impairment and psychiatric disorders: The Neuroscience of Depression (2021)
  • Author(s): Ryo Okubo , Jinzhong Xiao , Yutaka J. Matsuoka
  • Total Pages: 1166
  • Publisher: Academic Press
• [Book] The Role of Nutrition During Aging: A Handbook for Nutritional Neuroscience (2020)
  • Author(s): Dr. Nafisa M. Jadavji （分担執筆）大久保亮
  • Total Pages: 172
  • Publisher: Brain & Life Publishing
  • ISBN: 9781912533053