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Developing a mild exercise program enhancing memory in older adults: fMRI study targeting the hippocampus

Research Project

Project/Area Number 19K20176
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 59040:Nutrition science and health science-related
Research InstitutionRyutsu Keizai University (2020-2021)
University of Tsukuba (2019)

Principal Investigator

SUWABE KAZUYA  流通経済大学, スポーツ健康科学部, 助教 (80816413)

Project Period (FY) 2019-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2021: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords超低強度運動 / 認知機能 / 記憶 / 有酸素能力 / 身体活動量 / 気分 / 音楽 / スローエアロビック / 海馬 / fMRI
Outline of Research at the Start

運動は身体だけでなく脳、とりわけ学習・記憶を担う海馬にも有益な効果をもつことが明らかになるにつれ、認知症予防策としても注目される。申請者はこれまで、健常若齢者を対象にした高解像機能的MRI研究から、ヨガや太極拳などの軽運動を模した一過性の超低強度運動(最大酸素摂取量の37%以下)が記憶能を向上させること、その神経基盤として海馬の記憶システムが上方調節されることを明らかにした。本研究は、これを高齢者に応用し、加齢により低下した海馬記憶能に対する超低強度運動の効果とその脳内メカニズム解明する。加えて、現場への実装を念頭に、軽運動の効果をより高める音楽に合わせた楽しい軽運動プログラムの開発を目指す。

Outline of Final Research Achievements

Physical exercise has been shown to have positive impacts on cognitive function and is expected to be a preventive measure against dementia in older adults. This study aimed to verify the effect of very-light-intensity exercise (37% or less of maximal oxygen intake) on hippocampal memory function in older adults, and to develop a mild exercise program to enhance cognitive function. The results showed that (1) very-light-intensity physical activity has positive effects on hippocampal memory in healthy elderly women, (2) very-light-intensity exercise may rapidly enhance hippocampal memory in older adults, and (3) music and movement tempo that makes people feel energetic and positive is useful to improve cognitive function with mild exercise program.

Academic Significance and Societal Importance of the Research Achievements

本研究により、ヨガや太極拳のような超低強度運動に相当する軽運動が高齢者の海馬歯状回の機能を改善し、記憶能を高める可能性を支持する結果が得られた。今後、さらに検証を重ねることで超低強度運動の効果とそのメカニズムが明らかになれば、認知症予防を目的とした軽運動プログラムの開発が促進される。さらに、音楽や動きを工夫することで運動の楽しさや気分を高め、認知機能への効果を増大させる効果を明らかにした成果は、運動プログラムの現場実装する上で有用である。

Report

(4 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (22 results)

All 2022 2021 2020 2019

All Journal Article (14 results) (of which Int'l Joint Research: 6 results,  Peer Reviewed: 10 results,  Open Access: 10 results) Presentation (8 results) (of which Int'l Joint Research: 1 results,  Invited: 1 results)

  • [Journal Article] Groove rhythm stimulates prefrontal cortex function in groove enjoyers2022

    • Author(s)
      Fukuie Takemune、Suwabe Kazuya、Kawase Satoshi、Shimizu Takeshi、Ochi Genta、Kuwamizu Ryuta、Sakairi Yosuke、Soya Hideaki
    • Journal Title

      Scientific Reports

      Volume: 12 Issue: 1 Pages: 1-14

    • DOI

      10.1038/s41598-022-11324-3

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] スポーツ健康科学を学ぶ大学生におけるコロナ禍の生活習慣調査報告 : コロナ禍における睡眠質の変化とその要因の考察2022

    • Author(s)
      膳法 亜沙子, 諏訪部和也, 吉川 徹, 大槻 毅
    • Journal Title

      流通経済大学スポーツ健康科学部紀要

      Volume: 15 Pages: 65-80

    • Related Report
      2021 Annual Research Report
  • [Journal Article] 大学のスポーツ実技(エアロビックダンス)における対面授業及び遠隔授業の心理的効果2021

    • Author(s)
      伊藤理香・林田はるみ・諏訪部和也
    • Journal Title

      東海学園大学教育研究紀要

      Volume: 6 Pages: 24-32

    • NAID

      40022544404

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Exercise Intervention for Academic Achievement Among Children: A Randomized Controlled Trial2021

    • Author(s)
      Takehara Kenji、Togoobaatar Ganchimeg、Kikuchi Akihito、Lkhagvasuren Gundegmaa、Lkhagvasuren Altantsetseg、Aoki Ai、Fukuie Takemune、Shagdar Bat-Erdene、Suwabe Kazuya、Mikami Masashi、Mori Rintaro、Soya Hideaki
    • Journal Title

      Pediatrics

      Volume: 148 Issue: 5

    • DOI

      10.1542/peds.2021-052808

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Comparison Between the Effects of Continuous and Intermittent Light-Intensity Aerobic Dance Exercise on Mood and Executive Functions in Older Adults2021

    • Author(s)
      Hyodo Kazuki、Suwabe Kazuya、Yamaguchi Daisuke、Soya Hideaki、Arao Takashi
    • Journal Title

      Frontiers in Aging Neuroscience

      Volume: 13

    • DOI

      10.3389/fnagi.2021.723243

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] スポーツを学ぶ大学生を対象としたコロナ禍におけるクラウド型教育支援サービスを利用した健康教育の試みとその成果2021

    • Author(s)
      諏訪部和也, 膳法 亜沙子, 吉川 徹, 大槻 毅
    • Journal Title

      流通経済大学スポーツ健康科学部紀要

      Volume: 14 Pages: 123-131

    • NAID

      120007188202

    • Related Report
      2021 Annual Research Report
    • Open Access
  • [Journal Article] Exercise training and burdock root (Arctium lappa L.) extract independently improve abdominal obesity and sex hormones in elderly women with metabolic syndrome2021

    • Author(s)
      Ha Min-Seong、Yook Jang Soo、Lee Minchul、Suwabe Kazuya、Jeong Woo-Min、Kwak Jae-Jun、Soya Hideaki
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1

    • DOI

      10.1038/s41598-021-84301-x

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Positive Mood while Exercising Influences Beneficial Effects of Exercise with Music on Prefrontal Executive Function: A Functional NIRS Study2021

    • Author(s)
      Suwabe Kazuya、Hyodo Kazuki、Fukuie Takemune、Ochi Genta、Inagaki Kazuki、Sakairi Yosuke、Soya Hideaki
    • Journal Title

      Neuroscience

      Volume: 454 Pages: 61-71

    • DOI

      10.1016/j.neuroscience.2020.06.007

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Spontaneous Eye Blink Rate Connects Missing Link between Aerobic Fitness and Cognition2020

    • Author(s)
      KUWAMIZU RYUTA、SUWABE KAZUYA、DAMRONGTHAI CHORPHAKA、FUKUIE TAKEMUNE、OCHI GENTA、HYODO KAZUKI、HIRAGA TAICHI、NAGANO-SAITO ATSUKO、SOYA HIDEAKI
    • Journal Title

      Medicine & Science in Sports & Exercise

      Volume: Publish Ahead of Print Issue: 7 Pages: 1425-1433

    • DOI

      10.1249/mss.0000000000002590

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] 超低強度運動の認知機能増進効果2020

    • Author(s)
      諏訪部和也, 征矢英昭
    • Journal Title

      体育の科学

      Volume: 70 Pages: 238-243

    • Related Report
      2020 Research-status Report
  • [Journal Article] Acute Sprint Interval Exercise Increases Both Cognitive Functions and Peripheral Neurotrophic Factors in Humans: The Possible Involvement of Lactate2020

    • Author(s)
      Kujach Sylwester、Olek Robert Antoni、Byun Kyeongho、Suwabe Kazuya、Sitek Emilia J.、Ziemann Ewa、Laskowski Rados?aw、Soya Hideaki
    • Journal Title

      Frontiers in Neuroscience

      Volume: 13

    • DOI

      10.3389/fnins.2019.01455

    • NAID

      120007132779

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] ホモ・サピエンスとして重要な持久性と認知機能の連関2020

    • Author(s)
      桑水隆多, 諏訪部和也, 征矢英昭
    • Journal Title

      体育の科学

      Volume: 70 Pages: 7-13

    • Related Report
      2019 Research-status Report
  • [Journal Article] The effectiveness of exercise intervention for academic achievement, cognitive function, and physical health among children in Mongolia: a cluster RCT study protocol2019

    • Author(s)
      Takehara Kenji, Ganchimeg Togoobaatar, Kikuchi Akihito, Gundegmaa Lkagvasuren, Altantsetseg Lkagvasuren, Aoki Ai, Fukuie Takemune, Suwabe Kazuya, Bat-Erdene Shagdar, Mikami Masashi, Mori Rintaro, Soya Hideaki
    • Journal Title

      BMC Public Health

      Volume: 19 Issue: 1

    • DOI

      10.1186/s12889-019-6986-8

    • NAID

      120007133411

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Acute effects of light-intensity, slow-tempo aerobic dance exercise on mood and executive function in older adults2019

    • Author(s)
      Kazuki Hyodo, Takashi Jindo, Kazuya Suwabe, Hideaki Soya, Toshiya Nagamatsu
    • Journal Title

      BULLETIN OF THE PHYSICAL FITNESS RESEARCH INSTITUTE

      Volume: 117 Pages: 8-16

    • NAID

      130007732065

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 中高齢男性における立ち上がり台テストに関連する体格・体力特性の検討2021

    • Author(s)
      海野将輝、膳法亜沙子、諏訪部和也、大槻毅
    • Organizer
      第77回日本体力医学会大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 低酸素暴露を用いたヒト海馬認知疲労モデルの開発:心理状態が及ぼす影響の検討2021

    • Author(s)
      山崎雄大、越智元太、諏訪部和也、李東旻、征矢英昭
    • Organizer
      第77回日本体力医学会大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Acute moderate running boosts positive mood and executive function coinciding with prefrontal activation : An fNIRS study2021

    • Author(s)
      Chorphaka Damrongthai, Ryuta Kuwamizu, Kazuya Suwabe, Genta Ochi, Yudai Yamazaki, Kazutaka Adachi, Michael A. Yassa, Worachat Churdchomjan, Hideaki Soya
    • Organizer
      Society for Neuroscience annual meeting 2021 (virtual event)
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] 認知機能を高める軽運動:音楽に合わせた体操の可能性2020

    • Author(s)
      諏訪部和也
    • Organizer
      第16回日本体操学会体操研究集会
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] 音楽に合わせた軽体操の間欠的な実施は高齢者の気分・実行機能をより高めるか?2020

    • Author(s)
      兵頭和樹, 諏訪部和也, 山口大輔, 荒尾孝
    • Organizer
      第75回日本体力医学会大会
    • Related Report
      2020 Research-status Report
  • [Presentation] 音楽に合わせた運動により誘発されるポジティブな気分は前頭前野賦活と実行機能向上に関わる:機能的近赤外線分光法研究2019

    • Author(s)
      諏訪部和也, 兵頭和樹, 福家健宗, 越智元太, ビョンギョンホ, 稲垣和希, 坂入洋右, 征矢英昭
    • Organizer
      第42回日本神経科学大会
    • Related Report
      2019 Research-status Report
  • [Presentation] 音楽に合わせた運動で高める前頭前野の実行機能2019

    • Author(s)
      諏訪部和也, 福家健宗, 征矢英昭
    • Organizer
      第74回日本体力医学会大会
    • Related Report
      2019 Research-status Report
  • [Presentation] 音楽に合わせた運動で高める前頭前野の実行機能:ポジティブ気分の影響2019

    • Author(s)
      諏訪部和也, 兵頭和樹, 福家健宗, 征矢英昭
    • Organizer
      第74回日本体力医学会大会
    • Related Report
      2019 Research-status Report

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Published: 2019-04-18   Modified: 2023-01-30  

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