Development of a path-breaking medical imaging system that visualizes and quantifies molecular pathologies noninvasively
| Project/Area Number |
19K20676
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 90110:Biomedical engineering-related
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2019-04-01 – 2022-03-31
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| Project Status |
Completed (Fiscal Year 2021)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2021: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 非アルコール性脂肪性肝炎 / 代謝機能イメージング / ミトコンドリア機能 / 非アルコール性脂肪性肝疾患 / NASH / 分子病態の可視化 |
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| Outline of Research at the Start |
本研究では、磁気共鳴代謝イメージング装置（DNP－MRI装置）を用い、酸化ストレスやミトコンドリア機能異常が進行と共に変化する事が報告されているヒトおよびマウスのNASHモデルにおいて、生体内の酸化ストレスやミトコンドリア機能を非侵襲的に可視化し、NASHの病態を定量的に評価可能かどうかを明らかにすると共に、NAFLD/NASHの病態進行機序を解明する。
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| Outline of Final Research Achievements |
The number of obese patients and patients with cirrhosis caused by non-alcoholic fatty liver disease/hepatitis (NAFLD/NASH) is increasing. We developed a magnetic resonance metabolic imaging system (DNP-MRI system) that can accurately diagnose the pathology of NAFLD/NASH and tried to elucidate the pathological mechanism of NAFLD/NASH.
In our study, we found that the DNP-MRI system provided a good assessment of the disease progression of NAFLD/NASH. And we also found that the DNP-MRI system assessed mitochondrial function, suggesting that the DNP-MRI system may be a feasible tool for evaluating the mitochondrial function in the disease progression of AFLD/NASH.
The DNP-MRI system also assessed mitochondrial function, suggesting that mitochondria may be involved in the disease progression of NAFLD/NASH.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究の成果として得られた酸化還元反応、しいてはミトコンドリア機能を個体・組織・細胞レベルで可視化・評価できる診断機器は、NAFLD/NASHの正確な診断が非侵襲的に行える可能性が示唆された。
この診断機器は今まで侵襲的に行ってきた肝生検に変わるNAFLD/NASHの診断法となり得、治療効果の診断や病態メカニズム解明にも有用であると考えられる。
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Report
(4 results)
Research Products
(41 results)
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[Journal Article] Prognostic significance of systemic inflammation score in patients who undergo hepatic resection for hepatocellular carcinoma.2021
Author(s)
Inokuchi S, Itoh S, Yoshizumi T, Morinaga A, Toshima T, Takeishi K, Nagao Y, Harada N, Ikegami T, Shimokawa M, Mori M.
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Journal Title
Langenbecks Arch Surg.
Volume: Epub
Issue: 3
Pages: 773-779
DOI
Related Report
Peer Reviewed
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[Journal Article] Surgically resected hepatic mass caused by fascioliasis.2021
Author(s)
Wang H, Itoh S, Matsumoto Y, Nishie A, Kurihara T, Shimagaki T, Nagao Y, Toshima T, Harada N, Kohashi K, Oda Y, Ishigami K, Maruyama H, Yoshizumi T, Mori M.
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Journal Title
Clin J Gastroenterol.
Volume: 14(2)
Issue: 2
Pages: 662-667
DOI
Related Report
Peer Reviewed
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[Journal Article] Late recurrence of cancer stem cell-positive colorectal cancer liver metastases after 15 years.2021
Author(s)
Nagano T, Itoh S, Miyashita Y, Shimagaki T, Wang H, Kurihara T, Nagao Y, Toshima T, Harada N, Kohashi K, Ogata Y, Oki E, Oda Y, Yoshizumi T, Mori M.
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Journal Title
Clin J Gastroenterol.
Volume: 14(2)
Issue: 2
Pages: 613-616
DOI
Related Report
Peer Reviewed
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[Journal Article] Simultaneous splenectomy improves outcomes after adult living donor liver transplantation.2021
Author(s)
Yoshizumi T, Itoh S, Shimokawa M, Inokuchi S, Harada N, Takeishi K, Mano Y, Yoshiya S, Kurihara T, Nagao Y, Ikegami T, Soejima Y, Mori M.
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Journal Title
J Hepatol.
Volume: 74(2)
Issue: 2
Pages: 372-379
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Histidine-rich Glycoprotein alleviate Ischemia/Reperfusion Liver Injury in Mice with Nonalcoholic Steatohepatitis.2020
Author(s)
Guo J, Akahoshi T, Mizuta Y, Murata M, Narahara S, Kawano T, Nagao Y, Zhang S, Tomikawa M, Kawanaka H, Hashizume M.
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Journal Title
Liver Transpl.
Volume: Epub
Issue: 6
Pages: 840-853
DOI
Related Report
Peer Reviewed
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[Journal Article] Alteration in faecal bile acids, gut microbial composition and diversity after laparoscopic sleeve gastrectomy.2020
Author(s)
Ikeda T, Aida M, Yoshida Y, Matsumoto S, Tanaka M, Nakayama J, Nagao Y, Nakata R, Oki E, Akahoshi T, Okano S, Nomura M, Hashizume M, Maehara Y.
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Journal Title
Br J Surg.
Volume: 107
Issue: 12
Pages: 1673-1685
DOI
Related Report
Peer Reviewed
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