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Advanced PET detector with function of Compton camera for simultaneous multi-nuclide imaging

Research Project

Project/Area Number 19K20723
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 90130:Medical systems-related
Research InstitutionNational Institutes for Quantum and Radiological Science and Technology

Principal Investigator

Takyu Sodai  国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所 先進核医学基盤研究部, 博士研究員(任常) (60796473)

Project Period (FY) 2019-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2020: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2019: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords放射線検出器 / コンプトンカメラ / PET / 放射線計測
Outline of Research at the Start

PET(positron emission tomography)は、511 keV対消滅ガンマ線しか測定できないため、生体の複数の機能を同時に画像化することはできない。そこで本研究では、コンプトンカメラの機能を追加したPET検出器を開発する。具体的には、コンプトンカメラの吸収体としてシンチレータ全面または上下面に受光素子を取り付けた超高エネルギー分解能PET検出器を開発する。これを散乱体の検出器と組み合わせることで、複数核種の同時撮像が可能なイメージング技術を実現する。

Outline of Final Research Achievements

Positron emission tomography (PET), which is a nuclear medicine imaging modality, can only use 511 keV annihilation photons for imaging, and thus cannot visualize multiple functions of a living body simultaneously. In this study, we developed a PET detector with a function of Compton camera that can image a wide range of gamma ray energies simultaneously. A two-layered scatterer detector consisting of GSO scintillators and a multi-pixel photon counter (MPPC) array module was developed, and a PET detector developed in another project in our laboratory was used as an absorber detector to construct a PET detector with Compton camera function. Simultaneous imaging of point sources of Na-22 (511 keV and 1275 keV) and Cs-137 (662 keV) was performed, and each source could be visualized separately.

Academic Significance and Societal Importance of the Research Achievements

PETは他の核医学診断装置であるSPECT(単一光子放射断層撮影)に比べ空間分解能や画像の定量性に優れているが、複数の分子プローブを同時に使用することはできず、複数の因子が複雑に関与する疾患等の発生要因を明らかにすることはできない。そこで、様々なエネルギーのガンマ線を可視化できるコンプトンカメラの技術に着目した。PET検出器にコンプトンカメラの原理を応用すれば、PETとしての空間分解能・感度を維持しながら、複数核種の同時撮像が可能となり、核医学診断の分野において大きなイノベーションになると期待する。

Report

(3 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • Research Products

    (10 results)

All 2021 2020 2019 Other

All Int'l Joint Research (1 results) Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (7 results) (of which Int'l Joint Research: 3 results) Remarks (1 results)

  • [Int'l Joint Research] LMU Munchen(ドイツ)

    • Related Report
      2019 Research-status Report
  • [Journal Article] GAGG?MPPC detector with optimized light guide thickness for combined Compton-PET applications2021

    • Author(s)
      Takyu Sodai、Nishikido Fumihiko、Yoshida Eiji、Nitta Munetaka、Kamada Kei、Yoshikawa Akira、Yamaya Taiga
    • Journal Title

      Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment

      Volume: 990 Pages: 164998-164998

    • DOI

      10.1016/j.nima.2020.164998

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Presentation] Whole Gamma Imaging: 小動物用原理実証機の改良2020

    • Author(s)
      田久創大, 田島英朗, 吉田英治, 脇坂秀克, 小畠藤乃, 高橋美和子, 永津弘太郎, 辻厚至, Katia Parodi, 山谷泰賀
    • Organizer
      第60 回日本核医学会学術総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Whole Gamma Imaging: the 3rd Prototype With a Two-layer DOI GSOZ Scatterer Detector2020

    • Author(s)
      S. Takyu, H. Tashima, E. Yoshida, H. Wakizaka, F. Obata, M. Takahashi, K. Nagatsu, A. Tsuji, K. Parodi, T. Yamaya
    • Organizer
      2020 IEEE Nuclear Science Symposium and Medical Imaging Conference
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Zr-89 Whole Gamma Imaging のための2 層DOI 型GSO 散乱検出器の開発2020

    • Author(s)
      田久創大, 田島英朗, 吉田英治, 脇坂秀克, 小畠藤乃, 高橋美和子, 永津弘太郎, 辻厚至, Katia Parodi, 山谷泰賀
    • Organizer
      第81 回応用物理学会秋季学術講演会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Development of a two-layer staggered detector for a scatterer of whole gamma imaging2020

    • Author(s)
      Sodai Takyu, Eiji Yoshida, Akram Mohammadi, Kei Kamada, Taiga Yamaya
    • Organizer
      第119 回日本医学物理学会学術大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Reduction of readout channels of a monolithic LaBr3:Ce detector by resistive-chain and neural networks2019

    • Author(s)
      S. Takyu, S. Liprandi, H. G. Kang, M. Kawula, M. Nitta, F. Nishikido, N. Inadama, K. Parodi, P. Thirolf, T. Yamaya
    • Organizer
      2019 IEEE Nuclear Science Symposium (NSS) and Medical Imaging Conference (MIC)
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Two-Layer DOI Staggered GAGG Scatterer Detector for WGI2019

    • Author(s)
      S. Takyu, E. Yoshida, A. Mohammadi, K. Kamada, T. Yamaya
    • Organizer
      2019 IEEE Nuclear Science Symposium (NSS) and Medical Imaging Conference (MIC)
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Whole gamma imaging のための 2 層スタガー型 GAGG 散乱検出器2019

    • Author(s)
      田久創大, 吉田英治, 仁科匠, 菅幹生, 鎌田圭, 山谷泰賀
    • Organizer
      第 80 回応用物理学会秋季学術講演会
    • Related Report
      2019 Research-status Report
  • [Remarks] 次世代PET開発研究会報告書

    • URL

      https://www.nirs.qst.go.jp/usr/medical-imaging/ja/study/main.html

    • Related Report
      2020 Annual Research Report 2019 Research-status Report

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Published: 2019-04-18   Modified: 2022-01-27  

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