| Project/Area Number |
19K21121
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| Project/Area Number (Other) |
18H05967 (2018)
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Multi-year Fund (2019)
Single-year Grants (2018) |
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| Review Section |
0403:Biomedical engineering and related fields
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| Research Institution | National Institutes for Quantum and Radiological Science and Technology |
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Principal Investigator |
Kang Han Gyu 国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所 先進核医学基盤研究部, 研究員(任常) (90824467)
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| Project Period (FY) |
2018-08-24 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | Laparoscope / Sentinel lymph node / Gamma imaging / Optical imaging / Hybrid laparoscope / Gamma / Intraoperative surgery / Fluorescence / Optical/gamma imaging / NIR / SLN |
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| Outline of Research at the Start |
The purpose of the research is to develop a hybrid optical/gamma laparoscope which can provide simultaneous NIR/gamma/visible fusion image for intraoperative cancer surgery.
The proposed hybrid optical/gamma imaging system can improve the cancer detection efficiency during the laparoscopic cancer surgery.
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| Outline of Final Research Achievements |
The goal of this study is to develop a novel hybrid optical/gamma laparoscope which can visualize the sentinel lymph node (SLN) during the laparoscopic cancer surgery. For this project, two different modalities, one is the gamma camera, and the other is optical imaging system (fluorescence + visible) should be developed an integrated into a single laparoscope. The gamma camera part was developed using tungsten pinhole collimator, GAGG scintillation crystal and SipM 8x8 array photo sensor. The SiPM signals were multiplexed by using a custom-made front-end electronics. The output of the front-end electronics were digitized by using CAMAC DAQ system. The SLN phantom filled with 99mTc solution was clearly visualized by using the gamma camera. For the optical imaging part, the optical system design was finished and the currently under development. In the near future, the hybrid optical/gamma laparoscope will be developed for SLN mapping during cancer surgery.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究の研究成果の学術的意義はガンマ線と光信号を同時に検出することができる小型装置の基礎研究である。ガンマ線検出器用の電子回路の小型化とコンパクト光学レンズのためガンマ／光学ハイブリッド腹腔鏡の実現が可能である。
本研究で開発された技術は腹腔鏡下がん切除の際にガンマ／光学イメージを同時に提供することでリンパ節の検出精度を改善できる可能性がある。
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