A study on cerebral malaria and blood cerebrospinal fluid barrier
| Project/Area Number |
19K21254
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| Project/Area Number (Other) |
18H06139 (2018)
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Multi-year Fund (2019)
Single-year Grants (2018) |
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| Review Section |
0803:Pathology, infection/immunology, and related fields
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| Research Institution | Gunma University |
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Principal Investigator |
Imai Takashi 群馬大学, 大学院医学系研究科, 助教 (10513434)
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| Project Period (FY) |
2018-08-24 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | マラリア / Malaria / 脳マラリア / 血液脳脊髄液関門 / 血液脳関門 / cerebral malaria / 血液脳脊髄関門 / B-CSF-B |
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| Outline of Research at the Start |
マラリアは人類が克服すべき最重要課題の一つです。脳マラリアは、マラリアの死因の一つでありその発症メカニズムの解明が求められています。脳には「血液脳関門」と「血液脳脊髄液関門」と呼ばれる2つの関門が存在し、様々な物質の移動が制限されています。脳マラリアでは血液脳関門が破綻することが知られていますが、血液脳脊髄液関門については不明です。そこで本研究では、マラリアと血液脳脊髄液関門の関係の解明を目指します。
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| Outline of Final Research Achievements |
Malaria is one of the largest infectious diseases in the world. Cerebral malaria, which causes death due to neuropathology, is a problem. There are blood-brain barrier (BBB) and blood-cerebrospinal fluid barrier (BCSFB) in the brain, and disruption of BBB in cerebral malaria is known, but that of BCSFB is unknown.
In this study, we investigated BCSFB using a mouse malaria infection model. As a result, 70-80% of PbA-infected mice that developed cerebral malaria, was disrupted BCSFB. Furthermore, we detected malaria-derived products in the choroid plexus which composes BCSFB and hemorrhaging in the ventricles. Break down of BCSFB was not seen in non-cerebral malaria or the PbA infected mice depleted with killer T cells.
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| Academic Significance and Societal Importance of the Research Achievements |
今まで不明だった、マラリア感染における血液脳脊髄液関門の状態が明らかになりました。このことにより、マラリアの病理の理解がさらに進みます。
脳マラリアでは血液脳関門と血液脳脊髄液関門の両者の透過性が向上し、破綻しますがこのメカニズムを さらに詳しく解き明かすことで、関門を超えて脳神経細胞に作用する薬の開発に役立つかもしれません。
今回、血液脳脊髄液関門の破綻を評価する新しい手法を開発しました。この方法は、脳マラリアだけでなく他の病気の研究にも応用することが可能です。
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Report
(3 results)
Research Products
(15 results)
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[Journal Article] Chimeric Plasmodium falciparum parasites expressing Plasmodium vivax circumsporozoite protein fail to produce salivary gland sporozoites2018
Author(s)
Catherin Marin-Mogollon, Fiona J. A. van Pul, Shinya Miyazaki, Takashi Imai, Jai Ramesar, Ahmed M. Salman, Beatrice M. F. Winkel, Ahmad Syibli Othman, Hans Kroeze, Severine Chevalley-Maurel, Arturo Reyes-Sandoval, Meta Roestenberg, Blandine Franke-Fayard, Chris J. Janse and Shahid M. Khan
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Journal Title
Malaria Journal
Volume: 17
Issue: 1
Pages: 291-291
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] OX40 stimulation enhances protective immune responses induced after vaccination with attenuated malaria parasites2018
Author(s)
Ahmad Syibli Othman, Blandine M. Franke-Fayard, Takashi Imai, Esme T. I. van der Gracht, Anke Redeker, Ahmed M. Salman, Catherin Marin-Mogollon, Jai Ramesar, Severine Chevalley-Maurel, Chris J. Janse, Ramon Arens and Shahid M. Khan.
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Journal Title
Front Cell Infect Microbiol
Volume: 8
Pages: 247-247
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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