• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

A study on cerebral malaria and blood cerebrospinal fluid barrier

Research Project

Project/Area Number 19K21254
Project/Area Number (Other) 18H06139 (2018)
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeMulti-year Fund (2019)
Single-year Grants (2018)
Review Section 0803:Pathology, infection/immunology, and related fields
Research InstitutionGunma University

Principal Investigator

Imai Takashi  群馬大学, 大学院医学系研究科, 助教 (10513434)

Project Period (FY) 2018-08-24 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywordsマラリア / Malaria / 脳マラリア / 血液脳脊髄液関門 / 血液脳関門 / cerebral malaria / 血液脳脊髄関門 / B-CSF-B
Outline of Research at the Start

マラリアは人類が克服すべき最重要課題の一つです。脳マラリアは、マラリアの死因の一つでありその発症メカニズムの解明が求められています。脳には「血液脳関門」と「血液脳脊髄液関門」と呼ばれる2つの関門が存在し、様々な物質の移動が制限されています。脳マラリアでは血液脳関門が破綻することが知られていますが、血液脳脊髄液関門については不明です。そこで本研究では、マラリアと血液脳脊髄液関門の関係の解明を目指します。

Outline of Final Research Achievements

Malaria is one of the largest infectious diseases in the world. Cerebral malaria, which causes death due to neuropathology, is a problem. There are blood-brain barrier (BBB) and blood-cerebrospinal fluid barrier (BCSFB) in the brain, and disruption of BBB in cerebral malaria is known, but that of BCSFB is unknown.
In this study, we investigated BCSFB using a mouse malaria infection model. As a result, 70-80% of PbA-infected mice that developed cerebral malaria, was disrupted BCSFB. Furthermore, we detected malaria-derived products in the choroid plexus which composes BCSFB and hemorrhaging in the ventricles. Break down of BCSFB was not seen in non-cerebral malaria or the PbA infected mice depleted with killer T cells.

Academic Significance and Societal Importance of the Research Achievements

今まで不明だった、マラリア感染における血液脳脊髄液関門の状態が明らかになりました。このことにより、マラリアの病理の理解がさらに進みます。
脳マラリアでは血液脳関門と血液脳脊髄液関門の両者の透過性が向上し、破綻しますがこのメカニズムを さらに詳しく解き明かすことで、関門を超えて脳神経細胞に作用する薬の開発に役立つかもしれません。
今回、血液脳脊髄液関門の破綻を評価する新しい手法を開発しました。この方法は、脳マラリアだけでなく他の病気の研究にも応用することが可能です。

Report

(3 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Annual Research Report
  • Research Products

    (15 results)

All 2019 2018 Other

All Int'l Joint Research (4 results) Journal Article (6 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 6 results,  Open Access: 5 results) Presentation (5 results) (of which Int'l Joint Research: 1 results,  Invited: 1 results)

  • [Int'l Joint Research] Johns Hopkins University/Vanderbilt University Medical Center,(米国)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] Leiden University Medical Center/Radboud University Medical Center(オランダ)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] University of Oxford(英国)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] Universiti Sultan Zainal Abidin(マレーシア)

    • Related Report
      2019 Annual Research Report
  • [Journal Article] A P. falciparum NF54 Reporter Line Expressing mCherry-Luciferase in Gametocytes, Sporozoites, and Liver-Stages2019

    • Author(s)
      Marin-Mogollon Catherin、Salman Ahmed、Koolen Karin、Bolscher Judith、van Pul Fiona、Miyazaki Shinya、Imai Takashi、Othman Ahmad Syibli、Ramesar Jai、van Gemert Geert-Jan、Kroeze Hans、Chevalley-Maurel Severine、Franke-Fayard Blandine、Sauerwein Robert、Hill Adrian、Dechering Koen、Janse Chris、Khan Shahid.
    • Journal Title

      Frontiers in Cellular and Infection Microbiology

      Volume: 9

    • DOI

      10.3389/fcimb.2019.00096

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Fluctuations of Spleen Cytokine and Blood Lactate, Importance of Cellular Immunity in Host Defense Against Blood Stage Malaria Plasmodium yoelii.2019

    • Author(s)
      Imai T, Suzue K, Ngo-Thanh H, et al.
    • Journal Title

      Front Immunol.

      Volume: 10:2207.

    • DOI

      10.3389/fimmu.2019.02207

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Glutathione S-transferases promote proinflammatory astrocyte-microglia communication during brain inflammation2019

    • Author(s)
      Kano Shin-ichi、Choi Eric Y.、Dohi Eisuke、Agarwal Swati、Chang Daniel J.、Wilson Ashley M.、Lo Brian D.、Rose Indigo V. L.、Gonzalez Santiago、Imai Takashi、Sawa Akira
    • Journal Title

      Science Signaling

      Volume: 12 Issue: 569 Pages: 2124-2124

    • DOI

      10.1126/scisignal.aar2124

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Suppression of obesity by an intestinal helminth through interactions with intestinal microbiota.2019

    • Author(s)
      Shimokawa C, Obi S, Shibata M, Olia A, Imai T, Suzue K, Hisaeda H.
    • Journal Title

      Infection and Immunity

      Volume: 印刷中 Issue: 6

    • DOI

      10.1128/iai.00042-19

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Chimeric Plasmodium falciparum parasites expressing Plasmodium vivax circumsporozoite protein fail to produce salivary gland sporozoites2018

    • Author(s)
      Catherin Marin-Mogollon, Fiona J. A. van Pul, Shinya Miyazaki, Takashi Imai, Jai Ramesar, Ahmed M. Salman, Beatrice M. F. Winkel, Ahmad Syibli Othman, Hans Kroeze, Severine Chevalley-Maurel, Arturo Reyes-Sandoval, Meta Roestenberg, Blandine Franke-Fayard, Chris J. Janse and Shahid M. Khan
    • Journal Title

      Malaria Journal

      Volume: 17 Issue: 1 Pages: 291-291

    • DOI

      10.1186/s12936-018-2431-1

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] OX40 stimulation enhances protective immune responses induced after vaccination with attenuated malaria parasites2018

    • Author(s)
      Ahmad Syibli Othman, Blandine M. Franke-Fayard, Takashi Imai, Esme T. I. van der Gracht, Anke Redeker, Ahmed M. Salman, Catherin Marin-Mogollon, Jai Ramesar, Severine Chevalley-Maurel, Chris J. Janse, Ramon Arens and Shahid M. Khan.
    • Journal Title

      Front Cell Infect Microbiol

      Volume: 8 Pages: 247-247

    • DOI

      10.3389/fcimb.2018.00247

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Cytotoxic activities of CD8+ T cells collaborate with macrophage to protect against blood-stage murine malaria2019

    • Author(s)
      Takashi Imai, Hidekazu Ishida, Kazutomo Suzue, Makoto Hirai, Tomoyo Taniguchi, Hiroko Okada, Chikako Shimokawa and Hajime Hisaeda
    • Organizer
      keystone symposium malaria endgame
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] CD8T 細胞は細胞傷害性分子によりマクロファージと協調してマウス赤内期マラリア感染防御に働く2019

    • Author(s)
      今井 孝, 石田 英和, 鈴江 一友, 谷口 委代, 岡田 紘子, 下川 周子, 久枝 一
    • Organizer
      第88回日本寄生虫学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ネズミマラリア原虫感染における病態形成への腸内細菌の関与2019

    • Author(s)
      谷口 委代, 鈴江 一友, 今井 孝, 下川 周子, Olia Alex, Thanhha Ngo, 久枝 一
    • Organizer
      第88回日本寄生虫学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Suppression of obesity by norepinephrine produced in parasitic infection2019

    • Author(s)
      下川 周子, 小尾 誠司, 柴田 実央子, Olia Alex, 今井 孝, 鈴江 一友, 久枝 一
    • Organizer
      第88回日本寄生虫学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 「スポロゾイト、メロゾイト、T細胞、赤血球」、 あなたはどの細胞が好き?2018

    • Author(s)
      今井 孝
    • Organizer
      第26回分子寄生虫学ワークショップ/第16回分子寄生虫・マラリア研究フォーラム合同大会
    • Related Report
      2018 Annual Research Report
    • Invited

URL: 

Published: 2018-08-27   Modified: 2024-03-26  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi