| Project/Area Number |
19K21470
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| Project/Area Number (Other) |
18H06391 (2018)
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Multi-year Fund (2019)
Single-year Grants (2018) |
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| Review Section |
0908:Society medicine, nursing, and related fields
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| Research Institution | Osaka University |
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Principal Investigator |
DONG JIAYI 大阪大学, 医学系研究科, 特任助教 (90823625)
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| Project Period (FY) |
2018-08-24 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2019: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Keywords | flavonoid; / fruit; / cardiovascular disease; / cohort study; / meta-analysis; / prevention / flavonoid / cardiovascular disease / cohort study / preventive medicine / fruit / flavonoids / prevention medicine / epidemiology |
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| Outline of Research at the Start |
The present research aims to estimate the flavonoid intake in the general Japanese population, (II) determine the association of flavonoid intake with risk of cardiovascular disease, (III) examine the effects of flavonoid consumption on cardiovascular risk factors by conducting a meta-analysis.
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| Outline of Final Research Achievements |
We examined the association between flavonoid intake and risk of cardiovascular disease using the data of a large Japanese cohort study. We found that higher intake of flavonoids, compared with lower intake, was associated with an decreased risk of cardiovascular disease. Regarding specific flavonoid-rich fruits, we observed significant inverse associations for citrus fruit, strawberry, and grapes.
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| Academic Significance and Societal Importance of the Research Achievements |
冠動脈性心疾患と脳卒中は、日本において死因の第2位と第4位に位置している。心血管疾患の予防は依然として大きな課題であり、危険因子、特に修正可能な食生活因子を特定することの重要性が強調されている。本研究は大規模コホート研究のデータを用いて、フラボノイドの摂取量と循環器疾患発症リスクとの関連を検討した。その結果、食事性フラボノイドの高摂取は心血管疾患のリスク低下と関連していた。また、柑橘類、イチゴ、ブドウなどのフラボノイド豊富な果物は、心血管疾患の予防に役立つ可能性が示唆された。
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