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A cross-sectional analysis of HEIJO-KYO cohort study about physical activity rhythm and sarcopenia or frailty

Research Project

Project/Area Number 19K21475
Project/Area Number (Other) 18H06396 (2018)
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeMulti-year Fund (2019)
Single-year Grants (2018)
Review Section 0908:Society medicine, nursing, and related fields
Research InstitutionNara Medical University

Principal Investigator

YAMAGAMI Yuki  奈良県立医科大学, 医学部, 助教 (90823956)

Project Period (FY) 2018-08-24 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywordsサルコペニア / フレイル / 身体活動リズム / 疫学 / コホート研究 / サーカディアンリズム / 身体活動
Outline of Research at the Start

サルコペニア・フレイルは加齢に伴う機能低下であり、これらを予防することは高齢化率が高い我が国において重要な課題である。近年、身体機能の向上に身体活動のリズムが関連すること分かってきたが、これまで日常生活の身体活動リズムを客観的測定しサルコペニア・フレイルとの関連を検討した大規模疫学研究は乏しい。 本研究では、60歳以上の男女480名を対象に、①日常生活の身体活動リズムをアクチグラフで客観的に測定し、②身体活動リズムとサルコペニア・フレイルとの関連を明らかにする。

Outline of Final Research Achievements

The objective of this study is to investigate the association between physical activity rhythm and sarcopenia and frailty. We assessed frailty and physical activity rhythm (amplitude, mesor, robustness, and acrophase)among 1501 older adults.
In stratified analysis (under 75years or 75years and over), multivariable analysis adjusted for gender suggested that higher average amplitude of physical activity was significantly associated with higher prevalence of pre frailty or frailty in both age groups. In 75 years and over group, multivariable analysis adjusted for gender suggested that higher average mesor of physical activity was significantly associated with faster walking speed and higher average robustness of physical activity was significantly associated with higher prevalence of pre frailty or frailty.

Academic Significance and Societal Importance of the Research Achievements

身体機能の低下を防ぎサルコペニア・フレイルを予防するためには、身体活動量や運動の内容だけでなく高齢者が実際に活動を行う時間帯や振幅などの身体活動リズムにも着目することが望ましいがこれまで検証されていなかった。本研究において大規模データを用いて高齢者の日常生活の身体活動リズムを検証したことは、学術的重要性が高いと考える。身体活動リズムの振幅や平均、リズムの頑健性などがサルコペニアやフレイル関連指標と関連するという結果から、サルコペニア・フレイル予防につながる具体的な身体活動を考案する上での重要な資料となり、社会的反響は大きいと考える。

Report

(3 results)
  • 2020 Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Annual Research Report
  • Research Products

    (27 results)

All 2020 2019 2018 Other

All Journal Article (9 results) (of which Peer Reviewed: 9 results,  Open Access: 2 results) Presentation (15 results) Remarks (3 results)

  • [Journal Article] Lower Incidence of In-Hospital Falls in Patients Hospitalized in Window Beds Than Nonwindow Beds2020

    • Author(s)
      Iwamoto Junko、Saeki Keigo、Kobayashi Miwa、Yamagami Yuki、Yoshida Osamu、Kurumatani Norio、Obayashi Kenji
    • Journal Title

      Journal of the American Medical Directors Association

      Volume: 21 Issue: 4 Pages: 476-480

    • DOI

      10.1016/j.jamda.2019.07.006

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Bedroom lighting environment  and  incident diabetes mellitus: a longitudinal study of the HEIJO-KYO cohort2020

    • Author(s)
      Obayashi K, Yamagami Y, Kurumatani N, Saeki K
    • Journal Title

      Sleep medicine

      Volume: 65 Pages: 1-3

    • DOI

      10.1016/j.sleep.2019.07.006

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Quantitative Associations between Objective Sleep Measures and Early-Morning Mobility in Parkinson’s Disease: Cross-Sectional Analysis of the PHASE Study2020

    • Author(s)
      Kataoka H, Saeki K, Yamagami Y, Sugie K, Obayashi K
    • Journal Title

      Sleep

      Volume: 43(1) Issue: 1

    • DOI

      10.1093/sleep/zsz203

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Objectively Measured Physical Activity Relates to Night-time Blood Pressure in Older Adults: Cross-sectional analysis in the HEIJO-KYO cohort2020

    • Author(s)
      Yamagami Y, Saeki K, Tai Y, Maegawa T, Iwamoto J, Kataoka H, Kurumatani N, Obayashi K
    • Journal Title

      Journal of Hypertension

      Volume: 38(4) Pages: 649-655

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Indoor light pollution  and progression of carotid atherosclerosis: A longitudinal study of the HEIJO-KYO cohort2019

    • Author(s)
      Obayashi K, Yamagami Y, Tatsumi S, Kurumatani N, Saeki K
    • Journal Title

      Environ Int.

      Volume: 133(Pt B) Pages: 105184-105184

    • DOI

      10.1016/j.envint.2019.105184

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association between timing of hot water bathing before bedtime and night-/sleep-time blood pressure and dipping in the elderly: a longitudinal analysis for repeated measurements in home settings2019

    • Author(s)
      Tai Yoshiaki、Saeki Keigo、Yamagami Yuki、Yoshimoto Kiyomi、Kurumatani Norio、Nishio Kenji、Obayashi Kenji
    • Journal Title

      Chronobiology International

      Volume: 36 Issue: 12 Pages: 1714-1722

    • DOI

      10.1080/07420528.2019.1675685

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Pre-Awake Light Exposure and Sleep Disturbances: Findings from the HEIJO-KYO Cohort.2019

    • Author(s)
      Obayashi K, Yamagami Y, Kurumatani N, Saeki K..
    • Journal Title

      Sleep Med

      Volume: 54 Pages: 121-125

    • DOI

      10.1016/j.sleep.2018.10.027

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Farming Habit, Light Exposure, Physical Activity, and Depressive Symptoms: A Cross-Sectional Study of the HEIJO-KYO Cohort.2018

    • Author(s)
      Asai Y, Obayashi K, Oume M, Ogura M, Takeuchi K, Yamagami Y, Tai Y, Kurumatani N, Saeki K..
    • Journal Title

      J Affect Disord

      Volume: 241 Pages: 235-240

    • DOI

      10.1016/j.jad.2018.08.003

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gender Differences in the Association between Melatonin Secretion and Diabetes in Elderly: the HEIJO-KYO Cohort.2018

    • Author(s)
      Obayashi K, Yamagami Y, Iwamoto J, Kurumatani N, Saeki K.
    • Journal Title

      Clin Endocrinol

      Volume: 89 Issue: 6 Pages: 750-756

    • DOI

      10.1111/cen.13842

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Presentation] 高齢者における身体活動強度と夜間血圧の関連:平城京コホート横断分析2019

    • Author(s)
      山上優紀, 佐伯圭吾, 岩本淳子, 車谷典男, 大林賢史
    • Organizer
      第29回日本疫学会学術総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 寝室の明るさと動脈硬化の進行:平城京コホートスタディ縦断分析2019

    • Author(s)
      大林賢史, 山上優紀, 巽志伸, 車谷典男, 佐伯圭吾
    • Organizer
      第29回日本疫学会学術総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 寝室の温度環境と客観測定した睡眠の横断的関連2019

    • Author(s)
      佐伯圭吾, 山上優紀, 田井義彬, 小松雅代, 石塚理香, 根津智子, 車谷典男, 大林賢史
    • Organizer
      第29回日本疫学会学術総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 窓側病床への入院が病院内転倒率に及ぼす影響2019

    • Author(s)
      岩本淳子, 佐伯圭吾, 小林美和, 小辻俊通, 松井利江, 山上優紀, 吉田修, 車谷典男, 大林賢史
    • Organizer
      第29回日本疫学会学術総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 日常生活における光曝露リズムの記述疫学研究2019

    • Author(s)
      大林賢史, 山上優紀, 車谷典男, 佐伯圭吾
    • Organizer
      第89回日本衛生学会学術総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 室内で曝露する温度と外気温の関連2019

    • Author(s)
      佐伯圭吾, 山上優紀, 車谷典男, 大林賢史
    • Organizer
      第89回日本衛生学会学術総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Bedroom noise exposure at night and sleep quality in elderly individuals: cross-sectional analysis in the HEIJO-KYO cohort2018

    • Author(s)
      Yuki Yamagami, Kenji Obayashi, Yoshiaki Tai, Jyunko Iwamoto, Norio Kurumatani, Keigo Saeki
    • Organizer
      日本睡眠学会第43回定期学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Effect of bathing on objective sleep quality among elderly: a longitudinal analysis of repeated measurements in the HEIJO-KYO cohort2018

    • Author(s)
      Yoshiaki Tai, Kenji Obayashi, Yuki Yamagami, Kiyomi Yoshimoto, Norio Kurumatani, Kenji Nishio, Keigo Saeki
    • Organizer
      日本睡眠学会第44回定期学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Prediction of morningness-eveningness preference using two-night actigraphy based sleep-mid time: findings from the HEIJO-KYO cohort2018

    • Author(s)
      Shinobu Tatsumi, Kenji Obayashi, Yuki Yamagami, Yoshiaki Tai, Junko Iwamoto, Norio Kurumatani, Keigo Saeki
    • Organizer
      日本睡眠学会第45回定期学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Physical activity and nighttime BP in elderly individuals: the HEIJO-KYO cohort2018

    • Author(s)
      Yuki Yamagami, Keigo Saeki, Junko Iwamoto, Rika Ishizuka, Norio Kurumatani, Kenji Obayashi
    • Organizer
      第77回日本公衆衛生学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 高齢者のクロノタイプと身体活動量の関連:平城京スタディ横断解析2018

    • Author(s)
      山上優紀, 佐伯圭吾, 中井昌弘, 巽志伸, 車谷典男, 大林賢史
    • Organizer
      第25回日本時間生物学会学術大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 高齢者のクロノタイプと光曝露量および睡眠障害の関連:平城京スタディ横断解析2018

    • Author(s)
      中井昌弘, 佐伯圭吾, 山上優紀, 巽志伸, 車谷典男, 大林賢史
    • Organizer
      第25回日本時間生物学会学術大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 夜間寝室内騒音レベルと睡眠の質の関連: 平城京コホート研究横断分析2018

    • Author(s)
      山上優紀, 佐伯圭吾, 車谷典男, 大林賢史
    • Organizer
      奈良県公衆衛生学会 2018
    • Related Report
      2018 Annual Research Report
  • [Presentation] 夜間血圧と動脈硬化の関連:平城京スタディ横断分析2018

    • Author(s)
      山口知剛, 佐伯圭吾, 山上優紀, 車谷典男, 大林賢史
    • Organizer
      奈良県公衆衛生学会 2018
    • Related Report
      2018 Annual Research Report
  • [Presentation] 明日香村におけるフレイル予防体操の実施報告2018

    • Author(s)
      前川妙子, 大林賢史, 山上優紀, 浦野夕香, 中屋幸恵, 車谷典男, 佐伯圭吾
    • Organizer
      奈良県公衆衛生学会 2018
    • Related Report
      2018 Annual Research Report
  • [Remarks] 奈良県立医科大学 疫学・予防医学講座ホームページ

    • URL

      http://www.naramed-u.ac.jp/~epi/index.html

    • Related Report
      2018 Annual Research Report
  • [Remarks] Research gate

    • URL

      https://www.researchgate.net/profile/Yuki_Yamagami

    • Related Report
      2018 Annual Research Report
  • [Remarks] researchmap

    • URL

      https://researchmap.jp/y_yamagami/

    • Related Report
      2018 Annual Research Report

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Published: 2018-08-27   Modified: 2024-03-26  

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