Proposal for a new definition of Sarcopenic-Obesity focusing on Intra-muscular adipose tissue

• Project/Area Number: 19K21576
• Research Category: Grant-in-Aid for Challenging Research (Exploratory)
• Allocation Type: Multi-year Fund
• Review Section: Studies on the Super-Aging Society
• Research Institution: University of Tsukuba
• Principal Investigator: Yamada Minoru 筑波大学, 人間系, 教授 (30525572)
• Co-Investigator(Kenkyū-buntansha): 荒井 秀典 国立研究開発法人国立長寿医療研究センター, 理事長 (60232021)
• Project Period (FY): 2019-06-28 – 2022-03-31
• Project Status: Completed (Fiscal Year 2021)
• Budget Amount: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000); Fiscal Year 2021: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2020: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2019: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: サルコペニア / サルコペニア肥満 / 骨格筋 / 転倒 / 超音波画像 / インピーダンス / エコー輝度 / 骨格筋内脂肪 / 超音波

Outline of Research at the Start

本研究は、サルコペニア肥満研究の課題となっている定義を抜本的に見直す提案を行う。従来の報告による定義では、サルコペニア肥満に該当する割合が低く過小評価している可能性がある。そこで本研究では、異所性脂肪の一つである骨格筋内脂肪に注目し検討を行う。
具体的には、骨格筋量と骨格筋内脂肪の組み合わせから、サルコペニア肥満の新たな基準を作成することが出来ないか検討する。コホート研究より、骨格筋量と骨格筋内脂肪の組み合せによって分類した群で、有害健康転帰に及ぼす影響を検討する。このことで、本組み合わせによって定義したサルコペニア肥満が妥当かどうかを検証する。同時に、バイオマーカーや累積発生などの検証も行う。

Outline of Final Research Achievements

Older adults with poor muscle quality and quantity had a significantly increased risk of incident falls compared to older adults with better muscle quality and quantity. On the other hand, there was no significant association between skeletal muscle status and the incidence of fall-related fractures due to insufficient sample size. These findings suggest that prevention of falls may be necessary for managing muscle quality and quantity in community-dwelling older adults.

Academic Significance and Societal Importance of the Research Achievements

これまでの研究では、主に骨格筋の量に焦点が当てられることが多かった。しかし、近年では、骨格筋の質も重視されるようになり、”骨格筋”の捉え方が大きく変化している。その中で、本研究では骨格筋の量と質の両者が重要であり、いずれも低下することで転倒発生の危険性を高めることを示した。この内容は、今後の対策方法を検討する上でも重要な情報となり、骨格筋の量と質の両者を改善させるトレーニングプログラムの必要性を示した。

Research Products

• [Journal Article] Five‐repetition sit‐to‐stand test: End with the fifth stand or sit? (2022)
  • Author(s): Yamada Minoru、Lim Jae‐Young、Assantachai Prasert、Tanaka Tomoki、Kim Miji、Lee Sang Yoon、Lim Wee‐Shiong、Arai Hidenori
  • Journal Title: Geriatrics & Gerontology International Volume: 22 Issue: 4 Pages: 362-364
  • DOI: 10.1111/ggi.14358
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Factors Associated with Increased Caregiver Burden of Informal Caregivers during the COVID-19 Pandemic in Japan (2022)
  • Author(s): Otobe Yuhei、Kimura Y.、Suzuki M.、Koyama S.、Kojima I.、Yamada M.
  • Journal Title: The journal of nutrition, health & aging Volume: 26 Issue: 2 Pages: 157-160
  • DOI: 10.1007/s12603-022-1730-y
  • Peer Reviewed
• [Journal Article] Effects of Active Learning Education on Arterial Stiffness of Older Adults with Low Health Literacy: A Randomized Controlled Trial (2021)
  • Author(s): Uemura Kazuki、Yamada Minoru、Kuzuya Masafumi、Okamoto Hiroshi
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 28 Issue: 8 Pages: 865-872
  • DOI: 10.5551/jat.58354
  • NAID: 130008070395
  • ISSN: 1340-3478, 1880-3873
  • Year and Date: 2021-08-01
  • Peer Reviewed / Open Access
• [Journal Article] Relationship between expression of gratitude by home-based care receivers and caregiver burden among family caregivers (2021)
  • Author(s): Otobe Yuhei、Suzuki Mizue、Kimura Yosuke、Koyama Shingo、Kojima Iwao、Ichikawa Takeo、Terao Yusuke、Yamada Minoru
  • Journal Title: Archives of Gerontology and Geriatrics Volume: 97 Pages: 104507-104507
  • DOI: 10.1016/j.archger.2021.104507
  • Peer Reviewed
• [Journal Article] Relationship between the Kihon Checklist and all‐cause hospitalization among community‐dwelling older adults (2021)
  • Author(s): Koyama Shingo、Otobe Yuhei、Suzuki Mizue、Kimura Yosuke、Ishiyama Daisuke、Kojima Iwao、Masuda Hiroaki、Kusumi Haruhiko、Yamada Minoru
  • Journal Title: Geriatrics & Gerontology International Volume: 22 Issue: 2 Pages: 132-137
  • DOI: 10.1111/ggi.14331
  • Peer Reviewed
• [Journal Article] Implication of frailty and disability prevention measures during the COVID‐19 pandemic (2021)
  • Author(s): Yamada Minoru、Arai Hidenori
  • Journal Title: AGING MEDICINE Volume: 4 Issue: 4 Pages: 242-246
  • DOI: 10.1002/agm2.12182
  • Peer Reviewed / Open Access
• [Journal Article] Physical Exercise Improves Cognitive Function in Older Adults with Stage 3?4 Chronic Kidney Disease: A Randomized Controlled Trial (2021)
  • Author(s): Otobe Yuhei、Yamada Minoru、Hiraki Koji、Onari Satoshi、Taki Yasuhiro、Sumi Hirofumi、Hachisuka Rina、Han Wei、Takahashi Masaki、Suzuki Mizue、Kimura Yosuke、Koyama Shingo、Masuda Hiroaki、Shibagaki Yugo、Tominaga Naoto
  • Journal Title: American Journal of Nephrology Volume: 52 Issue: 12 Pages: 929-939
  • DOI: 10.1159/000520230
  • Peer Reviewed
• [Journal Article] Feasibility of active learning health education by video conferencing among older adults (2021)
  • Author(s): Uemura Kazuki、Watanabe Atsuya、Kamitani Tsukasa、Yamada Minoru、Saho Kenshi、Okamoto Hiroshi
  • Journal Title: Geriatrics & Gerontology International Volume: 21 Issue: 11 Pages: 1064-1066
  • DOI: 10.1111/ggi.14281
  • Peer Reviewed
• [Journal Article] Effects of different rehabilitation provision systems on functional recovery in patients with subacute stroke (2021)
  • Author(s): Kimura Yosuke、Suzuki Mizue、Ichikawa Takeo、Otobe Yuhei、Koyama Shingo、Tanaka Shu、Hamanaka Koji、Tanaka Naoki、Yamada Minoru
  • Journal Title: PM&R Volume: In press Issue: 10 Pages: 1167-1176
  • DOI: 10.1002/pmrj.12689
  • Peer Reviewed
• [Journal Article] Relationship between longitudinal changes in skeletal muscle characteristics over time and functional recovery during intensive rehabilitation of patients with subacute stroke (2021)
  • Author(s): Tanaka Shu、Ito Daisuke、Kimura Yosuke、Ishiyama Daisuke、Suzuki Mizue、Koyama Shingo、Narita Yuya、Masuda Hiroaki、Suzukawa Katsumi、Yamada Minoru
  • Journal Title: Topics in Stroke Rehabilitation Volume: 29 Issue: 5 Pages: 1-10
  • DOI: 10.1080/10749357.2021.1940724
  • Peer Reviewed
• [Journal Article] Validating muscle mass cutoffs of four international sarcopenia‐working groups in Japanese people using DXA and BIA (2021)
  • Author(s): Yamada Yosuke、Yamada Minoru、Yoshida Tsukasa、Miyachi Motohiko、Arai Hidenori
  • Journal Title: Journal of Cachexia, Sarcopenia and Muscle Volume: 12 Issue: 4 Pages: 1000-1010
  • DOI: 10.1002/jcsm.12732
  • Peer Reviewed / Open Access
• [Journal Article] Diagnosis and Treatment of Sarcopenic Dysphagia: A Scoping Review (2021)
  • Author(s): Wakabayashi Hidetaka、The Japanese Working Group on Sarcopenic Dysphagia、Kishima Masako、Itoda Masataka、Fujishima Ichiro、Kunieda Kenjiro、Ohno Tomohisa、Shigematsu Takashi、Oshima Fumiko、Mori Takashi、Ogawa Nami、Nishioka Shinta、Yamada Minoru、Ogawa Sumito
  • Journal Title: Dysphagia Volume: 36 Issue: 3 Pages: 523-531
  • DOI: 10.1007/s00455-021-10266-8
  • Peer Reviewed
• [Journal Article] Impact of physical, cognitive, and psychological functions on incident homebound status after discharge among hospitalized older patients: A clinical-based prospective study (2021)
  • Author(s): Koyama Shingo、Komatsu Takuma、Ishiyama Daisuke、Suzuki Mizue、Kimura Yosuke、Otobe Yuhei、Taguchi Ryota、Shino Shuhei、Yamada Minoru、Yamatoku Masato
  • Journal Title: Archives of Gerontology and Geriatrics Volume: 92 Pages: 104258-104258
  • DOI: 10.1016/j.archger.2020.104258
  • Peer Reviewed
• [Journal Article] Are Japanese Older Adults Rejuvenating? Changes in Health-Related Measures Among Older Community Dwellers in the Last Decade (2021)
  • Author(s): Suzuki Takao、Nishita Yukiko、Jeong Seungwon、Shimada Hiroyuki、Otsuka Rei、Kondo Katsunori、Kim Hunkyung、Fujiwara Yoshinori、Awata Shuichi、Kitamura Akihiko、Obuchi Shuichi、Iijima Katsuya、Yoshimura Noriko、Watanabe Shuichiro、Yamada Minoru、Toba Kenji、Makizako Hyuma
  • Journal Title: Rejuvenation Research Volume: 24 Issue: 1 Pages: 37-48
  • DOI: 10.1089/rej.2019.2291
  • NAID: 120007163371
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Longitudinal Effects of Active Learning Education on Lifestyle Behavior and Physical Function in Older Adults (2021)
  • Author(s): Uemura Kazuki、Kamitani Tsukasa、Yamada Minoru、Okamoto Hiroshi
  • Journal Title: Journal of the American Medical Directors Association Volume: 22 Issue: 2 Pages: 459-463
  • DOI: 10.1016/j.jamda.2020.05.014
  • Peer Reviewed
• [Journal Article] Digastric muscle mass and intensity in older patients with sarcopenic dysphagia by ultrasonography (2020)
  • Author(s): Ogawa Nami、Wakabayashi Hidetaka、Mori Takashi、Fujishima Ichiro、Oshima Fumiko、Itoda Masataka、Kunieda Kenjiro、Shigematsu Takashi、Nishioka Shinta、Tohara Haruka、Ohno Tomohisa、Nomoto Akiko、Shimizu Akio、Yamada Minoru、Ogawa Sumito
  • Journal Title: Geriatrics & Gerontology International Volume: 21 Issue: 1 Pages: 14-19
  • DOI: 10.1111/ggi.14079
  • Peer Reviewed
• [Journal Article] The Mass of Geniohyoid Muscle Is Associated with Maximum Tongue Pressure and Tongue Area in Patients with Sarcopenic Dysphagia (2020)
  • Author(s): Mori T.、Wakabayashi Hidetaka、Ogawa N.、Fujishima I.、Oshima F.、Itoda M.、Kunieda K.、Shigematsu T.、Nishioka S.、Tohara H.、Yamada M.、Ogawa S.
  • Journal Title: The journal of nutrition, health & aging Volume: 25 Issue: 3 Pages: 356-360
  • DOI: 10.1007/s12603-020-1528-8
  • Peer Reviewed
• [Journal Article] Relationship between physical activity levels during rehabilitation hospitalization and life-space mobility following discharge in stroke survivors: A multicenter prospective study (2020)
  • Author(s): Kimura Yosuke、Nishio Naohito、Abe Yuki、Ogawa Hideyuki、Taguchi Ryota、Otobe Yuhei、Koyama Shingo、Suzuki Mizue、Kikuchi Tomoe、Masuda Hiroaki、Kusumi Haruhiko、Yamada Minoru
  • Journal Title: Topics in Stroke Rehabilitation Volume: 20 Issue: 7 Pages: 1-7
  • DOI: 10.1080/10749357.2020.1834276
  • Peer Reviewed
• [Journal Article] The associations of phase angle with the structural severity and quadriceps strength among patients with hip osteoarthritis: the SPSS-OK study (2020)
  • Author(s): Wada Osamu、Yamada Minoru、Kamitani Tsukasa、Mizuno Kiyonori、Kurita Noriaki
  • Journal Title: Clinical Rheumatology Volume: 40 Issue: 4 Pages: 1539-1546
  • DOI: 10.1007/s10067-020-05419-3
  • Peer Reviewed
• [Journal Article] The impact of wheelchair propulsion based physical activity on functional recovery in stroke rehabilitation: a multicenter observational study (2020)
  • Author(s): Kimura Yosuke、Ohji Shunsuke、Nishio Naohito、Abe Yuki、Ogawa Hideyuki、Taguchi Ryota、Otobe Yuhei、Yamada Minoru
  • Journal Title: Disability and Rehabilitation Volume: 7 Issue: 10 Pages: 1-6
  • DOI: 10.1080/09638288.2020.1821249
  • Peer Reviewed
• [Journal Article] Relationship between Sarcopenia and Swallowing Capacity in Community-Dwelling Older Women (2020)
  • Author(s): Suzuki Mizue、Kimura Yosuke、Otobe Yuhei、Kikuchi Tomoe、Masuda Hiroaki、Taguchi Ryota、Tanaka Shu、Narita Yuya、Shino Shuhei、Kusumi Haruhiko、Yamada Minoru
  • Journal Title: Gerontology Volume: 66 Issue: 6 Pages: 549-552
  • DOI: 10.1159/000511359
  • Peer Reviewed
• [Journal Article] Long-Term Care System in Japan (2020)
  • Author(s): Yamada Minoru、Arai Hidenori
  • Journal Title: Annals of Geriatric Medicine and Research Volume: 24 Issue: 3 Pages: 174-180
  • DOI: 10.4235/agmr.20.0037
  • NAID: 120007146581
  • Peer Reviewed
• [Journal Article] Recovery of Physical Activity Among Older Japanese Adults Since the First Wave of the COVID-19 Pandemic (2020)
  • Author(s): Yamada Minoru、Kimura Y.、Ishiyama D.、Otobe Y.、Suzuki M.、Koyama S.、Kikuchi T.、Kusumi H.、Arai H.
  • Journal Title: The journal of nutrition, health & aging Volume: 24(9) Pages: 1036-1037
  • DOI: 10.1007/s12603-020-1466-5
  • Peer Reviewed
• [Journal Article] Applications of physical performance measures to routine diabetes care for frailty prevention concept: fundamental data with grip strength, gait speed, timed chair stand speed, standing balance, and knee extension strength (2020)
  • Author(s): Yokoyama Hiroki、Shiraiwa Toshihiko、Takahara Mitsuyoshi、Iwamoto Masahiro、Kuribayashi Nobuichi、Nomura Takuo、Yamada Minoru、Sone Hirohito、Araki Shin-ichi
  • Journal Title: BMJ Open Diabetes Research & Care Volume: 8 Issue: 1 Pages: e001562-e001562
  • DOI: 10.1136/bmjdrc-2020-001562
  • NAID: 120007159555
  • Peer Reviewed / Open Access
• [Journal Article] Effect of the COVID-19 Epidemic on Physical Activity in Community-Dwelling Older Adults in Japan: A Cross-Sectional Online Survey (2020)
  • Author(s): Yamada Minoru、Kimura Y.、Ishiyama D.、Otobe Y.、Suzuki M.、Koyama S.、Kikuchi T.、Kusumi H.、Arai H.
  • Journal Title: The journal of nutrition, health & aging Volume: 24(9) Pages: 948-950
  • DOI: 10.1007/s12603-020-1424-2
  • Peer Reviewed
• [Journal Article] The influence of the combination of visiting frequency of family caregivers and pre-admission frailty status on dependency after discharge among hospitalized older patients: a clinically-based prospective study (2020)
  • Author(s): Koyama Shingo、Komatsu Takuma、Ishiyama Daisuke、Fujimoto Junko、Suzuki Mizue、Kimura Yosuke、Otobe Yuhei、Yamada Minoru、Yamatoku Masato
  • Journal Title: European Geriatric Medicine Volume: 11 Issue: 3 Pages: 483-490
  • DOI: 10.1007/s41999-020-00322-1
  • Peer Reviewed
• [Journal Article] Structural severity, phase angle, and quadriceps strength among patients with knee osteoarthritis: the SPSS-OK study (2020)
  • Author(s): Wada Osamu、Kurita Noriaki、Yamada Minoru、Mizuno Kiyonori
  • Journal Title: Clinical Rheumatology Volume: 39 Issue: 10 Pages: 3049-3056
  • DOI: 10.1007/s10067-020-05056-w
  • Peer Reviewed
• [Journal Article] Factors associated with post‐stroke apathy in subacute stroke patients (2020)
  • Author(s): Ito Daisuke、Tanaka Tomoya、Kunieda Yota、Kimura Yosuke、Ishiyama Daisuke、Nishio Naohito、Otobe Yuhei、Koyama Shingo、Ohji Shunsuke、Suzuki Mizue、Ichikawa Takeo、Ogawa Hideyuki、Narita Yuya、Yoshida Taiki、Yamada Minoru、Kondo Kunitsugu
  • Journal Title: Psychogeriatrics Volume: 20 Issue: 5 Pages: 780-781
  • DOI: 10.1111/psyg.12551
  • Peer Reviewed
• [Journal Article] Asian Working Group for Sarcopenia: 2019 Consensus Update on Sarcopenia Diagnosis and Treatment. (2020)
  • Author(s): Chen LK, Woo J, Assantachai P, Auyeung TW, Chou MY, Iijima K, Jang HC, Kang L, Kim M, Kim S, Kojima T, Kuzuya M, Lee JSW, Lee SY, Lee WJ, Lee Y, Liang CK, Lim JY, Lim WS, Peng LN, Sugimoto K, Tanaka T, Won CW, Yamada M, Zhang T, Akishita M, Arai H.
  • Journal Title: J Am Med Dir Assoc Volume: 19 Issue: 3 Pages: 30872-2
  • DOI: 10.1016/j.jamda.2019.12.012
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Relationship between tongue muscle quality and swallowing speed in community-dwelling older women. (2020)
  • Author(s): Suzuki M, Koyama S, Kimura Y, Ishiyama D, Ohji S, Otobe Y, Nishio N, Kunieda Y, Ichikawa T, Ito D, Ogawa H, Yamada M.
  • Journal Title: Aging Clin Exp Res. Volume: 印刷中 Issue: 10 Pages: 2073-2079
  • DOI: 10.1007/s40520-019-01388-z
  • Peer Reviewed
• [Journal Article] Comprehensive geriatric intervention in community‐dwelling older adults: a cluster‐randomized controlled trial (2020)
  • Author(s): Watanabe Yuya、Yamada Yosuke、Yoshida Tsukasa、Yokoyama Keiichi、Miyake Motoko、Yamagata Emi、Yamada Minoru、Yoshinaka Yasuko、Kimura Misaka、for Kyoto‐Kameoka Study Group
  • Journal Title: Journal of Cachexia, Sarcopenia and Muscle Volume: 11 Issue: 1 Pages: 26-37
  • DOI: 10.1002/jcsm.12504
  • Peer Reviewed / Open Access
• [Journal Article] Factors associated with functional recovery in Japanese patients with convalescent stroke stratified by age: a multicenter observational study. (2019)
  • Author(s): Kimura Y, Ohji S, Ishiyama D, Nishio N, Otobe Y, Suzuki M, Ogawa H, Ichikawa T, Taguchi R, Shino S, Tanaka S, Yamada M.
  • Journal Title: Int J Rehabil Res. Volume: 42 Issue: 3 Pages: 249-255
  • DOI: 10.1097/mrr.0000000000000359
  • Peer Reviewed
• [Journal Article] Development and validation of the Comprehensive Gait Assessment using Iner Tial Sensor score (C-GAITS score) derived from acceleration and angular velocity data at heel and lower trunk among community-dwelling older adults. (2019)
  • Author(s): Misu S, Asai T, Doi T, Sawa R, Ueda Y, Murata S, Saito T, Sugimoto T, Isa T, Tsuboi T, Yamada M, Ono R.
  • Journal Title: J Neuroeng Rehabil Volume: 16 Issue: 1 Pages: 62-62
  • DOI: 10.1186/s12984-019-0539-3
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Presence of sarcopenic obesity and evaluation of the associated muscle quality in Japanese older men with prostate cancer undergoing androgen deprivation therapy. (2019)
  • Author(s): Kimura Y, Yamada M, Ohji S, Ishiyama D, Nishio N, Otobe Y, Koyama S, Suzuki M, Ichikawa T, Ito D, Maehori N, Nagae H.
  • Journal Title: J Geriatr Oncol. Volume: 10 Issue: 5 Pages: 835-838
  • DOI: 10.1016/j.jgo.2019.03.017
  • Peer Reviewed / Open Access
• [Journal Article] Measurement of self-propulsion distance of wheelchair using cycle computer excluding assistance distance by touch switch: A pilot study. (2019)
  • Author(s): Ohji S, Kimura Y, Otobe Y, Nishio N, Ito D, Taguchi R, Ogawa H, Yamada M.
  • Journal Title: Spinal Cord Med. Volume: 11 Issue: 2 Pages: 1-5
  • DOI: 10.1080/10790268.2019.1601936
  • Peer Reviewed / Open Access
• [Journal Article] Association of bioimpedance phase angle and prospective falls in older adults. (2019)
  • Author(s): Uemura K, Yamada M, Okamoto H.
  • Journal Title: Geriatr Gerontol Int. Volume: 19 Issue: 6 Pages: 503-507
  • DOI: 10.1111/ggi.13651
  • Peer Reviewed / Open Access
• [Journal Article] Synergistic effect of bodyweight resistance exercise and protein supplementation on skeletal muscle in sarcopenic or dynapenic older adults (2019)
  • Author(s): Yamada Minoru、Kimura Yosuke、Ishiyama Daisuke、Nishio Naohito、Otobe Yuhei、Tanaka Tomoya、Ohji Shunsuke、Koyama Shingo、Sato Atsushi、Suzuki Mizue、Ogawa Hideyuki、Ichikawa Takeo、Ito Daisuke、Arai Hidenori
  • Journal Title: Geriatrics & Gerontology International Volume: 印刷中 Issue: 5 Pages: 429-437
  • DOI: 10.1111/ggi.13643
  • Peer Reviewed / Open Access