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The roles of basolateral amygdala in regulation of optimism and pessimism

Research Project

Project/Area Number 19K21807
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Review Section Medium-sized Section 10:Psychology and related fields
Research InstitutionUniversity of Tsukuba

Principal Investigator

ZHANG Qi  筑波大学, 人間系, 助教 (20525604)

Project Period (FY) 2019-06-28 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2020: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2019: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Keywordsoptimism and pessimism / basolateral amygadla / neural circuit / fiber photometry / calcium imaging / optogenetics / basolateral amygdala / cognitive bias / retrograde tracing / single cell analysis / optimism / pessimism / cognitive bias, / optimism, / pessimism, / basolateral amygdala, / stereotype, / neural circuit, / amygdala / circuit
Outline of Research at the Start

Pessimistic individuals have great risks to catch many diseases. Current project will use cutting-edge technology to elucidate the neural mechanisms underlying optimism and pessimism, and in turn to provide a new approach for health improvement, prevention and therapeutic intervention of diseases.

Outline of Final Research Achievements

Human beings show different personality stereotype in their ways of thinking: either more optimistic or more pessimistic. Although fMRI studies in humans implicate that prefrontal cortex and amygdala are involved, the neural circuit mechanisms underlying optimism and pessimism are poorly understood and can only be fully examined in animal models. To date no study has been really done to investigate the cellular and neural circuit mechanisms underlying optimism and pessimism. Current project used advanced behavioral analysis, calcium imaging and optogenetics technology to identify the critical neural populations in basolateral amygdala responsible for optimism and pessimism. This project will provide a new approach for health improvement, and prevention and therapeutic invention of many diseases. It will also deepen our understandings on the neural mechanisms mediating personality stereotypes, which is becoming a hot topic in neuroscience.

Academic Significance and Societal Importance of the Research Achievements

Successful living requires a fine balance between optimistic and pessimistic thinking. Understanding of the neural circuit mechanisms underlying optimism and pessimism will provide a new approach for health improvement, and prevention and therapeutic invention of many diseases.

Report

(4 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (24 results)

All 2021 2020 2019 Other

All Journal Article (3 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 3 results,  Open Access: 3 results) Presentation (16 results) (of which Int'l Joint Research: 15 results,  Invited: 11 results) Remarks (2 results) Funded Workshop (3 results)

  • [Journal Article] On the Origins of Diversity in Social Behavior2021

    • Author(s)
      Larry Young, Qi Zhang
    • Journal Title

      Japanese Journal of Animal Psychology

      Volume: 71 Issue: 1 Pages: 45-61

    • DOI

      10.2502/janip.71.1.4

    • NAID

      130008055551

    • ISSN
      0916-8419, 1880-9022
    • Related Report
      2021 Annual Research Report 2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Limb-clasping, cognitive deficit and increased vulnerability to kainic acid - induced seizures in neuronal GPI anchor deficiency mouse models.2021

    • Author(s)
      Kandasamy L, Tsukamoto M, Banov V, Tsetsegee S, Nagasawa Y, Kato M, Matsumoto N, Takeda J, Itohara S, Ogawa S, Young L, Zhang Q
    • Journal Title

      Human Molecular Genetics

      Volume: 30(9) Issue: 9 Pages: 758-770

    • DOI

      10.1093/hmg/ddab052

    • Related Report
      2021 Annual Research Report 2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The hippocampus encodes delay and value information during delay-discounting decision making.2020

    • Author(s)
      Masuda A, Sano C, Zhang Q, Goto H, McHugh TJ, Fujisawa S, Itohara S.
    • Journal Title

      Elife

      Volume: - Pages: 52466-52466

    • DOI

      10.7554/elife.52466

    • Related Report
      2021 Annual Research Report 2020 Research-status Report 2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Oxytocin receptor and the diversity in social behaviors.2021

    • Author(s)
      Qi Zhang
    • Organizer
      The Social Brain Symposium 2.0: Social Neuroscience in the Post Pandemic Era, Tsukuba Conference 2021
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] On the origin of diversity in social behavior.2021

    • Author(s)
      Qi Zhang
    • Organizer
      East/South East Asia Social Brain Symposium
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Inhibitory neurons play key roles in mediating multiple phenotypes in a mouse model of inherited glycosylphosphatidylinositol deficiency disease.2021

    • Author(s)
      Qi Zhang
    • Organizer
      The 15th International Conference on Genetic Disorders and Gene Therapy
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Toward creating a mouse loyal to its partner.2021

    • Author(s)
      Qi Zhang
    • Organizer
      The Annual Meeting of Japan Neuroscience Society
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Limb-clasping, cognitive deficit and increased vulnerability to kainic acid-induced seizures in neuronal glycosylphosphatidylinositol deficiency mouse models.2021

    • Author(s)
      Kandasamy LC, Zhang Q
    • Organizer
      The 44th Annual Meeting of Japan Neuroscience Society
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] The trait-like differences in cognitive bias in outbred CD-1 mice.2021

    • Author(s)
      Tsetsegee S, Zhang Q
    • Organizer
      The 44th Annual Meeting of Japan Neuroscience Society
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] The trait-like differences in cognitive bias in outbred CD-1 mice2021

    • Author(s)
      Sambuu Tsetsegee, Vitaliy Banov, Maria Pires Fraga, Lenin C Kandasamy, Shigeyoshi Itohara, Larry J Young, Qi Zhang
    • Organizer
      The 44th Annual Meeting of Japan Neuroscience Society
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] Limb-clasping, cognitive deficit and increased vulnerability to kainic acid-induced seizures in neuronal glycosylphosphatidylinositol deficiency mouse models2021

    • Author(s)
      Lenin C Kandasamy, Mina Tsukamoto, Vitaliy Banov, Sambuu Tsetsegee, Yutaro Nagasawa, Mitsuhiro Kato, Naomichi Matsumoto, Junji Takeda, Shigeyoshi Itohara, Sonoko Ogawa, Larry J Young, Qi Zhang
    • Organizer
      The 44th Annual Meeting of Japan Neuroscience Society
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] On the origin of diversity in social behavior.2021

    • Author(s)
      Larry J Young, Qi Zhang
    • Organizer
      East/South East Asia Social Brain Symposium
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] GPI protein in neuroscience and neurological diseases.2021

    • Author(s)
      Qi Zhang
    • Organizer
      Tsukuba University symposium of advanced science
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] Toward creating a mouse loyal to its partner.2020

    • Author(s)
      Qi Zhang
    • Organizer
      The 43rd Annual Meeting of Japan Neuroscience Society
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] The important roles of PIGA gene in brain development and epileptic encephalopathy revealed by tissue-specific knockout.2020

    • Author(s)
      Kandasamy LC, Kato M, Matsumoto N, Takeda J, Itohara S, Ogawa S, Young LJ, Zhang Q
    • Organizer
      The 43rd Annual Meeting of Japan Neuroscience Society
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] Toward creating a mouse loyal to its partner.2020

    • Author(s)
      Zhang Q
    • Organizer
      The 43rd Annual Meeting of Japan Neuroscience Society, Kobe, Japan, July2020(Chair of the symposium and invited talk)
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] The important roles of PIGA gene in brain development and epileptic encephalopathy revealed by tissue-specific knockout2020

    • Author(s)
      Kandasamy LC, Kato M, Matsumoto N, Takeda J, Itohara S, Ogawa S, Young LJ, Zhang Q .
    • Organizer
      The 43rd Annual Meeting of Japan Neuroscience Society, Kobe, Japan, July2020
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] A study of the neural circuit mechanisms underlying the emotional symptoms associated with Alzheimer’s Disease.2019

    • Author(s)
      Banov V, Ando R, Kobayashi Y, Saito T, Saido T, Itohara S, Ogawa S, Young L, Zhang Q.
    • Organizer
      Neuroscience 2019 abstract, Society for Neuroscience 2019-S-11710-SfN
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Netrin-G1 regulates anxiety and fear through different neural networks.2019

    • Author(s)
      Zhang Q
    • Organizer
      The Third Sino-Japan Symposium on the Frontier of Behavioral Neuroendocrinology, The 30th Meetining of JSBN, Tsukuba, Japan, March2019 (Invited talk)
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research / Invited
  • [Remarks] lab webpage

    • URL

      https://www.qizhanglab.com/

    • Related Report
      2021 Annual Research Report
  • [Remarks] my lab webpage

    • URL

      https://www.qizhanglab.com/

    • Related Report
      2020 Research-status Report
  • [Funded Workshop] The 44th Annual Meeting of Japan Neuroscience Society2021

    • Related Report
      2021 Annual Research Report
  • [Funded Workshop] East/South East Asia Social Brain Symposium2021

    • Related Report
      2020 Research-status Report
  • [Funded Workshop] The 43rd Annual Meeting of Japan Neuroscience Society2020

    • Related Report
      2020 Research-status Report

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Published: 2019-07-04   Modified: 2024-01-30  

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