• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Sence of agency in experimental animals

Research Project

Project/Area Number 19K21825
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Review Section Medium-sized Section 10:Psychology and related fields
Research InstitutionNational Center of Neurology and Psychiatry

Principal Investigator

SEKI KAZUHIKO  国立研究開発法人国立精神・神経医療研究センター, 神経研究所 モデル動物開発研究部, 部長 (00226630)

Co-Investigator(Kenkyū-buntansha) 今水 寛  東京大学, 大学院人文社会系研究科(文学部), 教授 (30395123)
Project Period (FY) 2019-06-28 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2020: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2019: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Keywords身体意識 / 運動主体感 / 実験動物 / 時間知覚 / 遠心性コピー / 意識 / サル / ラット / 誘発電位 / 筋電図
Outline of Research at the Start

自分の意図によって行動した場合、私たちは「自分がこの行為の主体である」という感覚を持つ。この感覚は「身体意識」の一つであり、運動主体感 (sense of agency) と呼ばれている。運動主体感は様々な面で人間社会の基盤となっているが、それを形成する脳内メカニズムは不明である。本研究の目的は、心理学実験課題を用いて実験動物の運動主体感を客観的に計測する方法を確立する。

Outline of Final Research Achievements

In order to establish an objective evaluation method for the sense of agency in experimental animals, nerve cuff electrodes were chronically implanted in the peripheral sensory nerves, wire electrodes in the limb muscles, and ECoG electrodes in the cerebral cortex of rats and marmosets. Each activity was recorded wirelessly, and furthermore, by stimulating the cuff electrodes wirelessly, it became possible to record evoked potentials from the ECOG electrodes. In the future, we would like to prove that the amplitude of the sensory evoked potentials changes during animal behavior and that the amplitude of the SEP recordings also changes with closed-loop stimulation.

Academic Significance and Societal Importance of the Research Achievements

運動主体感は様々な面で人間社会の基盤となっている。エンジニアリングの分野での人間の使う「道具」の開発は、自己の身体意識を道具に拡張する人間の能力が前提条件となっている。労働福祉の分野では、受け身の作業でなく、自己判断を用いた仕事に従事したほうが、仕事への運動主体感を生み、労働者の精神健康がより向上する。精神医学の分野では運動主体感の異常は生活の質に甚大な影響を与える。このように運動主体感は人間社会を構成する基盤要素であるから、それを人間の脳が作り出すメカニズムが明らかになれば、人間社会全体に影響を及ぼす発見となる。この点から、運動主体感の神経機構の解明は社会的な重要性を有する。

Report

(3 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • Research Products

    (39 results)

All 2021 2020 2019

All Journal Article (13 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 13 results,  Open Access: 10 results) Presentation (25 results) (of which Int'l Joint Research: 11 results,  Invited: 7 results) Book (1 results)

  • [Journal Article] Approaches to Revealing the Neural Basis of Muscle Synergies: A Review and A Critique2021

    • Author(s)
      Cheung Vincent C. K.、Seki Kazuhiko
    • Journal Title

      Journal of Neurophysiology

      Volume: - Issue: 5 Pages: 1580-1597

    • DOI

      10.1152/jn.00625.2019

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Distinct sensorimotor feedback loops for dynamic and static control of primate precision grip2020

    • Author(s)
      Tomomichi Oya, Tomohiko Takei, and Kazuhiko Seki
    • Journal Title

      Communications Biology

      Volume: 3 Issue: 1 Pages: 156-156

    • DOI

      10.1038/s42003-020-0861-0

    • NAID

      120006823945

    • Related Report
      2020 Annual Research Report 2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Characterization of Brain-Targeted Drug Delivery Enhanced by a Combination of Lipid-Based Microbubbles and Non-Focused Ultrasound2020

    • Author(s)
      Omata Daiki、Hagiwara Fumiko、Munakata Lisa、Shima Tadamitsu、Kageyama Saori、Suzuki Yuno、Azuma Takashi、Takagi Shu、Seki Kazuhiko、Maruyama Kazuo、Suzuki Ryo
    • Journal Title

      Journal of Pharmaceutical Sciences

      Volume: 109 Issue: 9 Pages: 2827-2835

    • DOI

      10.1016/j.xphs.2020.06.008

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Forelimb force direction and magnitude independently controlled by spinal modules in the macaque2020

    • Author(s)
      Yaron Amit、Kowalski David、Yaguchi Hiroaki、Takei Tomohiko、Seki Kazuhiko
    • Journal Title

      Proceedings of the National Academy of Sciences

      Volume: 117 Issue: 44 Pages: 27655-27666

    • DOI

      10.1073/pnas.1919253117

    • NAID

      120006892060

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Categorical Perception of Control2020

    • Author(s)
      Wen Wen、Shimazaki Naoto、Ohata Ryu、Yamashita Atsushi、Asama Hajime、Imamizu Hiroshi
    • Journal Title

      eneuro

      Volume: 7 Issue: 5 Pages: ENEURO.0258-20.2020

    • DOI

      10.1523/eneuro.0258-20.2020

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Active Sensing of Control Difference2020

    • Author(s)
      Wen Wen、Shibata Hiroshi、Ohata Ryu、Yamashita Atsushi、Asama Hajime、Imamizu Hiroshi
    • Journal Title

      iScience

      Volume: 23 Issue: 5 Pages: 101112-101112

    • DOI

      10.1016/j.isci.2020.101112

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Passive training with upper extremity exoskeleton robot affects proprioceptive acuity and performance of motor learning.2020

    • Author(s)
      Chiyohara, S., Furukawa, J., Noda, T., Morimoto, J., and Imamizu, H.
    • Journal Title

      Science Reports

      Volume: 10

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Statistical Learning Model of the Sense of Agency2020

    • Author(s)
      Yano S., Hayashi Y., Murata Y., Imamizu H., Maeda T., Kondo T.
    • Journal Title

      Frontiers in Psychology

      Volume: 11:539957 Pages: 539957-539957

    • DOI

      10.3389/fpsyg.2020.539957

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Sense of Agency Beyond Sensorimotor Process: Decoding Self-Other Action Attribution in the Human Brain2020

    • Author(s)
      Ohata Ryu、Asai Tomohisa、Kadota Hiroshi、Shigemasu Hiroaki、Ogawa Kenji、Imamizu Hiroshi
    • Journal Title

      Cerebral Cortex

      Volume: 30 Issue: 7 Pages: 4076-4091

    • DOI

      10.1093/cercor/bhaa028

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Decoding of muscle activity from the sensorimotor cortex in freely behaving monkeys2019

    • Author(s)
      Umeda Tatsuya、Koizumi Masashi、Katakai Yuko、Saito Ryoichi、Seki Kazuhiko
    • Journal Title

      NeuroImage

      Volume: 197 Pages: 512-526

    • DOI

      10.1016/j.neuroimage.2019.04.045

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Optogenetic recruitment of spinal reflex pathways from large‐diameter primary afferents in non‐transgenic rats transduced with AAV9/Channelrhodopsin 22019

    • Author(s)
      Kubota Shinji、Sidikejiang Wupuer、Kudo Moeko、Inoue Ken‐ichi、Umeda Tatsuya、Takada Masahiko、Seki Kazuhiko
    • Journal Title

      The Journal of Physiology

      Volume: 597 Issue: 19 Pages: 5025-5040

    • DOI

      10.1113/jp278292

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Compress global, dilate local: Intentional binding in action?outcome alternations2019

    • Author(s)
      Imaizumi Shu、Tanno Yoshihiko、Imamizu Hiroshi
    • Journal Title

      Consciousness and Cognition

      Volume: 73 Pages: 102768-102768

    • DOI

      10.1016/j.concog.2019.102768

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] 主体感の認知神経機構2019

    • Author(s)
      今泉 修, 浅井智久, 高橋英彦, 今水 寛
    • Journal Title

      精神医学

      Volume: 61(5) Pages: 541-549

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Presentation] 運動結果の自他帰属が運動学習に与える影響2021

    • Author(s)
      田中 大,井澤 淳,今水 寛
    • Organizer
      第2回超適応領域全体会議
    • Related Report
      2020 Annual Research Report
  • [Presentation] 自分の音声により高められる発話時の運動主体感2021

    • Author(s)
      大畑 龍,浅井智久,今泉 修,今水 寛
    • Organizer
      第2回超適応領域全体会議
    • Related Report
      2020 Annual Research Report
  • [Presentation] 生物の感覚運動機能を左右する閉ループ神経回路とその非侵襲的制御.2020

    • Author(s)
      関和彦、高木周、東隆、丸山和雄、鈴木亮
    • Organizer
      第43回日本神経科学大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 自由行動下における皮質脳波から筋活動情報を解読する ―野生型及び脳梗塞モデルサルにおける検討例―2020

    • Author(s)
      関和彦
    • Organizer
      第22回日本ヒト脳機能マッピング学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Are primates just big frogs? Forelimb force direction and amplitude are independently controlled by spinal motor modules.2020

    • Author(s)
      Yaron A, Kowalski D, Yaguchi H, Takei T, Seki K
    • Organizer
      Neuromatch meeting
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 霊長類は単なる巨大化したカエルか?神経プリミティブ仮説の再検討2020

    • Author(s)
      関和彦
    • Organizer
      Motor Control 研究会第1回オンライン講演会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 人工物と脳:人工物への適応と脳活動の変化2020

    • Author(s)
      今水 寛
    • Organizer
      第3回「サスティナブルな日本のものづくり」研究会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 操作感の脳科学2020

    • Author(s)
      今水 寛
    • Organizer
      東京大学オープンイノベーションフォーラム「ロボティクスの新展開」
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] Modular control of limb movement: from neural correlates to clinical relevance2019

    • Author(s)
      Seki K
    • Organizer
      WORKSHOP on NEUROROBOTICS
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Neural adaptation to surgical relocation of primate hand muscles2019

    • Author(s)
      Seki K
    • Organizer
      Tokyo Hand Meeting(NCM Ancillary Meeting)
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Spinal and cortical neural mechanism for active inference in volitional movement.2019

    • Author(s)
      Seki K
    • Organizer
      The Satellite Meeting/29th NCM Annual Meeting
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Decoding muscle activity using electrocorticographic signals in freely behaving marmosets2019

    • Author(s)
      Umeda T, Koizumi M, Katakai Y, Saito R, Seki K
    • Organizer
      29th NCM Annual Meeting
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Emergence of spinomuscular and corticomuscular loops in dynamic vs. static phases of precision grip.2019

    • Author(s)
      Oya T, Takei T, Seki K
    • Organizer
      29th NCM Annual Meeting
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Linear summation of spinally-induced forearm force field in macaque monkeys.2019

    • Author(s)
      Yaron A, Yaguchi H, Kowalski D, Takei T, Seki K
    • Organizer
      29th NCM Annual Meeting
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Gain control of spinal proprioceptive reflex in awake, behaving monkeys.2019

    • Author(s)
      Seki K
    • Organizer
      Neuroscience 2019
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Mini-symposium “Gain Control in the Sensorimotor System: From Neural Circuit Organization to Behavioral Function2019

    • Author(s)
      Seki K, E. Azim
    • Organizer
      Neuroscience 2019
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Presynaptic inhibition acts as a spatiotemporal dynamic filter of proprioceptive afferent input during voluntary movement.2019

    • Author(s)
      Tomatsu S, Kim G, Kubota S, Seki K
    • Organizer
      Neuroscience 2019
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] 協調的筋活動を作り出す神経機構2019

    • Author(s)
      関 和彦
    • Organizer
      第58回日本運動障害研究会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 自由行動下における皮質脳波から筋活動のデコーディング2019

    • Author(s)
      梅田 達也, 小泉 昌司 , 片貝 祐子, 齋藤 亮一, 関 和彦
    • Organizer
      第42回日本神経科学大会
    • Related Report
      2019 Research-status Report
  • [Presentation] 後根神経節(DRG)細胞への細胞種特異的遺伝子導入法: 齧歯類と霊長類における比較2019

    • Author(s)
      工藤もゑこ, Wupuer Sidikejiang, 井上 謙一, 高田 昌彦, 関 和彦
    • Organizer
      第42回日本神経科学大会
    • Related Report
      2019 Research-status Report
  • [Presentation] 筋電解析による身体変化に対する神経適応メカニズムの解明2019

    • Author(s)
      内田直輝, Roland Philipp, 大屋知徹, 舩戸徹郎, 関和彦
    • Organizer
      第13回Motor Control研究会
    • Related Report
      2019 Research-status Report
  • [Presentation] 運動主体感の神経基盤~新学術領域・身体性システムの成果から2019

    • Author(s)
      今水 寛
    • Organizer
      第13回Motor Control研究会 シンポジウム
    • Related Report
      2019 Research-status Report
  • [Presentation] 誤差の原因帰属の主観的判断が運動学習に与える影響2019

    • Author(s)
      田中 大, 井澤 淳, 今水 寛
    • Organizer
      第13回Motor Control研究会
    • Related Report
      2019 Research-status Report
  • [Presentation] Response to gaining and losing control in human brain.2019

    • Author(s)
      Imamizu, H
    • Organizer
      日本心理学会第83回大会 公募シンポジウム38 「The role of sense of agency in explorative and exploitative actions」
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 運動主体感の成立に関わる脳のネットワーク2019

    • Author(s)
      今水 寛
    • Organizer
      日本心理学会第83回大会 公募シンポジウム63 「融合社会脳研究―自己の主体性を考える」
    • Related Report
      2019 Research-status Report
    • Invited
  • [Book] 社会脳から心を探る―自己と他者をつなぐ社会適応の脳内メカニズム 第6章2020

    • Author(s)
      今水 寛, 大木紫, 前田貴記, 村田 哲
    • Total Pages
      203
    • Publisher
      日本学術協力財団
    • Related Report
      2019 Research-status Report

URL: 

Published: 2019-07-04   Modified: 2022-01-27  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi