Revealing chiral self-sorting mechanisms
| Project/Area Number |
19K22196
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| Research Category |
Grant-in-Aid for Challenging Research (Exploratory)
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| Allocation Type | Multi-year Fund |
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| Review Section |
Medium-sized Section 34:Inorganic/coordination chemistry, analytical chemistry, and related fields
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Hiraoka Shuichi 東京大学, 大学院総合文化研究科, 教授 (10322538)
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| Project Period (FY) |
2019-06-28 – 2022-03-31
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| Project Status |
Completed (Fiscal Year 2021)
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| Budget Amount *help |
¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2020: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2019: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Keywords | 超分子化学 / 分子自己集合 / 自己集合過程 / キラルセルフソーティング / キラリティー / 速度論 / 質量分析 / Pd(II)イオン / かご形錯体 |
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| Outline of Research at the Start |
本研究では、キラルな多座配位子と金属イオンから形成されるホモキラルな自己集合性錯体系について、キラルな多座配位子のソーティング過程を実験的に明らかにする。全ての中間体を直接観測することは不可能なため、本研究では研究代表者が開発したQASAP (Quantitative Analysis of Self-Assembly Process)によりNMR分光により間接的に中間体の情報を得る。さらにキラルな多座配位子の一部を重水素化し、質量分析により中間体におけるキラル多座配位子の分配に関する情報を得る。これにより、化学平衡へ至る過程におけるキラル分子間の認識過程を解明する。
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| Outline of Final Research Achievements |
Chiral self-sorting is the phenomenon where chiral building blocks are sorted in molecular self-assembly, which is the ordering process recognizing one side of enantiomers and the other. Although many examples of chiral self-soring have been reported in artificial self-assembly systems so far, investigation of their sorting mechanisms is scarce. In this research, we focus on chiral self-sorting system in coordination self-assembly composed of chiral multitopic ligands and Pd(II) ions and revealed the self-assembly process and chiral self-sorting process by experiments to find (1) which step chiral self-soring mainly takes place in and (2) what is the deterministic factor of the major soring step.
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| Academic Significance and Societal Importance of the Research Achievements |
生命は片側の鏡像体のみからなるキラルな世界でその営みを維持しており、キラル認識なしに、生命の緻密な機能の発現はあり得ない。自然界におけるホモキラルな物質の起源（選択過程）にキラルセルフソーティングが直結するわけではないが、鏡像体が集団でそれぞれを複雑に識別する機構を理解することで、キラリティーの起源の解明や生命に似たホモキラルな分子システムの開発にも役立つ。
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Report
(4 results)
Research Products
(41 results)
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[Journal Article] Bifurcation of Self-assembly Pathways to Sheet or Cage Controlled by Kinetic Template Effect2019
Author(s)
L. H. Foianesi-Takeshige, S. Takahashi, T. Tateishi, R. Sekine, A. Okazawa, W. Zhu, T. Kojima, K. Harano, E. Nakamura, H. Sato, and S. Hiraoka
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Journal Title
Communications Chemistry
Volume: 2
Issue: 1
Pages: 128-128
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] The effect of isotope and polarizability on dispersion interactions in water2020
Author(s)
JIANG, Qichun; ZHAN, Yiyang; ISHII, Kentaro; KOIDE, Takuya; KOBAYASHI, Osamu; KOJIMA, Tatsuo; TAKAHASHI, Satoshi; TACHIKAWA, Masanori; UCHIYAMA, Susumu; HIRAOKA, Shuichi
Organizer
日本化学会 第100春季年会
Related Report
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[Presentation] The faster the better: selection of the self-assembly product by the use of a kinetic template2020
Author(s)
TAKESHIGE, Leonardo Hayato; TAKAHASHI, Satoshi; TATEISHI, Tomoki; SEKINE, Ryosuke; OKAZAWA, Atsushi; ZHU, Wenchao; KOJIMA, Tatsuo; HARANO, Koji; NAKAMURA, Eiichi; SATO, Hirofumi; HIRAOKA, Shuichi
Organizer
日本化学会 第100春季年会
Related Report
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