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Inhibition of light-induced stomatal opening with aromatic amines

Research Project

Project/Area Number 19K22251
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Review Section Medium-sized Section 37:Biomolecular chemistry and related fields
Research InstitutionKwansei Gakuin University (2020-2021)
Nagoya University (2019)

Principal Investigator

Murakami Kei  関西学院大学, 理学部, 准教授 (90732058)

Project Period (FY) 2019-06-28 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2020: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2019: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Keywordsaromatic amination / stomata / ヘテロ芳香環 / アミノ化 / 気孔 / 開口阻害 / ヘテロ官能基化 / 芳香環
Outline of Research at the Start

研究代表者が作成した50種類の芳香族イミド化分子のパイロットライブラリーから見つけたシード分子である芳香族アミンSIM1について、研究を行う。この分子が植物気孔の運動を停止することをすでに明らかにしている。本研究では、反応化学者である研究代表者の強みを最大限に生かし、反応開発からスタートして、一気に構造活性相関研究と作用機序の解明まで行う。反応開発においては、新しい芳香族アミノ化反応の開発を行う。またその反応を利用し、分子プローブの合成を行うとともに、プルダウン法を行う。

Outline of Final Research Achievements

We have developed various C-H amination reactions and, with these reactions in hand, prepared a C-H amination-based arylamine collection. Through phenotype-based screening, we have evaluated the bioactivity of the arylamines towards plant stomata. From the collection, we accomplished the successful identification of the lead candidate SIM1 (a sulfonimidated 2,4-diphenyloxazole) that inhibits light-induced stomatal opening. Further structure-activity relationship (SAR) study allowed us to prepare an array of SIM1 derivatives. This led to the identification of SIM3* (a sulfonamidated oxazole) which showed stronger activity and greater selectivity towards the stomatal opening cascade. Since stomata play an important role in regulating leaf transpiration, it is expected that our research will lead to the development of drought tolerance-conferring agrochemicals.

Academic Significance and Societal Importance of the Research Achievements

本研究は、基礎科学的な有機反応開発によって得られた生成物から、気孔開口を阻害する分子を発見した内容である。特に有機反応開発で行う適用範囲の検討により得られた生成物がそのまま構造活性相関研究に応用可能であり、分子の活性に対する情報を一挙に得られる。反応開発の利点を活かした分野横断的研究であり、有機化学と植物学の共同研究により、新しい生物活性分子を創出した。同様のアプローチは展開が可能であり、今後の発展が期待される。

Report

(4 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (28 results)

All 2022 2021 2020 2019

All Journal Article (2 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 2 results,  Open Access: 1 results) Presentation (26 results) (of which Int'l Joint Research: 9 results,  Invited: 7 results)

  • [Journal Article] Identification of stomatal-regulating molecules from de novo arylamine collection through aromatic C-H amination2022

    • Author(s)
      Toda Yosuke、Perry Gregory J. P.、Inoue Shimpei、Ito Eri、Kawakami Takahiro、Narouz Mina R.、Takahashi Koji、Aihara Yusuke、Maeda Bumpei、Kinoshita Toshinori、Itami Kenichiro、Murakami Kei
    • Journal Title

      Scientific Reports

      Volume: 12 Issue: 1 Pages: 949-949

    • DOI

      10.1038/s41598-022-04947-z

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Rapid Access to Kinase Inhibitor Pharmacophores by Regioselective C-H Arylation of Thieno[2,3-d]pyrimidine2020

    • Author(s)
      Yamada Shuya、Flesch Kaylin Nicole、Murakami Kei、Itami Kenichiro
    • Journal Title

      Organic Letters

      Volume: 22 Issue: 4 Pages: 1547-1551

    • DOI

      10.1021/acs.orglett.0c00143

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] 含窒素分子の触媒的合成2021

    • Author(s)
      村上慧
    • Organizer
      第6回有機若手ワークショップ
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] Photoredox-catalyzed direct aminomethylation towards aryl bromides: Straightforward synthesis of primary benzylamine2021

    • Author(s)
      Jaehyun Jung, Yota Sakakibara, Kei Murakami, Kenichiro Itami
    • Organizer
      GTR Annual Meeting 2020 (Online)
    • Related Report
      2020 Research-status Report
  • [Presentation] Photoredox-catalyzed direct aminomethylation towards aryl bromides2021

    • Author(s)
      Jaehyun Jung, Yota Sakakibara, Kei Murakami, Kenichiro Itami
    • Organizer
      3rd ICReDD International Symposium
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] Photoredox-catalyzed decarboxylative direct aminomethylation towards aryl bromides: Straightforward synthesis of primary benzylamine2021

    • Author(s)
      Jaehyun Jung, Yota Sakakibara, Kei Murakami, Kenichiro Itami
    • Organizer
      IRCCS 第4回国際シンポジウム “Multidimensional control over material structure and function”
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] 光レドックス触媒が駆動するハロゲン化アリールの脱炭酸型アミノメチル化反応2021

    • Author(s)
      Jaehyun Jung, Yota Sakakibara, Kei Murakami, Kenichiro Itami
    • Organizer
      日本化学会第101春季年会
    • Related Report
      2020 Research-status Report
  • [Presentation] Decarboxylative transformation modulated by photocatalyst2021

    • Author(s)
      榊原陽太,村上慧,伊丹健一郎
    • Organizer
      日本化学会第101春季年会
    • Related Report
      2020 Research-status Report
  • [Presentation] Synthesis of negatively curved polyaromatics by annulative coupling that forms an eight-membered ring2021

    • Author(s)
      松原聡志、古賀義人、村上慧、伊丹健一郎
    • Organizer
      GTR Annual Meeting 2020 (Online)
    • Related Report
      2020 Research-status Report
  • [Presentation] 窒素に着目した反応開発と生物活性分子の創出2020

    • Author(s)
      村上慧
    • Organizer
      ACE meeting online II
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] Photoredox-catalyzed Decarboxylative Cross-coupling of Aryl Halides and Glycine2020

    • Author(s)
      Jaehyun Jung, Yota Sakakibara, Kei Murakami, Kenichiro Itami
    • Organizer
      The 9th JACI/GSC Symposium (Online)
    • Related Report
      2020 Research-status Report
  • [Presentation] 光レドックス触媒が駆動するアリール酢酸の脱炭酸型変換2020

    • Author(s)
      榊原陽太,村上慧,伊丹健一郎
    • Organizer
      ACE meeting online II
    • Related Report
      2020 Research-status Report
  • [Presentation] Decarboxylative methylamination of aryl halides toward the synthesis of benzylamine derivatives2020

    • Author(s)
      Jaehyun Jung, Yota Sakakibara, Kei Murakami, and Kenichiro Itami
    • Organizer
      The 3rd IRCCS _ The 2nd Reaction Infography Joint International Symposium: “Reaction Imaging Meets Materials Science”
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Switchable sp2/sp3 C_H acylation of N-alkylaniline via EDA complex2020

    • Author(s)
      Bumpei Maeda, Genki Mori, Yota Sakakibara, Akiko Yagi, Kei Murakami, and Kenichiro Itami
    • Organizer
      The 3rd IRCCS _ The 2nd Reaction Infography Joint International Symposium: “Reaction Imaging Meets Materials Science”
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Synthesis of benzoate esters with photoredox catalyst2020

    • Author(s)
      榊原 陽太, 村上 慧, 伊丹 健一郎
    • Organizer
      日本化学会第100春季年会
    • Related Report
      2019 Research-status Report
  • [Presentation] 光レドックス触媒が駆動するハロゲン化アリールとグリシンの脱炭酸型カップリング2020

    • Author(s)
      鄭 在_, 榊原 陽太, 村上 慧, 伊丹 健一郎
    • Organizer
      日本化学会第100春季年会
    • Related Report
      2019 Research-status Report
  • [Presentation] Photoredox-catalyzed Decarboxylative Cross-coupling of Aryl Halides and Glycine2020

    • Author(s)
      鄭 在_, 榊原 陽太, 村上 慧, 伊丹 健一郎
    • Organizer
      2019年度 GTR年次報告会
    • Related Report
      2019 Research-status Report
  • [Presentation] Photoinduced C_H acylation of arylamine2020

    • Author(s)
      前田 文平, 森 元気, 榊原 陽太, 八木 亜樹子, 村上 慧, 伊丹 健一郎
    • Organizer
      2019年度 GTR年次報告会
    • Related Report
      2019 Research-status Report
  • [Presentation] Catalytic aromatic functionalization toward unexplored functional molecules2019

    • Author(s)
      村上慧
    • Organizer
      the second ACES & GDCh Symposium
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Catalytic aromatic functionalization toward unexplored functional molecules2019

    • Author(s)
      村上慧
    • Organizer
      2019 International C-H Functionalization Workshop
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 有機化学が創りだす次世代機能性分子2019

    • Author(s)
      村上慧
    • Organizer
      名大MIRAI GSC第1ステージ
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] Catalyst-enabling aromatic functionalization ~Annulative coupling and C_H amination~2019

    • Author(s)
      村上慧
    • Organizer
      The 2nd Hybrid Wakate Dojo
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Catalyst-enabling aromatic functionalization toward synthesis of unexplored functional molecules2019

    • Author(s)
      村上慧
    • Organizer
      日本化学会第100春季年会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] Photoredox-catalyzed decarboxylative functionalization of arylacetic acids2019

    • Author(s)
      Yota Sakakibara, Eri Ito, Phillippa Cooper, Kei Murakami, Kenichiro Itami
    • Organizer
      IBS-CCHF, ITbM, NSF-CCHF Joint Summer Workshop
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Development of new HAT reagent to functionalize terminal C_H of alkyl group2019

    • Author(s)
      Bumpei Maeda, Yota Sakakibara, Kei Murakami, Kenichiro Itami
    • Organizer
      NU-UoE JD and JSPS Core-to Core Joint-Workshop on “New Horizons in Chemistry and Materials Science”
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] EDA錯体を経由するN-アルキルアニリンのスイッチング可能なsp2/sp3C_Hアリール化反応2019

    • Author(s)
      前田 文平, 森 元気, 榊原 陽太, 八木 亜樹子, 村上 慧, 伊丹 健一郎
    • Organizer
      Exciting Organic Chemistry with Light _ GTR/ITbM Chemistry Workshop 2019
    • Related Report
      2019 Research-status Report
  • [Presentation] Control of site selectivity of HAT reaction with bulkiness2019

    • Author(s)
      前田 文平, 森 元気, 榊原 陽太, 八木 亜樹子, 村上 慧, 伊丹 健一郎
    • Organizer
      統合物質第5回国内シンポジウム
    • Related Report
      2019 Research-status Report
  • [Presentation] Development of new HAT reagent to functionalize terminal C_H of alkyl group2019

    • Author(s)
      前田 文平, 榊原 陽太, 村上 慧, 伊丹 健一郎
    • Organizer
      ITbM コンソーシアム 2019年度第3回ワークショップ
    • Related Report
      2019 Research-status Report

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Published: 2019-07-04   Modified: 2023-01-30  

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