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Domestication Process in Addiction: Understanding Addiction from the Evolutionary Perspective

Research Project

Project/Area Number 19K22511
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Review Section Medium-sized Section 48:Biomedical structure and function and related fields
Research InstitutionKyoto University

Principal Investigator

Goto Yukiori  京都大学, 霊長類研究所, 准教授 (10645584)

Project Period (FY) 2019-06-28 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2021: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Keywords依存症 / 認知機能 / 情動機能 / 攻撃性 / 意思決定 / ドーパミン / エピゲノム / 前頭前皮質 / 環境刺激 / アイトラッキング / 認知バイアス / 自己認識 / 進化 / 訓化 / セロトニン
Outline of Research at the Start

薬物・行為依存症は、依存性薬物の摂取や特定の行為に対して制御不能となる脳神経機能の変化をともなう精神障害である。依存症に対する効果的な治療法はまだ存在せず、そのメカニズムの理解と治療法の開発は喫緊の課題である。現在、広く受け入れられている依存症のメカニズムの説は、強い報酬の繰り返しによる動機付けられた欲求に対する抑制機能の障害、または強固な動機付けられた習慣形成である。しかし、従来の説では依存症と密接な関係があることが示唆されている攻撃性などの説明が困難である。本研究では、進化論的な視点から仮説を立て、依存症の病理生理学に関する新しい知見を得ることを目的とする。

Outline of Final Research Achievements

This study investigated cognitive, affective, and physiological deficits that characterize behavioral addiction, by conducting a battery of psychological tests and questionnaire surveys, along with physiological assessments, such as prefrontal cortical activity using functional near-infrared spectroscopy, blood monoamine concentrations using HPLC, and whole-genome DNA methylation analysis. We found that patients with behavioral addiction exhibited deficits in probability judgements, associated with attenuated prefrontal cortical activity, and heightened negative affects, such as anxiety, stress, and depression. Moreover, alterations in blood concentrations of monoamines, such as dopamine and serotonin, as well as DNA methylation on the genes associated with synaptic transmission and immune system, were observed in the patients. These results suggest that behavioral addiction may involve deficits of biological systems that are mutual with those with drug addiction.

Academic Significance and Societal Importance of the Research Achievements

近年、ゲーム障害やインターネット依存など、行動嗜癖(行動依存症)に注目が集まっている。しかし、行動嗜癖の概念自体は近年登場した新しいものであり、例えば他の精神障害のカテゴリー強迫性障害との区別も曖昧であり、未だ十分な知見は得られていない。また、行動依存症を特徴づけるような神経メカニズムの知見はなく、これまで研究の進んできた物質に対する依存症との共通点・相違点も明らかになっていない。本研究において、我々は、行動嗜癖の認知機能、情動機能、ならびに生理学的特徴は、薬物依存症と多くが共通することを見出し、行動嗜癖の依存症としての位置づけを発展させた。

Report

(4 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (15 results)

All 2021 2020 2019

All Journal Article (5 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 2 results,  Open Access: 2 results) Presentation (10 results) (of which Int'l Joint Research: 4 results,  Invited: 1 results)

  • [Journal Article] Comparable level of aggression between patients with behavioural addiction and healthy subjects2021

    • Author(s)
      Asaoka Yui、Won Moojun、Morita Tomonari、Ishikawa Emi、Goto Yukiori
    • Journal Title

      Translational Psychiatry

      Volume: 11 Issue: 1 Pages: 375-375

    • DOI

      10.1038/s41398-021-01502-8

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cognitive and Affective Processes Associated with Social Biases2021

    • Author(s)
      Kaneko Asuka、Asaoka Yui、Lee Young-A、Goto Yukiori
    • Journal Title

      International Journal of Neuropsychopharmacology

      Volume: 24 Issue: 8 Pages: 645-655

    • DOI

      10.1093/ijnp/pyab022

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Higher Risk Taking and Impaired Probability Judgment in Behavioral Addiction2020

    • Author(s)
      Asaoka Yui、Won Moojun、Morita Tomonari、Ishikawa Emi、Goto Yukiori
    • Journal Title

      International Journal of Neuropsychopharmacology

      Volume: 23 Issue: 10 Pages: 662-672

    • DOI

      10.1093/ijnp/pyaa044

    • NAID

      120006867140

    • Related Report
      2020 Research-status Report
  • [Journal Article] Heightened Negative Affects Associated With Neurotic Personality in Behavioral Addiction2020

    • Author(s)
      Asaoka Yui、Won Moojun、Morita Tomonari、Ishikawa Emi、Goto Yukiori
    • Journal Title

      Frontiers in Psychiatry

      Volume: 11 Pages: 561713-561713

    • DOI

      10.3389/fpsyt.2020.561713

    • Related Report
      2020 Research-status Report
  • [Journal Article] Monoamine and genome-wide DNA methylation investigation in behavioral addiction2020

    • Author(s)
      Asaoka Yui、Won Moojun、Morita Tomonari、Ishikawa Emi、Lee Young-A、Goto Yukiori
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1 Pages: 11760-11760

    • DOI

      10.1038/s41598-020-68741-5

    • NAID

      120006870879

    • Related Report
      2020 Research-status Report
  • [Presentation] Cognitive and affective process involved in social biases2021

    • Author(s)
      Kaneko A, Asaoka Y, Lee YA, and Goto Y
    • Organizer
      第44回日本神経科学学会年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Information processing of environmental stimuli that provokes addicted behavior in behavioral addiction2021

    • Author(s)
      Asaoka Y, Won MJ, Ishikawa E, Morita T, and Goto Y
    • Organizer
      第10回日本情動学会年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Explore-exploit decision making in smokers and non-smokers2021

    • Author(s)
      Kadam ST and Goto Y
    • Organizer
      第10回日本情動学会年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 行動依存症:その認知・情動・生理学的特徴2021

    • Author(s)
      Goto Y
    • Organizer
      第194回日仏生物学会例会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] Affective dysfunction and its association with cognitive bias in behavioral addiction.2021

    • Author(s)
      Asaoka Y, Won MJ, Ishikawa E, Morita T, and Goto Y
    • Organizer
      32nd CINP World Congress of Neuropsychopharmacology
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] Cognitive characteristics associated with behavioral addiction.2020

    • Author(s)
      Asaoka Y, Won MJ, Ishikawa E, Morita T, and Goto Y
    • Organizer
      第43回日本神経科学学会年会
    • Related Report
      2020 Research-status Report
  • [Presentation] Alterations of peripheral monoamine and DNA methylation in behavioral addiction.2020

    • Author(s)
      Asaoka Y, Won MJ, Ishikawa E, Morita T, and Goto Y
    • Organizer
      59th Annual Meeting of the American College of Neuropsychopharmacology
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] Characterization of behavioral addiction: affects, personality, and cognitive bias.2019

    • Author(s)
      Asaoka Y, Won MJ, Ishikawa E, Morita T, and Goto Y
    • Organizer
      10th IBRO World Congress of Neuroscience
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Altered affective function, personality trait, and decision making style characterizing behavioral addiction.2019

    • Author(s)
      Asaoka Y, Won MJ, Ishikawa E, Morita T, and Goto Y
    • Organizer
      6th Congress of Asian College of Neuropsychopharmacology
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] 行動依存症の情動的背景と認知バイアス2019

    • Author(s)
      浅岡由衣、元武俊、石川恵己、森田智也、後藤幸織
    • Organizer
      日本情動学会第9回大会
    • Related Report
      2019 Research-status Report

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Published: 2019-07-04   Modified: 2023-01-30  

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