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Exploration of novel regulatory mechanisms of translation in bacteria

Research Project

Project/Area Number 19K22715
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Review Section Medium-sized Section 57:Oral science and related fields
Research InstitutionKagoshima University (2020-2022)
Osaka University (2019)

Principal Investigator

Nakata Masanobu  鹿児島大学, 医歯学域歯学系, 教授 (90444497)

Co-Investigator(Kenkyū-buntansha) 住友 倫子  大阪大学, 大学院歯学研究科, 講師 (50423421)
山口 雅也  大阪大学, 大学院歯学研究科, 准教授 (00714536)
Project Period (FY) 2019-06-28 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2020: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2019: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Keywordsレンサ球菌 / 翻訳効率 / エンドリボヌクレアーゼ / 化膿レンサ球菌 / 線毛 / mRNA / 細菌
Outline of Research at the Start

上気道や皮膚に感染する化膿レンサ球菌などの細菌は,体内コア温度と比較して低温の環境で定着し,感染成立を果たす.一方,病原細菌が感染部位から深部組織に伝播する際,周囲の環境変化に対応して,生存に必要あるいは不必要な因子群を選択する機構が存在すると考えられる.本研究では,温度を感知し,タンパク質への翻訳過程に影響を与える核酸構造を明らかにするとともに,細菌の病原性への関与を検討する.

Outline of Final Research Achievements

The human pathogen Streptococcus pyogenes modulates virulence in response to ambient temperature during the infection process. We searched for bacterial factors that alter translation efficiency in response to temperature shifts. Our findings suggested that not only stem-loop structures located near mRNA translation initiation sites, but also mRNA structures in 5´-untranslated regions are likely involved in the temperature-sensitive translational regulation. In addition, our data revealed that the endoribonuclease RNase Y is crucial for pilus production from strains possessing a specific transcriptional regulator.

Academic Significance and Societal Importance of the Research Achievements

化膿レンサ球菌はヒトに多様な疾患を引き起こす.上市されているワクチンはなく,感染者数の増加が懸念されている.したがって,ワクチン抗原の選択や治療法開発の礎となる病態発症機序の解明が求められる.体内と比較して温度が低い皮膚や咽頭などの初発感染部位から体内へ感染が拡大する際,本菌は環境温度の変化に対応して,様々な因子の発現量を調節すると考えられている.感染過程における細菌の温度感知機構を理解することにより,細菌因子発現部位の予測や治療標的・ワクチン抗原を選択する際の指標となり得る.

Report

(5 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (69 results)

All 2023 2022 2021 2020 2019 Other

All Int'l Joint Research (4 results) Journal Article (18 results) (of which Int'l Joint Research: 6 results,  Peer Reviewed: 18 results,  Open Access: 14 results) Presentation (41 results) (of which Int'l Joint Research: 1 results,  Invited: 6 results) Book (3 results) Remarks (3 results)

  • [Int'l Joint Research] University Medicine Rostock(ドイツ)

    • Related Report
      2022 Annual Research Report
  • [Int'l Joint Research] ロストック大学医学部病院(ドイツ)

    • Related Report
      2021 Research-status Report
  • [Int'l Joint Research] ロストック大学医学部病院(ドイツ)

    • Related Report
      2020 Research-status Report
  • [Int'l Joint Research] ロストック大学医学部病院(ドイツ)

    • Related Report
      2019 Research-status Report
  • [Journal Article] Involvement of ribonuclease Y in pilus production by M49 <i>Streptococcus pyogenes</i> strain via modulation of messenger RNA level of transcriptional regulator2023

    • Author(s)
      Kubota Seiko、Nakata Masanobu、Hirose Yujiro、Yamaguchi Masaya、Kreikemeyer Bernd、Uzawa Narikazu、Sumitomo Tomoko、Kawabata Shigetada
    • Journal Title

      Microbiology and Immunology

      Volume: - Issue: 7 Pages: 319-333

    • DOI

      10.1111/1348-0421.13069

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Secondary streptococcal infection following influenza.2022

    • Author(s)
      Okahashi N, Sumitomo T, Nakata M, Kawabata S.
    • Journal Title

      Microbiol. Immunol.

      Volume: In press Issue: 6 Pages: 253-263

    • DOI

      10.1111/1348-0421.12965

    • Related Report
      2022 Annual Research Report 2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Oral mitis group streptococci: A silent majority in our oral cavity.2022

    • Author(s)
      Okahashi N, Nakata M, Kuwata H, Kawabata S.
    • Journal Title

      MICROBIOLOGY AND IMMUNOLOGY

      Volume: 66 Issue: 12 Pages: 539-551

    • DOI

      10.1111/1348-0421.13028

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Oral mitis group streptococci reduce infectivity of influenza A virus via acidification and H2O2?production.2022

    • Author(s)
      Okahashi N, Sumitomo T, Nakata M, Kuwata H, Kawabata S.
    • Journal Title

      PLOS ONE

      Volume: 17 Issue: 11 Pages: e0276293-e0276293

    • DOI

      10.1371/journal.pone.0276293

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pneumococcal BgaA promotes host organ bleeding and coagulation in a mouse sepsis model.?2022

    • Author(s)
      Takemura M, Yamaguchi M, Kobayashi M, Sumitomo T, Hirose Y, Okuzaki D, Ono M, Motooka D, Goto K, Nakata M, Uzawa N, Kawabata S.
    • Journal Title

      FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY

      Volume: 12 Pages: 844000-844000

    • DOI

      10.3389/fcimb.2022.844000

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comprehensive characterization of sortase A-dependent surface proteins in Streptococcus mutans.2022

    • Author(s)
      Katsumata T, Nguyen-Tra Le M, Kawada-Matsuo M, Taniguchi Y, Ouhara K, Oogai Y, Nakata M, Mizuno N, Nishitani Y, Komatsuzawa H.
    • Journal Title

      Microbiol. Immunol.

      Volume: 66 Issue: 3 Pages: 145-156

    • DOI

      10.1111/1348-0421.12958

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Small regulatory RNAs of oral streptococci and periodontal bacteria2021

    • Author(s)
      Yuichi Oogai and Masanobu Nakata
    • Journal Title

      Jpn Dent Sci Rev .

      Volume: 57 Pages: 209-216

    • DOI

      10.1016/j.jdsr.2021.09.004

    • NAID

      210000172857

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comprehensive analysis of bacteriocins in Streptococcus mutans2021

    • Author(s)
      Watanabe Atsuko、Kawada-Matsuo Miki、Le Mi Nguyen-Tra、Hisatsune Junzo、Oogai Yuichi、Nakano Yoshio、Nakata Masanobu、Miyawaki Shouichi、Sugai Motoyuki、Komatsuzawa Hitoshi
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1 Pages: 12963-12963

    • DOI

      10.1038/s41598-021-92370-1

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] GP96 drives exacerbation of secondary bacterial pneumonia following influenza A virus infection.2021

    • Author(s)
      Sumitomo T, Nakata M, Nagase S, Takahara Y, Honda-Ogawa M, Mori Y, Akamatsu Y, Yamaguchi M, Okamoto S, Kawabata S.
    • Journal Title

      mBio

      Volume: 12 Issue: 3

    • DOI

      10.1128/mbio.03269-20

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Genetics, Structure, and Function of Group A Streptococcal Pili2021

    • Author(s)
      Nakata M, Kreikemeyer B.
    • Journal Title

      Frontiers in Microbiology

      Volume: 12 Pages: 616508-616508

    • DOI

      10.3389/fmicb.2021.616508

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Streptococcus pyogenes upregulates arginine catabolism to exert its pathogenesis on the skin surface2021

    • Author(s)
      Hirose Yujiro、Yamaguchi Masaya、Sumitomo Tomoko、Nakata Masanobu、Hanada Tomoki、Okuzaki Daisuke、Motooka Daisuke、Mori Yasushi、Kawasaki Hiroshi、Coady Alison、Uchiyama Satoshi、Hiraoka Masanobu、Zurich Raymond H.、Amagai Masayuki、Nizet Victor、Kawabata Shigetada
    • Journal Title

      Cell Reports

      Volume: 34 Issue: 13 Pages: 108924-108924

    • DOI

      10.1016/j.celrep.2021.108924

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Streptococcal H2O2 Inhibits IgE-triggered Degranulation of RBL-2H3 Mast Cell/Basophil Cell Line by Inducing Cell Death2020

    • Author(s)
      Okahashi N, Nakata M, Hirose Y, Morisaki H, Kataoka H, Kuwata H, KawabataS.
    • Journal Title

      PLoS One

      Volume: 15 Issue: 4 Pages: e0231101-e0231101

    • DOI

      10.1371/journal.pone.0231101

    • Related Report
      2020 Research-status Report 2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Role of BgaA as a pneumococcal virulence factor elucidated by molecular evolutionary analysis.2020

    • Author(s)
      Yamaguchi M, Takemura M, Higashi K, Goto K, Hirose Y, Sumitomo T, Nakata M, Uzawa N, Kawabata S.
    • Journal Title

      Front Microbiol

      Volume: 11 Pages: 582437-582437

    • DOI

      10.3389/fmicb.2020.582437

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Genetic characterization of Streptococcus pyogenes emm89 strains isolated in Japan from 2011 to 2019.2020

    • Author(s)
      Hirose Y, Yamaguchi M, Takemoto N, Miyoshi-Akiyama T, Sumitomo T, Nakata M, Ikebe T, Hanada T, Yamaguchi T, Kawahara R, Okuno R, Otsuka H, Matsumoto Y, Terashima Y, Kazawa Y, Nakanishi N, Uchida K, Akiyama Y, Iwabuchi K. Nakagawa C, Yamamoto K, Nizet V, Kawabata S.
    • Journal Title

      Infect. Microbe Dis.

      Volume: 2 Issue: 4 Pages: 160-166

    • DOI

      10.1097/im9.0000000000000038

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Thermosensitive pilus production by FCT type 3 Streptococcus pyogenes controlled by Nra regulator translational efficiency.2020

    • Author(s)
      Nakata M, Sumitomo T, Patenge N, Kreikemeyer B, Kawabata S.
    • Journal Title

      Mol Microbiol

      Volume: 113 Issue: 1 Pages: 173-189

    • DOI

      10.1111/mmi.14408

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Streptococcus pneumoniae surface adhesin PfbA exhibits host specificity by binding to human serum albumin but not bovine,rabbit and porcine serum albumins.2020

    • Author(s)
      Sankar S,Yamaguchi M,Kawabata S,Ponnuraj K.
    • Journal Title

      Protein J.

      Volume: 39 Issue: 1 Pages: 1-9

    • DOI

      10.1007/s10930-019-09875-y

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Streptococcus pneumoniae evades host cell phagocytosis and limits host mortality through its cell wall anchoring protein PfbA.2019

    • Author(s)
      Yamaguchi M, Hirose Y, Takemura M, Ono M, Sumitomo T, Nakata M, Terao Y, Kawabata S.
    • Journal Title

      Front Cell Infect Microbiol

      Volume: 9 Pages: 301-301

    • DOI

      10.3389/fcimb.2019.00301

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Streptococcus pyogenes transcriptome changes in the inflammatory environment of necrotizing fasciitis.2019

    • Author(s)
      Hirose Y, Yamaguchi M, Okuzaki D, Motooka D, Hamamoto H, Hanada T, Sumitomo T, Nakata M, Kawabata S.
    • Journal Title

      Appl Environ Microbiol

      Volume: 85 Issue: 21

    • DOI

      10.1128/aem.01428-19

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 肺炎球菌のニューモライシン依存的な鼻粘膜上皮バリア傷害と脳伝播機構の解析2022

    • Author(s)
      高原 悠樹, 住友 倫子, 河野 正充, 赤松 由佳子, 山口 雅也, 中田 匡宣, 保富 宗城, 川端 重忠
    • Organizer
      第52回 レンサ球菌研究会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 肺炎球菌を感染させた三次元肺組織モデルにおける上皮バリアの機能障害と炎症応答の解析2022

    • Author(s)
      赤松 由佳子,住友 倫子,高原 悠樹,山口 雅也,中田 匡宣,明石 満,川端 重忠
    • Organizer
      第64回 歯科基礎医学会学術大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 交互積層細胞コーティング法を用いた三次元肺組織モデルの構築と感染モデルへの応用2022

    • Author(s)
      赤松 由佳子, 住友倫子, 高原悠樹, 広瀬雄二郎, 山口雅也, 中田匡宣, 秋山茂久, 明石満, 川端重忠
    • Organizer
      第75回 日本細菌学会関西支部総会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 肺炎球菌のニューモライシンによる鼻粘膜上皮バリアの傷害と脳伝播機構の解析2022

    • Author(s)
      高原悠樹,住友倫子,河野正充,山口雅也,中田匡宣,保富宗城,川端重忠.
    • Organizer
      第95回日本細菌学会総会
    • Related Report
      2021 Research-status Report
  • [Presentation] Nasal epithelial barrier dysfunction involved in non-hematogenous pneumococcal dissemination to brain tissue2021

    • Author(s)
      Takahara Y., Sumitomo T., Kono M., Yamaguchi M., Nakata M., Hotomi M., Kawabata S.
    • Organizer
      The 3rd Asian Pneumococcal Symposium
    • Related Report
      2021 Research-status Report
  • [Presentation] 肺炎球菌のニューモライシン依存的な鼻粘膜バリア傷害と脳への伝播機構の関連2021

    • Author(s)
      高原悠樹, 住友倫子, 山口雅也, 中田匡宣, 川端重忠
    • Organizer
      第63回歯科基礎医学会学術大会
    • Related Report
      2021 Research-status Report
  • [Presentation] 化膿レンサ球菌におけるサーモセンサーの発見2021

    • Author(s)
      中田匡宣
    • Organizer
      第3回南九州歯学会学術大会
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] 結晶構造解析に基づく化膿レンサ球菌におけるヒアルロン酸分解酵素の分子機構解明2021

    • Author(s)
      東 孝太郎,山口雅也,中田匡宣,武部克希,住友倫子,鈴木守,川端重忠.
    • Organizer
      第94回日本細菌学会総会
    • Related Report
      2020 Research-status Report
  • [Presentation] 鼻咽腔に定着する肺炎球菌が非血行性に脳へ伝播する機構の解析.2021

    • Author(s)
      高原悠樹,住友倫子,河野正充,山口雅也,中田匡宣,保富宗城,川端重忠.
    • Organizer
      第94回日本細菌学会総会
    • Related Report
      2020 Research-status Report
  • [Presentation] 化膿レンサ球菌における温度感受性の線毛産生を担う分子機構の解析2021

    • Author(s)
      中田 匡宣
    • Organizer
      第4回鹿大細菌カンファレンス
    • Related Report
      2020 Research-status Report
  • [Presentation] 血清型M49型Streptococcus pyogenesのCvfAは病原因子の発現と温度依存性の線毛産生に関与する.2020

    • Author(s)
      窪田星子,中田匡宣,広瀬雄二郎,山口雅也,住友倫子,川端重忠.
    • Organizer
      第62回歯科基礎医学会学術大会
    • Related Report
      2020 Research-status Report
  • [Presentation] 肺炎球菌のニューモライシンに依存する非血行性脳伝播機構の解析.2020

    • Author(s)
      高原悠樹,住友倫子,河野正充,山口雅也,中田匡宣,保富宗城,川端重忠.
    • Organizer
      第73回日本細菌学会関西支部総会
    • Related Report
      2020 Research-status Report
  • [Presentation] Sreptococcus pyogenesのCvfAと温度依存性の線毛産生機構の解析.2020

    • Author(s)
      窪田星子,中田匡宣,広瀬雄二郎,山口雅也,住友倫子,川端重忠.
    • Organizer
      第73回日本細菌学会関西支部総会
    • Related Report
      2020 Research-status Report
  • [Presentation] 化膿レンサ球菌におけるヒアルロン酸分解酵素の分子系統解析およびタンパク質結晶構造解析2020

    • Author(s)
      東孝太郎,山口雅也,中田匡宣,武部克希,住友倫子,鈴木守,川端重忠.
    • Organizer
      第43回日本分子生物学会年会
    • Related Report
      2020 Research-status Report
  • [Presentation] 肺炎球菌の菌体表層タンパク質群に着目した病態形成機構の解明.2020

    • Author(s)
      山口雅也.
    • Organizer
      第93回日本細菌学会総会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 肺炎球菌の菌体表層タンパク質BgaAが病態形成に果たす役割.2020

    • Author(s)
      竹村萌,山口雅也,広瀬雄二郎,住友倫子,中田匡宣,川端重忠.
    • Organizer
      第93回日本細菌学会総会
    • Related Report
      2019 Research-status Report
  • [Presentation] Streptococcus pyogenes emm 89型の侵襲性に寄与する因子の検索.2020

    • Author(s)
      広瀬雄二郎,山口雅也,秋山徹,竹本訓彦,奥野ルミ,山口貴弘,大塚仁,住友倫子,中田匡宣,川端重忠.
    • Organizer
      第93回日本細菌学会総会
    • Related Report
      2019 Research-status Report
  • [Presentation] インフルエンザに続発する細菌性肺炎の発症におけるGP96の機能解析.2020

    • Author(s)
      住友倫子,中田匡宣,長瀬賢史,高原悠樹,山口雅也,岡本成史,川端重忠.
    • Organizer
      第93回日本細菌学会総会
    • Related Report
      2019 Research-status Report
  • [Presentation] mRNAサーモセンサーにより制御される化膿レンサ球菌の温度感受性線毛産生.2020

    • Author(s)
      中田匡宣.
    • Organizer
      第93回日本細菌学会総会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 化膿レンサ球菌のアルギニン代謝系は皮膚上で病原性発揮機構に寄与する.2019

    • Author(s)
      広瀬雄二郎,山口雅也,住友倫子,川端重忠.
    • Organizer
      第93回日本感染症学会総会
    • Related Report
      2019 Research-status Report
  • [Presentation] 化膿レンサ球菌による温度依存性の線毛産生(Temperature-dependent pilus production of Streptococcus pyogenes).2019

    • Author(s)
      中田匡宣,住友倫子,川端重忠.
    • Organizer
      第92回日本細菌学会総会
    • Related Report
      2019 Research-status Report
  • [Presentation] Influenza virus-induced dysfunction of pulmonary epithelial barrier promotes secondary bacterial infection.2019

    • Author(s)
      住友倫子.
    • Organizer
      第92回日本細菌学会総会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] Streptococcus pyogenes のアルギニン代謝系が病変形成に果たす役割の解析.2019

    • Author(s)
      広瀬雄二郎,山口雅也,毛利泰士,後藤花奈,住友倫子,中田匡宣,川端重忠.
    • Organizer
      第92回日本細菌学会総会
    • Related Report
      2019 Research-status Report
  • [Presentation] Component analysis of cell-wall anchored pili in Streptococcus sanguinis.2019

    • Author(s)
      李怡萱,中田匡宣,岡橋暢夫,山口雅也,住友倫子,川端重忠.
    • Organizer
      第92回日本細菌学会総会
    • Related Report
      2019 Research-status Report
  • [Presentation] Involvement of two-component regulatory system TCS08 in pneumococcal pneumonia pathogenesis.2019

    • Author(s)
      本多-小川真理子,住友倫子,Dalia Hamd,毛利泰士,山口雅也,中田匡宣,川端重忠.
    • Organizer
      第92回日本細菌学会総会
    • Related Report
      2019 Research-status Report
  • [Presentation] 肺炎球菌の β-ガラクトシダーゼ BgaA の進化的な保存性と病態に 果たす役割の解析.2019

    • Author(s)
      竹村萌,山口雅也,後藤花奈,広瀬雄二郎,住友倫子,中田匡宣,川端重忠.
    • Organizer
      第92回日本細菌学会総会
    • Related Report
      2019 Research-status Report
  • [Presentation] 進化的な保存性の評価に基づく肺炎球菌の病原因子の探索.2019

    • Author(s)
      山口雅也,後藤 花奈,竹村 萌,広瀬 雄二郎,住友 倫子,中田 匡宣,川端重忠.
    • Organizer
      第92回日本細菌学会総会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 日本における劇症型感染症由来Streptococcus pyogenes emm 89型の解析.2019

    • Author(s)
      広瀬雄二郎,山口雅也,奥野ルミ,秋山徹,菅原庸,浜田茂幸,住友倫子,中田匡宣,川端重忠.
    • Organizer
      第51回レンサ球菌研究会
    • Related Report
      2019 Research-status Report
  • [Presentation] Two-component regulatory system TCS08 contributes to pathogenesis in pneumococcal pneumonia.2019

    • Author(s)
      Sumitomo T,Hamd DT,Honda-Ogawa M,Mori Y,Yamaguchi M,Nakata M,Kawabata S.
    • Organizer
      ASM Microbe 2019
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] 肺炎球菌のβ-ガラクトシダーゼBgaAは敗血症の病原因子として働く.2019

    • Author(s)
      竹村萌,山口雅也,住友倫子,中田匡宣,鵜澤成一,川端重忠.
    • Organizer
      大阪大学歯学会第128回例会
    • Related Report
      2019 Research-status Report
  • [Presentation] Streptococcus pneumoniae のコリン結合タンパク質CbpJおよびCbpLの機能解析.2019

    • Author(s)
      後藤花奈,山口雅也,川端重忠.
    • Organizer
      大阪大学歯学会第128回例会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 宿主―細菌相互作用による肺炎重症化メカニズム解析.2019

    • Author(s)
      土門久哲,永井康介,山口雅也,川端重忠,寺尾豊.
    • Organizer
      第13回細菌学若手コロッセウムin みやぎ蔵王
    • Related Report
      2019 Research-status Report
  • [Presentation] 肺炎球菌の菌体表層タンパク質PfbAが自然免疫系に対して果たす役割の解明.2019

    • Author(s)
      山口雅也,広瀬雄二郎,竹村萌,大野誠之,住友倫子,中田匡宣,寺尾豊,川端重忠.
    • Organizer
      第13回細菌学若手コロッセウムin みやぎ蔵王
    • Related Report
      2019 Research-status Report
  • [Presentation] マウス壊死性筋膜炎モデルの感染局所におけるStreptococcus pyogenesの遺伝子発現解析.2019

    • Author(s)
      花田知己,広瀬雄二郎,山口雅也,住友倫子,中田匡宣,川端重忠.
    • Organizer
      第61回歯科基礎医学会学術大会
    • Related Report
      2019 Research-status Report
  • [Presentation] インフルエンザ感染によるGP96シャペロンの活性化は肺炎球菌の肺胞上皮細胞への付着を亢進させる.2019

    • Author(s)
      住友倫子,中田匡宣,山口雅也,川端重忠.
    • Organizer
      第61回歯科基礎医学会学術大会
    • Related Report
      2019 Research-status Report
  • [Presentation] Restoration of intact nra into serotype M18 Streptococcus pyogenes restored thermosensitive pilus production.2019

    • Author(s)
      Li Y,Nakata M,Sumitomo T,Hirose Y,Takemura M,Yamaguchi M,Okahashi N,Kawabata S.
    • Organizer
      第61回歯科基礎医学会学術大会
    • Related Report
      2019 Research-status Report
  • [Presentation] Streptococcus pyogenesは低グルコース環境においてアルギニン代謝依存的に遺伝子発現を変動させる.2019

    • Author(s)
      広瀬雄二郎,山口雅也,花田知己,住友倫子,中田匡宣,川端重忠.
    • Organizer
      第61回歯科基礎医学会学術大会
    • Related Report
      2019 Research-status Report
  • [Presentation] Streptococcus pneumoniaeは種特異的なタンパク質PfbAにより過剰な免疫応答を伴う宿主の死亡を抑制する.2019

    • Author(s)
      山口雅也,広瀬雄二郎,竹村萌,大野誠之,住友倫子,中田匡宣,寺尾豊,川端重忠.
    • Organizer
      第61回歯科基礎医学会学術大会
    • Related Report
      2019 Research-status Report
  • [Presentation] 温度感受性転写因子の翻訳効率に依存する化膿レンサ球菌の線毛発現.2019

    • Author(s)
      中田匡宣,住友倫子,川端重忠.
    • Organizer
      第61回歯科基礎医学会学術大会
    • Related Report
      2019 Research-status Report
  • [Presentation] Restoration of transcriptional regulator nra in serotype M18 Streptococcus pyogenes leads to phenotypic change.2019

    • Author(s)
      Li Y,Nakata M,Sumitomo T,Hirose Y,Takemura M,Yamaguchi M,Kawabata S.
    • Organizer
      第7回口腔微生物研究会
    • Related Report
      2019 Research-status Report
  • [Presentation] Identification of pneumococcal virulence factors based on selective pressure analysis.2019

    • Author(s)
      山口雅也.
    • Organizer
      2019年「先進ゲノム支援」拡大班会議
    • Related Report
      2019 Research-status Report
  • [Book] 口腔微生物学・免疫学 第5版2021

    • Author(s)
      中田匡宣
    • Total Pages
      17
    • Publisher
      医歯薬出版株式会社
    • ISBN
      9784263458662
    • Related Report
      2021 Research-status Report
  • [Book] Detection of fibronectin-binding proteins of Streptococcus pyogenes by ligand-blot analysis. Ed: Thomas Proft and Jacelyn Loh, Methods in Molecular Biology, Group A Streptococcus: Methods and Protocols.2020

    • Author(s)
      Nakata M, Kawabata S.
    • Total Pages
      10
    • Publisher
      Springer Nature
    • Related Report
      2020 Research-status Report
  • [Book] Group A Streptococcus Methods and Protocols (Editors: Proft T, Loh J)2020

    • Author(s)
      Nakata M, Kawabata S.
    • Total Pages
      10
    • Publisher
      Springer
    • Related Report
      2019 Research-status Report
  • [Remarks] 鹿児島大学大学院医歯学総合研究科 口腔微生物学分野

    • URL

      https://www2.kufm.kagoshima-u.ac.jp/field/health-research/f004/06.html

    • Related Report
      2022 Annual Research Report
  • [Remarks] 鹿児島大学大学院 医歯学総合研究科 口腔微生物学分野

    • URL

      https://www2.kufm.kagoshima-u.ac.jp/field/health-research/f004/06.html

    • Related Report
      2021 Research-status Report 2020 Research-status Report
  • [Remarks] 大阪大学 大学院歯学研究科 口腔細菌学教室ホームページ

    • URL

      https://web.dent.osaka-u.ac.jp/mcrbio/index.html

    • Related Report
      2019 Research-status Report

URL: 

Published: 2019-07-04   Modified: 2024-01-30  

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