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Is prognostication useful as a trigger for advance care planning? A randomised controlled trial.

Research Project

Project/Area Number 19K22760
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Review Section Medium-sized Section 58:Society medicine, nursing, and related fields
Research InstitutionUniversity of Tsukuba (2022)
Kobe University (2019-2021)

Principal Investigator

Kizawa Yoshiyuki  筑波大学, 医学医療系, 教授 (80289181)

Co-Investigator(Kenkyū-buntansha) 森田 達也  聖隷クリストファー大学, 看護学研究科, 臨床教授 (70513000)
Project Period (FY) 2019-06-28 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2021: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2020: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2019: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywordsアドバンス・ケア・プランニング / 予後予測 / 緩和ケア / ランダム化比較試験 / がん
Outline of Research at the Start

アドバンス・ケア・プランニング(ACP)は実施されれば効果があることがわかっているが、問題なのは、「ACPを始めるきっかけがない」ことである。医師がACPをはじめるきっかけとして、サプライズクエスチョンをきっかけにして患者にアプローチすることが推奨されているが精度が低い。申請者は、血液検査とバイタルサインという客観的な指標のみを組み合わせた予後予測モデルを開発し、臨床兆候を用いた従来の方法を上回る予測精度が得られることを示した本研究の目的は、医師がACPの話し合いを始めるきっかけとして、客観的指標のみを用いた精度の高い予後予測を提示することが有効かを検証することである。

Outline of Final Research Achievements

The aim of this study was to examine, using a randomised controlled trial, whether presenting accurate prognostic predictions using objective measures improves the willingness of ACPs to discuss them. Physicians currently treating cancer were randomly selected into two groups: the control group was given a subjective prognosis for their patients, while the intervention group was given an objective prognostic estimate (50% chance of survival at 56 days and 70% at 28 days). 223 physicians participated in the study. The willingness of the intervention group to implement ACP was 96.5%, compared with 94.3% of the control group. There was also no significant difference in the willingness of the two groups to determine a surrogate decision-maker. The results of this study show that informing doctors about objective prognostic predictions does not lead to an increase in doctors' willingness to implement ACP.

Academic Significance and Societal Importance of the Research Achievements

本研究の結果からは、精度の高い予後予測を提示することは、ACP実施に対する意欲を変化させないことが示唆される。ACPの実践をすすめる為には、話し合いに対する患者のバリアを下げる努力(例:予め話し合われる内容を開示する)、両者が安全に話し合いができる環境の整備(例:話し合いの意欲がある患者を予め選択しておく)、医師に対する話し合いの方法の教育(コミュニケーションスキルトレーニングなど)が有効な可能性があり、今後これらを用いた研究の実施が必要である。

Report

(5 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (8 results)

All 2021 2020 2019

All Journal Article (5 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 5 results,  Open Access: 1 results) Presentation (3 results) (of which Invited: 2 results)

  • [Journal Article] Physician's Communication in Code Status Discussions for Terminally Ill Cancer Patients in Inpatient Hospice/Palliative Care Units in Japan: A Nationwide Post-Bereavement Survey2021

    • Author(s)
      Kizawa Yoshiyuki、Yamaguchi Takashi、Sakashita Akihiro、Aoyama Maho、Morita Tatsuya、Tsuneto Satoru、Shima Yasuo、Miyashita Mitsunori
    • Journal Title

      Journal of Pain and Symptom Management

      Volume: * Issue: 3 Pages: e120-e129

    • DOI

      10.1016/j.jpainsymman.2021.03.011

    • NAID

      120007148945

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effects of Brief Nurse Advance Care Planning Intervention with Visual Materials on Goal-of-Care Preference of Japanese Elderly Patients with Chronic Disease: A Pilot Randomized-Controlled Trial2020

    • Author(s)
      Kizawa Yoshiyuki、Okada Hiroko、Kawahara Takuya、Morita Tatsuya
    • Journal Title

      Journal of Palliative Medicine

      Volume: 23 Issue: 8 Pages: 1076-1083

    • DOI

      10.1089/jpm.2019.0512

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Frequency of discussing and documenting advance care planning in primary care: secondary analysis of a multicenter cross-sectional observational study2020

    • Author(s)
      Hamano Jun、Oishi Ai、Morita Tatsuya、Kizawa Yoshiyuki
    • Journal Title

      BMC Palliative Care

      Volume: 19 Issue: 1 Pages: 32-32

    • DOI

      10.1186/s12904-020-00543-y

    • NAID

      120006826793

    • Related Report
      2020 Research-status Report 2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] End-of-life decision-making in Asia: A need for in-depth cultural consideration2020

    • Author(s)
      Mori Masanori、Morita Tatsuya
    • Journal Title

      Palliative Medicine

      Volume: ー Issue: 2 Pages: NP4-NP5

    • DOI

      10.1177/0269216319896932

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] 2019 Taipei Declaration on Advance Care Planning: A Cultural Adaptation of End-of-Life Care Discussion2019

    • Author(s)
      Lin, C. P., Cheng, S. Y., Mori, M., Suh, S. Y., Chan, H. Y., Martina, D., . . . Chiu, T. Y.
    • Journal Title

      Journal of Palliative Medicine

      Volume: 22 Issue: 10 Pages: 1175-1177

    • DOI

      10.1089/jpm.2019.0247

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] ACP「アドバンス・ケア・プランニング」2021

    • Author(s)
      木澤義之
    • Organizer
      第18回日本臨床腫瘍学会学術集会.
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] がん患者の遺族のアドバンス・ケア・プランニング(ACP)が他者との関係性や死生観に与える影響.2020

    • Author(s)
      宮地由佳、塩崎麻里子、恒藤暁、森田達也、木澤義之、 升川研人、 宮下光令、 志真泰夫.
    • Organizer
      緩和・支持・心のケア 合同学術大会2020.
    • Related Report
      2020 Research-status Report
  • [Presentation] 終末期の意思決定支援を考える-EOLDとACP.2020

    • Author(s)
      木澤義之
    • Organizer
      第61回日本肺癌学会学術集会.
    • Related Report
      2020 Research-status Report
    • Invited

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Published: 2019-07-04   Modified: 2024-01-30  

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