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Development of care program based on autonomic function analysis in patients with cancer.

Research Project

Project/Area Number 19K22772
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Review Section Medium-sized Section 58:Society medicine, nursing, and related fields
Research InstitutionKyoto Prefectural University of Medicine

Principal Investigator

Yamanaka Ryuya  京都府立医科大学, 医学部, 特任教授 (20323991)

Co-Investigator(Kenkyū-buntansha) 高島 康郎  京都府立医科大学, 医学(系)研究科(研究院), 研究員 (50621083)
田村 沙織  大阪大学, 医学系研究科, 助教 (50756210)
川口 淳  佐賀大学, 医学部, 教授 (60389319)
Project Period (FY) 2019-06-28 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2021: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2020: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2019: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywordsがん患者 / 自律神経機能 / ケアプログラム / 自律神経
Outline of Research at the Start

がん患者のがん種毎および抗がん剤レジメンと自律神経障害やがんサーバイバーの自律神経障害の詳細な検討を行う。がん患者の自律神経機能障害の実態が明らかにされ、より適切なケアプログラム、副作用対策、薬物療法開発の端緒となる可能性が期待される。さらに、化学療法誘発自律神経機能障害モデルのin vitro, in vivoの確立は、将来の化学療法誘発自律神経機能障害の病態の理解とその治療法の開発に貢献するものと考えられる。

Outline of Final Research Achievements

In palliative care hospitals in Japan, mechanical bathing is conducted to maintain cleanliness. The objective of this study was to assess, using physiological and psychological indices, the effects of mechanical bathing care for patients in the terminal stage of cancer. The heart rate variability analysis method was used to measure autonomic nervous system function. The patients' state of anxiety was assessed using the State-Trait Anxiety Inventory (STAI), a psychological index, and patients' verbal responses were also collected after mechanical bathing. Their sympathetic and parasympathetic nervous activity did not differ before and after bathing. A significant difference was found between pre- and post-bathing anxiety, as evaluated by STAI.Patients were more relaxed after mechanical bathing according to STAI evaluation and their verbal responses. The findings suggest that the method of bathing used in this study is safe and pain-relieving for terminal stage cancer patients.

Academic Significance and Societal Importance of the Research Achievements

がん患者の自律神経機能障害の実態が明らかにされることにより、がん患者の抱える自律神経機能障害を早期に診断し、より科学的なエビデンスに基づくケアプログラム、副作用対策、介入療法の開発の端緒となる可能性が考えられる。

Report

(4 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (24 results)

All 2021 2020 2019 Other

All Journal Article (13 results) (of which Peer Reviewed: 11 results,  Open Access: 10 results) Presentation (8 results) Remarks (3 results)

  • [Journal Article] Survival prediction based on the gene expression associated with cancer morphology and microenvironment in primary central nervous system lymphoma2021

    • Author(s)
      Takashima Yasuo、Kawaguchi Atsushi、Fukai Junya、Iwadate Yasuo、Kajiwara Koji、Hondoh Hiroaki、Yamanaka Ryuya
    • Journal Title

      PLOS ONE

      Volume: 16 Issue: 6 Pages: e0251272-e0251272

    • DOI

      10.1371/journal.pone.0251272

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] GSEA-assisted gene signatures valid for combinations of prognostic markers in PCNSL2020

    • Author(s)
      Takashima Y, Hamano M, Fukai J, Iwadate Y, Kajiwara K, Kobayashi T, Hondoh H, Yamanaka R.
    • Journal Title

      Sci Rep

      Volume: 10 Issue: 1 Pages: 8435-8435

    • DOI

      10.1038/s41598-020-65463-6

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Metabolome Analysis Reveals Excessive Glycolysis via PI3K/AKT/mTOR and RAS/MAPK Signaling in Methotrexate-Resistant Primary CNS Lymphoma-Derived Cells2020

    • Author(s)
      Takashima Y, Hayano A, Yamanaka R
    • Journal Title

      Clin Cancer Res

      Volume: - Pages: 2754-2766

    • DOI

      10.1158/1078-0432.ccr-18-3851

    • Related Report
      2020 Research-status Report 2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] miR-101, miR-548b, miR-554, and miR-1202 are reliable prognosis predictors of the miRNAs associated with cancer immunity in primary central nervous system lymphoma2020

    • Author(s)
      Takashima Y, Kawaguchi A, Iwadate Y, Hondoh H, Fukai J, Kajiwara K, Hayano A, Yamanaka R
    • Journal Title

      PLoS One

      Volume: 15(2) Issue: 2 Pages: e0229577-e0229577

    • DOI

      10.1371/journal.pone.0229577

    • Related Report
      2020 Research-status Report 2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 中枢神経系原発悪性リンパ腫のがん細胞ダイレクトリプログラミング候補因子の同定.2020

    • Author(s)
      高島康郎,山中龍也
    • Journal Title

      Medical Science Digest

      Volume: 46(8) Pages: 52-53

    • Related Report
      2020 Research-status Report
  • [Journal Article] 中枢神経系原発悪性リンパ腫における予後予測因子の次世代がん治療再生への応用.2020

    • Author(s)
      高島康郎,山中龍也
    • Journal Title

      Precision Medicine

      Volume: 3(13) Pages: 1231-1232

    • Related Report
      2020 Research-status Report
  • [Journal Article] MicroRNA signature constituted of miR-30d, miR-93, and miR-181b is a promising prognostic marker in primary central nervous system lymphoma2019

    • Author(s)
      Takashima Yasuo、Kawaguchi Atsushi、Iwadate Yasuo、Hondoh Hiroaki、Fukai Junya、Kajiwara Koji、Hayano Azusa、Yamanaka Ryuya
    • Journal Title

      PLOS ONE

      Volume: 14 Issue: 1 Pages: e0210400-e0210400

    • DOI

      10.1371/journal.pone.0210400

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Concerns and Returns to Work in Patients with Breast Cancer Receiving Outpatient Chemotherapy: a Pilot Study2019

    • Author(s)
      Tamura Saori、Sakaguchi Koichi、Yamanaka Ryuya
    • Journal Title

      Asia-Pacific Journal of Oncology Nursing

      Volume: 6 Issue: 2 Pages: 187-187

    • DOI

      10.4103/apjon.apjon_58_18

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cell-type specific sensitivity of bortezomib in the methotrexate-resistant primary central nervous system lymphoma cells2019

    • Author(s)
      Hayano Azusa、Takashima Yasuo、Yamanaka Ryuya
    • Journal Title

      International Journal of Clinical Oncology

      Volume: April Issue: 9 Pages: 1020-1029

    • DOI

      10.1007/s10147-019-01451-9

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] CD276 and the gene signature composed of GATA3 and LGALS3 enable prognosis prediction of glioblastoma multiforme2019

    • Author(s)
      Takashima Yasuo、Kawaguchi Atsushi、Hayano Azusa、Yamanaka Ryuya
    • Journal Title

      PLOS ONE

      Volume: 14 Issue: 5 Pages: e0216825-e0216825

    • DOI

      10.1371/journal.pone.0216825

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Differential expression of individual transcript variants of PD-1 and PD-L2 genes on Th-1/Th-2 status is guaranteed for prognosis prediction in PCNSL2019

    • Author(s)
      Takashima Y, Kawaguchi A, Sato R, Yoshida K, Hayano A, Homma J, Fukai J, Iwadate Y, Kajiwara K, Ishizawa S, Hondoh H, Nakano M, Ogawa S, Tashiro K, Yamanaka R
    • Journal Title

      Sci Rep

      Volume: 9(1) Issue: 1 Pages: 10004-10004

    • DOI

      10.1038/s41598-019-46473-5

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Differential expression of N-linked oligosaccharides in methotrexate-resistant primary central nervous system lymphoma cells2019

    • Author(s)
      Takashima Y, Yoshimura T, Kano Y, Hayano A, Hondoh H, Ikenaka K, Yamanaka R
    • Journal Title

      BMC Cancer

      Volume: 19(1) Issue: 1 Pages: 910-910

    • DOI

      10.1186/s12885-019-6129-8

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Promising Prognosis Marker Candidates on the Status of Epithelial-Mesenchymal Transition and Glioma Stem Cells in Glioblastoma2019

    • Author(s)
      Takashima Y, Kawaguchi A, Yamanaka R
    • Journal Title

      Cells

      Volume: 8(11) Issue: 11 Pages: 1312-1312

    • DOI

      10.3390/cells8111312

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 心臓血管手術後ICUに入室した患者の入院前と退院時のQOLの変化 ~SF-36を用いて.2021

    • Author(s)
      山田親代,岩脇陽子, 森本昌史, 夜久均, 山中龍也.
    • Organizer
      第48回日本集中治療医学会学術集会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 中枢神経系原発悪性リンパ腫におけるがん免疫マイクロRNAによる予後予測.2021

    • Author(s)
      高島康郎, 川口淳, 岩立康男, 本道洋昭,深井順也, 梶原浩司, 早野あづさ, 山中龍也.
    • Organizer
      第80回日本癌学会学術総会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 中枢神経系原発悪性リンパ腫におけるがんの形態及び微小環境に関連する遺伝子の発現パターンによる予後予測2021

    • Author(s)
      高島康郎, 川口淳,深井順也, 岩立康男, 梶原浩司,本道洋昭, 山中龍也.
    • Organizer
      第44回日本分子生物学会年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] メトトレキサート耐性原発性中枢神経系リンパ腫におけるmTORおよび低酸素シグナル伝達経路による解糖系の亢進.2020

    • Author(s)
      高島康郎,早野あづさ,山中龍也.
    • Organizer
      第79回日本癌学会学術総会
    • Related Report
      2020 Research-status Report
  • [Presentation] 膠芽腫における上皮間葉転換およびグリオーマ幹細胞に関する遺伝子発現による予後予測.2020

    • Author(s)
      高島康郎,川口淳,山中龍也.
    • Organizer
      第43回日本分子生物学会年会
    • Related Report
      2020 Research-status Report
  • [Presentation] The miRNA signature constituted of miR-30d, miR-93, and miR-181b as promising prognostic markers in primary CNS lymphoma.2019

    • Author(s)
      Takashima Y, Kawaguchi A, Iwadate Y, Hondoh H, Fukai J, Kajiwara K, Hayano A, Yamanaka R
    • Organizer
      第78回日本癌学会学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] 消化器がん患者に対する足浴の生理学・心理学的効果の検討.2019

    • Author(s)
      大北沙由利, 岩脇陽子, 末平智子, 安田照美, 中西正芳, 大辻英吾, 山中龍也
    • Organizer
      第57回日本癌治療学会学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] 中枢神経系原発悪性リンパ腫におけるTh1/Th2バランスとPD-1およびPD-L2遺伝子発現による予後予測.2019

    • Author(s)
      高島康郎, 川口淳, 佐藤隆一, 吉田健一, 早野あづさ, 本間順平, 深井順也, 岩立康男, 梶原浩司, 石澤伸, 本道洋昭, 中野正和, 小川誠司, 田代啓, 山中龍也.
    • Organizer
      第42回日本分子生物学会年会
    • Related Report
      2019 Research-status Report
  • [Remarks] 山中研究室ホームページ

    • URL

      https://square.umin.ac.jp/kpum-yamanaka1/index.html

    • Related Report
      2021 Annual Research Report
  • [Remarks] 再発脳腫瘍モデルにおけるがんの代謝経路とATPエネルギー産生経路の解明

    • URL

      https://www.kpu-m.ac.jp/doc/news/2020/20200304.html

    • Related Report
      2020 Research-status Report
  • [Remarks] プレスリリース

    • URL

      https://www.kpu-m.ac.jp/doc/news/2020/files/23279.pdf

    • Related Report
      2019 Research-status Report

URL: 

Published: 2019-07-04   Modified: 2023-01-30  

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