Regulation of Skeletal Muscle Function by Cardiokines

• Project/Area Number: 19K22791
• Research Category: Grant-in-Aid for Challenging Research (Exploratory)
• Allocation Type: Multi-year Fund
• Review Section: Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
• Research Institution: Hokusho University
• Principal Investigator: Takada Shingo 北翔大学, 生涯スポーツ学部, 准教授 (60722329)
• Co-Investigator(Kenkyū-buntansha): 植田 幸嗣 公益財団法人がん研究会, がんプレシジョン医療研究センター がんオーダーメイド医療開発プロジェクト, プロジェクトリーダー (10509110)
• Project Period (FY): 2019-06-28 – 2023-03-31
• Project Status: Completed (Fiscal Year 2022)
• Budget Amount: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000); Fiscal Year 2021: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2020: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2019: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 骨格筋 / 心不全 / ミトコンドリア / Cardiokine / 運動能力 / 脂肪酸酸化 / 心筋細胞 / 心筋由来内分泌因子 / 骨格筋異常 / 分泌因子 / サルコペニア / フレイル / 内分泌因子

Outline of Research at the Start

我々は、心不全モデルマウスの骨格筋異常の機序として、ミトコンドリア生合成障害や脂肪酸酸化の低下、それらシグナルの低下が関与することを観察したが（Cardiovasc Res 2016; Circulation 2018）、骨格筋異常の最上流因子は不明なままである。
本研究は心筋梗塞よる左室心筋細胞の減少が心筋由来生理活性物質（cardiokine）の分泌の変化により骨格筋異常を引き起こすと仮説を立て、検証する。

Outline of Final Research Achievements

Exercise intolerance in heart failure (HF) is partly attributed to skeletal muscle abnormalities (Takada S. et al. Caridiovasc Res 2016, 2021; Circulation 2018; Front Cardiovasc Med 2020; Circ Heart Fail 2021; Am J Physiol 2022). Here, we tested the hypothesis that skeletal muscle abnormalities in HF are initially caused by cardiokines. Plasma in mouse can regulate cultured skeletal muscle cell signaling.

Academic Significance and Societal Importance of the Research Achievements

心不全におけるcardiokineの役割解明は骨格筋異常以外の多臓器障害の機序解明や治療法の確立にも貢献しうる。また、多臓器障害は心不全だけでなく、幅広い病態にかかわるユニバーサルな現象であり、循環器領域だけではなく、多くの異分野への波及効果も大きい。

Research Products

• [Int'l Joint Research] University of Copenhagen(デンマーク)
• [Journal Article] Protective roles of MITOL against myocardial senescence and ischemic injury partly via Drp1 regulation (2022)
  • Author(s): Tokuyama T、Uosaki H、Sugiura A、Nishitai G、Takeda K、Nagashima S、Shiiba I、Ito N、Amo T、Mohri S、Nishimura A、Nishida M、Konno A、Hirai H、Ishido S、Yoshizawa T、Shindo T、Takada S、Kinugawa S、Inatome R、Yanagi S
  • Journal Title: iScience Volume: 25 Issue: 7 Pages: 104582-104582
  • DOI: 10.1016/j.isci.2022.104582
  • Peer Reviewed / Open Access
• [Journal Article] Succinyl-CoA-based energy metabolism dysfunction in chronic heart failure (2022)
  • Author(s): Takada Shingo、Maekawa Satoshi、Furihata Takaaki、Kakutani Naoya、Setoyama Daiki、Ueda Koji、Nambu Hideo、Hagiwara Hikaru、Handa Haruka、Fumoto Yoshizuki、Hata Soichiro、Masunaga Tomoka、Fukushima Arata、Yokota Takashi、Kang Dongchon、Kinugawa Shintaro、Sabe Hisataka
  • Journal Title: Proceedings of the National Academy of Sciences Volume: 119 Issue: 41 Pages: 1-9
  • DOI: 10.1073/pnas.2203628119
  • Peer Reviewed / Open Access
• [Journal Article] Treatments for skeletal muscle abnormalities in heart failure: sodium-glucose transporter 2 and ketone bodies (2022)
  • Author(s): Takada Shingo、Sabe Hisataka、Kinugawa Shintaro
  • Journal Title: American Journal of Physiology-Heart and Circulatory Physiology Volume: 322 Issue: 2 Pages: H117-H128
  • DOI: 10.1152/ajpheart.00100.2021
  • Peer Reviewed / Open Access
• [Journal Article] Cross-disease communication between cancer and heart failure provides a rational approach to prevention and treatment of both diseases (2022)
  • Author(s): Takada Shingo、Kinugawa Shintaro、Handa Haruka、Yokota Takashi、Sabe Hisataka
  • Journal Title: Frontiers in Oncology Volume: 12 Pages: 1-5
  • DOI: 10.3389/fonc.2022.1006322
  • Peer Reviewed / Open Access
• [Journal Article] Ergogenic effects of caffeine are mediated by myokines (2022)
  • Author(s): Takada Shingo、Fumoto Yoshizuki、Kinugawa Shintaro
  • Journal Title: Frontiers in Sports and Active Living Volume: 4 Pages: 1-8
  • DOI: 10.3389/fspor.2022.969623
  • Peer Reviewed / Open Access
• [Journal Article] Brain-Derived Neurotrophic Factor Improves Impaired Fatty Acid Oxidation Via the Activation of Adenosine Monophosphate-Activated Protein Kinase-alpha- Proliferator-Activated Receptor-r Coactivator-1alpha Signaling in Skeletal Muscle of Mice With Heart Failure (2021)
  • Author(s): Matsumoto Junichi、Takada Shingo、Furihata Takaaki、Nambu Hideo、Kakutani Naoya、Maekawa Satoshi、Mizushima Wataru、Nakano Ippei、Fukushima Arata、Yokota Takashi、Tanaka Shinya、Handa Haruka、Sabe Hisataka、Kinugawa Shintaro
  • Journal Title: Circulation: Heart Failure Volume: 14 Issue: 1
  • DOI: 10.1161/circheartfailure.119.005890
  • Peer Reviewed / Open Access
• [Journal Article] Blood Flow Restriction Improves Executive Function after Walking (2021)
  • Author(s): SUGIMOTO TAKESHI、SUGA TADASHI、TOMOO KEIGO、DORA KENTO、MOK ERNEST、TSUKAMOTO HAYATO、TAKADA SHINGO、HASHIMOTO TAKESHI、ISAKA TADAO
  • Journal Title: Medicine & Science in Sports & Exercise Volume: 53 Issue: 1 Pages: 131-138
  • DOI: 10.1249/mss.0000000000002446
  • Peer Reviewed
• [Journal Article] Effect of very low-intensity resistance exercise with slow movement and tonic force generation on post-exercise inhibitory control (2021)
  • Author(s): Kento Dora, Tadashi Suga, Keigo Tomoo, Takeshi Sugimoto, Ernest Mok, Hayato Tsukamoto, Shingo Takada, Takeshi Hashimoto, Tadao Isak
  • Journal Title: Heliyon Volume: 7 Issue: 2 Pages: e06261-e06261
  • DOI: 10.1016/j.heliyon.2021.e06261
  • Peer Reviewed / Open Access
• [Journal Article] Cardiac-specific loss of mitoNEET expression is linked with age-related heart failure (2021)
  • Author(s): Furihata T, Takada S, Kakutani N, Maekawa S, Tsuda M, Matsumoto J, Mizushima W, Fukushima A, Yokota T, Enzan N, Matsushima S, Handa H, Fumoto Y, Nio-Kobayashi J, Iwanaga T, Tanaka S, Tsutsui H, Sabe H, Kinugawa S.
  • Journal Title: Commun Biol. Volume: 4 Issue: 1 Pages: 138-138
  • DOI: 10.1038/s42003-021-01675-4
  • Peer Reviewed / Open Access
• [Journal Article] Systemic oxidative stress is associated with lower aerobic capacity and impaired skeletal muscle energy metabolism in heart failure patients (2021)
  • Author(s): Yokota Takashi、Kinugawa Shintaro、Hirabayashi Kagami、Yamato Mayumi、Takada Shingo、Suga Tadashi、Nakano Ippei、Fukushima Arata、Matsushima Shouji、Okita Koichi、Tsutsui Hiroyuki
  • Journal Title: Scientific Reports Volume: 11 Issue: 1 Pages: 2272-2272
  • DOI: 10.1038/s41598-021-81736-0
  • Peer Reviewed
• [Journal Article] Impact of Inadequate Calorie Intake on Mortality and Hospitalization in Stable Patients with Chronic Heart Failure (2021)
  • Author(s): Obata Yoshikuni、Kakutani Naoya、Kinugawa Shintaro、Fukushima Arata、Yokota Takashi、Takada Shingo、Ono Taisuke、Sota Takeshi、Kinugasa Yoshiharu、Takahashi Masashige、Matsuo Hisashi、Matsukawa Ryuichi、Yoshida Ichiro、Yokota Isao、Yamamoto Kazuhiro、Tsuchihashi-Makaya Miyuki
  • Journal Title: Nutrients Volume: 13 Issue: 3 Pages: 874-874
  • DOI: 10.3390/nu13030874
  • Peer Reviewed
• [Journal Article] Premedication with pioglitazone prevents doxorubicin-induced left ventricular dysfunction in mice (2021)
  • Author(s): Furihata Takaaki、Maekawa Satoshi、Takada Shingo、Kakutani Naoya、Nambu Hideo、Shirakawa Ryosuke、Yokota Takashi、Kinugawa Shintaro
  • Journal Title: BMC Pharmacology and Toxicology Volume: 22 Issue: 1 Pages: 27-27
  • DOI: 10.1186/s40360-021-00495-w
  • Peer Reviewed
• [Journal Article] Angiotensin‐converting enzyme inhibitor prevents skeletal muscle fibrosis in diabetic mice (2021)
  • Author(s): Kakutani Naoya、Takada Shingo、Nambu Hideo、Maekawa Satoshi、Hagiwara Hikaru、Yamanashi Katsuma、Obata Yoshikuni、Nakano Ippei、Fumoto Yoshizuki、Hata Soichiro、Furihata Takaaki、Fukushima Arata、Yokota Takashi、Kinugawa Shintaro
  • Journal Title: Experimental Physiology Volume: 106 Issue: 8 Pages: 1785-1793
  • DOI: 10.1113/ep089375
  • Peer Reviewed
• [Journal Article] Similar improvements in cognitive inhibitory control following low-intensity resistance exercise with slow movement and tonic force generation and high-intensity resistance exercise in healthy young adults: a preliminary study (2021)
  • Author(s): Dora Kento、Suga Tadashi、Tomoo Keigo、Sugimoto Takeshi、Mok Ernest、Tsukamoto Hayato、Takada Shingo、Hashimoto Takeshi、Isaka Tadao
  • Journal Title: The Journal of Physiological Sciences Volume: 71 Issue: 1 Pages: 1-12
  • DOI: 10.1186/s12576-021-00806-0
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Exercise adherence‐related perceptual responses to low‐load blood flow restriction resistance exercise in young adults: A pilot study (2021)
  • Author(s): Suga Tadashi、Dora Kento、Mok Ernest、Sugimoto Takeshi、Tomoo Keigo、Takada Shingo、Hashimoto Takeshi、Isaka Tadao
  • Journal Title: Physiological Reports Volume: 9 Issue: 23
  • DOI: 10.14814/phy2.15122
  • Peer Reviewed / Open Access
• [Journal Article] Impact of Inter-Set Short Rest Interval Length on Inhibitory Control Improvements Following Low-Intensity Resistance Exercise in Healthy Young Males (2021)
  • Author(s): Tomoo Keigo、Suga Tadashi、Dora Kento、Sugimoto Takeshi、Mok Ernest、Tsukamoto Hayato、Takada Shingo、Hashimoto Takeshi、Isaka Tadao
  • Journal Title: Frontiers in Physiology Volume: 12 Pages: 741966-741966
  • DOI: 10.3389/fphys.2021.741966
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Serum Brain-Derived Neurotrophic Factor Levels Are Associated with Skeletal Muscle Function but Not with Muscle Mass in Patients with Heart Failure (2020)
  • Author(s): Nakano Ippei、Kinugawa Shintaro、Hori Hiroaki、Fukushima Arata、Yokota Takashi、Takada Shingo、Kakutani Naoya、Obata Yoshikuni、Yamanashi Katsuma、Anzai Toshihisa
  • Journal Title: International Heart Journal Volume: 61 Issue: 1 Pages: 96-102
  • DOI: 10.1536/ihj.19-400
  • NAID: 130007792874
  • ISSN: 1349-2365, 1349-3299
  • Year and Date: 2020-01-31
  • Peer Reviewed
• [Journal Article] Inhibition of xanthine oxidase in the acute phase of myocardial infarction prevents skeletal muscle abnormalities and exercise intolerance (2020)
  • Author(s): Nambu Hideo、Takada Shingo、Yasui Hironobu、Higashikawa Kei、Kuge Yujiら
  • Journal Title: Cardiovascular Research Volume: 117 Issue: 3 Pages: 805-819
  • DOI: 10.1093/cvr/cvaa127
  • Peer Reviewed
• [Journal Article] Type 2 diabetes is an independent predictor of lowered peak aerobic capacity in heart failure patients with non-reduced or reduced left ventricular ejection fraction (2020)
  • Author(s): Abe Takahiro、Yokota Takashi、Fukushima Arata、Kakutani Naoya、Katayama Takashi、Shirakawa Ryosuke、Maekawa Satoshi、Nambu Hideo、Obata Yoshikuni、Yamanashi Katsuma、Nakano Ippei、Takada Shingo、Yokota Isao、Okita Koichi、Kinugawa Shintaro、Anzai Toshihisa
  • Journal Title: Cardiovascular Diabetology Volume: 19 Issue: 1 Pages: 142-142
  • DOI: 10.1186/s12933-020-01114-4
  • Peer Reviewed
• [Journal Article] Negative effects of blood flow restriction on perceptual responses to walking in healthy young adults: A pilot study (2020)
  • Author(s): Mok Ernest、Suga Tadashi、Sugimoto Takeshi、Tomoo Keigo、Dora Kento、Takada Shingo、Hashimoto Takeshi、Isaka Tadao
  • Journal Title: Heliyon Volume: 6 Issue: 8 Pages: e04745-e04745
  • DOI: 10.1016/j.heliyon.2020.e04745
  • Peer Reviewed
• [Journal Article] Work volume is an important variable in determining the degree of inhibitory control improvements following resistance exercise (2020)
  • Author(s): Tomoo Keigo、Suga Tadashi、Sugimoto Takeshi、Tanaka Daichi、Shimoho Kento、Dora Kento、Mok Ernest、Matsumoto Shawn、Tsukamoto Hayato、Takada Shingo、Hashimoto Takeshi、Isaka Tadao
  • Journal Title: Physiological Reports Volume: 8 Issue: 15
  • DOI: 10.14814/phy2.14527
  • Peer Reviewed
• [Journal Article] Validation of gene therapy for mutant mitochondria by delivering mitochondrial RNA using a MITO-Porter, a liposome-based nano device (2020)
  • Author(s): Kawamura E, Maruyama M, Abe J, Sudo A, Takeda A, Takada S, Yokota T, Kinugawa S, Harashima H, Yamada Y
  • Journal Title: Mol. Ther. - Nucleic Acids Volume: - Pages: 687-698
  • DOI: 10.1016/j.omtn.2020.04.004
  • Peer Reviewed / Open Access
• [Journal Article] Loop diuretic use is associated with skeletal muscle wasting in patients with heart failure (2020)
  • Author(s): Nakano Ippei、Tsuda Masaya、Kinugawa Shintaro、Fukushima Arata、Kakutani Naoya、Takada Shingo、Yokota Takashi
  • Journal Title: Journal of Cardiology Volume: 76 Issue: 1 Pages: 109-114
  • DOI: 10.1016/j.jjcc.2020.01.003
  • Peer Reviewed
• [Journal Article] Angiotensin-converting-enzyme inhibitor prevents skeletal muscle fibrosis in myocardial infarction mice (2020)
  • Author(s): Kakutani Naoya、Takada Shingo、Nambu Hideo、Matsumoto Junichi、Furihata Takaaki、Yokota Takashi、Fukushima Arata、Kinugawa Shintaro
  • Journal Title: Skeletal Muscle Volume: 10 Issue: 1 Pages: 11-11
  • DOI: 10.1186/s13395-020-00230-9
  • Peer Reviewed / Open Access
• [Journal Article] Correlation between increased atrial expression of genes related to fatty acid metabolism and autophagy in patients with chronic atrial fibrillation (2020)
  • Author(s): Shingu Yasushige、Takada Shingo、Yokota Takashi、Shirakawa Ryosuke、Yamada Akira、Ooka Tomonori、Katoh Hiroki、Kubota Suguru、Matsui Yoshiro
  • Journal Title: PLOS ONE Volume: 15 Issue: 4 Pages: e0224713-e0224713
  • DOI: 10.1371/journal.pone.0224713
  • Peer Reviewed
• [Journal Article] Branched-chain amino acid supplementation ameliorates angiotensin II-induced skeletal muscle atrophy. (2020)
  • Author(s): Yamanashi K, Kinugawa S, Fukushima A, Kakutani N, Takada S, Obata Y, Nakano I, Yokota T, Kitaura Y, Shimomura Y, Anzai T.
  • Journal Title: Life Sciences Volume: 250 Pages: 117593-117595
  • DOI: 10.1016/j.lfs.2020.117593
  • Peer Reviewed
• [Journal Article] The disruption of invariant natural killer T cells exacerbates cardiac hypertrophy and failure caused by pressure overload in mice (2020)
  • Author(s): Takahashi Masashige、Kinugawa Shintaro、Takada Shingo、Kakutani Naoya、Furihata Takaaki、Sobirin Mochamad Ali、Fukushima Arata、Obata Yoshikuni、Saito Akimichi、Ishimori Naoki、Iwabuchi Kazuya、Tsutsui Hiroyuki
  • Journal Title: Experimental Physiology Volume: 105 Issue: 3 Pages: 489-501
  • DOI: 10.1113/ep087652
  • Peer Reviewed / Open Access
• [Journal Article] Activation of invariant natural killer T cells by alpha-galactosylceramide ameliorates doxorubicin-induced cardiotoxicity in mice (2020)
  • Author(s): Obata Yoshikuni、Ishimori Naoki、Saito Akimichi、Kinugawa Shintaro、Yokota Takashi、Takada Shingo、Nakano Ippei、Kakutani Naoya、Yamanashi Katsuma、Anzai Toshihisa
  • Journal Title: European Journal of Preventive Cardiology Volume: - Issue: 19 Pages: 2358-2361
  • DOI: 10.1177/2047487319901208
  • NAID: 120006940624
  • Peer Reviewed
• [Journal Article] Mitochondrial respiration of complex II is not lower than that of complex I in mouse skeletal muscle (2020)
  • Author(s): Maekawa Satoshi、Takada Shingo、Furihata Takaaki、Fukushima Arata、Yokota Takashi、Kinugawa Shintaro
  • Journal Title: Biochemistry and Biophysics Reports Volume: 21 Pages: 100717-100717
  • DOI: 10.1016/j.bbrep.2019.100717
  • Peer Reviewed
• [Journal Article] Empagliflozin restores lowered exercise endurance capacity via the activation of skeletal muscle fatty acid oxidation in a murine model of heart failure (2020)
  • Author(s): Nambu Hideo、Takada Shingo、Fukushima Arata、Matsumoto Junichi、Kakutani Naoya、Maekawa Satoshi、Shirakawa Ryosuke、Nakano Ippei、Furihata Takaaki、Katayama Takashi、Yamanashi Katsuma、Obata Yoshikuni、Saito Akimichi、Yokota Takashi、Kinugawa Shintaro
  • Journal Title: European Journal of Pharmacology Volume: 866 Pages: 172810-172810
  • DOI: 10.1016/j.ejphar.2019.172810
  • Peer Reviewed
• [Journal Article] Clinical Impacts and Associated Factors of Delayed Ambulation in Patients with Acute Heart Failure (2020)
  • Author(s): 23.Ishikawa K, Fukushima A, Yokota T, Takada S, Furihata T, Kakutani N, Yamanashi, K, Obata Y, Nakano I, Abe T, Kinugawa S, Anzai T.
  • Journal Title: Circulation Reports Volume: 1 Pages: 179-186
  • NAID: 130007630368
  • Peer Reviewed
• [Journal Article] Abnormalities of Skeletal Muscle, Adipocyte Tissue, and Lipid Metabolism in Heart Failure: Practical Therapeutic Targets (2020)
  • Author(s): Takada Shingo、Sabe Hisataka、Kinugawa Shintaro
  • Journal Title: Frontiers in Cardiovascular Medicine Volume: 7 Pages: 79-79
  • DOI: 10.3389/fcvm.2020.00079
  • Peer Reviewed
• [Journal Article] Clinical Impact and Associated Factors of Delayed Ambulation in Patients With Acute Heart Failure (2019)
  • Author(s): Ishikawa Koji、Fukushima Arata、Yokota Takashi、Takada Shingo、Furihata Takaaki、Kakutani Naoya、Yamanashi Katsuma、Obata Yoshikuni、Nakano Ippei、Abe Takahiro、Kinugawa Shintaro、Anzai Toshihisa
  • Journal Title: Circulation Reports Volume: 1 Issue: 4 Pages: 179-186
  • DOI: 10.1253/circrep.CR-18-0022
  • NAID: 130007630368
  • ISSN: 2434-0790
  • Year and Date: 2019-04-10
  • Peer Reviewed / Open Access
• [Journal Article] Enhanced Echo Intensity of Skeletal Muscle Is Associated With Exercise Intolerance in Patients With Heart Failure (2019)
  • Author(s): Nakano Ippei、Hori Hiroaki、Fukushima Arata、Yokota Takashi、Kinugawa Shintaro、Takada Shingo、Yamanashi Katsuma、Obata Yoshikuni、Kitaura Yasuyuki、Kakutani Naoya、Abe Takahiro、Anzai Toshihisa
  • Journal Title: Journal of Cardiac Failure Volume: - Issue: 8 Pages: 30416-30419
  • DOI: 10.1016/j.cardfail.2019.09.001
  • Peer Reviewed
• [Journal Article] Resistance training with interval blood flow restriction effectively enhances intramuscular metabolic stress with less ischemic duration and discomfort. (2019)
  • Author(s): Okita K, Takada S, Morita N, Takahashi M, Hirabayashi K, Yokota T, Kinugawa S.
  • Journal Title: Appl Physiol Nutr Metab Volume: in press Issue: 7 Pages: 759-764
  • DOI: 10.1139/apnm-2018-0321
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Impaired mitochondrial oxidative phosphorylation capacity in epicardial adipose tissue is associated with decreased concentration of adiponectin and severity of coronary atherosclerosis. (2019)
  • Author(s): Nakajima T, Yokota T, Shingu Y, Yamada A, Iba Y, Ujihira K, Wakasa S, Ooka T, Takada S, Shirakawa R, Katayama T, Furihata T, Fukushima A, Matsuoka R, Nishihara H, Dela F, Nakanishi K, Matsui Y, Kinugawa S.
  • Journal Title: Sci Rep Volume: 9 Issue: 1 Pages: 3535-3535
  • DOI: 10.1038/s41598-019-40419-7
  • NAID: 120006603703
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A mitochondrial delivery system using liposome-based nanocarriers that target myoblast cells (2019)
  • Author(s): Katayama Takashi、Kinugawa Shintaro、Takada Shingo、Furihata Takaaki、Fukushima Arata、Yokota Takashi、Anzai Toshihisa、Hibino Mitsue、Harashima Hideyoshi、Yamada Yuma
  • Journal Title: Mitochondrion Volume: 49 Pages: 66-72
  • DOI: 10.1016/j.mito.2019.07.005
  • Peer Reviewed / Open Access
• [Journal Article] Mitochondrial reactive oxygen species generation in blood cells is associated with disease severity and exercise intolerance in heart failure patients (2019)
  • Author(s): Shirakawa Ryosuke、Yokota Takashi、Nakajima Takayuki、Takada Shingo、Yamane Miwako、Furihata Takaaki、Maekawa Satoshi、Nambu Hideo、Katayama Takashi、Fukushima Arata、Saito Akimichi、Ishimori Naoki、Dela Flemming、Kinugawa Shintaro、Anzai Toshihisa
  • Journal Title: Scientific Reports Volume: 9 Issue: 1 Pages: 14709-14709
  • DOI: 10.1038/s41598-019-51298-3
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Linoleic acid improves assembly of the CII subunit and CIII2/CIV complex of the mitochondrial oxidative phosphorylation system in heart failure (2019)
  • Author(s): Maekawa Satoshi、Takada Shingo、Nambu Hideo、Furihata Takaaki、Kakutani Naoya、Setoyama Daiki、Ueyanagi Yasushi、Kang Dongchon、Sabe Hisataka、Kinugawa Shintaro
  • Journal Title: Cell Communication and Signaling Volume: 17 Issue: 1 Pages: 128-128
  • DOI: 10.1186/s12964-019-0445-0
  • Peer Reviewed / Open Access
• [Journal Article] Mitofusin 2 is involved in chemotaxis of neutrophil-like differentiated HL-60 cells (2019)
  • Author(s): Mazaki Yuichi、Takada Shingo、Nio-Kobayashi Junko、Maekawa Satoshi、Higashi Tsunehito、Onodera Yasuhito、Sabe Hisataka
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 513 Issue: 3 Pages: 708-713
  • DOI: 10.1016/j.bbrc.2019.04.037
  • Peer Reviewed / Open Access
• [Journal Article] Arrhythmogenic β-adrenergic signaling in cardiac hypertrophy: The role of small-conductance calcium-activated potassium channels via activation of CaMKII (2019)
  • Author(s): Kamada Rui、Yokoshiki Hisashi、Mitsuyama Hirofumi、Watanabe Masaya、Mizukami Kazuya、Tenma Taro、Takahashi Masayuki、Takada Shingo、Anzai Toshihisa
  • Journal Title: European Journal of Pharmacology Volume: 844 Pages: 110-117
  • DOI: 10.1016/j.ejphar.2018.12.011
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] シンポジウム「加齢・病態における骨格筋異常とその治療法」「心疾患おける骨格筋異常の発症機序」 (2022)
  • Author(s): 髙田真吾、絹川真太郎
  • Organizer: 第77回日本体力医学会大会
  • Invited
• [Presentation] シンポジウム「HUMAN BIOLOGYを志向したミトコンドリア生化学」「不全心筋におけるミトコンドリア代謝リプログラミング」 (2021)
  • Author(s): Shingo Takada
  • Organizer: 第94回日本生化学学会大会
  • Invited
• [Presentation] シンポジウム「骨格筋内外における環境への適応と異常」「骨格筋における線維化の意義」 (2021)
  • Author(s): 髙田真吾、絹川真太郎
  • Organizer: 第76回日本体力医学会大会
  • Invited
• [Presentation] パネルディスカッション8：「超急性期心臓リハビリテーションのエビデンス構築に向けて」「心疾患の超急性期における骨格筋異常発症機序」 (2021)
  • Author(s): Shingo Takada、Shintaro Kinugawa
  • Organizer: 第27回日本心臓リハビリテーション学会
  • Invited
• [Presentation] シンポジウム「他臓器における理解と治療法」「不全心筋における栄養療法」 (2020)
  • Author(s): 髙田真吾、絹川真太郎．
  • Organizer: 第75回日本体力医学会大会
  • Invited
• [Presentation] シンポジウム「病態を癒す．運動のサイエンス～基礎研究から臨床研究まで～」「骨格筋線維化における予防とその意義」 (2020)
  • Author(s): 髙田真吾、角谷尚哉、絹川真太郎．
  • Organizer: 第39回日本臨床運動療法学会学術集会
  • Invited
• [Presentation] シンポジウム：「骨格筋をターゲットとした治療法の開発」「脳由来神経栄養因子による心不全骨格筋治療」 (2020)
  • Author(s): 髙田真吾
  • Organizer: 第26回日本心臓リハビリテーション学会
  • Invited
• [Presentation] 心不全の骨格筋におけるミトコンドリア複合体II (2020)
  • Author(s): 皆田崇照、髙田真吾、中村圭孝、前川 聡、絹川真太郎．
  • Organizer: 第75回日本体力医学会大会
• [Presentation] 心筋ミトコンドリア複合体II機能は複合体I機能と同等である (2020)
  • Author(s): 中村圭孝、髙田真吾、皆田崇照、前川 聡、絹川真太郎
  • Organizer: 第75回日本体力医学会大会
• [Presentation] 心不全における骨格筋ミトコンドリア複合体IIの役割 (2020)
  • Author(s): 皆田崇照、髙田真吾、中村圭孝、前川 聡、絹川真太郎．
  • Organizer: 第39回日本臨床運動療法学会．
• [Presentation] 心筋ミトコンドリア複合体II機能は複合体I機能に匹敵する (2020)
  • Author(s): 中村圭孝、髙田真吾、皆田崇照、前川 聡、絹川真太郎
  • Organizer: 第39回日本臨床運動療法学会．
• [Presentation] 心不全患者における骨格筋輝度は運動耐容能と関連する (2019)
  • Author(s): 髙田真吾、福島 新、仲野一平、角谷尚哉、横田 卓、沖田孝一、絹川真太郎
  • Organizer: 第38回日本臨床運動療法学会学術集会
• [Presentation] 虚血プレコンディショニングが連続跳躍運動へ与える影響 (2019)
  • Author(s): 皆田崇照、髙田真吾、森田憲輝、石原 暢、苫米地伸泰、沖田孝一
  • Organizer: 第38回日本臨床運動療法学会学術集会
• [Presentation] 心不全の骨格筋異常発症におけるキサンチンオキダーゼの役割 (2019)
  • Author(s): 髙田真吾、南部秀雄、前川 聡、松本純一、角谷尚哉、絹川真太郎
  • Organizer: 第25回日本心臓リハビリテーション学術集会
• [Presentation] Empagliflozin restores lowered exercise endurance capacity via the activation of skeletal muscle fatty acid oxidation in murine heart failure (2019)
  • Author(s): Hideo Nambu, Shingo Takada, Arata Fukushima, Naoya Kakutani, Satoshi Maekawa, Ryosuke Shirakawa, Takaaki Furihata, Akimichi Saito, Takashi Yokota, Shintaro Kinugawa
  • Organizer: The 92nd Scientific Session of American Heart Association
  • Int'l Joint Research
• [Presentation] Linoleic acid improves assembly of the complex II subunit and complex III/IV complex of the mitochondrial oxidative phosphorylation system in heart failure (2019)
  • Author(s): Satoshi Maekawa, Shingo Takada, Hideo Nambu, Takaaki Furihata, Hisataka Sabe, Shintaro Kinugawa
  • Organizer: The 92nd Scientific Session of American Heart Association
  • Int'l Joint Research
• [Presentation] セッションテーマ：1S03m「ファンクショナルプロテオミクスの最前線 ~分子メカニズムの包括的解明から創薬へ~」「心不全における骨格筋由来分泌因子（マイオカイン）の役割－運動療法代替治療法の開発－」 (2019)
  • Author(s): 髙田真吾
  • Organizer: 第92回日本生化学学会大会
  • Invited
• [Presentation] 「未来の骨格筋治療の可能性に迫る」「心不全の骨格筋異常における治療法の開発」 (2019)
  • Author(s): 髙田真吾、角谷尚哉、絹川真太郎
  • Organizer: 第74回日本体力医学会大会
  • Invited
• [Presentation] mitoNEETにおけるミトコンドリア鉄制御による心不全発症・進展機序の解明 (2019)
  • Author(s): 髙田真吾
  • Organizer: 公益信託循環器学研究振興基金報告会
  • Invited
• [Presentation] 代謝制御による不全心筋ミトコンドリア治療法の開発 (2019)
  • Author(s): 髙田真吾
  • Organizer: Vascular Biology Innovationに関する研究助成（VBIC）
  • Invited
• [Presentation] 運動効果におけるマイオカインのエビデンス構築に向けた基盤研究 (2019)
  • Author(s): 髙田真吾、菅 唯志、棗 寿喜、橋本 亨、植田幸嗣
  • Organizer: 北海道大学COI拠点サイトビジット
  • Invited
• [Presentation] 代謝制御による不全心筋ミトコンドリア機能における治療法の開発 (2019)
  • Author(s): 髙田真吾
  • Organizer: 北海道大学医学研究院連携研究センター 研究成果発表会
  • Invited
• [Presentation] 食事・運動と抗老化・心不全予防（human biologyから見えてくること） (2019)
  • Author(s): 髙田真吾
  • Organizer: 一般社団法人日本がんと炎症・代謝研究会セミナー
  • Invited
• [Presentation] ジュニア期のスポーツ医学 (2019)
  • Author(s): 髙田真吾
  • Organizer: Hokkaido Junior Sports Club Association Coacher’s Seminar 2019
  • Invited
• [Book] スポーツ医科学によるアスリートの管理と支援「心不全の骨格筋異常におけるSGLT2阻害剤」 (2022)
  • Author(s): 1.髙田真吾
  • Total Pages: 4
  • Publisher: Precision Medicine
• [Book] Translational Cardiology―基礎から臨床へ―「慢性心不全における骨格筋異常」 (2021)
  • Author(s): 髙田真吾
  • Publisher: 心臓 53 (12)
• [Book] 心不全のミトコンドリア複合体会合不全を標的とした必須脂肪酸の有効性 (2020)
  • Author(s): 髙田真吾
  • Publisher: 地域ケアリング
• [Book] 心不全における骨格筋異常と治療法 (2020)
  • Author(s): 髙田真吾
  • Publisher: 細胞
• [Book] 心不全におけるミトコンドリア複合体の会合不全を標的としたΩ6脂肪酸による治療 (2020)
  • Author(s): 髙田真吾
  • Publisher: BIO Clinica
• [Book] 不全心筋におけるミトコンドリア複合体会合不全を標的としたΩ6脂肪酸による治療 (2020)
  • Author(s): 髙田真吾
  • Publisher: アグリバイオ
• [Book] 心不全のミトコンドリア複合体における会合不全を標的としたΩ脂肪酸による治療 (2020)
  • Author(s): 髙田真吾
  • Total Pages: 46
  • Publisher: Medical Science Digest
• [Book] 慢性腎臓病における身体活動と運動耐容能 (2020)
  • Author(s): 髙田真吾
  • Publisher: 腎と透析
• [Remarks] Frontiers in Sports and Active Livingにreviewが掲載
  • URL: https://www.health-medicine-science-pi-shingo-takada.com/
• [Remarks] Frontiers in Oncologyにreview articleが掲載
  • URL: https://www.health-medicine-science-pi-shingo-takada.com/
• [Remarks] Proc Natl Acad Sci U S A（PNAS）にoriginal articleが掲載
  • URL: https://www.health-medicine-science-pi-shingo-takada.com/
• [Remarks] iScienceにoriginal articleが掲載
  • URL: https://www.health-medicine-science-pi-shingo-takada.com/
• [Remarks] Am J Physiol Heart Circ PhysiolにReview articleが掲載
  • URL: https://www.health-medicine-science-pi-shingo-takada.com/
• [Remarks] Youtube
  • URL: https://www.youtube.com/channel/UCGLnhgNgW6Cs63Ytx2QqT7w
• [Remarks] 髙田真吾 - 北翔大学 ”健康医科学”研究室 ホームページ
  • URL: https://health-medicine-science-pi-shingo-takada.com/
• [Remarks] スポーツ教育学科髙田真吾講師らによる原著論文が「Circ Heart Fail」に掲載されました
  • URL: https://www.hokusho-u.ac.jp/info/?i=2763
• [Remarks] スポーツ教育学科講師 髙田真吾らによる原著論文が、「Sci Rep」に掲載されました
  • URL: https://www.hokusho-u.ac.jp/info/?i=2769
• [Remarks] 「Mol Ther Nucleic Acids.」に髙田真吾らによる原著論文が掲載されました。
  • URL: https://www.hokusho-u.ac.jp/info/?i=2501&cat=20
• [Remarks] スポーツ教育学科講師髙田真吾らによる原著論文が「Eur J Pharmacol.」に掲載されました
  • URL: https://www.hokusho-u.ac.jp/info/?i=2496&cldcat=131
• [Remarks] スポーツ教育学科髙田真吾講師が「第26回日本心臓リハビリテーション学会」で発表
  • URL: https://www.hokusho-u.ac.jp/info/?i=2457&cldcat=132
• [Remarks] スポーツ教育学科髙田真吾講師が「第39回日本臨床運動療法学会学術集会シンポジウム」で発表
  • URL: https://www.hokusho-u.ac.jp/info/?i=2458&cldcat=132
• [Remarks] スポーツ教育学科髙田真吾講師が「第75回日本体力医学会大会シンポジウム」で発表
  • URL: https://www.hokusho-u.ac.jp/info/?i=2459&cldcat=132
• [Remarks] スポーツ教育学科講師 髙田真吾らによる原著論文が、「J Card Fail.」に掲載されました。
  • URL: https://www.hokusho-u.ac.jp/info/?i=2498&cldcat=131
• [Remarks] 「第92回アメリカ心臓学会」の参加報告
  • URL: https://www.hokusho-u.ac.jp/info/?i=2193&cat=5
• [Remarks] 「Cell communication and signaling」に髙田真吾講師らの研究が原著論文
  • URL: https://www.hokusho-u.ac.jp/info/?i=2158&cat=5
• [Remarks] 「第74回日本体力医学会大会」で発表と受賞の報告
  • URL: https://www.hokusho-u.ac.jp/info/?i=2140&cat=5
• [Remarks] 髙田真吾講師らの研究が「European Journal of Pharmacology」に原著論文
  • URL: https://www.hokusho-u.ac.jp/info/?i=2138&cat=5
• [Remarks] 「第92回日本生化学学会大会」で髙田真吾講師がシンポジストとして発表しました！
  • URL: https://www.hokusho-u.ac.jp/info/?i=2121&cat=5
• [Patent(Industrial Property Rights)] 心不全の病態の評価法 (2019)
  • Inventor(s): 髙田真吾、前川 聡、佐邊壽孝、横田 卓、白川亮介
  • Industrial Property Rights Holder: 髙田真吾、前川 聡、佐邊壽孝、横田 卓、白川亮介
  • Industrial Property Rights Type: 特許
  • Filing Date: 2019
  • Overseas