Development of novel stroke-oriented nutrition science based on the regulation of neuroinflammation
| Project/Area Number |
19K22813
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| Research Category |
Grant-in-Aid for Challenging Research (Exploratory)
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| Allocation Type | Multi-year Fund |
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| Review Section |
Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
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| Research Institution | Kumamoto University |
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Principal Investigator |
Katsuki Hiroshi 熊本大学, 大学院生命科学研究部(薬), 教授 (40240733)
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| Project Period (FY) |
2019-06-28 – 2022-03-31
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| Project Status |
Completed (Fiscal Year 2021)
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| Budget Amount *help |
¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2021: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2020: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2019: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 脳神経疾患 / ビタミンA / レチノイド / トリプトファン / 神経保護 / 脳内炎症 / 脳出血 / ビタミンＡ / 炎症応答 / 強化補給 |
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| Outline of Research at the Start |
脳内出血は脳卒中のなかでも予後不良となる率が高く、適切な医療介入法の開拓が望まれている疾患である。脳内出血の病理形成過程には脳組織内における炎症応答が深く関わることを踏まえ、本研究では食事性に摂取される物質やその代謝物の炎症制御効果に焦点を当てる。特定のビタミン・アミノ酸・タンパク質の強化補給の効能に関する科学的証拠を集積し、旧来のカロリー補給や電解質管理の枠を超えた新規の脳卒中栄養学の概念を創出する。
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| Outline of Final Research Achievements |
This study addressed the effects of metabolites of dietary vitamins and amino acids on the pathogenic events of intracerebral hemorrhage (ICH) in experimental animals. Results showed that supplementation of vitamin A ameliorated motor dysfunction associated with ICH. Mechanisms of neuroprotection and suppression of neuroinflammation by several vitamin A-related compounds were also revealed in this study. Additionally, a tryptophan metabolite was found to produce therapeutic effect on ICH.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究は、脳内炎症の制御に焦点を当てて食事由来成分の効果を明らかにすることで、脳疾患治療に最適化された栄養管理・強化補給法の確立に資することを目指した。脳内出血に対する食事性強化補給法の確立において重要となるビタミンおよびアミノ酸代謝物の効力の一端を明らかにしたことで、カロリー補給や体液平衡維持といった従来の栄養管理の枠組みを超えた新たな視点からの「脳卒中栄養学」の創出に寄与するものである。
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Report
(4 results)
Research Products
(60 results)
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[Journal Article] Modular head-mounted cortical imaging device for chronic monitoring of intrinsic signals in mice.2022
Author(s)
Guinto MC, Haruta M, Kurauchi Y, Saigo T, Kurasawa K, Ryu S, Ohta Y, Kawahara M, Takehara H, Tashiro H, Sasagawa K, Katsuki H, Ohta J.
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Journal Title
J Biomed Opt.
Volume: 27
Issue: 02
Pages: 026501-026501
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Treadmill Exercise During Cerebral Hypoperfusion Has Only Limited Effects on Cognitive Function in Middle-Aged Subcortical Ischemic Vascular Dementia Mice.2021
Author(s)
Ohtomo R, Ishikawa H, Kinoshita K, Chung KK, Hamanaka G, Ohtomo G, Takase H, Wrann CD, Katsuki H, Iwata A, Lok J, Lo EH, Arai K.
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Journal Title
Front Aging Neurosci.
Volume: 13
Pages: 756537-756537
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Treadmill Exercise Suppresses Cognitive Decline and Increases White Matter Oligodendrocyte Precursor Cells in a Mouse Model of Prolonged Cerebral Hypoperfusion.2020
Author(s)
Ohtomo R, Kinoshita K, Ohtomo G, Takase H, Hamanaka G, Washida K, Islam MR, Wrann CD, Katsuki H, Iwata A, Lok J, Lo EH, Arai K.
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Journal Title
Transl Stroke Res.
Volume: －
Issue: 3
Pages: 496-502
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Antileukemic Activity of Twig Components of Caucasian Beech in Turkey2019
Author(s)
Shida Wataru、Tateishi Hiroshi、Tahara Yurika、Fujita Mikako、Husham Majeed Alsaadi Doaa、Watanabe Masato、Koga Ryoko、Radwan Mohamed O.、Ciftci Halil I.、Gezici Sevgi、Kurauchi Yuki、Katsuki Hiroshi、Otsuka Masami、Sugimura Koji、Wada Mikiyo、Sekeroglu Nazim、Watanabe Takashi
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Journal Title
Molecules
Volume: 24
Issue: 21
Pages: 3850-3850
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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