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Inter-organ network between gastrointestine and skeletal muscle on the regulation of skeletal muscle mass and function

Research Project

Project/Area Number 19K22825
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Review Section Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
Research InstitutionToyohashi Sozo University

Principal Investigator

Goto Katsumasa  豊橋創造大学, 保健医療学部, 教授 (70239961)

Project Period (FY) 2019-06-28 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2020: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2019: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Keywords臓器間ネットワーク / 消化管ホルモン / 骨格筋 / 胃抑制性ペプチド / gastrointestinal hormone / inter-organ network / skeletal muscle / GIP
Outline of Research at the Start

最近、臓器・組織間の連関・相互作用「臓器間ネットワーク」による生体諸機能の調節機構の存在が明らかになったが、骨格筋細胞と消化管ホルモン間の臓器間ネットワークの存在は不明である。そこで本研究では、骨格筋量を調節における消化管ホルモン胃抑制性ポリペプチド(gastric inhibitory polypeptide: GIP)」の役割を解明し、経口の食事の新たな生理学的意義を提示することを目的とする。

Outline of Final Research Achievements

Recent literatures suggest an interorgan communication network between skeletal muscle and gastric, since the receptor of GIP (GIPR) expresses in not only a gastrointestinal tract but also skeletal muscle cells. The purpose of this study was to investigate the effects of gastric inhibitory peptide (GIP) on myogenic differentiation, overload-associated hypertrophy, and unloading-associated atrophy of mouse skeletal muscle, and to elucidate a physiological role of oral diet, which stimulates the endocrine of GIP in the regulation of skeletal muscle function. GIP stimulates myogenic differentiation of C2C12 cells. Further GIP attenuates a slow-to-fast transition of myosin heavy chain phenotypes in unloading-associated muscle atrophy via upregulation of nuclear factor of activated T-cells (NFAT) c2. Evidences from this study suggest oral diet that stimulates the endocrine of GIP facilitates skeletal muscle hypertrophy.

Academic Significance and Societal Importance of the Research Achievements

食事により分泌されるGIPは消化吸収機能の制御に関与するのみと考えられてきたが、本研究により骨格筋量の調節においても役割を担っていることが明らかになった。経口の食事を摂るという行為自体が、GIPなどの消化管ホルモンを介して、健康寿命の延伸において重要な意味を持つという、経口の食事の新たな生理学的意義が示された。骨格筋萎縮対抗策の新たな標的になり得る食事に対するパラダイムシフトが必要であると考えている。

Report

(3 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • Research Products

    (26 results)

All 2021 2020 2019 Other

All Int'l Joint Research (1 results) Journal Article (8 results) (of which Peer Reviewed: 6 results,  Open Access: 5 results) Presentation (17 results) (of which Int'l Joint Research: 3 results)

  • [Int'l Joint Research] Minnesota University(米国)

    • Related Report
      2019 Research-status Report
  • [Journal Article] MBNL1-Associated Mitochondrial Dysfunction and Apoptosis in C2C12 Myotubes and Mouse Skeletal Muscle2020

    • Author(s)
      Yokoyama Shingo、Ohno Yoshitaka、Egawa Tatsuro、Ohashi Kazuya、Ito Rika、Ortuste Quiroga Huascar Pedro、Yamashita Tomohiro、Goto Katsumasa
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 21 Issue: 17 Pages: 6376-6376

    • DOI

      10.3390/ijms21176376

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Involvement of receptor for advanced glycation end products in microgravity-induced skeletal muscle atrophy in mice2020

    • Author(s)
      Egawa Tatsuro、Kido Kohei、Yokokawa Takumi、Fujibayashi Mami、Goto Katsumasa、Hayashi Tatsuya
    • Journal Title

      Acta Astronautica

      Volume: 176 Pages: 332-340

    • DOI

      10.1016/j.actaastro.2020.07.002

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Roles of satellite cells and/or myonuclei in the regulation of morphological properties of anti-gravitational skeletal muscle in response to mechanical stress2020

    • Author(s)
      Ohira Takashi、Kawano Fuminori、Ozaki Yusaku、Fukuda Shunya、Goto Katsumasa、Ohira Yoshinobu
    • Journal Title

      Biological Sciences in Space

      Volume: 34 Issue: 0 Pages: 1-11

    • DOI

      10.2187/bss.34.1

    • NAID

      130007869214

    • ISSN
      0914-9201, 1349-967X
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Role of active plantar-flexion and/or passive dorsi-flexion of ankle joints as the countermeasure for unloading-related effects in human soleus2020

    • Author(s)
      Okabe Hirooki、Ohira Takashi、Kawano Fuminori、Ohira Luna、Ohira Tomohiro、Kamibayashi Kiyotaka、Goto Katsumasa、Naito Hisashi、Ohira Yoshinobu
    • Journal Title

      Acta Astronautica

      Volume: 175 Pages: 174-178

    • DOI

      10.1016/j.actaastro.2020.05.057

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Role(s) of gravitational loading on the growth and development of neuromuscular propertiesIES2020

    • Author(s)
      Kawano Fuminori、Ohira Takashi、Goto Katsumasa、Ohira Yoshinobu
    • Journal Title

      Aerospace and Environmental Medicine

      Volume: 54 Issue: 6 Pages: 73-79

    • DOI

      10.21687/0233-528x-2020-54-6-73-79

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 筋トレの生化学:筋肥大のメカニズム2020

    • Author(s)
      後藤勝正
    • Journal Title

      臨床リハビリテーション

      Volume: 29 Pages: 116-122

    • Related Report
      2019 Research-status Report
  • [Journal Article] The Protective Effect of Brazilian Propolis against Glycation Stress in Mouse Skeletal Muscle2019

    • Author(s)
      Egawa T, Ohno Y, Yokoyama S, Yokokawa T, Tsuda S, Goto K, Hayashi T.
    • Journal Title

      Foods

      Volume: 8 Issue: 10 Pages: 439-439

    • DOI

      10.3390/foods8100439

    • NAID

      120006766120

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 宇宙医学研究からロコモティブシンドロームを解明する2019

    • Author(s)
      後藤勝正
    • Journal Title

      整形災害外科

      Volume: 62 Pages: 763-770

    • Related Report
      2019 Research-status Report
  • [Presentation] 微小重力および老化による骨格筋萎縮における糖化ストレス応答の差異2021

    • Author(s)
      江川達郎、木戸康平、横川拓海、後藤勝正、林達也
    • Organizer
      第66回日本宇宙航空環境医学会大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] The effect of glycation state on training effect in young male2020

    • Author(s)
      Egawa Tatsuro、Fujibayashi Mami、Ito Rika, Goto Katsumasa、Hayashi Tatsuya
    • Organizer
      第75回日本体力医学会大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 廃用性筋萎縮進行におけるRAGEシグナルの関与2020

    • Author(s)
      江川達郎、横川拓海、木戸康平、後藤勝正、林達也
    • Organizer
      第93回日本生化学会大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] The effect of glycation stress on strength-enhancing effect of resistance training in young male2020

    • Author(s)
      Egawa Tatsuro、Fujibayashi Mami、Ito Rika、Goto Katsumasa、Hayashi Tatsuya
    • Organizer
      American Physiological Society (APS) Integrative Physiology of Exercise
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 乳酸受容体刺激が骨格筋量に及ぼす影響2020

    • Author(s)
      大野善隆,須田陽平,安藤孝輝,松井佑樹,伊藤貴史,金子陽加里,大山明子,横山真吾,江川達郎,後藤勝正
    • Organizer
      第24回日本体力医学会東海地方会学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] A possible of gastric inhibitory polypeptide in the regulation of skeletal muscle mass2020

    • Author(s)
      Goto, K., Aoshima, M., Hagiwara, A., Yamashita, T., Ortuste Quiroga, H.P., Yokoyama, S.
    • Organizer
      第97回日本生理学会大会
    • Related Report
      2019 Research-status Report
  • [Presentation] 持続的なTRPV4チャネルの活性化と不活性化による筋管細胞の適応2019

    • Author(s)
      萩原ありさ,山下智大,Ortuste Quiroga, H.P.,伊藤理香,大野善隆,横山真吾,後藤勝正
    • Organizer
      第74回日本体力医学会大会
    • Related Report
      2019 Research-status Report
  • [Presentation] 筋細胞の分化におけるHSP70特異的核輸送体Hikeshiの役割2019

    • Author(s)
      山下智大,Ortuste Quiroga, H.P.,萩原ありさ,横山真吾,大野善隆,杉浦崇夫,大平充宣,吉岡利忠,後藤勝正
    • Organizer
      第74回日本体力医学会大会
    • Related Report
      2019 Research-status Report
  • [Presentation] Some aspects of mechanosensitive ion channels in myogenesis2019

    • Author(s)
      Ortuste Quiroga, H.P., Yamashita, Y., Hagiwara, A., Yokoyama, S., Suzuki, Y., Tominaga, M., Goto, K.
    • Organizer
      第74回日本体力医学会大会
    • Related Report
      2019 Research-status Report
  • [Presentation] 自発走運動によるマウス骨格筋適応に対する糖化ストレスの影響2019

    • Author(s)
      江川達郎,大野善隆,横山真吾,小川岳史,後藤勝正,林達也
    • Organizer
      第74回日本体力医学会大会
    • Related Report
      2019 Research-status Report
  • [Presentation] 長期間の機能的過負荷による筋サテライト細胞と筋タンパク合成シグナルの変化2019

    • Author(s)
      杉浦崇夫,森廣壮馬,芝口翼,内藤久士,後藤勝正,吉岡利忠
    • Organizer
      第74回日本体力医学会大会
    • Related Report
      2019 Research-status Report
  • [Presentation] Functional properties of a novel mechanosensitive Ca2+-permeable channel in mouse muscle satellite cells2019

    • Author(s)
      Ortuste Quiroga, H.P., Yamashita, T., Hagiwara, A., Yokoyama, S., Suzuki, Y., Tominaga, M., Goto, K.
    • Organizer
      Frontiers in Myogenesis, Skeletal Muscle: Development, Regeneration and Disease
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] HSP70-specific nuclear transporter Hikeshi in myogenic differentiation2019

    • Author(s)
      Yamashita, T., Ortuste Quiroga, H.P., Hagiwara, A., Yokoyama, S., Ohno, Y., Sugiura, T., Ohira, Y., Yoshioka, T., Goto, K.
    • Organizer
      Frontiers in Myogenesis, Skeletal Muscle: Development, Regeneration and Disease
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] ACL断裂症例のオーダーメイドリハプログラムの実現に向けて(第6報)-筋線維タイプからみた至適な手術日-2019

    • Author(s)
      小林哲士,植原健二,木城智,皆川直毅,鈴木智裕,小倉裕司,黒坂光寿,後藤勝正,仁木久照
    • Organizer
      第34回日本整形外科学会基礎学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] 骨格筋由来乳酸による骨格筋量調整に関する基礎的研究2019

    • Author(s)
      大野善隆,伊藤貴史,松井佑樹,安藤孝輝,須田陽平,横山真吾,後藤勝正
    • Organizer
      第24回日本基礎理学療法学会学術大会
    • Related Report
      2019 Research-status Report
  • [Presentation] 骨格筋細胞可塑性発現におけるTRPV4と機械的刺激の受容2019

    • Author(s)
      萩原ありさ,大野善隆,横山真吾,後藤勝正
    • Organizer
      第65回日本宇宙航空環境医学会大会
    • Related Report
      2019 Research-status Report
  • [Presentation] 後肢懸垂時に発生する糖化ストレスによるマウスヒラメ筋萎縮への影響2019

    • Author(s)
      江川達郎,横川拓海,木戸康平,後藤勝正,林達也
    • Organizer
      第65回日本宇宙航空環境医学会大会
    • Related Report
      2019 Research-status Report

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Published: 2019-07-04   Modified: 2022-01-27  

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