Development of in vivo cortical segmental mapping using 7 tesla ultra-high field MRI
| Project/Area Number |
19K22985
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| Research Category |
Grant-in-Aid for Challenging Research (Exploratory)
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| Allocation Type | Multi-year Fund |
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| Review Section |
Medium-sized Section 90:Biomedical engineering and related fields
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| Research Institution | National Institute for Physiological Sciences |
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Principal Investigator |
Fukunaga Masaki 生理学研究所, システム脳科学研究領域, 准教授 (40330047)
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| Co-Investigator(Kenkyū-buntansha) |
梅田 雅宏 明治国際医療大学, 医学教育研究センター, 教授 (60223608)
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| Project Period (FY) |
2019-06-28 – 2022-03-31
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| Project Status |
Completed (Fiscal Year 2021)
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| Budget Amount *help |
¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2020: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2019: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
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| Keywords | ７テスラMRI / 髄鞘密度 / 大脳皮質 / 高分解能MRI / 磁化率 / 7テスラMRI / 皮質分節 / 拡散 / ミエリン |
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| Outline of Research at the Start |
レイヤーレベルの大脳皮質髄鞘密度を反映するMyeloarchitectonic imaging法の開発と、個人脳データに基づく脳アトラス構築のために、①皮質内髄鞘分布を高度に反映する定量的磁化率画像および緩和画像の開発、②細胞微細形状計測に特化した拡散画像法の開発と7テスラ超高磁場MRIへの導入、③定量的磁化率画像、緩和画像および拡散画像から髄鞘密度分布様態を画像化、④Myeloarchitectonic imagingによる大脳皮質髄鞘密度分布解析と皮質分節再構築、の４課題を実施する。これらにより、個体レベルのデータから髄鞘分布形態に由来する大脳皮質分節マップの再構築を目指す。
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| Outline of Final Research Achievements |
The development of a multi-echo gradient echo for deriving quantitative magnetic susceptibility and T2*-relaxation time images specialized for microstructure in the cortex, and the development of an imaging technique for separately delineating paramagnetic and diamagnetic magnetic susceptibilities required to separate and identify myelin and iron in tissues. The proposed method significantly reduces the artifacts by maintaining the readout gradient scheme between echoes in the mirroring/balanced relationship. In the latter, a model separating paramagnetic and diamagnetic susceptibilities was generated from the frequency shift and R2' relaxation time, enabling the acquisition of diamagnetic susceptibility images highly consistent with intraparenchymal myelin distributions obtained from stained images of tissue specimens.
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| Academic Significance and Societal Importance of the Research Achievements |
従来の脳画像は、脳の大局的な形状（脳回や脳溝形状、体積や厚さなど）から異常を見出すことを目的とされてきた。しかし、脳の機能局在を示す脳領野は、大脳皮質のメゾスコピックな微細構造形状に基づくため、これらの描出技術が望まれる。本研究では、ヒト生体に応用可能な磁気共鳴法を用いて脳内の微細構造描出技術を開発した。本成果は、脳研究の発展のみならず、神経疾患の病態メカニズム探索にも応用可能と考えられる。
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Report
(4 results)
Research Products
(53 results)
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[Journal Article] Relationship between white matter microstructure and work hours2021
Author(s)
Matsumoto Junya、Fukunaga Masaki、Miura Kenichiro、Nemoto Kiyotaka、Koshiyama Daisuke、Okada Naohiro、Morita Kentaro、Yamamori Hidenaga、Yasuda Yuka、Fujimoto Michiko、Hasegawa Naomi、Watanabe Yoshiyuki、Kasai Kiyoto、Hashimoto Ryota
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Journal Title
Neuroscience Letters
Volume: 740
Pages: 135428-135428
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Promoter Activity-Based Case-Control Association Study on SLC6A4 Highlighting Hypermethylation and Altered Amygdala Volume in Male Patients With Schizophrenia2020
Author(s)
Ikegame T, Bundo M, Okada N, Murata Y, Koike S, Sugawara H, Saito T, Ikeda M, Owada K, Fukunaga M, Yamashita F, Koshiyama D, Natsubori T, Iwashiro N, Asai T, Yoshikawa A, Nishimura F, Kawamura Y, Ishigooka J, Kakiuchi C, Sasaki T, Abe O, Hashimoto R, Iwata N, Yamasue H, Kato T, Kasai K, Iwamoto K
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Journal Title
Schizophrenia Bulletin
Volume: 46
Issue: 6
Pages: 1577-1586
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Differentiation of schizophrenia using structural MRI with consideration of scanner differences: A real-world multi-site study.2020
Author(s)
Nemoto K, Shimokawa T, Fukunaga M, Yamashita F, Tamura M, Yamamori H, Yasuda Y, Azechi H, Kudo N, Watanabe Y, Kido M, Takahashi T, Koike S, Okada N, Hirano Y, Onitsuka T, Yamasue H, Suzuki M, Kasai K, Hashimoto R, Arai T.
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Journal Title
Psychiatry Clin Neurosci
Volume: 74(1)
Issue: 1
Pages: 56-63
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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