Development of in vivo cortical segmental mapping using 7 tesla ultra-high field MRI

• Project/Area Number: 19K22985
• Research Category: Grant-in-Aid for Challenging Research (Exploratory)
• Allocation Type: Multi-year Fund
• Review Section: Medium-sized Section 90:Biomedical engineering and related fields
• Research Institution: National Institute for Physiological Sciences
• Principal Investigator: Fukunaga Masaki 生理学研究所, システム脳科学研究領域, 准教授 (40330047)
• Co-Investigator(Kenkyū-buntansha): 梅田 雅宏 明治国際医療大学, 医学教育研究センター, 教授 (60223608)
• Project Period (FY): 2019-06-28 – 2022-03-31
• Project Status: Completed (Fiscal Year 2021)
• Budget Amount: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000); Fiscal Year 2020: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000); Fiscal Year 2019: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
• Keywords: ７テスラMRI / 髄鞘密度 / 大脳皮質 / 高分解能MRI / 磁化率 / 7テスラMRI / 皮質分節 / 拡散 / ミエリン

Outline of Research at the Start

レイヤーレベルの大脳皮質髄鞘密度を反映するMyeloarchitectonic imaging法の開発と、個人脳データに基づく脳アトラス構築のために、①皮質内髄鞘分布を高度に反映する定量的磁化率画像および緩和画像の開発、②細胞微細形状計測に特化した拡散画像法の開発と7テスラ超高磁場MRIへの導入、③定量的磁化率画像、緩和画像および拡散画像から髄鞘密度分布様態を画像化、④Myeloarchitectonic imagingによる大脳皮質髄鞘密度分布解析と皮質分節再構築、の４課題を実施する。これらにより、個体レベルのデータから髄鞘分布形態に由来する大脳皮質分節マップの再構築を目指す。

Outline of Final Research Achievements

The development of a multi-echo gradient echo for deriving quantitative magnetic susceptibility and T2*-relaxation time images specialized for microstructure　in the cortex, and the development of an imaging technique for separately delineating paramagnetic and diamagnetic magnetic susceptibilities required to separate and identify myelin and iron in tissues. The proposed method significantly reduces the artifacts by maintaining the readout gradient scheme between echoes in the mirroring/balanced relationship. In the latter, a model separating paramagnetic and diamagnetic susceptibilities was generated from the frequency shift and R2' relaxation time, enabling the acquisition of diamagnetic susceptibility images highly consistent with intraparenchymal myelin distributions obtained from stained images of tissue specimens.

Academic Significance and Societal Importance of the Research Achievements

従来の脳画像は、脳の大局的な形状（脳回や脳溝形状、体積や厚さなど）から異常を見出すことを目的とされてきた。しかし、脳の機能局在を示す脳領野は、大脳皮質のメゾスコピックな微細構造形状に基づくため、これらの描出技術が望まれる。本研究では、ヒト生体に応用可能な磁気共鳴法を用いて脳内の微細構造描出技術を開発した。本成果は、脳研究の発展のみならず、神経疾患の病態メカニズム探索にも応用可能と考えられる。

Research Products

• [Int'l Joint Research] Seoul National University(韓国)
• [Int'l Joint Research] NeuroSpin(フランス)
• [Int'l Joint Research] Maastricht University(オランダ)
• [Int'l Joint Research] National Institutes for Health/University of Minnesota(米国)
• [Int'l Joint Research] National Health Research Institutes(その他の国・地域)
• [Int'l Joint Research] Seoul National University(韓国)
• [Int'l Joint Research] NeuroSpin(フランス)
• [Int'l Joint Research] Maastricht University(オランダ)
• [Int'l Joint Research] National Institutes for Health/University of Minnesota(米国)
• [Int'l Joint Research] National Health Research Institutes(その他の国・地域)
• [Journal Article] Layer-specific activation in human primary somatosensory cortex during tactile temporal prediction error processing (2022)
  • Author(s): Yu Yinghua、Huber Laurentius、Yang Jiajia、Fukunaga Masaki、Chai Yuhui、Jangraw David C.、Chen Gang、Handwerker Daniel A.、Molfese Peter J.、Ejima Yoshimichi、Sadato Norihiro、Wu Jinglong、Bandettini Peter A.
  • Journal Title: NeuroImage Volume: 248 Pages: 118867-118867
  • DOI: 10.1016/j.neuroimage.2021.118867
  • NAID: 120007188347
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] χ-separation: Magnetic susceptibility source separation toward iron and myelin mapping in the brain (2021)
  • Author(s): Shin Hyeong-Geol、Lee Jingu、Yun Young Hyun、Yoo Seong Ho、Jang Jinhee、Oh Se-Hong、Nam Yoonho、Jung Sehoon、Kim Sunhye、Fukunaga Masaki、Kim Woojun、Choi Hyung Jin、Lee Jongho
  • Journal Title: NeuroImage Volume: 240 Pages: 118371-118371
  • DOI: 10.1016/j.neuroimage.2021.118371
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The integrative role of the M1 in motor sequence learning (2021)
  • Author(s): Hamano Yuki H.、Sugawara Sho K.、Fukunaga Masaki、Sadato Norihiro
  • Journal Title: Neuroscience Letters Volume: 760 Pages: 136081-136081
  • DOI: 10.1016/j.neulet.2021.136081
  • Peer Reviewed / Open Access
• [Journal Article] Cognitive control affects motor learning through local variations in GABA within the primary motor cortex (2021)
  • Author(s): Maruyama Shuki、Fukunaga Masaki、Sugawara Sho K.、Hamano Yuki H.、Yamamoto Tetsuya、Sadato Norihiro
  • Journal Title: Scientific Reports Volume: 11 Issue: 1 Pages: 18566-18566
  • DOI: 10.1038/s41598-021-97974-1
  • Peer Reviewed / Open Access
• [Journal Article] Association Study Between White Matter Microstructure and Intelligence Decline in Schizophrenia (2021)
  • Author(s): Matsumoto Junya、Miura Kenichiro、Fukunaga Masaki、Nemoto Kiyotaka、Koshiyama Daisuke、Okada Naohiro、Morita Kentaro、Yamamori Hidenaga、Yasuda Yuka、Fujimoto Michiko、Ito Satsuki、Hasegawa Naomi、Watanabe Yoshiyuki、Kasai Kiyoto、Hashimoto Ryota
  • Journal Title: Clinical EEG and Neuroscience Volume: in press Issue: 6 Pages: 0-0
  • DOI: 10.1177/15500594211063314
  • Peer Reviewed
• [Journal Article] Vestibular Morphological Asymmetry Associated With Motion Sickness Susceptibility (2021)
  • Author(s): Harada Takumi、Sugawara Tomoko、Ito Taeko、Wada Yoshiro、Fukunaga Masaki、Sadato Norihiro、Larroque Stephen K.、Demertzi Athena、Laureys Steven、Sakai Hiroyuki
  • Journal Title: Frontiers in Neuroscience Volume: 15 Pages: 763040-763040
  • DOI: 10.3389/fnins.2021.763040
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Relationship between white matter microstructure and work hours (2021)
  • Author(s): Matsumoto Junya、Fukunaga Masaki、Miura Kenichiro、Nemoto Kiyotaka、Koshiyama Daisuke、Okada Naohiro、Morita Kentaro、Yamamori Hidenaga、Yasuda Yuka、Fujimoto Michiko、Hasegawa Naomi、Watanabe Yoshiyuki、Kasai Kiyoto、Hashimoto Ryota
  • Journal Title: Neuroscience Letters Volume: 740 Pages: 135428-135428
  • DOI: 10.1016/j.neulet.2020.135428
  • Peer Reviewed / Open Access
• [Journal Article] Quantitative Evaluations of Geometrical Distortion Corrections in Cortical Surface‐Based Analysis of High‐Resolution Functional MRI Data at 7T (2020)
  • Author(s): Yamamoto Tetsuya、Fukunaga Masaki、Sugawara Sho K.、Hamano Yuki H.、Sadato Norihiro
  • Journal Title: Journal of Magnetic Resonance Imaging Volume: 53 Issue: 4 Pages: 1220-1234
  • DOI: 10.1002/jmri.27420
  • Peer Reviewed / Open Access
• [Journal Article] Differences in fractional anisotropy between the patients with schizophrenia and healthy comparison subjects. (2020)
  • Author(s): Koshiyama D, Fukunaga M, Okada N, Morita K, Nemoto K, Usui K, Yamamori H, Yasuda Y, Fujimoto M, et al.
  • Journal Title: Mol Psychiatry Volume: 25(4) Issue: 4 Pages: 697-698
  • DOI: 10.1038/s41380-020-0700-1
  • NAID: 120006950307
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Neuroimaging studies within Cognitive Genetics Collaborative Research Organization aiming to replicate and extend works of ENIGMA (2020)
  • Author(s): Koshiyama Daisuke、Miura Kenichiro、Nemoto Kiyotaka、Okada Naohiro、Matsumoto Junya、Fukunaga Masaki、Hashimoto Ryota
  • Journal Title: Human Brain Mapping Volume: in press Issue: 1 Pages: 182-193
  • DOI: 10.1002/hbm.25040
  • NAID: 120007180728
  • Peer Reviewed / Open Access
• [Journal Article] Promoter Activity-Based Case-Control Association Study on SLC6A4 Highlighting Hypermethylation and Altered Amygdala Volume in Male Patients With Schizophrenia (2020)
  • Author(s): Ikegame T, Bundo M, Okada N, Murata Y, Koike S, Sugawara H, Saito T, Ikeda M, Owada K, Fukunaga M, Yamashita F, Koshiyama D, Natsubori T, Iwashiro N, Asai T, Yoshikawa A, Nishimura F, Kawamura Y, Ishigooka J, Kakiuchi C, Sasaki T, Abe O, Hashimoto R, Iwata N, Yamasue H, Kato T, Kasai K, Iwamoto K
  • Journal Title: Schizophrenia Bulletin Volume: 46 Issue: 6 Pages: 1577-1586
  • DOI: 10.1093/schbul/sbaa075
  • Peer Reviewed / Open Access
• [Journal Article] Is Human Brain Activity During Driving Operations Modulated by the Viscoelastic Characteristics of a Steering Wheel?: An fMRI Study (2020)
  • Author(s): Okamoto Yoshihisa、Sasaoka Takafumi、Sadato Norihiro、Fukunaga Masaki、Yamamoto Tetsuya、Soh Zu、Nouzawa Takahide、Yamawaki Shigeto、Tsuji Toshio
  • Journal Title: IEEE Access Volume: 8 Pages: 215073-215090
  • DOI: 10.1109/access.2020.3040231
  • Peer Reviewed / Open Access
• [Journal Article] Differentiation of schizophrenia using structural MRI with consideration of scanner differences: A real-world multi-site study. (2020)
  • Author(s): Nemoto K, Shimokawa T, Fukunaga M, Yamashita F, Tamura M, Yamamori H, Yasuda Y, Azechi H, Kudo N, Watanabe Y, Kido M, Takahashi T, Koike S, Okada N, Hirano Y, Onitsuka T, Yamasue H, Suzuki M, Kasai K, Hashimoto R, Arai T.
  • Journal Title: Psychiatry Clin Neurosci Volume: 74(1) Issue: 1 Pages: 56-63
  • DOI: 10.1111/pcn.12934
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] 超高磁場MRIによる脳機能イメージング -種間比較をめざして (2019)
  • Author(s): 定藤規弘、福永雅喜
  • Journal Title: 医学のあゆみ Volume: 270 Pages: 685-691
• [Journal Article] Comparison of 3T and 7T MRI for the visualization of globus pallidus sub-segments (2019)
  • Author(s): Maruyama Shuki、Fukunaga Masaki、Fautz Hans-Peter、Heidemann Robin、Sadato Norihiro
  • Journal Title: Scientific Reports Volume: 9 Issue: 1 Pages: 18357-18357
  • DOI: 10.1038/s41598-019-54880-x
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] White matter microstructural alterations across four major psychiatric disorders: mega-analysis study in 2937 individuals (2019)
  • Author(s): Koshiyama Daisuke、(他38名18番目）Yamamoto Meeri
  • Journal Title: Molecular Psychiatry Volume: 25 Issue: 4 Pages: 883-895
  • DOI: 10.1038/s41380-019-0553-7
  • NAID: 120006980539
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] Reproducibility evaluation on resolving complex fiber orientations using diffusion spectrum imaging at 3T and 7T (2021)
  • Author(s): Chen NH, Cho KH, Chao YP, Huang SM, Sadato N, Kuo LW, Fukunaga M
  • Organizer: 2021 ISMRM & SMRT Annual Meeting & Exhibition
  • Int'l Joint Research
• [Presentation] Layer-specific activation of prediction in the human midcingulate cortex (2021)
  • Author(s): Yang J, Fukunaga M, Yu Y,Huber L, Bandettini PA, Sadato N
  • Organizer: 2021 ISMRM & SMRT Annual Meeting & Exhibition
  • Int'l Joint Research
• [Presentation] Ultra high field functional-structural MRI analysis of neural basis of intentional sharing (2021)
  • Author(s): Fukunaga M
  • Organizer: 第44回日本神経科学大会
• [Presentation] 追跡眼球運動中の大脳皮質活動特性：円滑追跡眼球運動と衝動性眼球運動の比較 (2021)
  • Author(s): 三浦健一郎，山本哲也，松田圭司，松本純弥，橋本亮太，小野誠司，定藤規弘，福永雅喜
  • Organizer: 第44回日本神経科学大会
• [Presentation] 追跡眼球運動中の大脳皮質活動特性：円滑追跡眼球運動と衝動性眼球運動の比較 (2021)
  • Author(s): 中山義久，菅原翔，福永雅喜，濱野友希，定藤規弘，西村幸男
  • Organizer: 第44回日本神経科学大会
• [Presentation] 7T-MR装置を用いた1H-CSIによる脳の代謝物計測 (2021)
  • Author(s): 梅田雅宏, 福永雅喜, 定藤規弘, 渡辺康晴, 河合裕子, 村瀬智一, 樋口敏宏
  • Organizer: 第49回日本磁気共鳴医学会大会
• [Presentation] Inferotemporal Lobe High-Resolution fMRI at Ultra-High Field Using Multi-Shot EPI. (2021)
  • Author(s): Waggoner RA, Fukunaga M, Tanskanen T, Ueno K, Sadato N, Tanaka K
  • Organizer: 第49回日本磁気共鳴医学会大会
• [Presentation] ７テスラ超高磁場MRIによる脳イメージング (2021)
  • Author(s): 福永雅喜
  • Organizer: 第39回神経治療学会学術大会シンポジウム
• [Presentation] Orientation Distribution Function (ODF) based reproducibility in diffusion spectrum imaging (DSI) at 3T and 7T (2021)
  • Author(s): Chen NH, Cho KH, Chao YP, Huang SM, Sadato N, Kuo LW, Fukunaga M
  • Organizer: ISMRM Diffusion Study Group Trainee Day: 24 Hours of DIFFUSION Around the World!
  • Int'l Joint Research
• [Presentation] Quantitative Evaluations of Geometric Distortion Corrections in Surface-Based Analysis of 7T fMRI (2020)
  • Author(s): etsuya Yamamoto, Sho Sugawara, Yuki Hamano, Masaki Fukunaga, Norihiro Sadato
  • Organizer: 2020 Organization for Human Brain Mapping Annual Meeting
  • Int'l Joint Research
• [Presentation] Linking Multimodal Parcellation 1.0 of Human Connectome Project to MNI Coordinates (2020)
  • Author(s): Tetsuya Yamamoto, Masaki Fukunaga, Norihiro Sadato
  • Organizer: 2020 Organization for Human Brain Mapping Annual Meeting
  • Int'l Joint Research
• [Presentation] Parcellation of the human brain cortex using a model free, sparse acquisition diffusion MRI approach (S-index) (2020)
  • Author(s): Yamamoto, Tetsuya Fukunaga, Masaki Sadato, Norihiro Le Bihan, Denis
  • Organizer: 2020 ISMRM & SMRT VIRTUAL CONFERENCE & EXHIBITION
  • Int'l Joint Research
• [Presentation] Diurnal fluctuation of glutathione measured with MR spectroscopy (2020)
  • Author(s): Urayama, Shin-ichi Yoshihara, Yujiro Fukunaga, Masaki Murai, Toshiya
  • Organizer: 2020 ISMRM & SMRT VIRTUAL CONFERENCE & EXHIBITION
  • Int'l Joint Research
• [Presentation] 統合失調症のbiotypeである認知機能障害と大脳白質構造異常の関連 (2020)
  • Author(s): 松本純弥、三浦健一郎、坂元竜馬、福永雅喜、越山太輔、根本清貴、岡田直大、森田健太郎、大井一高、長谷川尚美、藤本美智子、山森英長、安田由華、笠井清登、渡邉嘉之、橋本亮太
  • Organizer: NPBPPP 2020 合同年会
• [Presentation] 統合失調症患者と健常被験者における拡散テンソル画像を用いた大脳白質微細構造と認知機能、認知機能障害、労働時間との関連 (2020)
  • Author(s): 松本純弥、三浦健一郎、福永雅喜、越山太輔、根本清貴、大井一高、岡田直大、長谷川尚美、山森英長、安田由華、藤本美智子、鬼塚俊明、高橋努、尾崎紀夫、渡邉嘉之、橋本亮太
  • Organizer: NPBPPP 2020 合同年会
• [Presentation] Kinetic Oscillatory Stimulation in the Nasal Cavity Elicits Functional Brain Activation in the Limbic System of the Brain (2020)
  • Author(s): Xia Li, Masaki Fukunaga, Tie-Qiang Li
  • Organizer: 11th Annual Scientific Symposium Ultrahigh Field Magnetic Resonance: Clinical Needs, Research Promises and Technical Solutions
  • Int'l Joint Research
• [Presentation] 7T-MRI装置におけるMP2RAGEを用いた視床内部構造の描出 (2020)
  • Author(s): 中根俊樹、福永雅喜、田岡俊昭、川井恒、加藤裕、櫻井康雄、長縄慎二
  • Organizer: 第48回日本磁気共鳴医学会大会
• [Presentation] Feasibility study on a single-channel microstrip transmission-line RF coil integrated with PET detector module for a 7T whole-body MRI system. Virtual (2020)
  • Author(s): Akram MSH, Fukunaga M, Nishikido F, Takyu S, Obata T, Yamaya T.
  • Organizer: 2020 IEEE Nuclear Science Symposiu & Medical Imaging Conference.
  • Int'l Joint Research
• [Presentation] Brain Microstructure and Function using Ultra High Field MRI (2020)
  • Author(s): Masaki Fukunaga
  • Organizer: The 10th BRI International Symposium
  • Int'l Joint Research / Invited
• [Presentation] Brain microstructure and function using ultra high field MRI (2019)
  • Author(s): Masaki Fukunaga
  • Organizer: 第42回日本神経科学大会
  • Invited
• [Presentation] 超高磁場MRIによる脳機能画像研究 (2019)
  • Author(s): 福永雅喜
  • Organizer: 第47回日本磁気共鳴医学会大会
  • Invited
• [Presentation] 7TMRIを用いたヒト淡蒼球内部構造の描出: 3T MRIとの比較 (2019)
  • Author(s): 丸山修紀、福永雅喜、定藤規弘
  • Organizer: 第47回日本磁気共鳴医学会大会
• [Presentation] 7T-MR装置を用いたCSIによる脳の代謝物計測 (2019)
  • Author(s): 梅田雅宏、福永雅喜、定藤規弘、渡辺康晴、河合裕子、村瀬智一、樋口敏宏
  • Organizer: 第47回日本磁気共鳴医学会大会
• [Presentation] Origins of phase contrast in white matter (2019)
  • Author(s): Masaki Fukunaga, Jeff Duyn
  • Organizer: 5th INTERNATIONAL WORKSHOP ON MRI PHASE CONTRAST & QUANTITATIVE SUSCEPTIBILITY MAPPING
  • Int'l Joint Research / Invited
• [Presentation] Separating positive and negative susceptibility sources in QSM (2019)
  • Author(s): Hyeong-Geol Shin, Jingu Lee, Masaki Fukunaga, Yoonho Nam, Se-Hong Oh, Jongho Lee
  • Organizer: 5th INTERNATIONAL WORKSHOP ON MRI PHASE CONTRAST & QUANTITATIVE SUSCEPTIBILITY MAPPING
  • Int'l Joint Research
• [Book] 超高磁場MRIによる脳機能評価の実際 (2020)
  • Author(s): 福永雅喜
  • Total Pages: 4
  • Publisher: 株式会社インナービジョン
  • ISBN: 9784902131901
• [Book] 痛みのバイオマーカーとしての 機能的脳画像診断法 (2020)
  • Author(s): 倉田二郎
  • Total Pages: 384
  • Publisher: 真興交易 医書出版部
  • ISBN: 4880039292