| Project/Area Number |
19K23377
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Multi-year Fund |
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| Review Section |
0110:Psychology and related fields
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Project Period (FY) |
2019-08-30 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2020: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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| Keywords | Associative learning / Pavlovian conditioning / Optogenetics / Memory engram / Fear conditioning / Inferential processes / Learning and Memory / sensory preconditioning / fear conditioning / Sensory preconditioning / Fear memory / Amygdala / Decision Making / Inference |
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| Outline of Research at the Start |
Previous studies used extinction of a specific association
as a behavioral strategy to inhibit a subset of an integrated memory, and see whether or not it is necessary for the
CS1 to provoke a conditioned response. A particular feature of our project lies on the application of pharmacological
and optogenetic manipulation to specifically target and neutralize a subset of an integrated memory, without
thus involving the collateral effect of stimuli interaction.
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| Outline of Final Research Achievements |
After the end of my contract at Hokkaido University School of Medicine (Dpt. Neuropharmacology), my colleagues (Dr. Paul Craddock (Lille University, France) and Dr. Nathan Holmes (New South Wales University, Australia)) and I developed a new model of associative learning and memory based on neurophysiological evidence suggesting that disinhibitory brain mechanisms drive associative learning.
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| Academic Significance and Societal Importance of the Research Achievements |
Understanding mechanisms underlying associative learning is essential when investigating psychiatric diseases. The originality of our work is that it integrates our current understanding of neural disinhibitory mechanisms into a model of associative learning and memory.
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