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Pharmacological and Optogenetic Dissection of Inferentatial Decision Making

Research Project

Project/Area Number 19K23377
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeMulti-year Fund
Review Section 0110:Psychology and related fields
Research InstitutionHokkaido University

Principal Investigator

Bouchekioua Youcef  北海道大学, 医学研究院, 助教 (30843320)

Project Period (FY) 2019-08-30 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2020: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
KeywordsAssociative learning / Pavlovian conditioning / Optogenetics / Memory engram / Fear conditioning / Inferential processes / Learning and Memory / sensory preconditioning / fear conditioning / Sensory preconditioning / Fear memory / Amygdala / Decision Making / Inference
Outline of Research at the Start

Previous studies used extinction of a specific association
as a behavioral strategy to inhibit a subset of an integrated memory, and see whether or not it is necessary for the
CS1 to provoke a conditioned response. A particular feature of our project lies on the application of pharmacological
and optogenetic manipulation to specifically target and neutralize a subset of an integrated memory, without
thus involving the collateral effect of stimuli interaction.

Outline of Final Research Achievements

After the end of my contract at Hokkaido University School of Medicine (Dpt. Neuropharmacology), my colleagues (Dr. Paul Craddock (Lille University, France) and Dr. Nathan Holmes (New South Wales University, Australia)) and I developed a new model of associative learning and memory based on neurophysiological evidence suggesting that disinhibitory brain mechanisms drive associative learning.

Academic Significance and Societal Importance of the Research Achievements

Understanding mechanisms underlying associative learning is essential when investigating psychiatric diseases. The originality of our work is that it integrates our current understanding of neural disinhibitory mechanisms into a model of associative learning and memory.

Report

(3 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • Research Products

    (4 results)

All 2021 2020 2019

All Journal Article (3 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 3 results) Presentation (1 results)

  • [Journal Article] Disruption of model-based decision making by silencing of serotonin neurons in the dorsal raphe nucleus2021

    • Author(s)
      Ohmura Yu、Iwami Kentaro、Chowdhury Srikanta、Sasamori Hitomi、Sugiura Chiaki、Bouchekioua Youcef、Nishitani Naoya、Yamanaka Akihiro、 Yoshioka Mitsuhiro
    • Journal Title

      Current Biology

      Volume: 31 Issue: 11 Pages: 1-9

    • DOI

      10.1016/j.cub.2021.03.048

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Spatial inference without a cognitive map: the role of higher‐order path integration2020

    • Author(s)
      Bouchekioua Youcef、Blaisdell Aaron P.、Kosaki Yutaka、Tsutsui‐Kimura Iku、Craddock Paul、Mimura Masaru、Watanabe Shigeru
    • Journal Title

      Biological Reviews

      Volume: 96 Issue: 1 Pages: 52-65

    • DOI

      10.1111/brv.12645

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Behavioral characteristics of 5-HT2C receptor knockout mice: Locomotor activity, anxiety-, and fear memory-related behaviors2020

    • Author(s)
      Nebuka Mao、Ohmura Yu、Izawa Shuntaro、Bouchekioua Youcef、Nishitani Naoya、Yoshida Takayuki、Yoshioka Mitsuhiro
    • Journal Title

      Behavioural Brain Research

      Volume: 379 Pages: 112394-112394

    • DOI

      10.1016/j.bbr.2019.112394

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] Wireless Optogenetic Device Using μLED implants2019

    • Author(s)
      Youcef Bouchekioua, Yuu Ohmura, Mitsuhiro Yoshioka
    • Organizer
      Optogenetics 2019
    • Related Report
      2019 Research-status Report

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Published: 2019-09-03   Modified: 2025-01-30  

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