Brain-controlled neuroprosthetic for restoration of upper-limb function
| Project/Area Number |
19K23606
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Multi-year Fund |
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| Review Section |
0403:Biomedical engineering and related fields
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2019-08-30 – 2022-03-31
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| Project Status |
Completed (Fiscal Year 2021)
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| Budget Amount *help |
¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | brain-computer interface / neuroprosthetics / upper-limb / rehabilitation / neuroplasticity / neuromodulation / brain-machine interface / neurotechnology |
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| Outline of Research at the Start |
This research program aims to develop an advanced neurotechnology that can use brain signals to control paralyzed hand muscles of individuals with motor impairments by applying electrical stimulation to induce long-term cortical re-organization (neuroplasticity).
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| Outline of Final Research Achievements |
We developed a brain-controlled functional electrical stimulation (FES) system to elucidate the underlying mechanisms of upper limb motor recovery using Hebbian learning. We first tested the brain-controlled FES system and demonstrated that FES rapidly induced corticospinal excitability modulation. We then compared brain-controlled FES using primary motor cortex (M1) with FES using premotor cortex. Our results showed that the M1-based intervention was superior in eliciting corticospinal modulation. In summary, we developed a brain FES system with an accuracy of over 85% using threshold and machine learning methods and tested it. Our results demonstrate that brain control FES can rapidly neuromodulate the excitability of the central nervous system.
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| Academic Significance and Societal Importance of the Research Achievements |
Our research findings elucidated the underlying mechanisms implemented through brain-controlled FES. This can be used in neurorehabilitation practice to rapidly neuromodulate the central nervous system excitability, which could improve motor function after neurological injuries.
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Report
(4 results)
Research Products
(38 results)
