Prospective cohort study for intracranial aneurysm in the Hisayama elderly population based on brain MRI

• Project/Area Number: 19K23971
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Multi-year Fund
• Review Section: 0902:General internal medicine and related fields
• Research Institution: Kyushu University
• Principal Investigator: Furuta Yoshihiko 九州大学, 医学研究院, 助教 (60850005)
• Project Period (FY): 2019-08-30 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000); Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 疫学研究 / コホート研究 / 脳動脈瘤 / 脳卒中 / MRI / 地域一般住民 / 高齢者 / 有病率 / 発症率 / 危険因子 / 脳画像

Outline of Research at the Start

くも膜下出血は脳動脈瘤の破裂を主な原因とし、脳卒中のなかで最も重症度が高い。今後のさらなる高齢化とともに急速に患者数が増加し、社会への負担となることが懸念される。
福岡県久山町では1961年から地域住民を対象とした疫学研究（久山町研究）が継続されており、くも膜下出血を含む心血管病発症の追跡調査を行っている。また2012年と2017年に高齢者の約70%において頭部MRI検査を実施した実績を有する。そこで本研究では頭部MRI検査と追跡調査の成績を用いて、未破裂脳動脈瘤の有病率・危険因子、発症率とその後の破裂リスクの検討を行う。

Outline of Final Research Achievements

The prevalence of intracranial cerebral aneurysms was evaluated in 1,286 Hisayama residents aged 65 and over who underwent head MRI examination in 2012. As a result, a total of 54 cerebral aneurysms were found in 52 subjects, and the prevalence of cerebral aneurysms was 4.0%. The logistic regression analysis showed that women and smoking habits were significant risk factors for cerebral aneurysms.
Then, we examined the cumulative incidence of cerebral aneurysms in 866 people who did not have cerebral aneurysms in 2012 and underwent follow-up MRI examinations in 2017. The development of new cerebral aneurysms was observed in 8 subjects in MRI in 2017, and the cumulative incidence rate at 5 years was 0.92%. Due to the small number of cases with new cerebral aneurysms, it was difficult to investigate risk factors for the development of cerebral aneurysms.

Academic Significance and Societal Importance of the Research Achievements

本研究の結果から、地域一般高齢者における脳動脈瘤の有病率およびその後の発症率が示された。また女性と喫煙習慣が脳動脈瘤保有の危険因子であった。これらの情報はわが国の高齢者における脳動脈瘤・くも膜下出血の病態解明やその予防対策の確立に寄与し、ひいては国民の保健・医療・福祉の向上につながることが期待される。今後、本研究の成果を海外学術誌に報告予定である。

Research Products

• [Int'l Joint Research] King’s College London/Queen Mary University of London(英国)
• [Int'l Joint Research] Medical University of Innsbruck(オーストリア)
• [Journal Article] Development and Validation of a Risk Prediction Model for Atherosclerotic Cardiovascular Disease in Japanese Adults: The Hisayama Study (2022)
  • Author(s): Honda, Takanori; Chen, Sanmei; Hata, Jun; Yoshida, Daigo; Hirakawa, Yoichiro; Furuta, Yoshihiko; Shibata, Mao; Sakata, Satoko; Kitazono, Takanari; Ninomiya, Toshiharu;
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 29 Issue: 3 Pages: 345-361
  • DOI: 10.5551/jat.61960
  • NAID: 130008165681
  • ISSN: 1340-3478, 1880-3873
  • Year and Date: 2022-03-01
  • Peer Reviewed / Open Access
• [Journal Article] Risk Prediction Model for Incident Atrial Fibrillation in a General Japanese Population ― The Hisayama Study ― (2021)
  • Author(s): Hata Jun、Nagata Takuya、Sakata Satoko、Oishi Emi、Furuta Yoshihiko、Hirakawa Yoichiro、Honda Takanori、Yoshida Daigo、Kitazono Takanari、Ninomiya Toshiharu
  • Journal Title: Circulation Journal Volume: 85 Issue: 8 Pages: 1373-1382
  • DOI: 10.1253/circj.CJ-20-0794
  • NAID: 130008066724
  • ISSN: 1346-9843, 1347-4820
  • Year and Date: 2021-07-21
  • Peer Reviewed / Open Access
• [Journal Article] Prevalence and Mortality of Sarcopenia in a Community-dwelling Older Japanese Population: The Hisayama Study (2021)
  • Author(s): Kimitaka Nakamura, Daigo Yoshida, Takanori Honda, Jun Hata, Mao Shibata, Yoichiro Hirakawa, Yoshihiko Furuta, Hiro Kishimoto, Tomoyuki Ohara, Takanari Kitazono, Yasuharu Nakashima, Toshiharu Ninomiya
  • Journal Title: Journal of Epidemiology Volume: 31 Issue: 5 Pages: 320-327
  • DOI: 10.2188/jea.JE20190289
  • NAID: 130008034660
  • ISSN: 0917-5040, 1349-9092
  • Year and Date: 2021-05-05
  • Peer Reviewed / Open Access
• [Journal Article] Current status of the certification of long-term care insurance among individuals with dementia in a Japanese community: The Hisayama Study (2021)
  • Author(s): Ohara, Tomoyuki; Yoshida, Daigo; Hata, Jun; Shibata, Mao; Honda, Takanori; Furuta, Yoshihiko; Hirabayashi, Naoki; Kitazono, Takanari; Nakao, Tomohiro; Ninomiya, Toshiharu;
  • Journal Title: Psychiatry and clinical neurosciences Volume: - Issue: 5 Pages: 182-182
  • DOI: 10.1111/pcn.13204
  • Peer Reviewed / Open Access
• [Journal Article] High serum folate concentrations are associated with decreased risk of mortality among Japanese adults (2021)
  • Author(s): Sanmei Chen, Takanori Honda, Jun Hata, Satoko Sakata, Yoshihiko Furuta, Daigo Yoshida, Mao Shibata, Tomoyuki Ohara, Yoichiro Hirakawa, Emi Oishi, Takanari Kitazono, Toshiharu Ninomiya
  • Journal Title: The Journal of Nutrition Volume: 151 Issue: 3 Pages: 657-665
  • DOI: 10.1093/jn/nxaa382
  • Peer Reviewed / Open Access
• [Journal Article] Midlife and late-life diabetes and sarcopenia in a general older Japanese population: the Hisayama Study (2021)
  • Author(s): Kimitaka Nakamura, Daigo Yoshida, Takanori Honda, Jun Hata, Mao Shibata, Yoichiro Hirakawa, Yoshihiko Furuta, Hiro Kishimoto, Tomoyuki Ohara, Sanmei Chen, Takanari Kitazono, Yasuharu Nakashima, Toshiharu Ninomiya
  • Journal Title: J Diabetes Investig Volume: in press Issue: 10 Pages: 1-26
  • DOI: 10.1111/jdi.13550
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Association of Albuminuria With White Matter Hyperintensities Volume on Brain Magnetic Resonance Imaging in Elderly Japanese ― The Hisayama Study ― (2020)
  • Author(s): Yamasaki Keisuke、Hata Jun、Furuta Yoshihiko、Hirabayashi Naoki、Ohara Tomoyuki、Yoshida Daigo、Hirakawa Yoichiro、Nakano Toshiaki、Kitazono Takanari、Ninomiya Toshiharu
  • Journal Title: Circulation Journal Volume: 84 Issue: 6 Pages: 935-942
  • DOI: 10.1253/circj.CJ-19-1069
  • NAID: 130007846238
  • ISSN: 1346-9843, 1347-4820
  • Year and Date: 2020-05-25
  • Peer Reviewed / Open Access
• [Journal Article] Influence of the accumulation of unhealthy eating habits on obesity in a general Japanese population: the Hisayama Study. (2020)
  • Author(s): Ishida Y, Yoshida D, Honda T, Hirakawa Y, Shibata M, Sakata S, Furuta Y, Oishi E, Hata J, Kitazozno T, Ninomiya T
  • Journal Title: Nutrients Volume: 12 Issue: 10 Pages: 3160-3160
  • DOI: 10.3390/nu12103160
  • Peer Reviewed / Open Access
• [Journal Article] Serum N-terminal pro-B-type natriuretic peptide as a predictor for future development of atrial fibrillation in a general population: the Hisayama Study (2020)
  • Author(s): Nagata Takuya、Hata Jun、Sakata Satoko、Oishi Emi、Honda Takanori、Furuta Yoshihiko、Ohara Tomoyuki、Yoshida Daigo、Hirakawa Yoichiro、Shibata Mao、Ide Tomomi、Kitazono Takanari、Tsutsui Hiroyuki、Ninomiya Toshiharu
  • Journal Title: International Journal of Cardiology Volume: 320 Pages: 90-96
  • DOI: 10.1016/j.ijcard.2020.06.018
  • Peer Reviewed
• [Journal Article] Serum homocysteine and risk of dementia in Japan (2020)
  • Author(s): Chen Sanmei、Honda Takanori、Ohara Tomoyuki、Hata Jun、Hirakawa Yoichiro、Yoshida Daigo、Shibata Mao、Sakata Satoko、Oishi Emi、Furuta Yoshihiko、Kitazono Takanari、Ninomiya Toshiharu
  • Journal Title: Journal of Neurology, Neurosurgery & Psychiatry Volume: 91 Issue: 5 Pages: 540-546
  • DOI: 10.1136/jnnp-2019-322366
  • Peer Reviewed / Open Access
• [Journal Article] Elevated serum glycated albumin and glycated albumin to hemoglobin A1c ratio were associated with hippocampal atrophy in a general elderly population of Japanese: the Hisayama Study. (2020)
  • Author(s): Ohara Tomoyuki、Furuta Yoshihiko、Hirabayashi Naoki、Hata Jun、Hirakawa Yoichiro、Honda Takanori、Yoshida Daigo、Shibata Mao、Kitazono Takanari、Ninomiya Toshiharu
  • Journal Title: Journal of Diabetes Investigation Volume: - Issue: 4 Pages: 971-979
  • DOI: 10.1111/jdi.13220
  • Peer Reviewed / Open Access
• [Journal Article] Lifetime cumulative incidence of dementia in a community-dwelling elderly population in Japan (2020)
  • Author(s): Yoshida, Daigo; Ohara, Tomoyuki; Hata, Jun; Shibata, Mao; Hirakawa, Yoichiro; Honda, Takanori; Furuta, Yoshihiko; Oishi, Emi; Sakata, Satoko; Kanba, Shigenobu;
  • Journal Title: Neurology Volume: 95 Issue: 5
  • DOI: 10.1212/wnl.0000000000009917
  • Peer Reviewed / Open Access
• [Presentation] Association of serum folate and vitamin B-12 concentrations with all-cause mortality: the Hisayama Study. (2021)
  • Author(s): Chen S, Honda T, Hata J, Sakata S, Furuta Y, Yoshida D, Shibata M, Ohara T, Hirakawa Y, Oishi E, Kitazono T, Ninomiya T
  • Organizer: 第31回日本疫学会学術総会
• [Presentation] 動脈硬化性心血管疾患発症リスク予測モデルの開発：久山町研究． (2021)
  • Author(s): 本田貴紀、陳三妹、秦 淳、吉田大悟、平川洋一郎、古田芳彦、柴田舞欧、坂田智子、北園孝成、二宮利治
  • Organizer: 第31回日本疫学会学術総会
• [Presentation] 脳卒中の疫学 (2021)
  • Author(s): 古田芳彦
  • Organizer: 第46回日本脳卒中学会学術集会
• [Presentation] 脳卒中初発後の再発率・死亡率の時代的推移: 久山町研究 (2021)
  • Author(s): 中西泰之，秦淳，古田芳彦，吉田大悟，本田貴紀， 脇坂義信，吾郷哲朗，北園孝成，二宮利治
  • Organizer: 第46回日本脳卒中学会学術集会
• [Presentation] 認知症発症リスク予測モデルの開発：久山町研究． (2020)
  • Author(s): 本田貴紀、小原知之、吉田大悟、平川洋一郎、石田有紀、古田芳彦、大石絵美、坂田智子、柴田舞欧、秦 淳、北園孝成、二宮利治
  • Organizer: 第30回日本疫学会学術総会
• [Presentation] 地域一般住民における尿中NT-proBNPと心血管病の発症の関連：久山町研究． (2020)
  • Author(s): 山﨑景介、秦 淳、平川洋一郎、坂田智子、古田芳彦、北園孝成、二宮利治
  • Organizer: 第45回日本脳卒中学会学術集会
• [Presentation] Albuminuria is a biomarker for severity of white matter hyperintensities on brain MRI in a general elderly population of Japanese: the Hisayama Study. (2019)
  • Author(s): Yamasaki K, Hata J, Hirabayashi N, Furuta Y, Ohara T, Hirakawa Y, Nakano T, Kitazono T, Ninomiya T
  • Organizer: ASN Kidney Week 2019
  • Int'l Joint Research