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Extracting characteristics of older adults living in the community for tailored intervention to prevent dementia

Research Project

Project/Area Number 19K24188
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeMulti-year Fund
Review Section 0908:Society medicine, nursing, and related fields
Research InstitutionNational Center for Geriatrics and Gerontology

Principal Investigator

Katayama Osamu  国立研究開発法人国立長寿医療研究センター, 老年学・社会科学研究センター, 研究員 (60845999)

Project Period (FY) 2019-08-30 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords軽度認知障害 / ライフスタイル / 認知症 / 危険因子 / ライフスタイル活動 / 高齢者 / 認知症予防 / 潜在クラス分析
Outline of Research at the Start

軽度認知障害(MCI)の全てが認知症へと進展するわけではなく、正常の認知機能へ戻る場合もあることが明らかになった。認知症の危険因子には糖尿病、高血圧、肥満、身体不活動といった可変的因子が含まれ、これらの複数の因子に同時介入することが認知症予防に有効であることが示された。ただし、個人がこれらの危険因子を全て有するわけではないため、テーラード介入が望ましい。そこで本研究では、地域在住高齢者でMCIと判断されたが、その後の追跡調査において正常な認知機能へリバートした高齢者を対象に認知症の危険因子や活動の変化のパターンを潜在クラス分析を用いて個々人の特徴に基づいて分類することを目的とする。

Outline of Final Research Achievements

We determined the changes in lifestyle activity patterns and patterns of possessing modifiable risk factors of dementia among older adults with mild cognitive impairment (MCI). The reverters maintained multidomain lifestyle activities, converters discontinued multidomain lifestyle activities or were inactive, and maintainers maintained productive activities. The possession patterns of modifiable risk factors among the older adults with MCI were classified into five patterns: low risk, psychosocial, health behavior, educational, and smoking factors. According to the logistic regression analysis, the activity patterns of those who continued to engage in multidomain lifestyle activities and start activities, were more likely to help in reverting from MCI to normal cognition.

Academic Significance and Societal Importance of the Research Achievements

MCIを有する高齢者のライフスタイル活動パターンや認知症の修正可能な危険因子の保有パターンと正常な認知機能への回復との関連を明らかにしたことが学術的意義といえる。本研究成果の社会的意義は、臨床医をはじめとするMCIを有する高齢者に関わる者が日々の診療等で高齢者のライフスタイル活動パターンや認知症の修正可能な危険因子の保有パターンを評価し、高齢者中心のテーラード介入を実践することがMCI者の認知機能の回復につながる可能性があることを示唆したことといえる。

Report

(3 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • Research Products

    (12 results)

All 2021 2020 2019

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Open Access: 2 results) Presentation (8 results) (of which Int'l Joint Research: 4 results)

  • [Journal Article] Lifestyle changes and outcomes of older adults with mild cognitive impairment: A 4-year longitudinal study2021

    • Author(s)
      Katayama Osamu、Lee Sangyoon、Bae Seongryu、Makino Keitaro、Shinkai Yohei、Chiba Ippei、Harada Kenji、Shimada Hiroyuki
    • Journal Title

      Archives of Gerontology and Geriatrics

      Volume: 94 Pages: 104376-104376

    • DOI

      10.1016/j.archger.2021.104376

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lifestyle Activity Patterns Related to Physical Frailty and Cognitive Impairment in Urban Community-Dwelling Older Adults in Japan2021

    • Author(s)
      Katayama Osamu、Lee Sangyoon、Bae Seongryu、Makino Keitaro、Shinkai Yohei、Chiba Ippei、Harada Kenji、Shimada Hiroyuki
    • Journal Title

      Journal of the American Medical Directors Association

      Volume: 22 Issue: 3 Pages: 583-589

    • DOI

      10.1016/j.jamda.2020.05.031

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Modifiable Risk Factor Possession Patterns of Dementia in Elderly with MCI: A 4-Year Repeated Measures Study2020

    • Author(s)
      Katayama O, Lee S, Bae S, Makino K, Shinkai Y, Chiba I, Harada K, Shimada H.
    • Journal Title

      J Clin Med

      Volume: 9 Issue: 4 Pages: 1076-1076

    • DOI

      10.3390/jcm9041076

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Association between Neighborhood Amenities and Cognitive Function: Role of Lifestyle Activities2020

    • Author(s)
      Katayama O, Lee S, Makino K, Chiba I, Bae S, Shinkai Y, Harada K, Shimada H
    • Journal Title

      Journal of Clinical Medicine

      Volume: 9 Issue: 7 Pages: 2109-2109

    • DOI

      10.3390/jcm9072109

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Modifiable risk factor possession patterns of dementia in elderly with mild cognitive impairment: A 4-year longitudinal study2020

    • Author(s)
      Katayama Osamu、Lee Sangyoon、Bae Seongryu、Makino Keitaro、Shinkai Yohei、Chiba Ippei、Harada Kenji、Shimada Hiroyuki
    • Organizer
      AAIC (Amsterdam; virtual conference)
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Detection of cognitive frailty subtypes and relations with clinical characteristics: A Latent Class Analysis2020

    • Author(s)
      Katayama Osamu、Lee Sangyoon、Bae Seongryu、Makino Keitaro、Shinkai Yohei、Chiba Ippei、Harada Kenji、Shimada Hiroyuki
    • Organizer
      International Conference on Frailty and Sarcopenia Research ICFSR (France)
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 日常生活活動が新規要介護発生に及ぼす影響は自宅近隣の施設資源の豊かさにより異なる2020

    • Author(s)
      片山 脩、李 相侖、裵 成琉、牧野 圭太郎、千葉 一平、原田 健次、新海 陽平、島田 裕之
    • Organizer
      第7回日本地域理学療法学会学術大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 自宅近隣の施設資源の豊かさの違いによるライフスタイル活動の実施状況と認知機能との関係2020

    • Author(s)
      片山脩、李相侖、牧野圭太郎、千葉一平、裵成琉、原田健次、新海陽平、島田裕之
    • Organizer
      第7回日本予防理学療法学会学術大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 地域在住高齢者のライフスタイル活動パターンの抽出 -フレイルのタイプに着目した検討-2020

    • Author(s)
      片山脩、李相侖、裵成琉、牧野圭太郎、新海陽平、千葉一平、原田健次、島田裕之
    • Organizer
      第62回日本老年医学会学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Detection of cognitive frailty subtypes and relations with clinical characteristics: A Latent Class Analysis2020

    • Author(s)
      Osamu Katayama, Sangyoon Lee, Seongryu Bae, Keitaro Makino, Yohei Shinkai, Ippei Chiba, Kenji Harada, Hiroyuki Shimada
    • Organizer
      International Conference on Frailty & Sarcopenia Research ( ICFSR)
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Modifiable risk factor possession patterns of dementia in elderly with mild cognitive impairment: A 4-year longitudinal study2020

    • Author(s)
      Osamu Katayama, Sangyoon Lee, Seongryu Bae, Keitaro Makino, Yohei Shinkai, Ippei Chiba, Kenji Harada, Hiroyuki Shimada
    • Organizer
      Alzheimer's Association International Conference 2020 (AAIC)
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] 正常な認知機能に回復した軽度認知障害(MCI) を有する高齢者のライフスタイルの経時的変化パターンの分類2019

    • Author(s)
      片山脩、李相侖、裵成琉、牧野圭太郎、千葉一平、新海陽平、原田健次、島田裕之
    • Organizer
      日本認知症予防学会
    • Related Report
      2019 Research-status Report

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Published: 2019-09-03   Modified: 2022-01-27  

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