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Incontinence-associated dermatitis by infected urine: biological mechanisms and prevention strategies

Research Project

Project/Area Number 19K24194
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeMulti-year Fund
Review Section 0908:Society medicine, nursing, and related fields
Research InstitutionThe University of Tokyo

Principal Investigator

Koudounas Sofoklis  東京大学, 大学院医学系研究科(医学部), 特任助教 (70849968)

Project Period (FY) 2019-08-30 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
KeywordsIAD / skin barrier / incontinence / older patients / infected urine / urinary-incontinence / dermatitis / bacteria / rat
Outline of Research at the Start

IAD is a painful complication among elderly patients, leading to a reduced quality of life. Physiological urine does not lead to the development of IAD; however, infected urine is severely irritating and increases the risk of skin damage. How infected urine leads to the development of IAD has never been investigated. Therefore, this study aims to elucidate the histopathological/molecular mechanisms of IAD caused by infected urine in order to develop new nursing interventions for complete prevention of IAD and ultimately improve the patients’ quality of life.

Outline of Final Research Achievements

Therefore, in the next step I wanted to develop a novel animal model for IAD by combing urine and bacteria. My studies showed that bacteria on damaged skin, have the ability to invade the epidermis and this induces IAD which is characterized by skin barrier disruption, inflammation and persistent redness. I have presented my research findings at national and international conferences and received the Young Investigator award by the Japanese Society for Wound Healing.

Academic Significance and Societal Importance of the Research Achievements

My research findings are important for the development of new innovative prevention/treatment strategies for IAD. The animal model I have established can serve as the basis for future studies to test the effectiveness of novel strategies to prevent the development of IAD.

Report

(4 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (10 results)

All 2021 2020 2019 Other

All Journal Article (2 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 2 results,  Open Access: 2 results) Presentation (5 results) Remarks (3 results)

  • [Journal Article] Inhibiting effect of synthetic urine on the growth and mobility of <i>Pseudomonas aeruginosa</i>, <i>Escherichia coli</i>, <i>Proteus mirabilis</i> and <i>Klebsiella pneumoniae</i> shifts to a promoting effect during culture2021

    • Author(s)
      Sofoklis Koudounas , Takeo Minematsu , Yuko Mugida , Sanae Tomita , Ayano Nakai , Gojiro Nakagami and Hiromi Sanada
    • Journal Title

      Journal of Nursing Science and Engineering

      Volume: 8 Issue: 0 Pages: 220-229

    • DOI

      10.24462/jnse.8.0_220

    • NAID

      130008081322

    • ISSN
      2188-4323, 2432-6283
    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Does the presence of bacterial urinary infection contribute to the development of incontinence-associated dermatitis? A scoping review2021

    • Author(s)
      Sofoklis Koudounas, Yuko Mugita, Takeo Minematsu, Gojiro Nakagami, Carolina Weller, Hiromi Sanada
    • Journal Title

      Journal of Tissue Viability

      Volume: 30 Issue: 2 Pages: 256-261

    • DOI

      10.1016/j.jtv.2021.01.008

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Development of a rat model for incontinence-associated dermatitis in patients with urinary infections2021

    • Author(s)
      Sofoklis Koudounas, Takeo Minematsu, Yuko Mugita, Gojiro Nakagami and Hiromi Sanada
    • Organizer
      ‘Beyond Borders’-The 51st Annual Meeting of Japanese Society for Wound Healing
    • Related Report
      2021 Annual Research Report
  • [Presentation] Development of a rat model for incontinence-associated dermatitis in patients with urinary-infections2021

    • Author(s)
      Koudounas S, Minematsu T, Mugita Y, Nakagami G, Sanada H
    • Organizer
      The 9th Asia Pacific Enterostomal Therapy Nurse Association Conference
    • Related Report
      2021 Annual Research Report
  • [Presentation] Does the presence of bacterial urinary infection contribute to the development of incontinence-associated dermatitis? A scoping review2021

    • Author(s)
      Koudounas S, Mugita Y, Minematsu T, Nakagami G, Weller C, Sanada H
    • Organizer
      The 9th Asia Pacific Enterostomal Therapy Nurse Association Conference
    • Related Report
      2021 Annual Research Report
  • [Presentation] Development of an in vitro model of urinary infections to study the mechanisms leading to incontinence-associated dermatitis in patients with urinary incontinence2020

    • Author(s)
      Sofoklis Koudounas, Takeo Minematsu, Gojiro Nakagami, Yuko Mugita, Sanai Tomida, Hiromi Sanada
    • Organizer
      8th conference of the Japanese Society for Nursing Science and Engineering
    • Related Report
      2020 Research-status Report
  • [Presentation] The effects of urine on bacterial growth and motility: Implications in the development of incontinence-associated dermatitis2019

    • Author(s)
      Sofoklis Koudounas, Yuko Mugita, Takeo Minematsu, Gojiro Nakagami, Sanai Tomida, Hiromi Sanada
    • Organizer
      49th Japanese Society for Wound Healing
    • Related Report
      2019 Research-status Report
  • [Remarks] Department of Skincare Science

    • URL

      http://skincarescience.m.u-tokyo.ac.jp

    • Related Report
      2020 Research-status Report
  • [Remarks] Global Nursing Research Center

    • URL

      http://gnrc.m.u-tokyo.ac.jp/

    • Related Report
      2020 Research-status Report
  • [Remarks] Global Nursing Research Center, Univ Tokyo

    • URL

      http://gnrc.m.u-tokyo.ac.jp/

    • Related Report
      2019 Research-status Report

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Published: 2019-09-03   Modified: 2023-01-30  

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