Incontinence-associated dermatitis by infected urine: biological mechanisms and prevention strategies
| Project/Area Number |
19K24194
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Multi-year Fund |
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| Review Section |
0908:Society medicine, nursing, and related fields
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Koudounas Sofoklis 東京大学, 大学院医学系研究科(医学部), 特任助教 (70849968)
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| Project Period (FY) |
2019-08-30 – 2022-03-31
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| Project Status |
Completed (Fiscal Year 2021)
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| Budget Amount *help |
¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | IAD / skin barrier / incontinence / older patients / infected urine / urinary-incontinence / dermatitis / bacteria / rat |
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| Outline of Research at the Start |
IAD is a painful complication among elderly patients, leading to a reduced quality of life. Physiological urine does not lead to the development of IAD; however, infected urine is severely irritating and increases the risk of skin damage. How infected urine leads to the development of IAD has never been investigated. Therefore, this study aims to elucidate the histopathological/molecular mechanisms of IAD caused by infected urine in order to develop new nursing interventions for complete prevention of IAD and ultimately improve the patients’ quality of life.
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| Outline of Final Research Achievements |
Therefore, in the next step I wanted to develop a novel animal model for IAD by combing urine and bacteria. My studies showed that bacteria on damaged skin, have the ability to invade the epidermis and this induces IAD which is characterized by skin barrier disruption, inflammation and persistent redness. I have presented my research findings at national and international conferences and received the Young Investigator award by the Japanese Society for Wound Healing.
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| Academic Significance and Societal Importance of the Research Achievements |
My research findings are important for the development of new innovative prevention/treatment strategies for IAD. The animal model I have established can serve as the basis for future studies to test the effectiveness of novel strategies to prevent the development of IAD.
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Report
(4 results)
Research Products
(10 results)
