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Sex-specific impacts of gene and environmental factors on diabetic complications

Research Project

Project/Area Number 19K24229
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeMulti-year Fund
Review Section 0908:Society medicine, nursing, and related fields
Research InstitutionKyushu University

Principal Investigator

Toshiaki Ohkuma  九州大学, 大学病院, 助教 (20709258)

Project Period (FY) 2019-08-30 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords糖尿病 / コホート研究 / 性差 / コホート
Outline of Research at the Start

近年、糖尿病合併症の発症、進展における性差が明らかとなり、性差医療、性差医学の推進の必要性が指摘されている。合併症の環境要因、遺伝要因には人種差があるが、過去のエビデンスは欧米人に基づくものが大半で、我が国において合併症とその危険因子の影響の性差を明らかにした研究は稀である。
そこで本研究では、5000人を超える日本人糖尿病患者のゲノムコホート研究において、環境因子、遺伝因子、発症した合併症の情報などを統合したデータベースを構築し、糖尿病合併症発症率の性差、及び環境因子、遺伝因子の性特異的影響を明らかにすることを目的とする。

Outline of Final Research Achievements

Although sex differences in the incidence of diabetic complications have been observed mainly in Western countries, few studies have examined this issue in Japan. We therefore constructed genomic cohort study comprising 5131 Japanese patients with diabetes attending diabetes centers in Fukuoka Prefecture. In this study, we investigated sex differences in the incidence of diabetic complications, and sex-specific associations of environmental and genetic factors with diabetic complications and its risk factors.

Academic Significance and Societal Importance of the Research Achievements

本研究の成果により、糖尿病患者の死亡率や糖尿病合併症の発症率に性差があることや、合併症の危険因子が合併症の発症に及ぼす影響にも性差があることが示された。このように、我が国の糖尿病患者の大規模コホートをもとにしたエビデンスにより、我が国における性差医学・医療の推進・発展に貢献することができると考える。

Report

(3 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • Research Products

    (5 results)

All 2021 2020

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Open Access: 2 results) Presentation (1 results)

  • [Journal Article] Defecation frequency and glycemic control in patients with diabetes: The Fukuoka Diabetes Registry2021

    • Author(s)
      Ohkuma Toshiaki、Iwase Masanori、Fujii Hiroki、Ide Hitoshi、Komorita Yuji、Yoshinari Masahito、Oku Yutaro、Higashi Taiki、Nakamura Udai、Kitazono Takanari
    • Journal Title

      Journal of Diabetes and its Complications

      Volume: 35 Issue: 2 Pages: 107751-107751

    • DOI

      10.1016/j.jdiacomp.2020.107751

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Incidence of stroke and its association with glycemic control and lifestyle in Japanese patients with type 2 diabetes mellitus: The Fukuoka diabetes registry2021

    • Author(s)
      Iwase Masanori、Komorita Yuji、Ohkuma Toshiaki、Fujii Hiroki、Ide Hitoshi、Yoshinari Masahito、Oku Yutaro、Higashi Taiki、Nakamura Udai、Kitazono Takanari
    • Journal Title

      Diabetes Research and Clinical Practice

      Volume: 172 Pages: 108518-108518

    • DOI

      10.1016/j.diabres.2020.108518

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Additive effects of green tea and coffee on all-cause mortality in patients with type 2 diabetes mellitus: the Fukuoka Diabetes Registry2020

    • Author(s)
      Komorita Y, Iwase M, Fujii H, Ohkuma T, Ide H, Yoshinari M, Oku Y, Nakamura U, Kitazono T
    • Journal Title

      BMJ Open Diabetes Research & Care

      Volume: 8 Issue: 1 Pages: e001252-e001252

    • DOI

      10.1136/bmjdrc-2020-001252

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Incidence of severe hypoglycemia and its association with serum adiponectin in Japanese patients with type 1 and insulin-treated type 2 diabetes: The Fukuoka Diabetes Registry2020

    • Author(s)
      Iwase M, Komorita Y, Fujii H, Ohkuma T, Ide H, Yoshinari M, Oku Y, Higashi T, Nakamura U, Kitazono T
    • Journal Title

      J Diabetes Investig

      Volume: - Issue: 5 Pages: 1258-1264

    • DOI

      10.1111/jdi.13253

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 2型糖尿病患者においてコーヒーや緑茶の摂取は死亡リスクの低下と関連する :福岡県糖尿病患者データベース研究2020

    • Author(s)
      小森田祐二,岩瀬正典,藤井裕樹,大隈俊明,井手均,吉成匡人,於久祐太郎,東大 樹,北村環,佐々木伸浩,佐藤雄一,五島大祐,井元博文,野原栄,南昌江,和田美也,横溝由史,菊池正統,野見山理久,中村晋,田代憲司,吉成元孝,市川晃治郎,大星博明,中村宇大,北園孝成
    • Organizer
      第63回日本糖尿病学会年次学術集会
    • Related Report
      2020 Annual Research Report

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Published: 2019-09-03   Modified: 2022-01-27  

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