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心血管形成と代謝環境

Research Project

Project/Area Number 19K24689
Research Category

Fund for the Promotion of Joint International Research (Home-Returning Researcher Development Research)

Allocation TypeMulti-year Fund
Review Section Biological Sciences
Research InstitutionJikei University School of Medicine

Principal Investigator

中野 敦  東京慈恵会医科大学, 医学部, 教授 (10504368)

Project Period (FY) 2021-03-12 – 2025-03-31
Project Status Granted (Fiscal Year 2023)
Budget Amount *help
¥56,030,000 (Direct Cost: ¥43,100,000、Indirect Cost: ¥12,930,000)
Keywords心臓発生 / 心臓代謝 / 胎生期造血 / 心筋リモデリング / 代謝 / マクロファージ / 造血 / 高血糖 / 心血管発生 / 代謝環境 / 心内膜造血 / レチノイン酸代謝 / 心血管リモデリング
Outline of Annual Research Achievements

2023年には、原著論文3報、総説1報、コメンタリー1報を発表し、講演を2回行った。
1.Nakano H and Nakano A. Curr Top Dev Biol. 2024. Review 2.Perez-Ramirez CA, et al. Cell. 2024;187:204-215 3 Nakano A and Liu N, Dev Cell. 2023:1513-1514. Commentary 4.Liu N, et al. Nat Commun. 2023. 5.Liu N, et al. Aging (Albany NY). 2023;15:4035-4050.PMC10258037

Current Status of Research Progress
Current Status of Research Progress

4: Progress in research has been delayed.

Reason

論文としては、Cell, Nat Communをはじめ3年間で10報と満足のいく結果であったが、これが次の科研費の取得につながっておらず、ここで研究が中断されるという点で、遅れていると言わざるを得ない。

Strategy for Future Research Activity

研究を推進するためには科研費の獲得が喫緊の課題である。

Report

(3 results)
  • 2023 Research-status Report
  • 2022 Research-status Report
  • 2021 Research-status Report
  • Research Products

    (16 results)

All 2024 2023 2022 2021 Other

All Int'l Joint Research (4 results) Journal Article (5 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 5 results,  Open Access: 5 results) Presentation (6 results) (of which Int'l Joint Research: 4 results,  Invited: 4 results) Funded Workshop (1 results)

  • [Int'l Joint Research] UCLA/Stanford University/U Oklahoma(米国)

    • Related Report
      2023 Research-status Report
  • [Int'l Joint Research] Pontificia Universidad(チリ)

    • Related Report
      2023 Research-status Report
  • [Int'l Joint Research] UCLA(米国)

    • Related Report
      2022 Research-status Report
  • [Int'l Joint Research] Stanford University/UCLA(米国)

    • Related Report
      2021 Research-status Report
  • [Journal Article] Atlas of fetal metabolism during mid-to-late gestation and diabetic pregnancy2024

    • Author(s)
      Perez-Ramirez Cesar A.、Nakano Haruko、Law Richard C.、Matulionis Nedas、Thompson Jennifer、Pfeiffer Andrew、Park Junyoung O.、Nakano Atsushi、Christofk Heather R.
    • Journal Title

      Cell

      Volume: 187 Issue: 1 Pages: 204-215.e14

    • DOI

      10.1016/j.cell.2023.11.011

    • Related Report
      2023 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The role of metabolism in cardiac development2024

    • Author(s)
      Nakano Haruko、Nakano Atsushi
    • Journal Title

      Curr Top Dev Biol

      Volume: 156 Pages: 201-243

    • DOI

      10.1016/bs.ctdb.2024.01.005

    • ISBN
      9780128232972
    • Related Report
      2023 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Response to Matters Arising: Intercellular genetic tracing of cardiac endothelium in the developing heart2023

    • Author(s)
      Nakano Atsushi、Liu Norika
    • Journal Title

      Developmental Cell

      Volume: 58 Issue: 16 Pages: 1513-1514

    • DOI

      10.1016/j.devcel.2023.05.020

    • Related Report
      2023 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Notch and retinoic acid signals regulate macrophage formation from endocardium downstream of Nkx2-52023

    • Author(s)
      Liu Norika、Kawahira Naofumi、Nakashima Yasuhiro、Nakano Haruko、Iwase Akiyasu、Uchijima Yasunobu、Wang Mei、Wu Sean M.、Minamisawa Susumu、Kurihara Hiroki、Nakano Atsushi
    • Journal Title

      Nature Communications

      Volume: 14 Issue: 1 Pages: 5398-5398

    • DOI

      10.1038/s41467-023-41039-6

    • Related Report
      2023 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Changes in macrophage immunometabolism as a marker of skeletal muscle dysfunction across the lifespan2023

    • Author(s)
      Liu Norika、Butcher Joshua T.、Nakano Atsushi、del Campo Andrea
    • Journal Title

      Aging

      Volume: 15 Issue: 10 Pages: 4035-4050

    • DOI

      10.18632/aging.204750

    • Related Report
      2023 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Pathophysiology of diabetic embryopathy2024

    • Author(s)
      Atsushi Nakano
    • Organizer
      第101回日本生理学会
    • Related Report
      2023 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 心内膜造血の発見とその意義2023

    • Author(s)
      中野 敦
    • Organizer
      ISHR
    • Related Report
      2023 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 心内膜造血におけるNotchシグナルの役割2022

    • Author(s)
      劉孟佳
    • Organizer
      第100回日本生理学会
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] Abnormal nucleotide nucleotide metabolism in the embryonic heart of the diabetic pregnancy causes mitochondrial dysfunction via AMPK2022

    • Author(s)
      中野 治子
    • Organizer
      Weinstein Cardiovascular Conference
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] 心内膜造血とその役割2021

    • Author(s)
      中野 敦
    • Organizer
      第20回日本心臓発生研究会
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] 心内膜造血におけるNotchシグナルの役割2021

    • Author(s)
      劉孟佳
    • Organizer
      第67回宇宙医学研究会
    • Related Report
      2021 Research-status Report
    • Invited
  • [Funded Workshop] The JIKEI Cardiovascular Research Symposium2023

    • Related Report
      2022 Research-status Report

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Published: 2020-03-25   Modified: 2024-12-25  

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